{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:12:21Z","timestamp":1791821541322,"version":"4.3.4"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1038\/ajg.2016.481","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T08:02:33Z","timestamp":1479196953000},"page":"95-101","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Long-Term Proton Pump Inhibitor Use Is Not Associated With Changes in Bone Strength and Structure"],"prefix":"10.14309","volume":"112","author":[{"given":"Laura E","family":"Targownik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L","family":"Goertzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhua","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-22-20210210","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1053\/j.gastro.2008.08.044","article-title":"American Gastroenterological Association Institute technical review on the management of gastroesophageal reflux disease.","volume":"135","author":"Kahrilas","year":"2008","journal-title":"Gastroenterology"},{"key":"R2-22-20210210","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/ajg.2012.444","article-title":"Guidelines for the diagnosis and management of gastroesophageal reflux disease.","volume":"108","author":"Katz","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"R3-22-20210210","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2036.2008.03905.x","article-title":"Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: benefits versus risks.","volume":"29","author":"Rostom","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"R5-22-20210210","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12916-015-0285-8","article-title":"Safe prescribing of non-steroidal anti-inflammatory drugs in patients with osteoarthritis-an expert consensus addressing benefits as well as gastrointestinal and cardiovascular risks.","volume":"13","author":"Scarpignato","year":"2015","journal-title":"BMC Med"},{"key":"R6-22-20210210","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1001\/jamainternmed.2015.42","article-title":"Continuous proton pump inhibitor therapy and the associated risk of recurrent clostridium difficile infection.","volume":"175","author":"McDonald","year":"2015","journal-title":"JAMA Intern Med"},{"key":"R7-22-20210210","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1136\/gutjnl-2013-304738","article-title":"Proton pump inhibitors and the risk of hospitalisation for community-acquired pneumonia: replicated cohort studies with meta-analysis.","volume":"63","author":"Filion","year":"2013","journal-title":"Gut"},{"key":"R8-22-20210210","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1053\/j.ajkd.2010.03.013","article-title":"Severe hypomagnesemia during long-term treatment with a proton pump inhibitor.","volume":"56","author":"Regolisti","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"R9-22-20210210","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1001\/jamaneurol.2015.4791","article-title":"Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis.","volume":"73","author":"Gomm","year":"2016","journal-title":"JAMA Neurol"},{"key":"R10-22-20210210","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1503\/cmaj.071330","article-title":"Use of proton pump inhibitors and risk of osteoporosis-related fractures.","volume":"179","author":"Targownik","year":"2008","journal-title":"CMAJ"},{"key":"R11-22-20210210","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1001\/jama.296.24.2947","article-title":"Long-term proton pump inhibitor therapy and risk of hip fracture.","volume":"296","author":"Yang","year":"2006","journal-title":"JAMA"},{"key":"R12-22-20210210","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00198-012-2112-9","article-title":"The effect of proton pump inhibitors on fracture risk: report from the Canadian Multicenter Osteoporosis Study.","volume":"24","author":"Fraser","year":"2013","journal-title":"Osteoporos Int"},{"key":"R13-22-20210210","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.amjmed.2011.01.007","article-title":"Proton pump inhibitors and risk of fractures: a meta-analysis of 11 international studies.","volume":"124","author":"Yu","year":"2011","journal-title":"Am J Med"},{"key":"R14-22-20210210","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/ajg.2011.113","article-title":"Proton pump inhibitors and risk of fracture: a systematic review and meta-analysis of observational studies.","volume":"106","author":"Ngamruengphong","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"R15-22-20210210","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00198-015-3365-x","article-title":"Proton-pump inhibitors and risk of fractures: an update meta-analysis.","volume":"27","author":"Zhou","year":"2016","journal-title":"Osteoporos Int"},{"key":"R16-22-20210210","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/archinternmed.2010.94","article-title":"Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women: results from the Womens Health Initiative.","volume":"170","author":"Gray","year":"2010","journal-title":"Arch Intern Med"},{"key":"R17-22-20210210","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1053\/j.gastro.2009.11.014","article-title":"Proton pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss.","volume":"138","author":"Targownik","year":"2010","journal-title":"Gastroenterology"},{"key":"R18-22-20210210","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/ajg.2012.200","article-title":"The relationship between proton pump inhibitor use and longitudinal change in bone mineral density: a population-based study corrected from the Canadian Multicentre Osteoporosis Study (CaMos).","volume":"107","author":"Targownik","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"R19-22-20210210","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF01352010","article-title":"Effect of omeprazole, an inhibitor of H,K()-ATPase, on bone resorption in humans.","volume":"53","author":"Mizunashi","year":"1993","journal-title":"Calcif Tissue Int"},{"key":"R20-22-20210210","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1111\/febs.12478","article-title":"Dose-dependent inhibitory effects of proton pump inhibitors on human osteoclastic and osteoblastic cell activity.","volume":"280","author":"Costa-Rodrigues","year":"2013","journal-title":"FEBS J"},{"key":"R21-22-20210210","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1097\/BOT.0b013e31815ea2a4","article-title":"Qualitative and quantitative assessment of bone fragility and fracture healing using conventional radiography and advanced imaging technologies-focus on wrist fracture.","volume":"22","author":"Firoozabadi","year":"2008","journal-title":"J Orthop Trauma"},{"key":"R22-22-20210210","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00198-013-2401-y","article-title":"Distribution of bone density and cortical thickness in the proximal femur and their association with hip fracture in postmenopausal women: a quantitative computed tomography study.","volume":"25","author":"Yang","year":"2014","journal-title":"Osteoporos Int"},{"key":"R23-22-20210210","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1002\/jbmr.1693","article-title":"Distribution of bone density in the proximal femur and its association with hip fracture risk in older men: the osteoporotic fractures in men (MrOS) study.","volume":"27","author":"Yang","year":"2012","journal-title":"J Bone Miner Res"},{"key":"R24-22-20210210","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1359\/jbmr.1997.12.11.1761","article-title":"Prevalence of low femoral bone density in older U.S. adults from NHANES III.","volume":"12","author":"Looker","year":"1997","journal-title":"J Bone Miner Res"},{"key":"R25-22-20210210","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jocd.2015.01.002","article-title":"Inverse correlation at the hip between areal bone mineral density measured by dual-energy x-ray absorptiometry and cortical volumetric bone mineral density measured by quantitative computed tomography.","volume":"19","author":"Amstrup","year":"2015","journal-title":"J Clin Densitom"},{"key":"R26-22-20210210","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1359\/jbmr.070712","article-title":"Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: the Rotterdam Study.","volume":"22","author":"Rivadeneira","year":"2007","journal-title":"J Bone Miner Res"},{"key":"R27-22-20210210","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1056\/NEJM198507113130202","article-title":"Calcium absorption and achlorhydria.","volume":"313","author":"Recker","year":"1985","journal-title":"N Engl J Med"},{"key":"R28-22-20210210","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/BF02563819","article-title":"Absorbability of calcium sources: the limited role of solubility.","volume":"46","author":"Heaney","year":"1990","journal-title":"Calcif Tissue Int"},{"key":"R29-22-20210210","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1172\/JCI111254","article-title":"An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium.","volume":"73","author":"Bo-Linn","year":"1984","journal-title":"J Clin Invest"},{"key":"R30-22-20210210","doi-asserted-by":"crossref","first-page":"h4183","DOI":"10.1136\/bmj.h4183","article-title":"Calcium intake and bone mineral density: systematic review and meta-analysis.","volume":"351","author":"Tai","year":"2015","journal-title":"BMJ"},{"key":"R31-22-20210210","doi-asserted-by":"crossref","first-page":"h4580","DOI":"10.1136\/bmj.h4580","article-title":"Calcium intake and risk of fracture: systematic review.","volume":"351","author":"Bolland","year":"2015","journal-title":"BMJ"},{"key":"R32-22-20210210","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/jbmr.1848","article-title":"Inflammatory bowel disease and the risk of fracture after controlling for FRAX.","volume":"28","author":"Targownik","year":"2013","journal-title":"J Bone Miner Res"},{"key":"R33-22-20210210","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1053\/j.gastro.2009.11.014","article-title":"Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss.","volume":"138","author":"Targownik","year":"2010","journal-title":"Gastroenterology"},{"key":"R34-22-20210210","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF02556841","article-title":"Omeprazole, a specific inhibitor of H-K-ATPase, inhibits bone resorption in vitro.","volume":"38","author":"Tuukkanen","year":"1986","journal-title":"Calcif Tissue Int"},{"key":"R35-22-20210210","first-page":"222","article-title":"Osteopetrosis.","volume":"32","author":"Kocher","year":"2003","journal-title":"Am J Orthop"},{"key":"R36-22-20210210","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1007\/s00198-012-2173-9","article-title":"Atypical fractures do not have a thicker cortex.","volume":"23","author":"Koeppen","year":"2012","journal-title":"Osteoporos Int"},{"key":"R37-22-20210210","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2165\/00002018-200932090-00002","article-title":"Low-energy femoral fractures associated with the long-term use of bisphosphonates: a case series from a swiss university hospital.","volume":"32","author":"Ing-Lorenzini","year":"2009","journal-title":"Drug Saf"},{"key":"R38-22-20210210","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00296-015-3323-0","article-title":"Factors associated with atypical femoral fracture.","volume":"36","author":"Kim","year":"2016","journal-title":"Rheumatol Int"},{"key":"R39-22-20210210","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/jama.2011.190","article-title":"Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women.","volume":"305","author":"Park-Wyllie","year":"2011","journal-title":"JAMA"},{"key":"R40-22-20210210","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bone.2013.09.014","article-title":"Use of proton pump inhibitors is associated with lower trabecular bone density in older individuals.","volume":"57","author":"Maggio","year":"2013","journal-title":"Bone"},{"key":"R41-22-20210210","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1001\/jamainternmed.2013.2851","article-title":"Proton pump inhibitors and risk of 1-year mortality and rehospitalization in older patients discharged from acute care hospitals.","volume":"173","author":"Maggio","year":"2013","journal-title":"JAMA Int Med"},{"key":"R42-22-20210210","first-page":"1604","article-title":"Use of proton pump inhibitors and mortality among institutionalized older people.","volume":"170","author":"Bell","year":"2010","journal-title":"Arch Intern Med"},{"key":"R43-22-20210210","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3109\/02813432.2010.493315","article-title":"Use of proton-pump inhibitors and their associated risks among frail elderly nursing home residents.","volume":"28","author":"Teramura-Gronblad","year":"2010","journal-title":"Scand J Prim Health Care"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ajg2016481.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2016481","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ajg2016481.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.ovid.com\/00000434-201701000-00022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:14:34Z","timestamp":1786547674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201701000-00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2016.481","relation":{},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]}}}