{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:18:38Z","timestamp":1792289918999,"version":"4.4.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T00:00:00Z","timestamp":1460332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1038\/aps.2016.14","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T09:03:13Z","timestamp":1460365393000},"page":"763-771","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Methylophiopogonanone A suppresses ischemia\/reperfusion-induced myocardial apoptosis in mice via activating PI3K\/Akt\/eNOS signaling pathway"],"prefix":"10.1038","volume":"37","author":[{"given":"Fei","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bang-long","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-jing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-xiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-long","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,11]]},"reference":[{"key":"BFaps201614_CR1","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1016\/j.jacc.2015.02.032","volume":"65","author":"B Ibanez","year":"2015","unstructured":"Ibanez B, Heusch G, Ovize M, Van de Werf F . Evolving therapies for myocardial ischemia\/reperfusion injury. J Am Coll Cardiol 2015; 65: 1454\u201371.","journal-title":"J Am Coll Cardiol"},{"key":"BFaps201614_CR2","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1056\/NEJMra071667","volume":"357","author":"DM Yellon","year":"2007","unstructured":"Yellon DM, Hausenloy DJ . Mechanisms of disease: myocardial reperfusion injury. New Engl J Med 2007; 357: 1121\u201335.","journal-title":"New Engl J Med"},{"key":"BFaps201614_CR3","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1161\/CIRCRESAHA.116.305348","volume":"116","author":"G Heusch","year":"2015","unstructured":"Heusch G . Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res 2015; 116: 674\u201399.","journal-title":"Circ Res"},{"key":"BFaps201614_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00395-015-0464-y","volume":"110","author":"S Hernandez-Resendiz","year":"2015","unstructured":"Hernandez-Resendiz S, Palma-Flores C, De Los Santos S, Roman-Anguiano NG, Flores M, de la Pena A, et al. Reduction of no-reflow and reperfusion injury with the synthetic 17beta-aminoestrogen compound Prolame is associated with PI3K\/Akt\/eNOS signaling cascade. Basic Res Cardiol 2015; 110: 1.","journal-title":"Basic Res Cardiol"},{"key":"BFaps201614_CR5","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1002\/jssc.200800732","volume":"32","author":"CJ Ma","year":"2009","unstructured":"Ma CJ, Li G, Zhang J, Zheng QS, Fan X, Wang ZH . An efficient combination of supercritical fluid extraction and high-speed counter-current chromatography to extract and purify homoisoflavonoids from Ophiopogon japonicus (Thunb) Ker-Gawler. J Sep Sci 2009; 32: 1949\u201356.","journal-title":"J Sep Sci"},{"key":"BFaps201614_CR6","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1039\/b304821g","volume":"21","author":"YZ Zhu","year":"2004","unstructured":"Zhu YZ, Huang SH, Tan BKH, Sun J, Whiteman M, Zhu YC . Antioxidants in Chinese herbal medicines: a biochemical perspective. Nat Prod Rep 2004; 21: 478\u201389.","journal-title":"Nat Prod Rep"},{"key":"BFaps201614_CR7","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.cardiores.2003.09.024","volume":"61","author":"DJ Hausenloy","year":"2004","unstructured":"Hausenloy DJ, Yellon DM . New directions for protecting the heart against ischaemia-reperfusion injury: targeting the reperfusion injury Salvage kinase (RISK)-pathway. Cardiovasc Res 2004; 61: 448\u201360.","journal-title":"Cardiovasc Res"},{"key":"BFaps201614_CR8","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1161\/01.RES.0000138303.76488.fe","volume":"95","author":"A Tsang","year":"2004","unstructured":"Tsang A, Hausenloy DJ, Mocanu MM, Yellon DM . Postconditioning: A form of \u201cmodified reperfusion\u201d protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ Res 2004; 95: 230\u20132.","journal-title":"Circ Res"},{"key":"BFaps201614_CR9","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/aps.2012.204","volume":"34","author":"MM Zhao","year":"2013","unstructured":"Zhao MM, Yang JY, Wang XB, Tang CS, Du JB, Jin HF . The PI3K\/Akt pathway mediates the protection of SO(2) preconditioning against myocardial ischemia\/reperfusion injury in rats. Acta Pharmacol Sin 2013; 34: 501\u20136.","journal-title":"Acta Pharmacol Sin"},{"key":"BFaps201614_CR10","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1161\/01.CIR.0000112575.66565.84","volume":"109","author":"J Oyama","year":"2004","unstructured":"Oyama J, Blais C, Liu XL, Pu MY, Kobzik L, Kelly RA, et al. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 2004; 109: 784\u20139.","journal-title":"Circulation"},{"key":"BFaps201614_CR11","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cca.2006.08.027","volume":"377","author":"BH Ren","year":"2007","unstructured":"Ren BH, Shen Y, Shao HT, Qian JJ, Wu HW, Jing H . Brain natriuretic peptide limits myocardial infarct size dependent of nitric oxide synthase in rats. Clin Chim Acta 2007; 377: 83\u20137.","journal-title":"Clin Chim Acta"},{"key":"BFaps201614_CR12","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.yjmcc.2009.12.015","volume":"48","author":"MA Salas","year":"2010","unstructured":"Salas MA, Valverde CA, Sanchez G, Said M, Rodriguez JS, Portiansky EL, et al. The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia\/reperfusion injury. J Mol Cell Cardiol 2010; 48: 1298\u2013306.","journal-title":"J Mol Cell Cardiol"},{"key":"BFaps201614_CR13","doi-asserted-by":"publisher","first-page":"15560","DOI":"10.1073\/pnas.0705891104","volume":"104","author":"JW Elrod","year":"2007","unstructured":"Elrod JW, Calvert JW, Morrison J, Doeller JE, Kraus DW, Tao L, et al. Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function. Proc Natl Acad Sci U S A 2007; 104: 15560\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFaps201614_CR14","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1016\/j.yexcr.2012.03.030","volume":"318","author":"SS Zhou","year":"2012","unstructured":"Zhou SS, He F, Chen AH, Hao PY, Song XD . Suppression of rat Frizzled-2 attenuates hypoxia\/reoxygenation-induced Ca2+ accumulation in rat H9c2 cells. Exp Cell Res 2012; 318: 1480\u201391.","journal-title":"Exp Cell Res"},{"key":"BFaps201614_CR15","first-page":"351","volume":"4","author":"S Lee","year":"2011","unstructured":"Lee S, Kim K, Kim YH, Chung MH, Kang I, Ha J, et al. Preventive role of propofol in hypoxia\/reoxygenation-induced apoptotic H9c2 rat cardiac myoblast cell death. Mol Med Rep 2011; 4: 351\u20136.","journal-title":"Mol Med Rep"},{"key":"BFaps201614_CR16","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3724\/SP.J.1009.2013.00222","volume":"11","author":"LH Li","year":"2013","unstructured":"Li LH, Wang JS, Kong LY . Protective effects of Shengmai San and its three fractions on cerebral ischemia-reperfusion injury. Chin J Nat Med 2013; 11: 222\u201330.","journal-title":"Chin J Nat Med"},{"key":"BFaps201614_CR17","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.fitote.2012.05.011","volume":"83","author":"N Li","year":"2012","unstructured":"Li N, Zhang JY, Zeng KW, Zhang L, Che YY, Tu PF . Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus. Fitoterapia 2012; 83: 1042\u20135.","journal-title":"Fitoterapia"},{"key":"BFaps201614_CR18","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/cddis.2011.130","volume":"2","author":"M Chiong","year":"2011","unstructured":"Chiong M, Wang ZV, Pedrozo Z, Cao DJ, Troncoso R, Ibacache M, et al. Cardiomyocyte death: mechanisms and translational implications. Cell Death Disease 2011; 2: 11.","journal-title":"Cell Death Disease"},{"key":"BFaps201614_CR19","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/cvr\/cvq082","volume":"87","author":"Y Cheng","year":"2010","unstructured":"Cheng Y, Zhu P, Yang J, Liu X, Dong S, Wang X, et al. Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia\/reperfusion injury via anti-apoptosis through its target PDCD4. Cardiovasc Res 2010; 87: 431\u20139.","journal-title":"Cardiovasc Res"},{"key":"BFaps201614_CR20","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s11010-009-0377-x","volume":"339","author":"C Wagner","year":"2010","unstructured":"Wagner C, Tillack D, Simonis G, Strasser RH, Weinbrenner C . Ischemic post-conditioning reduces infarct size of the in vivo rat heart: role of PI3-K, mTOR, GSK-3beta, and apoptosis. Mol Cell Biochem 2010; 339: 135\u201347.","journal-title":"Mol Cell Biochem"},{"key":"BFaps201614_CR21","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1172\/JCI59327","volume":"122","author":"AB Aurora","year":"2012","unstructured":"Aurora AB, Mahmoud AI, Luo X, Johnson BA, van Rooij E, Matsuzaki S, et al. MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death. J Clin Invest 2012; 122: 1222\u201332.","journal-title":"J Clin Invest"},{"key":"BFaps201614_CR22","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1161\/CIRCRESAHA.111.244442","volume":"110","author":"TG Hullinger","year":"2012","unstructured":"Hullinger TG, Montgomery RL, Seto AG, Dickinson BA, Semus HM, Lynch JM, et al. Inhibition of miR-15 protects against cardiac ischemic injury. Circ Res 2012; 110: 71\u201381.","journal-title":"Circ Res"},{"key":"BFaps201614_CR23","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.scr.2013.01.002","volume":"10","author":"F Arslan","year":"2013","unstructured":"Arslan F, Lai RC, Smeets MB, Akeroyd L, Choo A, Aguor ENE, et al. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K\/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia\/reperfusion injury. Stem Cell Res 2013; 10: 301\u201312.","journal-title":"Stem Cell Res"},{"key":"BFaps201614_CR24","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00395-010-0133-0","volume":"106","author":"L Breivik","year":"2011","unstructured":"Breivik L, Helgeland E, Aarnes EK, Mrdalj J, Jonassen AK . Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K\/Akt-dependent cell-survival signaling at reperfusion. Basic Res Cardiol 2011; 106: 135\u201345.","journal-title":"Basic Res Cardiol"},{"key":"BFaps201614_CR25","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1124\/jpet.104.070839","volume":"311","author":"Y Takada","year":"2004","unstructured":"Takada Y, Hashimoto M, Kasahara J, Aihara K, Fukunaga K . Cytoprotective effect of sodium orthovanadate on ischemia\/reperfusion-induced injury in the rat heart involves Akt activation and inhibition of fodrin breakdown and apoptosis. J Pharmacol Exp Ther 2004; 311: 1249\u201355.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFaps201614_CR26","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1159\/000374035","volume":"35","author":"H Wu","year":"2015","unstructured":"Wu H, Ye M, Yang J, Ding J, Yang J, Dong W, et al. Nicorandil protects the heart from Ischemia\/reperfusion injury by attenuating endoplasmic reticulum response-induced apoptosis through PI3K\/Akt signaling pathway. Cell Physiol Biochem 2015; 35: 2320\u201332.","journal-title":"Cell Physiol Biochem"},{"key":"BFaps201614_CR27","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1161\/01.CIR.0000130647.29030.90","volume":"109","author":"T Uchiyama","year":"2004","unstructured":"Uchiyama T, Engelman RM, Maulik N, Das DK . Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning. Circulation 2004; 109: 3042\u20139.","journal-title":"Circulation"},{"key":"BFaps201614_CR28","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s00394-011-0251-y","volume":"51","author":"S Bharti","year":"2012","unstructured":"Bharti S, Golechha M, Kumari S, Siddiqui KM, Arya DS . Akt\/GSK-3beta\/eNOS phosphorylation arbitrates safranal-induced myocardial protection against ischemia-reperfusion injury in rats. Eur J Nutr 2012; 51: 719\u201327.","journal-title":"Eur J Nutr"},{"key":"BFaps201614_CR29","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.freeradbiomed.2013.05.043","volume":"63","author":"T Wang","year":"2013","unstructured":"Wang T, Mao X, Li H, Qiao S, Xu A, Wang J, et al. N-Acetylcysteine and allopurinol up-regulated the Jak\/STAT3 and PI3K\/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes. Free Radical Biol Med 2013; 63: 291\u2013303.","journal-title":"Free Radical Biol Med"},{"key":"BFaps201614_CR30","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1161\/01.CIR.0000012529.00367.0F","volume":"105","author":"F Gao","year":"2002","unstructured":"Gao F, Gao E, Yue TL, Ohlstein EH, Lopez BL, Christopher TA, et al. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation 2002; 105: 1497\u2013502.","journal-title":"Circulation"},{"key":"BFaps201614_CR31","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.jdiacomp.2015.04.012","volume":"29","author":"X Peng","year":"2015","unstructured":"Peng X, Chen R, Wu Y, Huang B, Tang C, Chen J, et al. PPARgamma-PI3K\/AKT-NO signal pathway is involved in cardiomyocyte hypertrophy induced by high glucose and insulin. J Diabetes Complication 2015; 29: 755\u201360.","journal-title":"J Diabetes Complication"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/aps201614.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps201614","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps201614.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:34:01Z","timestamp":1684413241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/aps201614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,11]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["BFaps201614"],"URL":"https:\/\/doi.org\/10.1038\/aps.2016.14","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,11]]},"assertion":[{"value":"2 October 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}