{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T23:47:09Z","timestamp":1778975229922,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1038\/aps.2015.164","type":"journal-article","created":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T10:01:56Z","timestamp":1457949716000},"page":"545-554","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms"],"prefix":"10.1038","volume":"37","author":[{"given":"Hui-fang","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,14]]},"reference":[{"key":"BFaps2015164_CR1","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1440-1681.2012.05673.x","volume":"39","author":"JC Mak","year":"2012","unstructured":"Mak JC . Potential role of green tea catechins in various disease therapies: progress and promise. Clin Exp Pharmacol Physiol 2012; 39: 265\u201373.","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"BFaps2015164_CR2","first-page":"103","volume":"71","author":"JR Bell","year":"2000","unstructured":"Bell JR, Donovan JL, Wong R, Waterhouse AL, German JB, Walzem RL, et al. (+)-Catechin in human plasma after ingestion of a single serving of reconstituted red wine. Pharmacogn Rev 2000; 71: 103\u20138.","journal-title":"Pharmacogn Rev"},{"key":"BFaps2015164_CR3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/0006-2952(93)90371-3","volume":"45","author":"I Morel","year":"1993","unstructured":"Morel I, Lescoat G, Cogrel P, Sergent O, Pasdeloup N, Brissot P, et al. Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures. Biochem Pharmacol 1993; 45: 13\u20139.","journal-title":"Biochem Pharmacol"},{"key":"BFaps2015164_CR4","doi-asserted-by":"crossref","unstructured":"Li M . Pueraria lobata (Willd.) Ohwi (Gegen, Kudzu). Dietary Chinese Herbs: Springer; 2015. P 235\u201345.","DOI":"10.1007\/978-3-211-99448-1_26"},{"key":"BFaps2015164_CR5","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1021\/np0203887","volume":"66","author":"FL Hsu","year":"2003","unstructured":"Hsu FL, Liu IM, Kuo DH, Chen WC, Su HC, Cheng JT . Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. J Nat Prod 2003; 66: 788\u201392.","journal-title":"J Nat Prod"},{"key":"BFaps2015164_CR6","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.lfs.2006.01.016","volume":"79","author":"LP Yan","year":"2006","unstructured":"Yan LP, Chan SW, Chan AS, Chen SL, Ma XJ, Xu HX . Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. Life Sci 2006; 79: 324\u201330.","journal-title":"Life Sci"},{"key":"BFaps2015164_CR7","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1089\/jop.1999.15.207","volume":"15","author":"B Xuan","year":"1999","unstructured":"Xuan B, Zhou YH, Yang RL, Li N, Min ZD, Chiou GC . Improvement of ocular blood flow and retinal functions with puerarin analogs. J Ocul Pharmacol Ther 1999; 15: 207\u201316.","journal-title":"J Ocul Pharmacol Ther"},{"key":"BFaps2015164_CR8","first-page":"55","volume":"9","author":"X Song","year":"1988","unstructured":"Song X, Chen P, Chai X . Effects of puerarin on blood pressure and plasma renin activity in spontaneously hypertensive rat. Acta Pharmacol Sin 1988; 9: 55\u20138.","journal-title":"Acta Pharmacol Sin"},{"key":"BFaps2015164_CR9","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1089\/1096620041224102","volume":"7","author":"E Benlhabib","year":"2004","unstructured":"Benlhabib E, Baker JI, Keyler DE, Singh AK . Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. J Med Food 2004; 7: 180\u20136.","journal-title":"J Med Food"},{"key":"BFaps2015164_CR10","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1080\/07315724.2005.10719488","volume":"24","author":"Y Song","year":"2005","unstructured":"Song Y, Manson JE, Buring JE, Sesso HD, Liu S . Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis. J Am Coll Nutr 2005; 24: 376\u201384.","journal-title":"J Am Coll Nutr"},{"key":"BFaps2015164_CR11","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1093\/jn\/130.10.2409","volume":"130","author":"CS Yang","year":"2000","unstructured":"Yang CS, Landau JM . Effects of tea consumption on nutrition and health. J Nutr 2000; 130: 2409\u201312.","journal-title":"J Nutr"},{"key":"BFaps2015164_CR12","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1111\/j.1365-2621.2006.01363.x","volume":"42","author":"Z Geng","year":"2007","unstructured":"Geng Z, Zongdao C, Yimin W . Physicochemical properties of lotus (Nelumbo nucifera Gaertn) and kudzu (Pueraria hirsute Matsum) starches. Inter J Food Sci Tech 2007; 42: 1449\u201355.","journal-title":"Inter J Food Sci Tech"},{"key":"BFaps2015164_CR13","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/0891-5849(95)02227-9","volume":"20","author":"CA Rice-Evans","year":"1996","unstructured":"Rice-Evans CA, Miller NJ, Paganga G . Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Bio Med 1996; 20: 933\u201356.","journal-title":"Free Radical Bio Med"},{"key":"BFaps2015164_CR14","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1080\/10408399709527802","volume":"37","author":"L Tijburg","year":"1997","unstructured":"Tijburg L, Mattern T, Folts J, Weisgerber U, Katan M . Tea flavonoids and cardiovascular diseases: a review. Critl Rev Food Sci 1997; 37: 771\u201385.","journal-title":"Critl Rev Food Sci"},{"key":"BFaps2015164_CR15","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1097\/MNM.0b013e3283108995","volume":"29","author":"H Wan","year":"2008","unstructured":"Wan H, Zhu H, Tian M, Hu X, Yang J, Zhao C, et al. Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia. Nucl Med Commun 2008; 29: 1113\u201322.","journal-title":"Nucl Med Commun"},{"key":"BFaps2015164_CR16","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1016\/S0024-3205(00)00885-7","volume":"67","author":"M Guerra","year":"2000","unstructured":"Guerra M, Speroni E, Broccoli M, Cangini M, Pasini P, Minghetti A, et al. Comparison between Chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin: antioxidant properties and effects on rat liver CYP-catalysed drug metabolism. Life Sci 2000; 67: 2997\u20133006.","journal-title":"Life Sci"},{"key":"BFaps2015164_CR17","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1016\/0006-2952(71)90449-7","volume":"20","author":"N Das","year":"1971","unstructured":"Das N . Studies on flavonoid metabolism: Absorption and metabolism of (+)-catechin in man. Biochem Pharmacol 1971; 20: 3435\u201345.","journal-title":"Biochem Pharmacol"},{"key":"BFaps2015164_CR18","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jchromb.2011.11.021","volume":"880","author":"QH Zhang","year":"2012","unstructured":"Zhang QH, Wang WB, Li J, Chang YX, Wang YF, Zhang J, et al. Simultaneous determination of catechin, epicatechin and epicatechin gallate in rat plasma by LC\u2013ESI-MS\/MS for pharmacokinetic studies after oral administration of Cynomorium songaricum extract. J Chromatogr B Analyt Technol Biomed Life Sci 2012; 880: 168\u201371.","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"BFaps2015164_CR19","first-page":"6","volume":"2011","author":"L Zhao","year":"2011","unstructured":"Zhao L, Liu A, Sun M, Gu J, Wang H, Wang S, et al. Enhancement of oral bioavailability of puerarin by polybutylcyanoacrylate nanoparticles. J Nanomater 2011; 2011: 6.","journal-title":"J Nanomater"},{"key":"BFaps2015164_CR20","first-page":"27","volume":"8","author":"Jl Wong","year":"2011","unstructured":"Wong Jl, Zheng Z . The clinical research of Song Ling Xue Mai Kang ameliorating the compliance and endothelial function of artery in hypertensive patients. J Tradit Chin Med Univ Hunan 2011; 8: 27.","journal-title":"J Tradit Chin Med Univ Hunan"},{"key":"BFaps2015164_CR21","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0031-9422(00)80826-2","volume":"24","author":"Z Shen","year":"1985","unstructured":"Shen Z, Theander O . Flavonoid glycosides from needles of Pinus massoniana. Phytochemistry 1985; 24: 155\u20138.","journal-title":"Phytochemistry"},{"key":"BFaps2015164_CR22","first-page":"30","volume":"1","author":"HY Qiao","year":"2013","unstructured":"Qiao HY, Zhu WL, Luo R, Ke ZH, Hao XF, Ke X, et al. UPLC fingerprint and components identification of Songling Xuemaikang capsules by LC-MS\/MS. West China J Pharm Sci 2013; 1: 30.","journal-title":"West China J Pharm Sci"},{"key":"BFaps2015164_CR23","first-page":"601","volume":"18","author":"C Palleria","year":"2013","unstructured":"Palleria C, Di Paolo A, Giofr\u00e8 C, Caglioti C, Leuzzi G, Siniscalchi A, et al. Pharmacokinetic drug-drug interaction and their implication in clinical management. J Res Med Sci 2013; 18: 601\u201310.","journal-title":"J Res Med Sci"},{"key":"BFaps2015164_CR24","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1093\/jn\/134.8.1948","volume":"134","author":"JD Lambert","year":"2004","unstructured":"Lambert JD, Hong J, Kim DH, Mishin VM, Yang CS . Piperine enhances the bioavailability of the tea polyphenol (\u2212)-epigallocatechin-3-gallate in mice. J Nutr 2004; 134: 1948\u201352.","journal-title":"J Nutr"},{"key":"BFaps2015164_CR25","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.1093\/jn\/131.11.2885","volume":"131","author":"S Baba","year":"2001","unstructured":"Baba S, Osakabe N, Natsume M, Muto Y, Takizawa T, Terao J . In vivo comparison of the bioavailability of (+)-catechin,(\u2212)-epicatechin and their mixture in orally administered rats. J Nutr 2001; 131: 2885\u201391.","journal-title":"J Nutr"},{"key":"BFaps2015164_CR26","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jchromb.2012.12.011","volume":"915-916","author":"Li Jiang","year":"2013","unstructured":"Jiang L, Dai J, Huang Z, Du Q, Lin J, Wang Y . Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci 2013; 915\u2013916: 8\u201312.","journal-title":"Journal of Chromatography B"},{"key":"BFaps2015164_CR27","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/S0891-5849(99)00159-8","volume":"27","author":"C Manach","year":"1999","unstructured":"Manach C, Texier O, Morand C, Crespy V, R\u00e9g\u00e9rat F, Demign\u00e9 C, et al. Comparison of the bioavailability of quercetin and catechin in rats. Free Radical Biol Med 1999; 27: 1259\u201366.","journal-title":"Free Radical Biol Med"},{"key":"BFaps2015164_CR28","first-page":"944","volume":"65","author":"J K\u00f6nig","year":"2013","unstructured":"K\u00f6nig J, M\u00fcller F, Fromm MF . Transporters and drug-drug interactions: important determinants of drug disposition and effects. Pharmacogn Rev 2013; 65: 944\u201366.","journal-title":"Pharmacogn Rev"},{"key":"BFaps2015164_CR29","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.jep.2012.10.011","volume":"144","author":"XL Liang","year":"2012","unstructured":"Liang XL, Zhao LJ, Liao ZG, Zhao GW, Zhang J, Chao YC, et al. Transport properties of puerarin and effect of Radix Angelicae Dahuricae extract on the transport of puerarin in Caco-2 cell model. J Ethnopharmacol 2012; 144: 677\u201382.","journal-title":"J Ethnopharmacol"},{"key":"BFaps2015164_CR30","first-page":"41","volume":"39","author":"L Song","year":"2008","unstructured":"Song L, Zhang N, Xu DS . Absorption mechanism of paeoniflorin across Caco-2 monolayer model. Chin Tradit and Herbal Drugs 2008; 39: 41.","journal-title":"Chin Tradit and Herbal Drugs"},{"key":"BFaps2015164_CR31","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1046\/j.1365-2710.2003.00487.x","volume":"28","author":"R Wang","year":"2003","unstructured":"Wang R, Kuo C, Lien L, Lien E . Structure\u2013activity relationship: analyses of P-glycoprotein substrates and inhibitors. J Clin Pharm Ther 2003; 28: 203\u201328.","journal-title":"J Clin Pharm Ther"},{"key":"BFaps2015164_CR32","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1248\/bpb.28.2274","volume":"28","author":"S Kitagawa","year":"2005","unstructured":"Kitagawa S, Nabekura T, Takahashi T, Nakamura Y, Sakamoto H, Tano H, et al. Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells. Biol Pharm Bull 2005; 28: 2274\u20138.","journal-title":"Biol Pharm Bull"},{"key":"BFaps2015164_CR33","first-page":"713","volume":"7","author":"V Saxena","year":"2012","unstructured":"Saxena V, Hussain MD . Poloxamer 407\/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer. Int J Nanomed 2012; 7: 713\u201321.","journal-title":"Int J Nanomed"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/aps2015164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps2015164","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps2015164.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:32:58Z","timestamp":1684413178000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/aps2015164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,14]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["BFaps2015164"],"URL":"https:\/\/doi.org\/10.1038\/aps.2015.164","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,14]]},"assertion":[{"value":"2 September 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}