{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:27:06Z","timestamp":1791559626820,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T00:00:00Z","timestamp":1411948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1038\/aps.2014.82","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T08:58:36Z","timestamp":1411981116000},"page":"1411-1420","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats"],"prefix":"10.1038","volume":"35","author":[{"given":"Shan-shan","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-fei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-feng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-meng","family":"Xuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-li","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-xiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,29]]},"reference":[{"key":"BFaps201482_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s11745-003-1041-9","volume":"38","author":"JC Peters","year":"2003","unstructured":"Peters JC . Dietary fat and body weight control. Lipids 2003; 38: 123\u20137.","journal-title":"Lipids"},{"key":"BFaps201482_CR2","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.freeradbiomed.2013.08.007","volume":"65","author":"G Murdolo","year":"2013","unstructured":"Murdolo G, Bartolini D, Tortoioli C, Piroddi M, Iuliano L, Galli F . Lipokines and oxysterols: Novel adipose-derived lipid hormones linking adipose dysfunction and insulin resistance. Free Radic Biol Med 2013; 65: 811\u201320.","journal-title":"Free Radic Biol Med"},{"key":"BFaps201482_CR3","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.plipres.2011.12.004","volume":"51","author":"H Shimano","year":"2012","unstructured":"Shimano H . Novel qualitative aspects of tissue fatty acids related to metabolic regulation: lessons from Elovl6 knockout. Prog Lipid Res 2012; 51: 267\u201371.","journal-title":"Prog Lipid Res"},{"key":"BFaps201482_CR4","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1161\/CIRCULATIONAHA.111.060889","volume":"125","author":"A Chokshi","year":"2012","unstructured":"Chokshi A, Drosatos K, Cheema FH, Ji R, Khawaja T, Yu S, et al. Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure. Circulation 2012; 125: 2844\u201353.","journal-title":"Circulation"},{"key":"BFaps201482_CR5","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/MOL.0b013e328321b3a8","volume":"20","author":"J Szendroedi","year":"2009","unstructured":"Szendroedi J, Roden M . Ectopic lipids and organ function. Curr Opin Lipidol 2009; 20: 50\u20136.","journal-title":"Curr Opin Lipidol"},{"key":"BFaps201482_CR6","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.2337\/diab.46.11.1768","volume":"46","author":"ND Oakes","year":"1997","unstructured":"Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW . Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 1997; 46: 1768\u201374.","journal-title":"Diabetes"},{"key":"BFaps201482_CR7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/hep.25789","volume":"57","author":"C Savard","year":"2013","unstructured":"Savard C, Tartaglione EV, Kuver R, Haigh WG, Farrell GC, Subramanian S, et al. Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis. Hepatology 2013; 57: 81\u201392.","journal-title":"Hepatology"},{"key":"BFaps201482_CR8","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/aps.2013.170","volume":"35","author":"QQ Tu","year":"2014","unstructured":"Tu QQ, Zheng RY, Li J, Hu L, Chang YX, Li L, et al. Palmitic acid induces autophagy in hepatocytes via JNK2 activation. Acta Pharmacol Sin 2014; 35: 504\u201312.","journal-title":"Acta Pharmacol Sin"},{"key":"BFaps201482_CR9","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1745-7254.2008.00717.x","volume":"29","author":"Y Sun","year":"2008","unstructured":"Sun Y, Ren M, Gao GQ, Gong B, Xin W, Guo H, et al. Chronic palmitate exposure inhibits AMPKalpha and decreases glucose-stimulated insulin secretion from beta-cells: modulation by fenofibrate. Acta Pharmacol Sin 2008; 29: 443\u201350.","journal-title":"Acta Pharmacol Sin"},{"key":"BFaps201482_CR10","doi-asserted-by":"publisher","first-page":"E1168","DOI":"10.1152\/ajpcell.1997.273.4.C1168","volume":"273","author":"BM Tannenbaum","year":"1997","unstructured":"Tannenbaum BM, Brindley DN, Tannenbaum GS, Dallman MF, McArthur MD, Meaney MJ . High-fat feeding alters both basal and stress-induced hypothalamic-pituitary-adrenal activity in the rat. Am J Physiol 1997; 273: E1168\u201377.","journal-title":"Am J Physiol"},{"key":"BFaps201482_CR11","first-page":"221","volume":"31","author":"WE Winter","year":"2001","unstructured":"Winter WE, Signorino MR . Review: molecular thyroidology. Ann Clin Lab Sci 2001; 31: 221\u201344.","journal-title":"Ann Clin Lab Sci"},{"key":"BFaps201482_CR12","unstructured":"Kronenberg HM, Polonsky KS, Larsen PR, Melmed S . Williams Textbook of Endocrinology, 12\/e Elsevier India; 2007."},{"key":"BFaps201482_CR13","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2147\/CIA.S23966","volume":"7","author":"IM Bensenor","year":"2012","unstructured":"Bensenor IM, Olmos RD, Lotufo PA . Hypothyroidism in the elderly: diagnosis and management. Clin Interv Aging 2012; 7: 97\u2013111.","journal-title":"Clin Interv Aging"},{"key":"BFaps201482_CR14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.4158\/1934-2403-8.6.457","volume":"8","author":"HJ Baskin","year":"2002","unstructured":"Baskin HJ, Cobin RH, Duick DS, Gharib H, Guttler RB, Kaplan MM, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract 2002; 8: 457\u201369.","journal-title":"Endocr Pract"},{"key":"BFaps201482_CR15","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1210\/en.2010-0026","volume":"151","author":"RL Araujo","year":"2010","unstructured":"Araujo RL, Andrade BM, Padron AS, Gaidhu MP, Perry RLS, Carvalho DP, et al. High-fat diet increases thyrotropin and oxygen consumption without altering circulating 3,5,3\u2032-triiodothyronine (T3) and thyroxine in rats: the role of iodothyronine deiodinases, reverse T3 production, and whole-body fat oxidation. Endocrinology 2010; 151: 3460\u20139.","journal-title":"Endocrinology"},{"key":"BFaps201482_CR16","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s12011-011-9300-x","volume":"147","author":"H Han","year":"2012","unstructured":"Han H, Xin P, Zhao L, Xu J, Xia Y, Yang X, et al. Excess iodine and high-fat diet combination modulates lipid profile, thyroid hormone, and hepatic LDLr expression values in mice. Biol Trace Elem Res 2012; 147: 233\u20139.","journal-title":"Biol Trace Elem Res"},{"key":"BFaps201482_CR17","doi-asserted-by":"publisher","first-page":"4810","DOI":"10.1210\/en.2009-0417","volume":"150","author":"M Mancini","year":"2009","unstructured":"Mancini M, Vergara E, Salvatore G, Greco A, Troncone G, Affuso A, et al. Morphological ultrasound microimaging of thyroid in living mice. Endocrinology 2009; 150: 4810\u20135.","journal-title":"Endocrinology"},{"key":"BFaps201482_CR18","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1083\/jcb.9.2.409","volume":"9","author":"JH Luft","year":"1961","unstructured":"Luft JH . Improvements in epoxy resin embedding methods. J Biophys Biochem Cytol 1961; 9: 409\u201314.","journal-title":"J Biophys Biochem Cytol"},{"key":"BFaps201482_CR19","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1093\/toxsci\/kfm312","volume":"102","author":"ED McLanahan","year":"2008","unstructured":"McLanahan ED, Andersen ME, Fisher JW . A biologically based dose-response model for dietary iodide and the hypothalamic-pituitary-thyroid axis in the adult rat: evaluation of iodide deficiency. Toxicol Sci 2008; 102: 241\u201353.","journal-title":"Toxicol Sci"},{"key":"BFaps201482_CR20","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1139\/y2012-046","volume":"90","author":"Ael-A Hussein","year":"2012","unstructured":"Hussein Ael-A, Abbas AM, El Wakil GA, Elsamanoudy AZ, El Aziz AA . Effect of chronic excess iodine intake on thyroid function and oxidative stress in hypothyroid rats. Can J Physiol Pharmacol 2012; 90: 617\u201325.","journal-title":"Can J Physiol Pharmacol"},{"key":"BFaps201482_CR21","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/1476-511X-12-100","volume":"12","author":"V Welch-White","year":"2013","unstructured":"Welch-White V, Dawkins N, Graham T, Pace R . The impact of high fat diets on physiological changes in euthyroid and thyroid altered rats. Lipids Health Dis 2013; 12: 100.","journal-title":"Lipids Health Dis"},{"key":"BFaps201482_CR22","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1055\/s-0031-1297941","volume":"44","author":"GS Argumedo","year":"2012","unstructured":"Argumedo GS, Sanz CR, Olguin HJ . Experimental models of developmental hypothyroidism. Horm Metab Res 2012; 44: 79\u201385.","journal-title":"Horm Metab Res"},{"key":"BFaps201482_CR23","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1007\/s00125-012-2686-y","volume":"55","author":"AD McNeilly","year":"2012","unstructured":"McNeilly AD, Williamson R, Balfour DJ, Stewart CA, Sutherland C . A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin. Diabetologia 2012; 55: 3061\u201370.","journal-title":"Diabetologia"},{"key":"BFaps201482_CR24","doi-asserted-by":"publisher","first-page":"E1162","DOI":"10.1152\/ajpendo.00169.2009","volume":"297","author":"M Flamment","year":"2009","unstructured":"Flamment M, Gueguen N, Wetterwald C, Simard G, Malthiery Y, Ducluzeau PH . Effects of the cannabinoid CB1 antagonist rimonabant on hepatic mitochondrial function in rats fed a high-fat diet. Am J Physiol Endocrinol Metab 2009; 297: E1162\u201370.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFaps201482_CR25","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1038\/aps.2009.150","volume":"30","author":"HX Guo","year":"2009","unstructured":"Guo HX, Liu DH, Ma Y, Liu JF, Wang Y, Du ZY, et al. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. Acta Pharmacol Sin 2009; 30: 1505\u201312.","journal-title":"Acta Pharmacol Sin"},{"key":"BFaps201482_CR26","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1139\/h11-153","volume":"37","author":"MC Louwe","year":"2012","unstructured":"Louwe MC, van der Hoorn JW, van den Berg SA, Jukema JW, Romijn JA, van Dijk KW, et al. Gender-dependent effects of high-fat lard diet on cardiac function in C57Bl\/6J mice. Appl Physiol Nutr Metab 2012; 37: 214\u201324.","journal-title":"Appl Physiol Nutr Metab"},{"key":"BFaps201482_CR27","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.2337\/diabetes.53.11.2844","volume":"53","author":"J Matsui","year":"2004","unstructured":"Matsui J, Terauchi Y, Kubota N, Takamoto I, Eto K, Yamashita T, et al. Pioglitazone reduces islet triglyceride content and restores impaired glucose-stimulated insulin secretion in heterozygous peroxisome proliferator-activated receptor-gamma-deficient mice on a high-fat diet. Diabetes 2004; 53: 2844\u201354.","journal-title":"Diabetes"},{"key":"BFaps201482_CR28","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1073\/pnas.97.4.1784","volume":"97","author":"YT Zhou","year":"2000","unstructured":"Zhou YT, Grayburn P, Karim A, Shimabukuro M, Higa M, Baetens D, et al. Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci U S A 2000; 97: 1784\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFaps201482_CR29","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1093\/ajcn\/79.3.502","volume":"79","author":"CS Lieber","year":"2004","unstructured":"Lieber CS, Leo MA, Mak KM, Xu Y, Cao Q, Ren C, et al. Model of nonalcoholic steatohepatitis. Am J Clin Nutr 2004; 79: 502\u20139.","journal-title":"Am J Clin Nutr"},{"key":"BFaps201482_CR30","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s002689910028","volume":"24","author":"BM Barraclough","year":"2000","unstructured":"Barraclough BM, Barraclough BH . Ultrasound of the thyroid and parathyroid glands. World J Surg 2000; 24: 158\u201365.","journal-title":"World J Surg"},{"key":"BFaps201482_CR31","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1097\/00013644-200312000-00002","volume":"19","author":"N Khati","year":"2003","unstructured":"Khati N, Adamson T, Johnson KS, Hill MC . Ultrasound of the thyroid and parathyroid glands. Ultrasound Q 2003; 19: 162\u201376.","journal-title":"Ultrasound Q"},{"key":"BFaps201482_CR32","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1939-1676.2002.tb01615.x","volume":"16","author":"BA Breuhaus","year":"2002","unstructured":"Breuhaus BA . Thyroid-stimulating hormone in adult euthyroid and hypothyroid horses. J Vet Intern Med 2002; 16: 109\u201315.","journal-title":"J Vet Intern Med"},{"key":"BFaps201482_CR33","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/j.1939-1676.2005.tb02717.x","volume":"19","author":"S Reese","year":"2005","unstructured":"Reese S, Breyer U, Deeg C, Kraft W, Kaspers B . Thyroid sonography as an effective tool to discriminate between euthyroid sick and hypothyroid dogs. J Vet Intern Med 2005; 19: 491\u20138.","journal-title":"J Vet Intern Med"},{"key":"BFaps201482_CR34","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.2460\/ajvr.73.11.1696","volume":"73","author":"BC Kot","year":"2012","unstructured":"Kot BC, Ying MT, Brook FM, Kinoshita RE, Cheng SC . Ultrasonographic assessment of the thyroid gland and adjacent anatomic structures in Indo-Pacific bottlenose dolphins (Tursiops aduncus). Am J Vet Res 2012; 73: 1696\u2013706.","journal-title":"Am J Vet Res"},{"key":"BFaps201482_CR35","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1007\/s12011-013-9811-8","volume":"155","author":"J Gao","year":"2013","unstructured":"Gao J, Lin X, Liu X, Yang Q, Zhang Z, Jiang Q, et al. Effect of combined excess iodine and low-protein diet on thyroid hormones and ultrastructure in Wistar rats. Biol Trace Elem Res 2013; 155: 416\u201322.","journal-title":"Biol Trace Elem Res"},{"key":"BFaps201482_CR36","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.etp.2013.02.001","volume":"65","author":"JM Tang","year":"2013","unstructured":"Tang JM, Li W, Xie YC, Guo HW, Cheng P, Chen HH, et al. Morphological and functional deterioration of the rat thyroid following chronic exposure to low-dose PCB118. Exp Toxicol Pathol 2013; 65: 989\u201394.","journal-title":"Exp Toxicol Pathol"},{"key":"BFaps201482_CR37","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/355033a0","volume":"355","author":"MJ Gething","year":"1992","unstructured":"Gething MJ, Sambrook J . Protein folding in the cell. Nature 1992; 355: 33\u201345.","journal-title":"Nature"},{"key":"BFaps201482_CR38","doi-asserted-by":"publisher","first-page":"e1000731","DOI":"10.1371\/journal.ppat.1000731","volume":"6","author":"H Goldshmidt","year":"2010","unstructured":"Goldshmidt H, Matas D, Kabi A, Carmi S, Hope R, Michaeli S . Persistent ER stress induces the spliced leader RNA silencing pathway (SLS), leading to programmed cell death in Trypanosoma brucei. PLoS Pathog 2010; 6: e1000731.","journal-title":"PLoS Pathog"},{"key":"BFaps201482_CR39","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.5754\/hge11419","volume":"59","author":"YY Xu","year":"2012","unstructured":"Xu YY, You YW, Ren XH, Ding Y, Cao J, Zang WD, et al. Endoplasmic reticulum stress-mediated signaling pathway of gastric cancer apoptosis. Hepatogastroenterology 2012; 59: 2377\u201384.","journal-title":"Hepatogastroenterology"},{"key":"BFaps201482_CR40","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s10495-013-0945-0","volume":"19","author":"SE Chow","year":"2014","unstructured":"Chow SE, Kao CH, Liu YT, Cheng ML, Yang YW, Huang YK, et al. Resveratrol induced ER expansion and ER caspase-mediated apoptosis in human nasopharyngeal carcinoma cells. Apoptosis 2014; 19: 527\u201341.","journal-title":"Apoptosis"},{"key":"BFaps201482_CR41","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.mrfmmm.2004.06.056","volume":"569","author":"M Schroder","year":"2005","unstructured":"Schroder M, Kaufman RJ . ER stress and the unfolded protein response. Mutat Res 2005; 569: 29\u201363.","journal-title":"Mutat Res"},{"key":"BFaps201482_CR42","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.semcdb.2007.09.003","volume":"18","author":"JD Malhotra","year":"2007","unstructured":"Malhotra JD, Kaufman RJ . The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol 2007; 18: 716\u201331.","journal-title":"Semin Cell Dev Biol"},{"key":"BFaps201482_CR43","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s11010-011-1211-9","volume":"364","author":"J Cao","year":"2012","unstructured":"Cao J, Dai DL, Yao L, Yu HH, Ning B, Zhang Q, et al. Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK\/ATF4\/CHOP signaling pathway. Mol Cell Biochem 2012; 364: 115\u201329.","journal-title":"Mol Cell Biochem"},{"key":"BFaps201482_CR44","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/srep00799","volume":"2","author":"N Kawasaki","year":"2012","unstructured":"Kawasaki N, Asada R, Saito A, Kanemoto S, Imaizumi K . Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue. Sci Rep 2012; 2: 799.","journal-title":"Sci Rep"},{"key":"BFaps201482_CR45","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0079-6603(00)66033-6","volume":"66","author":"G Damante","year":"2001","unstructured":"Damante G, Tell G, Di Lauro R . A unique combination of transcription factors controls differentiation of thyroid cells. Prog Nucleic Acid Res Mol Biol 2001; 66: 307\u201356.","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"BFaps201482_CR46","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1152\/physrev.2000.80.3.1083","volume":"80","author":"A De La Vieja","year":"2000","unstructured":"De La Vieja A, Dohan O, Levy O, Carrasco N . Molecular analysis of the sodium\/iodide symporter: impact on thyroid and extrathyroid pathophysiology. Physiol Rev 2000; 80: 1083\u2013105.","journal-title":"Physiol Rev"},{"key":"BFaps201482_CR47","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1242\/jcs.017202","volume":"121","author":"L Ulianich","year":"2008","unstructured":"Ulianich L, Garbi C, Treglia AS, Punzi D, Miele C, Raciti GA, et al. ER stress is associated with dedifferentiation and an epithelial-to-mesenchymal transition-like phenotype in PC Cl3 thyroid cells. J Cell Sci 2008; 121: 477\u201386.","journal-title":"J Cell Sci"},{"key":"BFaps201482_CR48","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1093\/carcin\/20.8.1567","volume":"20","author":"N Fujimoto","year":"1999","unstructured":"Fujimoto N, Onodera H, Mitsumori K, Tamura T, Maruyama S, Ito A . Changes in thyroid function during development of thyroid hyperplasia induced by kojic acid in F344 rats. Carcinogenesis 1999; 20: 1567\u201371.","journal-title":"Carcinogenesis"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/aps201482.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps201482","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps201482.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:32:04Z","timestamp":1684413124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/aps201482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,29]]},"references-count":48,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["BFaps201482"],"URL":"https:\/\/doi.org\/10.1038\/aps.2014.82","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,29]]},"assertion":[{"value":"20 February 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}