{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T18:26:16Z","timestamp":1776536776772,"version":"3.51.2"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12,1]]},"DOI":"10.1038\/ajh.2011.136","type":"journal-article","created":{"date-parts":[[2011,8,4]],"date-time":"2011-08-04T13:32:27Z","timestamp":1312464747000},"page":"1286-1293","source":"Crossref","is-referenced-by-count":44,"title":["Expression of Na+-K+-2Cl\u2212 Cotransporter 1 Is Epigenetically Regulated During Postnatal Development of Hypertension"],"prefix":"10.1093","volume":"24","author":[{"given":"Hyun-Min","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae-Ahm","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Soo","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Kyeom","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","reference":[{"key":"key\n\t\t\t\t20170523172016_rf1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1152\/physrev.00011.2004","article-title":"Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters","volume":"85","year":"2005","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170523172016_rf2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00424-004-1316-z","article-title":"Cell-volume-dependent vascular smooth muscle contraction: role of Na+, K+, 2Cl- cotransport, intracellular Cl- and L-type Ca2+ channels","volume":"449","year":"2004","journal-title":"Pflugers Arch"},{"key":"key\n\t\t\t\t20170523172016_rf3","doi-asserted-by":"crossref","first-page":"H1846","DOI":"10.1152\/ajpheart.00083.2002","article-title":"Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter","volume":"283","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170523172016_rf4","doi-asserted-by":"crossref","first-page":"H2100","DOI":"10.1152\/ajpheart.01402.2006","article-title":"Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone","volume":"292","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170523172016_rf5","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.bbrc.2009.01.018","article-title":"Excitation-contraction coupling in resistance mesenteric arteries: evidence for NKCC1-mediated pathway","volume":"379","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170523172016_rf6","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1159\/000025692","article-title":"Increased (Na+K+Cl) cotransport in rat arterial smooth muscle in deoxycorticosterone (DOCA)\/salt-induced hypertension","volume":"36","year":"1999","journal-title":"J Vasc Res"},{"key":"key\n\t\t\t\t20170523172016_rf7","doi-asserted-by":"crossref","first-page":"C629","DOI":"10.1152\/ajpcell.1989.257.4.C629","article-title":"Mechanism of angiotensin II stimulation of Na-K-Cl cotransport of vascular smooth muscle cells","volume":"257","year":"1989","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170523172016_rf8","doi-asserted-by":"crossref","first-page":"H1552","DOI":"10.1152\/ajpheart.00695.2003","article-title":"Blood pressure regulates the activity and function of the Na-K-2Cl cotransporter in vascular smooth muscle","volume":"286","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170523172016_rf9","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1161\/01.HYP.0000066128.04083.CA","article-title":"Aldosterone regulates the Na-K-2Cl cotransporter in vascular smooth muscle","volume":"41","year":"2003","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t20170523172016_rf10","doi-asserted-by":"crossref","first-page":"C511","DOI":"10.1152\/ajpcell.1999.276.3.C511","article-title":"Genetic and biochemical determinants of abnormal monovalent ion transport in primary hypertension","volume":"276","year":"1999","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t20170523172016_rf11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.pathophys.2007.09.006","article-title":"What can we learn from erythrocyte Na-K-Cl cotransporter NKCC1 in human hypertension","volume":"14","year":"2007","journal-title":"Pathophysiology"},{"key":"key\n\t\t\t\t20170523172016_rf12","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1242\/jcs.029223","article-title":"The regulation of salt transport and blood pressure by the WNK-SPAK\/OSR1 signalling pathway","volume":"121","year":"2008","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20170523172016_rf13","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.bbrc.2010.04.074","article-title":"Promoter hypomethylation upregulates Na+-K+-2Cl- cotransporter 1 in spontaneously hypertensive rats","volume":"396","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170523172016_rf14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4196\/kjpp.2010.14.1.51","article-title":"Calcium sensitization induced by sodium fluoride in permeabilized rat mesenteric arteries","volume":"14","year":"2010","journal-title":"Korean J Physiol Pharmacol"},{"key":"key\n\t\t\t\t20170523172016_rf15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","year":"2001","journal-title":"Methods"},{"key":"key\n\t\t\t\t20170523172016_rf16","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","article-title":"Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands","volume":"93","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170523172016_rf17","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1471-4159.2010.06772.x","article-title":"Possible involvement of DNA methylation in NKCC1 gene expression during postnatal development and in response to ischemia","volume":"114","year":"2010","journal-title":"J Neurochem"},{"key":"key\n\t\t\t\t20170523172016_rf18","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/01.RES.0000258855.60637.58","article-title":"Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension","volume":"100","year":"2007","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523172016_rf19","doi-asserted-by":"crossref","first-page":"478","DOI":"10.4161\/epi.6.4.14961","article-title":"Epigenetic regulation of somatic angiotensin-converting enzyme by DNA methylation and histone acetylation","volume":"6","year":"2011","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t20170523172016_rf20","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/nature08924","article-title":"CpG islands influence chromatin structure via the CpG-binding protein Cfp1","volume":"464","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170523172016_rf21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/321209a0","article-title":"CpG-rich islands and the function of DNA methylation","volume":"321","year":"1986","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170523172016_rf22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrg1748","article-title":"The epigenetic progenitor origin of human cancer","volume":"7","year":"2006","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20170523172016_rf23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mrfmmm.2008.08.006","article-title":"DNA methylation in development and human disease","volume":"647","year":"2008","journal-title":"Mutat Res"},{"key":"key\n\t\t\t\t20170523172016_rf24","first-page":"875","article-title":"Epigenetics and epigenetic mechanisms in disease with emphasis on autoimmune diseases","volume":"56","year":"2008","journal-title":"J Assoc Physicians India"},{"key":"key\n\t\t\t\t20170523172016_rf25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.atherosclerosis.2007.11.029","article-title":"Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension","volume":"199","year":"2008","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t20170523172016_rf26","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/CIRCRESAHA.107.171025","article-title":"Epigenetic regulation of vascular endothelial gene expression","volume":"102","year":"2008","journal-title":"Circ Res"},{"key":"key\n\t\t\t\t20170523172016_rf27","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1128\/MCB.19.5.3614","article-title":"The catenin p120(ctn) interacts with Kaiso, a novel BTB\/POZ domain zinc finger transcription factor","volume":"19","year":"1999","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170523172016_rf28","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1101\/gad.198501","article-title":"The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor","volume":"15","year":"2001","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170523172016_rf29","doi-asserted-by":"crossref","first-page":"C579","DOI":"10.1152\/ajpcell.2001.281.2.C579","article-title":"Contractile regulation of the Na(+)-K(+)-2Cl(-) cotransporter in vascular smooth muscle","volume":"281","year":"2001","journal-title":"Am J Physiol, Cell Physiol"},{"key":"key\n\t\t\t\t20170523172016_rf30","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1159\/000218187","article-title":"HCO3-dependent impact of Na+,K+,2Cl- cotransport in vascular smooth muscle excitation-contraction coupling","volume":"23","year":"2009","journal-title":"Cell Physiol Biochem"},{"key":"key\n\t\t\t\t20170523172016_rf31","doi-asserted-by":"crossref","first-page":"H2035","DOI":"10.1152\/ajpheart.00157.2007","article-title":"NKCC1 as a regulator of vascular tone and a novel target for antihypertensive therapeutics","volume":"292","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"key\n\t\t\t\t20170523172016_rf32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/MNH.0b013e3283360a46","article-title":"NKCC1 and hypertension: a novel therapeutic target involved in the regulation of vascular tone and renal function","volume":"19","year":"2010","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"key\n\t\t\t\t20170523172016_rf33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1203\/00006450-200108000-00018","article-title":"Loop diuretics and in vitro relaxation of human fetal and newborn mouse airways","volume":"50","year":"2001","journal-title":"Pediatr Res"}],"container-title":["American Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ajh\/article-pdf\/24\/12\/1286\/17459707\/24_12_1286.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T19:29:37Z","timestamp":1560454177000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ajh\/article-lookup\/doi\/10.1038\/ajh.2011.136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,1]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12,1]]}},"URL":"https:\/\/doi.org\/10.1038\/ajh.2011.136","relation":{},"ISSN":["0895-7061","1941-7225"],"issn-type":[{"value":"0895-7061","type":"print"},{"value":"1941-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,1]]}}}