{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:39:17Z","timestamp":1684471157148},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T00:00:00Z","timestamp":1339372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1038\/aps.2012.43","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T11:20:07Z","timestamp":1339413607000},"page":"979-980","source":"Crossref","is-referenced-by-count":0,"title":["Pretreatment with IFN-\u03b1 increases resistance to imatinib mesylate in patients with chronic myelocytic leukemia"],"prefix":"10.1038","volume":"33","author":[{"given":"Yin","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-hua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-jian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-chao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-dong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,6,11]]},"reference":[{"key":"BFaps201243_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1182\/blood-2009-10-247437","volume":"116","author":"A Sengupta","year":"2010","unstructured":"Sengupta A, Arnett J, Dunn S, Williams DA, Cancelas JA . Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo. Blood 2010; 116: 81\u20134.","journal-title":"Blood"},{"key":"BFaps201243_CR2","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1056\/NEJMoa022457","volume":"348","author":"SG O'Brien","year":"2003","unstructured":"O'Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348: 994\u20131004.","journal-title":"N Engl J Med"},{"key":"BFaps201243_CR3","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1182\/asheducation-2003.1.132","volume":"2003","author":"JV Melo","year":"2003","unstructured":"Melo JV, Hughes TP, Apperley JF . Chronic myeloid leukemia. Hematology Am Soc Hematol Educ Program 2003; 2003: 132\u201352.","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"BFaps201243_CR4","doi-asserted-by":"publisher","first-page":"420","DOI":"10.2174\/138945011794815301","volume":"12","author":"B Simonsson","year":"2011","unstructured":"Simonsson B, Hjorth-Hansen H, Bjerrum OW, Porkka K . Interferon alpha for treatment of chronic myeloid leukemia. Curr Drug Targets 2011; 12: 420\u20138.","journal-title":"Curr Drug Targets"},{"key":"BFaps201243_CR5","doi-asserted-by":"publisher","first-page":"4706","DOI":"10.1182\/blood-2010-08-258772","volume":"117","author":"JJ Kiladjian","year":"2011","unstructured":"Kiladjian JJ, Mesa RA, Hoffman R . The renaissance of interferon therapy for the treatment of myeloid malignancies. Blood 2011; 117: 4706\u201315.","journal-title":"Blood"},{"key":"BFaps201243_CR6","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.cytogfr.2007.06.015","volume":"18","author":"LA Kujawski","year":"2007","unstructured":"Kujawski LA, Talpaz M . The role of interferon-alpha in the treatment of chronic myeloid leukemia. Cytokine Growth Factor Rev 2007; 18: 459\u201371.","journal-title":"Cytokine Growth Factor Rev"},{"key":"BFaps201243_CR7","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1182\/blood-2002-09-2896","volume":"102","author":"S Branford","year":"2003","unstructured":"Branford S, Rudzki Z, Walsh S, Parkinson I, Grigg A, Szer J, et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 2003; 102: 276\u201383.","journal-title":"Blood"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/aps201243.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps201243","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps201243.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:28:17Z","timestamp":1684412897000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/aps201243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,11]]},"references-count":7,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["BFaps201243"],"URL":"https:\/\/doi.org\/10.1038\/aps.2012.43","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,11]]}}}