{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:30:24Z","timestamp":1782891024775,"version":"3.54.5"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Hypertension"],"published-print":{"date-parts":[[2008,11,1]]},"DOI":"10.1038\/ajh.2008.260","type":"journal-article","created":{"date-parts":[[2008,9,4]],"date-time":"2008-09-04T14:03:28Z","timestamp":1220537008000},"page":"1251-1257","source":"Crossref","is-referenced-by-count":74,"title":["Nebivolol Treatment Reduces Serum Levels of Asymmetric Dimethylarginine and Improves Endothelial Dysfunction in Essential Hypertensive Patients"],"prefix":"10.1093","volume":"21","author":[{"given":"A. F.","family":"Pasini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Garbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Stranieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Boccioletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mozzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Manfro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pasini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cominacini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cominacini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"1","key":"1_5672738","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1056\/NEJM199007053230105","volume":"323","author":"Panza","year":"1990","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"17","key":"2_17876494","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1161\/01.CIR.0000089507.19675.F9","volume":"108","author":"Ganz","year":"2003","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"3","key":"3_21967443","doi-asserted-by":"publisher","first-page":"H985","DOI":"10.1152\/ajpheart.00292.2006","volume":"291","year":"2006","journal-title":"American Journal of Physiology - Heart and Circulatory Physiology","ISSN":"https:\/\/id.crossref.org\/issn\/0363-6135","issn-type":"print"},{"issue":"2","key":"4_30070379","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1177\/0091270007310378","volume":"48","year":"2008","journal-title":"The Journal of Clinical Pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9754","issn-type":"print"},{"issue":"5","key":"5_11257993","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1161\/hc3001.094207","volume":"104","author":"Tzemos","year":"2001","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"10","key":"6_17932024","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1016\/j.jacc.2003.06.011","volume":"42","author":"Cominacini","year":"2003","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"24","key":"7_21130646","doi-asserted-by":"publisher","first-page":"3795","DOI":"10.1161\/CIRCULATIONAHA.105.556233","volume":"112","year":"2005","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"8","key":"8_22474328","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1440-1681.2006.04424.x","volume":"33","author":"Ladage","year":"2006","journal-title":"Clinical and experimental pharmacology & physiology","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1870","issn-type":"print"},{"issue":"1-3","key":"9_18651032","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ejphar.2004.11.043","volume":"508","author":"Georgescu","year":"2005","journal-title":"European journal of pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2999","issn-type":"print"},{"issue":"4","key":"10_17581585","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1161\/01.ATV.0000065234.70518.26","volume":"23","year":"2003","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0276-5047","issn-type":"print"},{"issue":"3","key":"11_18686240","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/01.hjh.0000160216.86597.ff","volume":"23","author":"Fratta Pasini","year":"2005","journal-title":"Journal of hypertension","ISSN":"https:\/\/id.crossref.org\/issn\/0263-6352","issn-type":"print"},{"issue":"6","key":"12_14601417","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/0955-0674(93)90080-A","volume":"5","author":"Clarke","year":"1993","journal-title":"Current opinion in cell biology","ISSN":"https:\/\/id.crossref.org\/issn\/0955-0674","issn-type":"print"},{"issue":"8793","key":"13_9741493","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/0140-6736(92)90865-Z","volume":"339","author":"Vallance","year":"1992","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"24","key":"14_10862704","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1161\/01.CIR.99.24.3092","volume":"99","author":"Ito","year":"1999","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"4","key":"15_17853711","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/S0008-6363(03)00500-5","volume":"59","author":"B\u00a0\u00a0ger","year":"2003","journal-title":"Cardiovascular Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-6363","issn-type":"print"},{"key":"16_44124197","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/j.1476-5381.1996.tb16069.x","volume":"119:","year":"1996","journal-title":"British journal of pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1188","issn-type":"print"},{"key":"17_28011923","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1042\/0264-6021:3430209","volume":"343","year":"1999","journal-title":"The Biochemical journal","ISSN":"https:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"key":"18_44041516","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.phrs.2007.09.015","volume":"56","year":"2007","journal-title":"Pharmaceutical research","ISSN":"https:\/\/id.crossref.org\/issn\/0724-8741","issn-type":"print"},{"issue":"2","key":"19_11474186","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0735-1097(01)01746-6","volume":"39","author":"Corretti","year":"2002","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"11","key":"20_17669457","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1016\/S0735-1097(03)00360-7","volume":"41","author":"Redberg","year":"2003","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"6","key":"21_10742031","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","volume":"130","author":"Levey","year":"1999","journal-title":"Annals of Internal Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4819","issn-type":"print"},{"issue":"12","key":"22_17360622","doi-asserted-by":"publisher","first-page":"5636","DOI":"10.1210\/jc.2002-020905","volume":"87","author":"Hermenegildo","year":"2002","journal-title":"Journal of Clinical Endocrinology & Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"17","key":"23_19547216","doi-asserted-by":"publisher","first-page":"13750","DOI":"10.1074\/jbc.M010612200","volume":"276","year":"2001","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"4","key":"24_10796664","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1097\/00005344-199904000-00020","volume":"33","author":"Surdacki","year":"1999","journal-title":"Journal of cardiovascular pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0160-2446","issn-type":"print"},{"issue":"9","key":"25_43949842","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.amjhyper.2004.05.005","volume":"17","year":"2004","journal-title":"American Journal of Hypertension","ISSN":"https:\/\/id.crossref.org\/issn\/0895-7061","issn-type":"print"},{"issue":"3","key":"26_19293968","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.jacc.2005.04.040","volume":"46","year":"2005","journal-title":"Journal of the American College of Cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0735-1097","issn-type":"print"},{"issue":"6","key":"27_17663388","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1161\/01.HYP.0000070956.57418.22","volume":"41","year":"2003","journal-title":"Hypertension","ISSN":"https:\/\/id.crossref.org\/issn\/0194-911X","issn-type":"print"},{"issue":"3","key":"28_28909988","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.pharmthera.2007.03.002","volume":"114","author":"Bode-Boger","year":"2007","journal-title":"Pharmacology & therapeutics","ISSN":"https:\/\/id.crossref.org\/issn\/0163-7258","issn-type":"print"},{"issue":"3","key":"29_10986561","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1046\/j.1365-2125.1999.00037.x","volume":"48","author":"Dawes","year":"1999","journal-title":"British journal of clinical pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0306-5251","issn-type":"print"},{"issue":"4","key":"30_10494528","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1046\/j.1365-2125.2000.00258.x","volume":"50","author":"Troost","year":"2000","journal-title":"British journal of clinical pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0306-5251","issn-type":"print"},{"issue":"11","key":"31_22700373","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1136\/hrt.2005.084079","volume":"92","author":"Gullu","year":"2006","journal-title":"Heart","ISSN":"https:\/\/id.crossref.org\/issn\/0007-0769","issn-type":"print"},{"issue":"4","key":"32_27962884","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.1365-2362.2007.01781.x","volume":"37","author":"Ardigo","year":"2007","journal-title":"European journal of clinical investigation","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2972","issn-type":"print"},{"issue":"2","key":"33_18255353","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.amjcard.2004.03.052","volume":"94","author":"Lu","year":"2004","journal-title":"The American journal of cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9149","issn-type":"print"},{"issue":"9","key":"34_17299245","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/S0002-9149(02)02664-4","volume":"90","author":"Chen","year":"2002","journal-title":"The American journal of cardiology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9149","issn-type":"print"},{"issue":"4","key":"35_28321219","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.phrs.2006.12.008","volume":"55","author":"Evangelista","year":"2007","journal-title":"Pharmacological research : the official journal of the Italian Pharmacological Society","ISSN":"https:\/\/id.crossref.org\/issn\/1043-6618","issn-type":"print"},{"issue":"6","key":"36_43911909","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.amjhyper.2005.09.021","volume":"19","year":"2006","journal-title":"American Journal of Hypertension","ISSN":"https:\/\/id.crossref.org\/issn\/0895-7061","issn-type":"print"},{"issue":"6","key":"37_10426225","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1161\/01.CIR.102.6.677","volume":"102","author":"Broeders","year":"2000","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"21","key":"38_17654622","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1161\/01.CIR.0000066912.58385.DE","volume":"107","year":"2003","journal-title":"Circulation","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"issue":"5","key":"39_28309036","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1097\/HJH.0b013e3280987710","volume":"25","author":"Grundt","year":"2007","journal-title":"Journal of hypertension","ISSN":"https:\/\/id.crossref.org\/issn\/0263-6352","issn-type":"print"},{"issue":"1","key":"40_30575348","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.cardiores.2006.09.020","volume":"73","year":"2007","journal-title":"Cardiovascular Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-6363","issn-type":"print"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajh\/article-pdf\/21\/11\/1251\/398963\/21_11_1251.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T20:17:16Z","timestamp":1557778636000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article-lookup\/doi\/10.1038\/ajh.2008.260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,1]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11,1]]}},"URL":"https:\/\/doi.org\/10.1038\/ajh.2008.260","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"value":"0895-7061","type":"print"},{"value":"1941-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,1]]}}}