{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:14:53Z","timestamp":1772691293487,"version":"3.50.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1038\/aps.2016.87","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T09:09:24Z","timestamp":1470647364000},"page":"1401-1412","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against A\u03b2-induced neuronal damage via the Akt\/JNK signaling pathway"],"prefix":"10.1038","volume":"37","author":[{"given":"Dan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-ke","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang-ying","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran-yao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai-lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan-hua","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"BFaps201687_CR1","doi-asserted-by":"crossref","unstructured":"Alzheimer's Association. 2012 Alzheimer's disease facts and figures. Alzheimers Dement 2012; 8: 131\u201368.","DOI":"10.1016\/j.jalz.2012.02.001"},{"key":"BFaps201687_CR2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jalz.2011.03.004","volume":"7","author":"CR Jack Jr","year":"2011","unstructured":"Jack CR Jr, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 257\u201362.","journal-title":"Alzheimers Dement"},{"key":"BFaps201687_CR3","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.neuropharm.2010.02.010","volume":"59","author":"PT Francis","year":"2010","unstructured":"Francis PT, Ram\u00edrez MJ, Lai MK . Neurochemical basis for symptomatic treatment of Alzheimer's disease. Neuropharmacology 2010; 59: 221\u20139.","journal-title":"Neuropharmacology"},{"key":"BFaps201687_CR4","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/j.neubiorev.2010.04.001","volume":"34","author":"I Klinkenberg","year":"2010","unstructured":"Klinkenberg I, Blokland A . The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev 2010; 34: 1307\u201350.","journal-title":"Neurosci Biobehav Rev"},{"key":"BFaps201687_CR5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/nrn1035","volume":"4","author":"S Darvesh","year":"2003","unstructured":"Darvesh S, Hopkins DA, Geula C . Neurobiology of butyrylcholinesterase. Nat Rev Neurosci 2003; 4: 131\u20138.","journal-title":"Nat Rev Neurosci"},{"key":"BFaps201687_CR6","doi-asserted-by":"publisher","first-page":"17213","DOI":"10.1073\/pnas.0508575102","volume":"102","author":"NH Greig","year":"2005","unstructured":"Greig NH, Utsuki T, Ingram DK, Wang Y, Pepeu G, Scali C, et al. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proc Natl Acad Sci U S A 2005; 102: 17213\u20138.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFaps201687_CR7","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.phrs.2003.11.017","volume":"50","author":"E Giacobini","year":"2004","unstructured":"Giacobini E . Cholinesterase inhibitors: new roles and therapeutic alternatives. Pharmacol Res 2004; 50: 433\u201340.","journal-title":"Pharmacol Res"},{"key":"BFaps201687_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/emboj\/cdg005","volume":"22","author":"Y Bourne","year":"2003","unstructured":"Bourne Y, Taylor P, Radi\u0107 Z, Marchot P . Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site. EMBO J 2003; 22: 1\u201312.","journal-title":"EMBO J"},{"key":"BFaps201687_CR9","doi-asserted-by":"publisher","first-page":"2818","DOI":"10.2174\/138161210793176536","volume":"16","author":"C Galdeano","year":"2010","unstructured":"Galdeano C, Viayna E, Arroyo P, Bidon-Chanal A, Blas JR, Mu\u00f1oz-Torrero D, et al. Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents. Curr Pharm Des 2010; 16: 2818\u201336.","journal-title":"Curr Pharm Des"},{"key":"BFaps201687_CR10","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/S0197-4580(02)00230-0","volume":"24","author":"T Rees","year":"2003","unstructured":"Rees T, Hammond PI, Soreq H, Younkin S, Brimijoin S . Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex. Neurobiol Aging 2003; 24: 777\u201387.","journal-title":"Neurobiol Aging"},{"key":"BFaps201687_CR11","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1097\/NEN.0b013e31823cc7a6","volume":"71","author":"S Darvesh","year":"2012","unstructured":"Darvesh S, Cash MK, Reid GA, Martin E, Mitnitski A, Geula C . Butyrylcholinesterase is associated with \u03b2-amyloid plaques in the transgenic APPSWE\/PSEN1dE9 mouse model of Alzheimer disease. J Neuropathol Exp Neurol 2012; 71: 2\u201314.","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFaps201687_CR12","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/j.1471-4159.2009.06490.x","volume":"112","author":"JA Bailey","year":"2010","unstructured":"Bailey JA, Lahiri DK . A novel effect of rivastigmine on pre-synaptic proteins and neuronal viability in a neurodegeneration model of fetal rat primary cortical cultures and its implication in Alzheimer's disease. J Neurochem 2010; 112: 843\u201353.","journal-title":"J Neurochem"},{"key":"BFaps201687_CR13","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1146\/annurev-neuro-061010-113613","volume":"34","author":"RJ O'Brien","year":"2011","unstructured":"O'Brien RJ, Wong PC . Amyloid precursor protein processing and Alzheimer's disease. Annu Rev Neurosci 2011; 34: 185\u2013204.","journal-title":"Annu Rev Neurosci"},{"key":"BFaps201687_CR14","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.neuroscience.2007.04.011","volume":"147","author":"E Sipos","year":"2007","unstructured":"Sipos E, Kurunczi A, Kasza A, Horv\u00e1th J, Felszeghy K, Laroche S, et al. Beta-amyloid pathology in the entorhinal cortex of rats induces memory deficits: implications for Alzheimer's disease. Neuroscience 2007; 147: 28\u201336.","journal-title":"Neuroscience"},{"key":"BFaps201687_CR15","doi-asserted-by":"publisher","first-page":"e 35823","DOI":"10.1371\/journal.pone.0035823","volume":"7","author":"X Zhu","year":"2012","unstructured":"Zhu X, Chen C, Ye D, Guan D, Ye L, Jin J, et al. Diammonium glycyrrhizinate upregulates PGC-1\u03b1 and protects against A\u03b21\u201342-induced neurotoxicity. PLoS One 2012; 7: e 35823.","journal-title":"PLoS One"},{"key":"BFaps201687_CR16","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/aps.2009.74","volume":"30","author":"RT Liu","year":"2009","unstructured":"Liu RT, Zou LB, L\u00fc QJ . Liquiritigenin inhibits A\u03b225\u201335-induced neurotoxicity and secretion of A\u03b21\u201340 in rat hippocampal neurons. Acta Pharmacol Sin 2009; 30: 899\u2013906.","journal-title":"Acta Pharmacol Sin"},{"key":"BFaps201687_CR17","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1177\/0960327111433898","volume":"31","author":"H Park","year":"2012","unstructured":"Park H, Oh MS . Houttuyniae Herba protects rat primary cortical cells from A\u03b225\u201335-induced neurotoxicity via regulation of calcium influx and mitochondria-mediated apoptosis. Hum Exp Toxicol 2012; 31: 698\u2013709.","journal-title":"Hum Exp Toxicol"},{"key":"BFaps201687_CR18","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/j.neurobiolaging.2011.02.007","volume":"33","author":"RA Quintanilla","year":"2012","unstructured":"Quintanilla RA, Dolan PJ, Jin YN, Johnson GV . Truncated tau and A\u03b2 cooperatively impair mitochondria in primary neurons. Neurobiol Aging 2012; 33: 619. e25\u201335.","journal-title":"Neurobiol Aging"},{"key":"BFaps201687_CR19","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","volume":"149","author":"H Clevers","year":"2012","unstructured":"Clevers H, Nusse R . WNT\/\u03b2-catenin signaling and disease. Cell 2012; 149: 1192\u2013205.","journal-title":"Cell"},{"key":"BFaps201687_CR20","first-page":"941","volume":"4","author":"S Oddo","year":"2014","unstructured":"Oddo S . The role of mTOR signal pathway in Alzheimer disease. Front Biosci 2014; 4: 941\u201352.","journal-title":"Front Biosci"},{"key":"BFaps201687_CR21","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1016\/j.cellsig.2014.08.019","volume":"26","author":"D Heras-Sandoval","year":"2014","unstructured":"Heras-Sandoval D, Perez-Rojas JM, Hernandez-Damian J, Pedraza-Chaverri J . The role of PI3K\/AKT\/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell signal 2014; 26: 2694\u2013701.","journal-title":"Cell signal"},{"key":"BFaps201687_CR22","doi-asserted-by":"publisher","first-page":"12230","DOI":"10.1523\/JNEUROSCI.1694-14.2014","volume":"34","author":"T Ma","year":"2014","unstructured":"Ma T, Chen Y, Vingtdeux V, Zhao H, Viollet B, Marambaud P, et al. Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid. J Neurosci 2014; 34: 12230\u20138.","journal-title":"J Neurosci"},{"key":"BFaps201687_CR23","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S1474-4422(11)70013-8","volume":"10","author":"DJ Bonda","year":"2011","unstructured":"Bonda DJ, Lee HG, Camins A, Pall\u00e0s M, Casadesus G, Smith MA, et al. The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. Lancet Neurol 2011; 10: 275\u20139.","journal-title":"Lancet Neurol"},{"key":"BFaps201687_CR24","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.1021\/ci400331p","volume":"53","author":"J Fang","year":"2013","unstructured":"Fang J, Yang RY, Gao L, Zhou D, Yang S, Liu AL, et al. Predictions of BuChE inhibitors using support vector machine and naive bayesian classification techniques in drug discovery. J Chem Inf Model 2013; 53: 3009\u201320.","journal-title":"J Chem Inf Model"},{"key":"BFaps201687_CR25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.pbb.2015.10.009","volume":"139","author":"RY Yang","year":"2015","unstructured":"Yang RY, Zhao G, Wang DM, Pang XC, Wang SB, Fang JS, et al. DL0410 can reverse cognitive impairment, synaptic loss and reduce plaque load in APP\/PS1 transgenic mice. Pharmacol Biochem Behav 2015; 139: 15\u201326.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFaps201687_CR26","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"GL Ellman","year":"1961","unstructured":"Ellman GL, Courtney KD, Andres V Jr, Feather-Stone RM . A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961; 7: 88\u201395.","journal-title":"Biochem Pharmacol"},{"key":"BFaps201687_CR27","doi-asserted-by":"publisher","first-page":"T482","DOI":"10.1016\/j.jalz.2008.05.1451","volume":"4","author":"DG Walker","year":"2008","unstructured":"Walker DG, Lue LF, Reid R, Sabbagh MN . P2\u2013273: chronic rivastigmine administration reduces beta-amyloid levels in transgenic mouse model for Alzheimer's disease. Alzheimer Dementia 2008; 4: T482.","journal-title":"Alzheimer Dementia"},{"key":"BFaps201687_CR28","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.pbb.2006.01.004","volume":"83","author":"L Song","year":"2006","unstructured":"Song L, Che W, Wang MW, Murakami Y, Matsumoto K . Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress. Pharmacol Biochem Behav 2006; 83: 186\u201393.","journal-title":"Pharmacol Biochem Behav"},{"key":"BFaps201687_CR29","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.bbi.2008.09.003","volume":"23","author":"J Lu","year":"2009","unstructured":"Lu J, Wu DM, Zheng YL, Sun DX, Hu B, Shan Q, et al. Trace amounts of copper exacerbate beta amyloid-induced neurotoxicity in the cholesterol-fed mice through TNF-mediated inflammatory pathway. Brain Behav Immun 2009; 23: 193\u2013203.","journal-title":"Brain Behav Immun"},{"key":"BFaps201687_CR30","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1185\/03007990903209332","volume":"25","author":"M Shanks","year":"2009","unstructured":"Shanks M, Kivipelto M, Bullock R, Lane R . Cholinesterase inhibition: is there evidence for disease-modifying effects? Curr Med Res Opin 2009; 25: 2439\u201346.","journal-title":"Curr Med Res Opin"},{"key":"BFaps201687_CR31","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/1741-7015-10-105","volume":"10","author":"R Liu","year":"2012","unstructured":"Liu R, Wu CX, Zhou D, Yang F, Tian S, Zhang L, et al. Pinocembrin protects against beta-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis. BMC Med 2012; 10: 105.","journal-title":"BMC Med"},{"key":"BFaps201687_CR32","doi-asserted-by":"crossref","unstructured":"Singh SK, Sinha P, Mishra L, Srikrishna S . Neuroprotective role of a novel copper chelator against A\u03b242 induced neurotoxicity. Int J Alzheimers Dis 2013; 567128.","DOI":"10.1155\/2013\/567128"},{"key":"BFaps201687_CR33","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/0006-291X(84)91209-9","volume":"122","author":"GG Glenner","year":"1984","unstructured":"Glenner GG, Wong CW . Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 1984; 122: 1131\u20135.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFaps201687_CR34","first-page":"369808","volume":"2012","author":"C Reitz","year":"2012","unstructured":"Reitz C . Alzheimer's disease and the amyloid cascade hypothesis: a critical review. Int J Alzheimers Dis 2012; 2012: 369808.","journal-title":"Int J Alzheimers Dis"},{"key":"BFaps201687_CR35","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/0304-3940(94)90239-9","volume":"170","author":"A Nitta","year":"1994","unstructured":"Nitta A, Itoh A, Hasegawa T, Nabeshima T . \u03b2-Amyloid protein-induced Alzheimer's disease animal model. Neurosci Lett 1994; 170: 63\u20136.","journal-title":"Neurosci Lett"},{"key":"BFaps201687_CR36","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1046\/j.1471-4159.1998.70052179.x","volume":"70","author":"S Kar","year":"1998","unstructured":"Kar S, Issa AM, Seto D, Auld DS, Collier B, Quirion R . Amyloid \u03b2-peptide inhibits high-affinity choline uptake and acetylcholine release in rat hippocampal slices. J Neurochem 1998; 70: 2179\u201387.","journal-title":"J Neurochem"},{"key":"BFaps201687_CR37","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jep.2010.04.027","volume":"130","author":"W Nakdook","year":"2010","unstructured":"Nakdook W, Khongsombat O, Taepavarapruk P, Taepavarapruk N, Ingkaninan K . The effects of Tabernaemontana divaricata root extract on amyloid beta-peptide 25\u201335 peptides induced cognitive deficits in mice. J Ethnopharmacol 2010; 130: 122\u20136.","journal-title":"J Ethnopharmacol"},{"key":"BFaps201687_CR38","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/S0006-291X(02)02072-7","volume":"296","author":"C Rovira","year":"2002","unstructured":"Rovira C, Arbez N, Mariani J . A\u03b225\u201335 and A\u03b21\u201340 act on different calcium channels in CA1 hippocampal neurons. Biochem Biophys Res Commun 2002; 296: 1317\u201321.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFaps201687_CR39","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.neuroscience.2007.04.011","volume":"147","author":"E Sipos","year":"2007","unstructured":"Sipos E, Kurunczi A, Kasza A, Horv\u00e1th J, Felszeghy K, Laroche S, et al. Beta-amyloid pathology in the entorhinal cortex of rats induces memory deficits: implications for Alzheimer's disease. Neuroscience 2007; 147: 28\u201336.","journal-title":"Neuroscience"},{"key":"BFaps201687_CR40","doi-asserted-by":"publisher","first-page":"6296","DOI":"10.1523\/JNEUROSCI.0506-05.2005","volume":"25","author":"EC Warburton","year":"2005","unstructured":"Warburton EC, Glover CP, Massey PV, Wan H, Johnson B, Bienemann A, et al. cAMP responsive element-binding protein phosphorylation is necessary for perirhinal long-term potentiation and recognition memory. J Neurosci 2005; 25: 6296\u2013303.","journal-title":"J Neurosci"},{"key":"BFaps201687_CR41","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.tox.2008.11.017","volume":"256","author":"SK Verma","year":"2009","unstructured":"Verma SK, Raheja G, Gill KD . Role of muscarinic signal transduction and CREB phosphorylation in dichlorvos-induced memory deficits in rats: an acetylcholine independent mechanism. Toxicology 2009; 256: 175\u201382.","journal-title":"Toxicology"},{"key":"BFaps201687_CR42","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.nlm.2005.12.002","volume":"86","author":"D Moncada","year":"2006","unstructured":"Moncada D, Viola H . Phosphorylation state of CREB in the rat hippocampus: a molecular switch between spatial novelty and spatial familiarity. Neurobiol Learn Mem 2006; 86: 9\u201318.","journal-title":"Neurobiol Learn Mem"},{"key":"BFaps201687_CR43","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1042\/BJ20111451","volume":"441","author":"J Lee","year":"2012","unstructured":"Lee J, Giordano S, Zhang J . Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J 2012; 441: 523\u201340.","journal-title":"Biochem J"},{"key":"BFaps201687_CR44","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3389\/fphys.2012.00285","volume":"3","author":"K Su","year":"2012","unstructured":"Su K, Bourdette D, Forte M . Genetic inactivation of mitochondria targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges. Front Physiol 2012; 3: 285.","journal-title":"Front Physiol"},{"key":"BFaps201687_CR45","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev.neuro.31.061307.090711","volume":"31","author":"KJ De Vos","year":"2008","unstructured":"De Vos KJ, Grierson AJ, Ackerley S, Miller CC . Role of axonal transport in neurodegenerative diseases. Annu Rev Neurosci 2008; 31: 151\u201373.","journal-title":"Annu Rev Neurosci"},{"key":"BFaps201687_CR46","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fncel.2013.00097","volume":"7","author":"C Silva-Alvarez","year":"2013","unstructured":"Silva-Alvarez C, Arr\u00e1zola MS, Godoy JA, Ordenes D, Inestrosa NC . Canonical Wnt signaling protects hippocampal neurons from A\u03b2 oligomers: role of non-canonical Wnt-5a\/Ca2+ in mitochondrial dynamics. Front Cell Neurosci 2013; 7: 97.","journal-title":"Front Cell Neurosci"},{"key":"BFaps201687_CR47","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1089\/ars.2011.4173","volume":"16","author":"K Leuner","year":"2012","unstructured":"Leuner K, Sch\u00fctt T, Kurz C, Eckert SH, Schiller C, Occhipinti A, et al. Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxid Redox Signal 2012; 16: 1421\u201333.","journal-title":"Antioxid Redox Signal"},{"key":"BFaps201687_CR48","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.brainres.2012.06.036","volume":"1471","author":"M De Butte-Smith","year":"2012","unstructured":"De Butte-Smith M, Zukin RS, Etgen AM . Effects of global ischemia and estradiol pretreatment on phosphorylation of Akt, CREB and STAT3 in hippocampal CA1 of young and middle-aged female rats. Brain Res 2012; 1471: 118\u201328.","journal-title":"Brain Res"},{"key":"BFaps201687_CR49","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.bbrc.2010.12.048","volume":"404","author":"XY Li","year":"2011","unstructured":"Li XY, Zhan XR, Liu XM, Wang XC . CREB is a regulatory target for the protein kinase Akt\/PKB in the differentiation of pancreatic ductal cells into islet \u03b2-cells mediated by hepatocyte growth factor. Biochem Biophys Res Commun 2011; 404: 711\u20136.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFaps201687_CR50","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1016\/j.cellsig.2011.05.004","volume":"23","author":"I Hers","year":"2011","unstructured":"Hers I, Vincent EE, Tavar\u00e9 JM . Akt signalling in health and disease. Cell Signal 2011; 23: 1515\u201327.","journal-title":"Cell Signal"},{"key":"BFaps201687_CR51","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1582-4934.2005.tb00337.x","volume":"9","author":"G Song","year":"2005","unstructured":"Song G, Ouyang G, Bao S . The activation of Akt\/PKB signaling pathway and cell survival. J Cell Mol Med 2005; 9: 59\u201371.","journal-title":"J Cell Mol Med"},{"key":"BFaps201687_CR52","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1016\/j.biocel.2007.06.013","volume":"39","author":"M Humar","year":"2007","unstructured":"Humar M, Loop T, Schmidt R, Hoetzel A, Roesslein M, Andriopoulos N, et al. The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun. Int J Biochem Cell Biol 2007; 39: 2278\u201388.","journal-title":"Int J Biochem Cell Biol"},{"key":"BFaps201687_CR53","doi-asserted-by":"publisher","first-page":"e140","DOI":"10.1038\/cddis.2011.22","volume":"2","author":"N Gao","year":"2011","unstructured":"Gao N, Budhraja A, Cheng S, Liu EH, Chen J, Yang Z, et al. Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways. Cell Death Dis 2011; 2: e140.","journal-title":"Cell Death Dis"},{"key":"BFaps201687_CR54","first-page":"112","volume":"115","author":"AL Liu","year":"2014","unstructured":"Liu AL, Zhou D, Yang RY, Liu R, Du GH . DL0410, a novel anti-alzheimer's disease candidate, protects neuron against A\u03b2-induced cell damage via \u03b17nAChR medicated intracellular Akt\/JNK signaling pathway. Basic Clin Pharmacol Toxicol 2014; 115: 112.","journal-title":"Basic Clin Pharmacol Toxicol"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/aps201687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps201687","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps201687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:35:01Z","timestamp":1684413301000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/aps201687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,8]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["BFaps201687"],"URL":"https:\/\/doi.org\/10.1038\/aps.2016.87","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,8]]},"assertion":[{"value":"10 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}