{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:17:13Z","timestamp":1789910233148,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2011,5,9]],"date-time":"2011-05-09T00:00:00Z","timestamp":1304899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1038\/aps.2010.229","type":"journal-article","created":{"date-parts":[[2011,5,9]],"date-time":"2011-05-09T10:19:44Z","timestamp":1304936384000},"page":"879-887","source":"Crossref","is-referenced-by-count":61,"title":["Metformin attenuates pressure overload-induced cardiac hypertrophy via AMPK activation"],"prefix":"10.1038","volume":"32","author":[{"given":"Yong-nan","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-wei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-yang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,5,9]]},"reference":[{"key":"BFaps2010229_CR1","doi-asserted-by":"crossref","unstructured":"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352: 854\u201365.","DOI":"10.1016\/S0140-6736(98)07037-8"},{"key":"BFaps2010229_CR2","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1056\/NEJMoa0806470","volume":"359","author":"RR Holman","year":"2008","unstructured":"Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA . 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008; 359: 1577\u201389.","journal-title":"N Engl J Med"},{"key":"BFaps2010229_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1113\/jphysiol.2006.108944","volume":"574","author":"DG Hardie","year":"2006","unstructured":"Hardie DG, Hawley SA, Scott JW . AMP-activated protein kinase-development of the energy sensor concept. J Physiol 2006; 574: 7\u201315.","journal-title":"J Physiol"},{"key":"BFaps2010229_CR4","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/aps.2010.31","volume":"31","author":"YJ Li","year":"2010","unstructured":"Li YJ, Wang PH, Chen C, Zou MH, Wang DW . Improvement of mechanical heart function by trimetazidine in db\/db mice. Acta Pharmacol Sin 2010; 31: 560\u20139.","journal-title":"Acta Pharmacol Sin"},{"key":"BFaps2010229_CR5","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1161\/01.RES.0000258446.23525.37","volume":"100","author":"M Arad","year":"2007","unstructured":"Arad M, Seidman CE, Seidman JG . AMP-activated protein kinase in the heart: role during health and disease. Circ Res 2007; 100: 474\u201388.","journal-title":"Circ Res"},{"key":"BFaps2010229_CR6","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1172\/JCI13505","volume":"108","author":"G Zhou","year":"2001","unstructured":"Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001; 108: 1167\u201374.","journal-title":"J Clin Invest"},{"key":"BFaps2010229_CR7","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1161\/CIRCRESAHA.108.190918","volume":"104","author":"S Gundewar","year":"2009","unstructured":"Gundewar S, Calvert JW, Jha S, Toedt-Pingel I, Ji SY, Nunez D, et al. Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ Res 2009; 104: 403\u201311.","journal-title":"Circ Res"},{"key":"BFaps2010229_CR8","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1161\/CIRCULATIONAHA.108.798561","volume":"119","author":"H Sasaki","year":"2009","unstructured":"Sasaki H, Asanuma H, Fujita M, Takahama H, Wakeno M, Ito S, et al. Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase. Circulation 2009; 119: 2568\u201377.","journal-title":"Circulation"},{"key":"BFaps2010229_CR9","first-page":"3824","volume":"96","author":"BH Lorell","year":"1997","unstructured":"Lorell BH . Transition from hypertrophy to failure. Circulation 1997; 96: 3824\u20137.","journal-title":"Circulation"},{"key":"BFaps2010229_CR10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","volume":"65","author":"N Frey","year":"2003","unstructured":"Frey N, Olson EN . Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol 2003; 65: 45\u201379.","journal-title":"Annu Rev Physiol"},{"key":"BFaps2010229_CR11","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1152\/physiolgenomics.00041.2003","volume":"16","author":"O Tarnavski","year":"2004","unstructured":"Tarnavski O, McMullen JR, Schinke M, Nie Q, Kong S, Izumo S . Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies. Physiol Genomics 2004; 16: 349\u201360.","journal-title":"Physiol Genomics"},{"key":"BFaps2010229_CR12","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1161\/01.RES.0000185833.42544.06","volume":"97","author":"J Wang","year":"2005","unstructured":"Wang J, Xu N, Feng X, Hou N, Zhang J, Cheng X, et al. Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure. Circ Res 2005; 97: 821\u20138.","journal-title":"Circ Res"},{"key":"BFaps2010229_CR13","doi-asserted-by":"publisher","first-page":"32771","DOI":"10.1074\/jbc.M403528200","volume":"279","author":"AY Chan","year":"2004","unstructured":"Chan AY, Soltys CL, Young ME, Proud CG, Dyck JR . Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. J Biol Chem 2004; 279: 32771\u20139.","journal-title":"J Biol Chem"},{"key":"BFaps2010229_CR14","doi-asserted-by":"publisher","first-page":"6745","DOI":"10.1158\/0008-5472.CAN-06-4447","volume":"67","author":"M Buzzai","year":"2007","unstructured":"Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, et al. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 2007; 67: 6745\u201352.","journal-title":"Cancer Res"},{"key":"BFaps2010229_CR15","doi-asserted-by":"publisher","first-page":"43940","DOI":"10.1074\/jbc.M404421200","volume":"279","author":"MH Zou","year":"2004","unstructured":"Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WG 4th, Schlattner U, et al. Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species. J Biol Chem 2004; 279: 43940\u201351.","journal-title":"J Biol Chem"},{"key":"BFaps2010229_CR16","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1053\/j.gastro.2006.03.020","volume":"130","author":"I Bergheim","year":"2006","unstructured":"Bergheim I, Guo L, Davis MA, Lambert JC, Beier JI, Duveau I, et al. Metformin prevents alcohol-induced liver injury in the mouse: critical role of plasminogen activator inhibitor-1. Gastroenterology 2006; 130: 2099\u2013112.","journal-title":"Gastroenterology"},{"key":"BFaps2010229_CR17","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1046\/j.1365-2796.1997.00236.x","volume":"242","author":"O Snorgaard","year":"1997","unstructured":"Snorgaard O, Kober L, Carlsen J . The effect of metformin on blood pressure and metabolism in nondiabetic hypertensive patients. J Intern Med 1997; 242: 407\u201312.","journal-title":"J Intern Med"},{"key":"BFaps2010229_CR18","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1093\/cvr\/cvq066","volume":"87","author":"H Xiao","year":"2010","unstructured":"Xiao H, Ma X, Feng W, Fu Y, Lu Z, Xu M, et al. Metformin attenuates cardiac fibrosis by inhibiting the TGF\u03b21-Smad3 signalling pathway. Cardiovasc Res 2010; 87: 504\u201313.","journal-title":"Cardiovasc Res"},{"key":"BFaps2010229_CR19","doi-asserted-by":"publisher","first-page":"H1253","DOI":"10.1152\/ajpheart.00578.2001","volume":"283","author":"S Rosenkranz","year":"2002","unstructured":"Rosenkranz S, Flesch M, Amann K, Haeuseler C, Kilter H, Seeland U, et al. Alterations of \u03b2-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-\u03b21 . Am J Physiol Heart Circ Physiol 2002; 283: H1253\u201362.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFaps2010229_CR20","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1172\/JCI0214190","volume":"109","author":"JJ Schultz","year":"2002","unstructured":"Schultz JJ, Witt SA, Glascock BJ, Nieman ML, Reiser PJ, Nix SL, et al. TGF-\u03b21 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. J Clin Invest 2002; 109: 787\u201396.","journal-title":"J Clin Invest"},{"key":"BFaps2010229_CR21","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1161\/01.CIR.0000020689.12472.E0","volume":"106","author":"F Kuwahara","year":"2002","unstructured":"Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K, et al. Transforming growth factor-\u03b2 function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation 2002; 106: 130\u20135.","journal-title":"Circulation"},{"key":"BFaps2010229_CR22","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1161\/01.HYP.0000111831.50834.93","volume":"43","author":"K Tokuda","year":"2004","unstructured":"Tokuda K, Kai H, Kuwahara F, Yasukawa H, Tahara N, Kudo H, et al. Pressure-independent effects of angiotensin II on hypertensive myocardial fibrosis. Hypertension 2004; 43: 499\u2013503.","journal-title":"Hypertension"},{"key":"BFaps2010229_CR23","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1161\/hc4001.097183","volume":"104","author":"R Tian","year":"2001","unstructured":"Tian R, Musi N, D'Agostino J, Hirshman MF, Goodyear LJ . Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy. Circulation 2001; 104: 1664\u20139.","journal-title":"Circulation"},{"key":"BFaps2010229_CR24","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1161\/HYPERTENSIONAHA.108.114702","volume":"52","author":"P Zhang","year":"2008","unstructured":"Zhang P, Hu X, Xu X, Fassett J, Zhu G, Viollet B, et al. AMP activated protein kinase-\u03b12 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice. Hypertension 2008; 52: 918\u201324.","journal-title":"Hypertension"},{"key":"BFaps2010229_CR25","doi-asserted-by":"publisher","first-page":"32562","DOI":"10.1074\/jbc.M801904200","volume":"283","author":"BJ Stuck","year":"2008","unstructured":"Stuck BJ, Lenski M, Bohm M, Laufs U . Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMP-activated protein kinase. J Biol Chem 2008; 283: 32562\u20139.","journal-title":"J Biol Chem"},{"key":"BFaps2010229_CR26","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.yjmcc.2008.06.008","volume":"45","author":"B Lei","year":"2008","unstructured":"Lei B, Chess DJ, Keung W, O'Shea KM, Lopaschuk GD, Stanley WC . Transient activation of p38 MAP kinase and up-regulation of Pim-1 kinase in cardiac hypertrophy despite no activation of AMPK. J Mol Cell Cardiol 2008; 45: 404\u201310.","journal-title":"J Mol Cell Cardiol"},{"key":"BFaps2010229_CR27","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.bbrc.2008.09.057","volume":"376","author":"E Zarrinpashneh","year":"2008","unstructured":"Zarrinpashneh E, Beauloye C, Ginion A, Pouleur AC, Havaux X, Hue L, et al. AMPK\u03b12 counteracts the development of cardiac hypertrophy induced by isoproterenol. Biochem Biophys Res Commun 2008; 376: 677\u201381.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFaps2010229_CR28","doi-asserted-by":"publisher","first-page":"28372","DOI":"10.1074\/jbc.M303521200","volume":"278","author":"Y Xing","year":"2003","unstructured":"Xing Y, Musi N, Fujii N, Zou L, Luptak I, Hirshman MF, et al. Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative \u03b12 subunit of AMP-activated protein kinase. J Biol Chem 2003; 278: 28372\u20137.","journal-title":"J Biol Chem"},{"key":"BFaps2010229_CR29","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1172\/JCI19297","volume":"114","author":"RR3rd Russell","year":"2004","unstructured":"Russell RR 3rd, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M, et al. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest 2004; 114: 495\u2013503.","journal-title":"J Clin Invest"},{"key":"BFaps2010229_CR30","doi-asserted-by":"publisher","first-page":"4070","DOI":"10.1074\/jbc.M410213200","volume":"280","author":"J Yang","year":"2005","unstructured":"Yang J, Holman GD . Insulin and contraction stimulate exocytosis, but increased AMP-activated protein kinase activity resulting from oxidative metabolism stress slows endocytosis of GLUT4 in cardiomyocytes. J Biol Chem 2005; 280: 4070\u20138.","journal-title":"J Biol Chem"},{"key":"BFaps2010229_CR31","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1161\/CIRCULATIONAHA.105.595231","volume":"113","author":"B DeBosch","year":"2006","unstructured":"DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, et al. Akt1 is required for physiological cardiac growth. Circulation 2006; 113: 2097\u2013104.","journal-title":"Circulation"},{"key":"BFaps2010229_CR32","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nrm1983","volume":"7","author":"J Heineke","year":"2006","unstructured":"Heineke J, Molkentin JD . Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 2006; 7: 589\u2013600.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFaps2010229_CR33","doi-asserted-by":"publisher","first-page":"3050","DOI":"10.1161\/01.CIR.0000130641.08705.45","volume":"109","author":"JR McMullen","year":"2004","unstructured":"McMullen JR, Sherwood MC, Tarnavski O, Zhang L, Dorfman AL, Shioi T, et al. Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation 2004; 109: 3050\u20135.","journal-title":"Circulation"},{"key":"BFaps2010229_CR34","doi-asserted-by":"publisher","first-page":"10804","DOI":"10.1158\/0008-5472.CAN-07-2310","volume":"67","author":"RJ Dowling","year":"2007","unstructured":"Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N . Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res 2007; 67: 10804\u201312.","journal-title":"Cancer Res"},{"key":"BFaps2010229_CR35","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","volume":"296","author":"LC Cantley","year":"2002","unstructured":"Cantley LC . The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655\u20137.","journal-title":"Science"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/aps2010229.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps2010229","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps2010229.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:23:57Z","timestamp":1684412637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/aps2010229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,9]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["BFaps2010229"],"URL":"https:\/\/doi.org\/10.1038\/aps.2010.229","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5,9]]}}}