{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:16:23Z","timestamp":1759482983985},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Hypertension"],"published-print":{"date-parts":[[2008,3,1]]},"DOI":"10.1038\/ajh.2007.56","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T19:32:15Z","timestamp":1201203135000},"page":"248-256","source":"Crossref","is-referenced-by-count":11,"title":["Establishing A New Option for Target-organ Protection: Rationale for ARB Plus ACE Inhibitor Combination Therapy"],"prefix":"10.1093","volume":"21","author":[{"given":"J. N.","family":"Cohn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"issue":"2A","key":"1_16908181","doi-asserted-by":"crossref","first-page":"3A","DOI":"10.1016\/S0002-9149(01)02321-9","volume":"89","author":"Unger","year":"2002","journal-title":"The American journal of cardiology","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9149","issn-type":"print"},{"issue":"1","key":"2_22313991","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.amjcard.2006.01.059","volume":"98","author":"Ferrario","year":"2006","journal-title":"The American journal of cardiology","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9149","issn-type":"print"},{"issue":"6","key":"3_17652608","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1097\/00004872-200306000-00001","volume":"21","year":"2003","journal-title":"Journal of hypertension","ISSN":"http:\/\/id.crossref.org\/issn\/0263-6352","issn-type":"print"},{"issue":"19","key":"4_17637576","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","volume":"289","year":"2003","journal-title":"JAMA","ISSN":"http:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"11","key":"5_17888702","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1097\/00004872-200311000-00002","volume":"21","author":"Whitworth","year":"2003","journal-title":"Journal of hypertension","ISSN":"http:\/\/id.crossref.org\/issn\/0263-6352","issn-type":"print"},{"issue":"1","key":"6_21566696","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10741-005-2346-0","volume":"10","author":"Joffe","year":"2005","journal-title":"Heart failure reviews","ISSN":"http:\/\/id.crossref.org\/issn\/1382-4147","issn-type":"print"},{"issue":"14","key":"7_19228739","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1056\/NEJMoa030207","volume":"348","year":"2003","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"10","key":"8_10933281","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1056\/NEJM199909023411001","volume":"341","author":"Pitt","year":"1999","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"3","key":"9_18762427","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1681\/ASN.2004100874","volume":"16","year":"2005","journal-title":"Journal of the American Society of Nephrology","ISSN":"http:\/\/id.crossref.org\/issn\/1046-6673","issn-type":"print"},{"issue":"6","key":"10_17951822","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1161\/01.HYP.0000101688.17370.87","volume":"42","year":"2003","journal-title":"Hypertension","ISSN":"http:\/\/id.crossref.org\/issn\/0194-911X","issn-type":"print"},{"issue":"2","key":"11_21269940","doi-asserted-by":"publisher","first-page":"221","DOI":"10.2215\/CJN.01201005","volume":"1","year":"2006","journal-title":"Clinical Journal of the American Society of Nephrology","ISSN":"http:\/\/id.crossref.org\/issn\/1555-9041","issn-type":"print"},{"issue":"9","key":"12_29213081","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1111\/j.1742-1241.2007.01473.x","volume":"61","author":"Nussberger","year":"2007","journal-title":"International journal of clinical practice","ISSN":"http:\/\/id.crossref.org\/issn\/1368-5031","issn-type":"print"},{"issue":"4","key":"13_19144908","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1113\/expphysiol.2005.030080","volume":"90","year":"2005","journal-title":"Experimental Physiology","ISSN":"http:\/\/id.crossref.org\/issn\/0033-5541","issn-type":"print"},{"key":"14_37208786","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/3-540-27661-0_15","volume":"170","year":"2005","ISSN":"http:\/\/id.crossref.org\/issn\/0171-2004","issn-type":"print"},{"issue":"3","key":"15_22328200","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1152\/physrev.00036.2005","volume":"86","author":"Paul","year":"2006","journal-title":"Physiological Reviews","ISSN":"http:\/\/id.crossref.org\/issn\/0031-9333","issn-type":"print"},{"key":"16_44199985","first-page":"S173","volume":"13(Suppl 3)","year":"2002","journal-title":"Journal of the American Society of Nephrology","ISSN":"http:\/\/id.crossref.org\/issn\/1046-6673","issn-type":"print"},{"issue":"1-3","key":"17_10515159","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0167-0115(00)00178-6","volume":"93","author":"Schmidt-Ott","year":"2000","journal-title":"Regulatory peptides","ISSN":"http:\/\/id.crossref.org\/issn\/0167-0115","issn-type":"print"},{"issue":"4","key":"18_17997599","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1159\/000073232","volume":"60","author":"Bragulat","year":"2003","journal-title":"British journal of biomedical science","ISSN":"http:\/\/id.crossref.org\/issn\/0967-4845","issn-type":"print"},{"issue":"14","key":"19_6548221","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1161\/01.CIR.101.14.1653","volume":"101","author":"Schiffrin","year":"2000","journal-title":"Circulation","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"16","key":"20_6566983","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1161\/01.CIR.101.16.1899","volume":"101","author":"Schachinger","year":"2000","journal-title":"Circulation","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"18","key":"21_17888010","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1161\/01.CIR.0000095031.51492.C5","volume":"108","year":"2003","journal-title":"Circulation","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"9","key":"22_6157290","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1097\/00004872-199816090-00014","volume":"16","author":"Bigazzi","year":"1998","journal-title":"Journal of hypertension","ISSN":"http:\/\/id.crossref.org\/issn\/0263-6352","issn-type":"print"},{"issue":"4","key":"23_11247392","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1001\/jama.286.4.421","volume":"286","author":"Gerstein","year":"2001","journal-title":"JAMA","ISSN":"http:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"4 Pt 2","key":"24_18823736","doi-asserted-by":"crossref","first-page":"100S","DOI":"10.1016\/j.amjhyper.2004.11.017","volume":"18","author":"Weir","year":"2005","journal-title":"American Journal of Hypertension","ISSN":"http:\/\/id.crossref.org\/issn\/0895-7061","issn-type":"print"},{"issue":"6","key":"25_11172849","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1046\/j.1523-1755.2001.00745.x","volume":"59","author":"Agarwal","year":"2001","journal-title":"Kidney international","ISSN":"http:\/\/id.crossref.org\/issn\/0085-2538","issn-type":"print"},{"issue":"9246","key":"26_10599035","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1016\/S0140-6736(00)03307-9","volume":"356","author":"Neal","year":"2000","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"2","key":"27_9853550","first-page":"85","volume":"6","author":"Cruickshank","year":"1992","journal-title":"Journal of human hypertension","ISSN":"http:\/\/id.crossref.org\/issn\/0950-9240","issn-type":"print"},{"issue":"2","key":"28_44850700","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1093\/ajh\/5.2.95","volume":"5","year":"1992","journal-title":"American Journal of Hypertension","ISSN":"http:\/\/id.crossref.org\/issn\/0895-7061","issn-type":"print"},{"issue":"19","key":"29_16215186","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1001\/jama.1996.03530430051039","volume":"275","author":"Schmieder","year":"1996","journal-title":"JAMA","ISSN":"http:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"6","key":"30_18198310","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.metabol.2003.12.021","volume":"53","author":"Anan","year":"2004","journal-title":"Metabolism: clinical and experimental","ISSN":"http:\/\/id.crossref.org\/issn\/0026-0495","issn-type":"print"},{"issue":"7","key":"31_22403071","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1111\/j.1524-6175.2006.05366.x","volume":"8","author":"Kjeldsen","year":"2006","journal-title":"Journal of clinical hypertension (Greenwich, Conn.)","ISSN":"http:\/\/id.crossref.org\/issn\/1524-6175","issn-type":"print"},{"issue":"6","key":"32_11190818","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1097\/00004872-200106000-00023","volume":"19","author":"Malmqvist","year":"2001","journal-title":"Journal of hypertension","ISSN":"http:\/\/id.crossref.org\/issn\/0263-6352","issn-type":"print"},{"key":"33_18030041","first-page":"59","volume":"19","author":"Suzuki","year":"2003","journal-title":"Advances in peritoneal dialysis. Conference on Peritoneal Dialysis","ISSN":"http:\/\/id.crossref.org\/issn\/1197-8554","issn-type":"print"},{"issue":"19","key":"34_6222617","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1161\/01.CIR.98.19.2037","volume":"98","author":"Thurmann","year":"1998","journal-title":"Circulation","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"11","key":"35_18205438","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1016\/j.jacc.2003.12.051","volume":"43","author":"Yasunari","year":"2004","journal-title":"Journal of the American College of Cardiology","ISSN":"http:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"9311","key":"36_16996317","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/S0140-6736(02)08089-3","volume":"359","author":"Dahl\u00a0\u00a0f","year":"2002","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"4","key":"37_21475780","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1161\/01.ATV.0000205849.22807.6e","volume":"26","year":"2006","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology","ISSN":"http:\/\/id.crossref.org\/issn\/0276-5047","issn-type":"print"},{"issue":"15","key":"38_16183005","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1056\/NEJM199604113341502","volume":"334","author":"Maschio","year":"1996","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"9200","key":"39_6469147","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0140-6736(99)12323-7","volume":"355","year":"2000","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"2","key":"40_11235714","doi-asserted-by":"crossref","first-page":"73","DOI":"10.7326\/0003-4819-135-2-200107170-00007","volume":"135","author":"Jafar","year":"2001","journal-title":"Annals of Internal Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0003-4819","issn-type":"print"},{"issue":"12","key":"41_11309766","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1056\/NEJMoa011489","volume":"345","author":"Parving","year":"2001","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"12","key":"42_11309765","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1056\/NEJMoa011161","volume":"345","author":"Brenner","year":"2001","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"12","key":"43_11309764","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1056\/NEJMoa011303","volume":"345","author":"Lewis","year":"2001","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"19","key":"44_19229706","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1056\/NEJMoa042274","volume":"351","year":"2004","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"9","key":"45_21607372","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1161\/CIRCULATIONAHA.105.595496","volume":"113","year":"2006","journal-title":"Circulation","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"7","key":"46_17683717","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1097\/00004872-200307000-00017","volume":"21","author":"Hope","year":"2003","journal-title":"Journal of hypertension","ISSN":"http:\/\/id.crossref.org\/issn\/0263-6352","issn-type":"print"},{"issue":"9","key":"47_29216572","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.jacc.2007.03.065","volume":"50","year":"2007","journal-title":"Journal of the American College of Cardiology","ISSN":"http:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"5","key":"48_18833583","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1161\/01.HYP.0000161880.59963.da","volume":"45","year":"2005","journal-title":"Hypertension","ISSN":"http:\/\/id.crossref.org\/issn\/0194-911X","issn-type":"print"},{"issue":"9583","key":"49_29165074","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0140-6736(07)61124-6","volume":"370","author":"Oparil","year":"2007","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"50_44199987","first-page":"39A","volume":"33(Suppl 1)","year":"2005","journal-title":"J INT MED RES"},{"issue":"23","key":"51_11404472","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1056\/NEJMoa010713","volume":"345","author":"Cohn","year":"2001","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"7","key":"52_32899512","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.ejheart.2004.09.005","volume":"6","year":"2004","journal-title":"European Journal of Heart Failure","ISSN":"http:\/\/id.crossref.org\/issn\/1388-9842","issn-type":"print"},{"issue":"19","key":"53_17838918","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1016\/S0195-668X(03)00477-9","volume":"24","author":"McKelvie","year":"2003","journal-title":"European Heart Journal","ISSN":"http:\/\/id.crossref.org\/issn\/0195-668X","issn-type":"print"},{"issue":"9386","key":"54_17817421","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0140-6736(03)14283-3","volume":"362","author":"McMurray","year":"2003","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"9386","key":"55_17817420","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/S0140-6736(03)14282-1","volume":"362","author":"Pfeffer","year":"2003","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"20","key":"57_19229138","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1056\/NEJMoa032292","volume":"349","year":"2003","journal-title":"New England Journal of Medicine","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"7274","key":"58_10579279","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1136\/bmj.321.7274.1440","volume":"321","author":"Mogensen","year":"2000","journal-title":"BMJ","ISSN":"http:\/\/id.crossref.org\/issn\/0959-8138","issn-type":"print"},{"issue":"2","key":"59_18682401","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2337\/diacare.28.2.273","volume":"28","author":"Andersen","year":"2005","journal-title":"Diabetes Care","ISSN":"http:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"issue":"8","key":"60_17739064","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.2337\/diacare.26.8.2268","volume":"26","author":"Rossing","year":"2003","journal-title":"Diabetes Care","ISSN":"http:\/\/id.crossref.org\/issn\/0149-5992","issn-type":"print"},{"issue":"9352","key":"61_17471943","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0140-6736(03)12229-5","volume":"361","author":"Nakao","year":"2003","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"11","key":"62_17813399","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1161\/01.CIR.0000091234.45664.62","volume":"108","year":"2003","journal-title":"Circulation","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"2A","key":"63_16908183","doi-asserted-by":"crossref","first-page":"18A","DOI":"10.1016\/S0002-9149(01)02323-2","volume":"89","author":"Yusuf","year":"2002","journal-title":"The American journal of cardiology","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9149","issn-type":"print"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajh\/article-pdf\/21\/3\/248\/237494\/21_3_248.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T09:38:34Z","timestamp":1557221914000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article-lookup\/doi\/10.1038\/ajh.2007.56"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,1]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1038\/ajh.2007.56","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"value":"0895-7061","type":"print"},{"value":"1941-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,1]]}}}