{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:26:40Z","timestamp":1790404000846,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1038\/ajg.2017.41","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T08:02:13Z","timestamp":1488268933000},"page":"763-774","source":"Crossref","is-referenced-by-count":98,"title":["Tenapanor Treatment of Patients With Constipation-Predominant Irritable Bowel Syndrome: A Phase 2, Randomized, Placebo-Controlled Efficacy and Safety Trial"],"prefix":"10.14309","volume":"112","author":[{"given":"William D","family":"Chey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J","family":"Lembo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P","family":"Rosenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-24-20210210","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders.","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"R2-24-20210210","first-page":"71","article-title":"The epidemiology of irritable bowel syndrome.","volume":"6","author":"Canavan","year":"2014","journal-title":"Clin Epidemiol"},{"key":"R3-24-20210210","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/jama.2015.0954","article-title":"Irritable bowel syndrome: a clinical review.","volume":"313","author":"Chey","year":"2015","journal-title":"JAMA"},{"key":"R4-24-20210210","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1053\/gast.2002.37095","article-title":"AGA technical review on irritable bowel syndrome.","volume":"123","author":"Drossman","year":"2002","journal-title":"Gastroenterology"},{"key":"R5-24-20210210","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1016\/j.clinthera.2006.10.010","article-title":"Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: baseline results from LOGIC (Longitudinal Outcomes Study of Gastrointestinal Symptoms in Canada), a naturalistic study.","volume":"28","author":"Pare","year":"2006","journal-title":"Clin Ther"},{"key":"R6-24-20210210","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1056\/NEJMcp0801447","article-title":"Clinical practice. Irritable bowel syndrome.","volume":"358","author":"Mayer","year":"2008","journal-title":"N Engl J Med"},{"key":"R8-24-20210210","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1053\/gast.2000.16484","article-title":"The impact of irritable bowel syndrome on health-related quality of life.","volume":"119","author":"Gralnek","year":"2000","journal-title":"Gastroenterology"},{"key":"R9-24-20210210","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1080\/00365520310004524","article-title":"Inflammatory bowel disease versus irritable bowel syndrome: a hospital-based, case-control study of disease impact on quality of life.","volume":"38","author":"Pace","year":"2003","journal-title":"Scand J Gastroenterol"},{"key":"R10-24-20210210","first-page":"1","article-title":"New and emerging treatment options for irritable bowel syndrome.","volume":"11","author":"Lacy","year":"2015","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"R11-24-20210210","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/01.mcg.0000139029.00451.c7","article-title":"Irritable bowel syndrome medications side effects survey.","volume":"38","author":"Lembo","year":"2004","journal-title":"J Clin Gastroenterol"},{"key":"R12-24-20210210","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/apt.12123","article-title":"Randomised clinical trials: linaclotide phase 3 studies in IBS-Ca prespecified further analysis based on European Medicines Agency-specified endpoints.","volume":"37","author":"Quigley","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"R13-24-20210210","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1038\/ajg.2012.254","article-title":"Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety.","volume":"107","author":"Chey","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"R14-24-20210210","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1365-2036.2008.03881.x","article-title":"Clinical trial: lubiprostone in patients with constipation-associated irritable bowel syndrome-results of two randomized, placebo-controlled studies.","volume":"29","author":"Drossman","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"R20-24-20210210","first-page":"307","article-title":"Guidelines-Rome III Diagnostic Criteria for Functional Gastrointestinal Disorders.","volume":"15","year":"2006","journal-title":"J Gastrointest Liver Dis"},{"key":"R21-24-20210210","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3109\/00365529709011203","article-title":"Stool form scale as a useful guide to intestinal transit time.","volume":"32","author":"Lewis","year":"1997","journal-title":"Scand J Gastroenterol"},{"key":"R24-24-20210210","doi-asserted-by":"crossref","first-page":"556","DOI":"10.3109\/00365520903551332","article-title":"Assessment of normal bowel habits in the general adult population: the Popcol study.","volume":"45","author":"Walter","year":"2010","journal-title":"Scand J Gastroenterol"},{"key":"R25-24-20210210","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/969","article-title":"Renal and intestinal absorptive defects in mice lacking the NHE3 NaH exchanger.","volume":"19","author":"Schultheis","year":"1998","journal-title":"Nat Genet"},{"key":"R26-24-20210210","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1038\/ajg.2013.197","article-title":"Randomized clinical trial: macrogolPEG 3350 plus electrolytes for treatment of patients with constipation associated with irritable bowel syndrome.","volume":"108","author":"Chapman","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"R27-24-20210210","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1365-2982.2009.01385.x","article-title":"Guanylate cyclase C-mediated antinociceptive effects of linaclotide in rodent models of visceral pain.","volume":"22","author":"Eutamene","year":"2010","journal-title":"Neurogastroenterol Motil"},{"key":"R28-24-20210210","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.2215\/CJN.09050815","article-title":"Effect of tenapanor on interdialytic weight gain in patients on hemodialysis.","volume":"11","author":"Block","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"R29-24-20210210","first-page":"239A","article-title":"A phase 2 study on the effect of tenapanor on albuminuria in patients with T2DM and CKD.","volume":"26","author":"Stefansson","year":"2015","journal-title":"J Am Soc Nephrol"}],"container-title":["American Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00000434-201705000-00024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:15:26Z","timestamp":1786547726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000434-201705000-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1038\/ajg.2017.41","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727355494.793551521","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.727355494.793536320","asserted-by":"object"}]},"ISSN":["0002-9270"],"issn-type":[{"value":"0002-9270","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]}}}