{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:58:21Z","timestamp":1780333101453,"version":"3.54.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T00:00:00Z","timestamp":1390780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1038\/aps.2013.181","type":"journal-article","created":{"date-parts":[[2014,1,27]],"date-time":"2014-01-27T10:06:21Z","timestamp":1390817181000},"page":"311-315","source":"Crossref","is-referenced-by-count":33,"title":["Neuronal nicotinic acetylcholine receptors are important targets for alcohol reward and dependence"],"prefix":"10.1038","volume":"35","author":[{"given":"Jie","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin H","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,27]]},"reference":[{"key":"BFaps2013181_CR1","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1001\/jama.291.10.1238","volume":"291","author":"AH Mokdad","year":"2004","unstructured":"Mokdad AH, Marks JS, Stroup DF, Gerberding JL . Actual causes of death in the United States, 2000. JAMA 2004; 291: 1238\u201345.","journal-title":"JAMA"},{"key":"BFaps2013181_CR2","unstructured":"World Health Organization Editors. Global status report on noncommunicable diseases. Geneva, Switzerland: World Health Organization; 2010."},{"key":"BFaps2013181_CR3","unstructured":"(CASA) TNCoAaSA Shoveling Up II: The impact of substance abuse on federal, state, and local budgets. New York, NY: Columbia University; 2009."},{"key":"BFaps2013181_CR4","first-page":"185","volume":"31","author":"NW Gilpin","year":"2008","unstructured":"Gilpin NW, Koob GF . Neurobiology of alcohol dependence: focus on motivational mechanisms. Alcohol Res Health 2008; 31: 185\u201395.","journal-title":"Alcohol Res Health"},{"key":"BFaps2013181_CR5","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1056\/NEJMoa022095","volume":"348","author":"KJ Mukamal","year":"2003","unstructured":"Mukamal KJ, Conigrave KM, Mittleman MA, Camargo CA Jr, Stampfer MJ, Willett WC, et al. Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med 2003; 348: 109\u201318.","journal-title":"N Engl J Med"},{"key":"BFaps2013181_CR6","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1161\/CIRCULATIONAHA.105.574749","volume":"112","author":"KJ Mukamal","year":"2005","unstructured":"Mukamal KJ, Maclure M, Muller JE, Mittleman MA . Binge drinking and mortality after acute myocardial infarction. Circulation 2005; 112: 3839\u201345.","journal-title":"Circulation"},{"key":"BFaps2013181_CR7","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1146\/annurev.ps.40.020189.001203","volume":"40","author":"RA Wise","year":"1989","unstructured":"Wise RA, Rompre PP . Brain dopamine and reward. Annu Rev Psychol 1989; 40: 191\u2013225.","journal-title":"Annu Rev Psychol"},{"key":"BFaps2013181_CR8","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0074-7742(10)91008-8","volume":"91","author":"H Morikawa","year":"2010","unstructured":"Morikawa H, Morrisett RA . Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs. Int Rev Neurobiol 2010; 91: 235\u201388.","journal-title":"Int Rev Neurobiol"},{"issue":"4","key":"BFaps2013181_CR9","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/npp.2013.291","volume":"39","author":"Dawei Li","year":"2013","unstructured":"Li D, Sulovari A, Cheng C, Zhao H, Kranzler HR, Gelernter J . Association of gamma-aminobutyric acid a receptor \u03b1 2 gene (GABRA2) with alcohol use disorder. Neuropsychopharmacology 2013; doi: 10.1038\/npp.2013.291.","journal-title":"Neuropsychopharmacology"},{"key":"BFaps2013181_CR10","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1146\/annurev.ne.19.030196.001535","volume":"19","author":"RA Wise","year":"1996","unstructured":"Wise RA . Addictive drugs and brain stimulation reward. Annu Rev Neurosci 1996; 19: 319\u201340.","journal-title":"Annu Rev Neurosci"},{"key":"BFaps2013181_CR11","doi-asserted-by":"publisher","first-page":"983","DOI":"10.15288\/jsa.1976.37.983","volume":"37","author":"J Ayers","year":"1976","unstructured":"Ayers J, Ruff CF, Templer DI . Alcoholism, cigarette smoking, coffee drinking and extraversion. J Stud Alcohol 1976; 37: 983\u20135.","journal-title":"J Stud Alcohol"},{"key":"BFaps2013181_CR12","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.pneurobio.2004.09.006","volume":"74","author":"C Gotti","year":"2004","unstructured":"Gotti C, Clementi F . Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol 2004; 74: 363\u201396.","journal-title":"Prog Neurobiol"},{"key":"BFaps2013181_CR13","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.bcp.2011.07.067","volume":"82","author":"J Wu","year":"2011","unstructured":"Wu J, Lukas RJ . Naturally-expressed nicotinic acetylcholine receptor subtypes. Biochem Pharmacol 2011; 82: 800\u20137.","journal-title":"Biochem Pharmacol"},{"key":"BFaps2013181_CR14","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1113\/jphysiol.2006.114645","volume":"576","author":"J Wu","year":"2006","unstructured":"Wu J, Liu Q, Yu K, Hu J, Kuo YP, Segerberg M, et al. Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors. J Physiol 2006; 576: 103\u201318.","journal-title":"J Physiol"},{"key":"BFaps2013181_CR15","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1523\/JNEUROSCI.21-05-01452.2001","volume":"21","author":"R Klink","year":"2001","unstructured":"Klink R, de Kerchove d'Exaerde A, Zoli M, Changeux JP . Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 2001; 21: 1452\u201363.","journal-title":"J Neurosci"},{"key":"BFaps2013181_CR16","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/sj.mp.4001035","volume":"7","author":"RD Shytle","year":"2002","unstructured":"Shytle RD, Silver AA, Lukas RJ, Newman MB, Sheehan DV, Sanberg PR . Nicotinic acetylcholine receptors as targets for antidepressants. Mol Psychiatry 2002; 7: 525\u201335.","journal-title":"Mol Psychiatry"},{"key":"BFaps2013181_CR17","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/0014-2999(93)90434-J","volume":"249","author":"O Blomqvist","year":"1993","unstructured":"Blomqvist O, Engel JA, Nissbrandt H, Soderpalm B . The mesolimbic dopamine-activating properties of ethanol are antagonized by mecamylamine. Eur J Pharmacol 1993; 249: 207\u201313.","journal-title":"Eur J Pharmacol"},{"key":"BFaps2013181_CR18","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0014-2999(96)00583-3","volume":"314","author":"O Blomqvist","year":"1996","unstructured":"Blomqvist O, Ericson M, Johnson DH, Engel JA, Soderpalm B . Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment. Eur J Pharmacol 1996; 314: 257\u201367.","journal-title":"Eur J Pharmacol"},{"key":"BFaps2013181_CR19","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s00213-007-0899-4","volume":"195","author":"E L\u00f6f","year":"2007","unstructured":"L\u00f6f E, Olausson P, deBejczy A, Stomberg R, McIntosh JM, Taylor JR, et al. Nicotinic acetylcholine receptors in the ventral tegmental area mediate the dopamine activating and reinforcing properties of ethanol cues. Psychopharmacology 2007; 195: 333\u201343.","journal-title":"Psychopharmacology"},{"key":"BFaps2013181_CR20","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s00213-008-1375-5","volume":"203","author":"A Kuzmin","year":"2009","unstructured":"Kuzmin A, Jerlhag E, Liljequist S, Engel J . Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior. Psychopharmacology 2009; 203: 99\u2013108.","journal-title":"Psychopharmacology"},{"key":"BFaps2013181_CR21","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00213-009-1488-5","volume":"204","author":"LM Hendrickson","year":"2009","unstructured":"Hendrickson LM, Zhao-Shea R, Tapper AR . Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL\/6J mice. Psychopharmacology 2009; 204: 563\u201372.","journal-title":"Psychopharmacology"},{"key":"BFaps2013181_CR22","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1159\/000219488","volume":"83","author":"JM Farook","year":"2009","unstructured":"Farook JM, Lewis B, Gaddis JG, Littleton JM, Barron S . Effects of mecamylamine on alcohol consumption and preference in male C57BL\/6J mice. Pharmacology 2009; 83: 379\u201384.","journal-title":"Pharmacology"},{"key":"BFaps2013181_CR23","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.bcp.2013.06.015","volume":"86","author":"L Liu","year":"2013","unstructured":"Liu L, Zhao-Shea R, McIntosh JM, Tapper AR . Nicotinic acetylcholine receptors containing the alpha6 subunit contribute to ethanol activation of ventral tegmental area dopaminergic neurons. Biochem Pharmacol 2013; 86: 1194\u2013200.","journal-title":"Biochem Pharmacol"},{"key":"BFaps2013181_CR24","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1177\/0269881111431749","volume":"26","author":"P Bhutada","year":"2012","unstructured":"Bhutada P, Mundhada Y, Ghodki Y, Dixit P, Umathe S, Jain K . Acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in mice: effects of exposure to stress and modulation by mecamylamine. J Psychopharmacol 2012; 26: 315\u201323.","journal-title":"J Psychopharmacol"},{"key":"BFaps2013181_CR25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0014-2999(03)01564-4","volume":"467","author":"M Ericson","year":"2003","unstructured":"Ericson M, Molander A, Lof E, Engel JA, Soderpalm B . Ethanol elevates accumbal dopamine levels via indirect activation of ventral tegmental nicotinic acetylcholine receptors. Eur J Pharmacol 2003; 467: 85\u201393.","journal-title":"Eur J Pharmacol"},{"key":"BFaps2013181_CR26","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.alcohol.2004.10.002","volume":"34","author":"A Larsson","year":"2004","unstructured":"Larsson A, Jerlhag E, Svensson L, Soderpalm B, Engel JA . Is an alpha-conotoxin MII-sensitive mechanism involved in the neurochemical, stimulatory, and rewarding effects of ethanol? Alcohol 2004; 34: 239\u201350.","journal-title":"Alcohol"},{"key":"BFaps2013181_CR27","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00213-009-1759-1","volume":"208","author":"HM Kamens","year":"2010","unstructured":"Kamens HM, Andersen J, Picciotto MR . Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice. Psychopharmacology 2010; 208: 613\u201326.","journal-title":"Psychopharmacology"},{"key":"BFaps2013181_CR28","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.alcohol.2012.03.001","volume":"46","author":"HM Kamens","year":"2012","unstructured":"Kamens HM, Hoft NR, Cox RJ, Miyamoto JH, Ehringer MA . The alpha6 nicotinic acetylcholine receptor subunit influences ethanol-induced sedation. Alcohol 2012; 46: 463\u201371.","journal-title":"Alcohol"},{"key":"BFaps2013181_CR29","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1111\/acer.12009","volume":"37","author":"N Santos","year":"2013","unstructured":"Santos N, Chatterjee S, Henry A, Holgate J, Bartlett SE . The alpha5 neuronal nicotinic acetylcholine receptor subunit plays an important role in the sedative effects of ethanol but does not modulate consumption in mice. Alcohol Clin Exp Res 2013; 37: 655\u201362.","journal-title":"Alcohol Clin Exp Res"},{"key":"BFaps2013181_CR30","doi-asserted-by":"publisher","first-page":"10169","DOI":"10.1523\/JNEUROSCI.2601-10.2010","volume":"30","author":"LM Hendrickson","year":"2010","unstructured":"Hendrickson LM, Zhao-Shea R, Pang X, Gardner PD, Tapper AR . Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption. J Neurosci 2010; 30: 10169\u201376.","journal-title":"J Neurosci"},{"key":"BFaps2013181_CR31","first-page":"233","volume":"24","author":"LJ Bierut","year":"2000","unstructured":"Bierut LJ, Schuckit MA, Hesselbrock V, Reich T . Co-occurring risk factors for alcohol dependence and habitual smoking. Alcohol Res Health 2000; 24: 233\u201341.","journal-title":"Alcohol Res Health"},{"key":"BFaps2013181_CR32","doi-asserted-by":"publisher","first-page":"S72","DOI":"10.1016\/j.brainres.2009.08.026","volume":"1305","author":"S Landgren","year":"2009","unstructured":"Landgren S, Engel JA, Andersson ME, Gonzalez-Quintela A, Campos J, Nilsson S, et al. Association of nAChR gene haplotypes with heavy alcohol use and body mass. Brain Res 2009; 1305: S72\u20139.","journal-title":"Brain Res"},{"key":"BFaps2013181_CR33","doi-asserted-by":"crossref","unstructured":"Taylor DH, Steffensen SC, Wu J . Nicotinic acetylcholine receptors in the ventral tegmental area are important targets for nicotine and ethanol co-dependence. Biochem Pharmacol 2013; doi:10.4172\/2167-0501.S1-002.","DOI":"10.4172\/2167-0501.S1-002"},{"key":"BFaps2013181_CR34","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/S0896-6273(00)80134-8","volume":"16","author":"LW Role","year":"1996","unstructured":"Role LW, Berg DK . Nicotinic receptors in the development and modulation of CNS synapses. Neuron 1996; 16: 1077\u201385.","journal-title":"Neuron"},{"key":"BFaps2013181_CR35","unstructured":"Taylor DH, Burman PN, Hansen MD, Wilcox RS, Larsen BR, Blanchard JK, et al. Nicotine enhances the excitability of gaba neurons in the ventral tegmental area via activation of alpha 7 nicotinic receptors on glutamate terminals. Biochem Pharmacol 2013; S1\u2013007."},{"key":"BFaps2013181_CR36","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/S0166-2236(96)10073-4","volume":"20","author":"S Wonnacott","year":"1997","unstructured":"Wonnacott S . Presynaptic nicotinic ACh receptors. Trends Neurosci 1997; 20: 92\u20138.","journal-title":"Trends Neurosci"},{"key":"BFaps2013181_CR37","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1124\/pr.108.000430","volume":"61","author":"AM Dopico","year":"2009","unstructured":"Dopico AM, Lovinger DM . Acute alcohol action and desensitization of ligand-gated ion channels. Pharmacol Rev 2009; 61: 98\u2013114.","journal-title":"Pharmacol Rev"},{"key":"BFaps2013181_CR38","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0014-2999(97)01220-X","volume":"334","author":"O Blomqvist","year":"1997","unstructured":"Blomqvist O, Ericson M, Engel JA, Soderpalm B . Accumbal dopamine overflow after ethanol: localization of the antagonizing effect of mecamylamine. Eur J Pharmacol 1997; 334: 149\u201356.","journal-title":"Eur J Pharmacol"},{"key":"BFaps2013181_CR39","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s002130050838","volume":"141","author":"P Nestby","year":"1999","unstructured":"Nestby P, Vanderschuren LJ, De Vries TJ, Mulder AH, Wardeh G, Hogenboom F, et al. Unrestricted free-choice ethanol self-administration in rats causes long-term neuroadaptations in the nucleus accumbens and caudate putamen. Psychopharmacology 1999; 141: 307\u201314.","journal-title":"Psychopharmacology"},{"key":"BFaps2013181_CR40","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0014-2999(98)00602-5","volume":"358","author":"M Ericson","year":"1998","unstructured":"Ericson M, Blomqvist O, Engel JA, Soderpalm B . Voluntary ethanol intake in the rat and the associated accumbal dopamine overflow are blocked by ventral tegmental mecamylamine. Eur J Pharmacol 1998; 358: 189\u201396.","journal-title":"Eur J Pharmacol"},{"key":"BFaps2013181_CR41","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0304-3940(96)13075-5","volume":"217","author":"K Nagata","year":"1996","unstructured":"Nagata K, Aistrup GL, Huang CS, Marszalec W, Song JH, Yeh JZ, et al. Potent modulation of neuronal nicotinic acetylcholine receptor-channel by ethanol. Neurosci Lett 1996; 217: 189\u201393.","journal-title":"Neurosci Lett"},{"key":"BFaps2013181_CR42","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0022-3565(24)38200-X","volume":"289","author":"RA Cardoso","year":"1999","unstructured":"Cardoso RA, Brozowski SJ, Chavez-Noriega LE, Harpold M, Valenzuela CF, Harris RA . Effects of ethanol on recombinant human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 1999; 289: 774\u201380.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFaps2013181_CR43","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1124\/mol.55.1.39","volume":"55","author":"GL Aistrup","year":"1999","unstructured":"Aistrup GL, Marszalec W, Narahashi T . Ethanol modulation of nicotinic acetylcholine receptor currents in cultured cortical neurons. Mol Pharmacol 1999; 55: 39\u201349.","journal-title":"Mol Pharmacol"},{"key":"BFaps2013181_CR44","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0006-8993(90)91118-Z","volume":"508","author":"MS Brodie","year":"1990","unstructured":"Brodie MS, Shefner SA, Dunwiddie TV . Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res 1990; 508: 65\u20139.","journal-title":"Brain Res"},{"key":"BFaps2013181_CR45","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/j.1530-0277.1998.tb03644.x","volume":"22","author":"MS Brodie","year":"1998","unstructured":"Brodie MS, Appel SB . The effects of ethanol on dopaminergic neurons of the ventral tegmental area studied with intracellular recording in brain slices. Alcohol Clin Exp Res 1998; 22: 236\u201344.","journal-title":"Alcohol Clin Exp Res"},{"key":"BFaps2013181_CR46","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1600-0773.1991.tb01215.x","volume":"68","author":"JK Christensen","year":"1991","unstructured":"Christensen JK, Moller IW, Ronsted P, Angelo HR, Johansson B . Dose-effect relationship of disulfiram in human volunteers. I: Clinical studies. Pharmacol Toxicol 1991; 68: 163\u20135.","journal-title":"Pharmacol Toxicol"},{"key":"BFaps2013181_CR47","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1001\/archpsyc.1992.01820110040006","volume":"49","author":"JR Volpicelli","year":"1992","unstructured":"Volpicelli JR, Alterman AI, Hayashida M, O'Brien CP . Naltrexone in the treatment of alcohol dependence. Arch Gen Psychiatry 1992; 49: 876\u201380.","journal-title":"Arch Gen Psychiatry"},{"key":"BFaps2013181_CR48","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.jpsychires.2006.02.002","volume":"40","author":"BJ Mason","year":"2006","unstructured":"Mason BJ, Goodman AM, Chabac S, Lehert P . Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: the role of patient motivation. J Psychiatr Res 2006; 40: 383\u201393.","journal-title":"J Psychiatr Res"},{"key":"BFaps2013181_CR49","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1152\/physrev.00013.2008","volume":"89","author":"R Spanagel","year":"2009","unstructured":"Spanagel R . Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev s 2009; 89: 649\u2013705.","journal-title":"Physiol Rev s"},{"key":"BFaps2013181_CR50","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2174\/157488912800673173","volume":"7","author":"S Rahman","year":"2012","unstructured":"Rahman S, Prendergast MA . Cholinergic receptor system as a target for treating alcohol abuse and dependence. Recent Pat CNS Drug Discov 2012; 7: 145\u201350.","journal-title":"Recent Pat CNS Drug Discov"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/aps2013181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps2013181","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps2013181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T17:33:16Z","timestamp":1746120796000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/aps2013181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,27]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["BFaps2013181"],"URL":"https:\/\/doi.org\/10.1038\/aps.2013.181","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,27]]}}}