{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:15:28Z","timestamp":1778674528864,"version":"3.51.4"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T00:00:00Z","timestamp":1521676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Pharmacol Sin"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1038\/aps.2017.148","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T11:01:01Z","timestamp":1521716461000},"page":"1273-1283","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs"],"prefix":"10.1038","volume":"39","author":[{"given":"Vikt\u00f3ria","family":"Varga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"N\u00e9meth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orsolya","family":"Ol\u00e1h","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria","family":"T\u00f3th-Sz\u0171ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikt\u00f3ria","family":"Kov\u00e1cs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Remzs\u0151","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"Domoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,22]]},"reference":[{"key":"116_CR1","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/j.1651-2227.1995.tb13794.x","volume":"84","author":"E Thornberg","year":"1995","unstructured":"Thornberg E, Thiringer K, Odeback A, Milsom I. Birth asphyxia: incidence, clinical course and outcome in a Swedish population. Acta Paediatr 1995; 84: 927\u201332.","journal-title":"Acta Paediatr"},{"key":"116_CR2","doi-asserted-by":"publisher","first-page":"F257","DOI":"10.1136\/adc.2003.047985","volume":"90","author":"V Pierrat","year":"2005","unstructured":"Pierrat V, Haouari N, Liska A, Thomas D, Subtil D, Truffert P. Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy: population based study. Arch Dis Child Fetal Neonatal Ed 2005; 90: F257\u201361.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"116_CR3","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1542\/peds.100.6.1004","volume":"100","author":"RC Vannucci","year":"1997","unstructured":"Vannucci RC, Perlman JM. Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics 1997; 100: 1004\u201314.","journal-title":"Pediatrics"},{"key":"116_CR4","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0065-2776(08)60430-7","volume":"62","author":"WL Smith","year":"1996","unstructured":"Smith WL, Dewitt DL. Prostaglandin endoperoxide H synthases-1 and -2. Adv Immunol 1996; 62: 167\u2013215.","journal-title":"Adv Immunol"},{"key":"116_CR5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1146\/annurev.biochem.69.1.145","volume":"69","author":"WL Smith","year":"2000","unstructured":"Smith WL, DeWitt DL, Garavito RM. Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem 2000; 69: 145\u201382.","journal-title":"Annu Rev Biochem"},{"key":"116_CR6","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S0090-6980(97)00128-7","volume":"54","author":"WE Kaufmann","year":"1997","unstructured":"Kaufmann WE, Andreasson KI, Isakson PC, Worley PF. Cyclooxygenases and the central nervous system. Prostaglandins 1997; 54: 601\u201324.","journal-title":"Prostaglandins"},{"key":"116_CR7","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/0896-6273(93)90192-T","volume":"11","author":"K Yamagata","year":"1993","unstructured":"Yamagata K, Andreasson KI, Kaufmann WE, Barnes CA, Worley PF. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 1993; 11: 371\u201386.","journal-title":"Neuron"},{"key":"116_CR8","doi-asserted-by":"publisher","first-page":"24615","DOI":"10.1074\/jbc.270.41.24615","volume":"270","author":"KG Peri","year":"1995","unstructured":"Peri KG, Hardy P, Li DY, Varma DR, Chemtob S. Prostaglandin G\/H synthase-2 is a major contributor of brain prostaglandins in the newborn. J Biol Chem 1995; 270: 24615\u201320.","journal-title":"J Biol Chem"},{"key":"116_CR9","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.brainresbull.2006.03.006","volume":"69","author":"GR Weerasinghe","year":"2006","unstructured":"Weerasinghe GR, Coon SL, Bhattacharjee AK, Harry GJ, Bosetti F. Regional protein levels of cytosolic phospholipase A2 and cyclooxygenase-2 in Rhesus monkey brain as a function of age. Brain Res Bull 2006; 69: 614\u201321.","journal-title":"Brain Res Bull"},{"key":"116_CR10","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.2174\/138161208784480144","volume":"14","author":"H Yang","year":"2008","unstructured":"Yang H, Chen C. Cyclooxygenase-2 in synaptic signaling. Curr Pharm Des 2008; 14: 1443\u201351.","journal-title":"Curr Pharm Des"},{"key":"116_CR11","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1093\/cercor\/bhq236","volume":"21","author":"T Hahn","year":"2011","unstructured":"Hahn T, Heinzel S, Plichta MM, Reif A, Lesch KP, Fallgatter AJ. Neurovascular coupling in the human visual cortex is modulated by cyclooxygenase-1 (COX-1) gene variant. Cereb Cortex 2011; 21: 1659\u201366.","journal-title":"Cereb Cortex"},{"key":"116_CR12","doi-asserted-by":"publisher","first-page":"9836","DOI":"10.1523\/JNEUROSCI.4943-10.2011","volume":"31","author":"C Lecrux","year":"2011","unstructured":"Lecrux C, Toussay X, Kocharyan A, Fernandes P, Neupane S, Levesque M, et al. Pyramidal neurons are \"neurogenic hubs\" in the neurovascular coupling response to whisker stimulation. J Neurosci 2011; 31: 9836\u201347.","journal-title":"J Neurosci"},{"key":"116_CR13","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1089\/089771500415436","volume":"17","author":"KI Strauss","year":"2000","unstructured":"Strauss KI, Barbe MF, Marshall RM, Raghupathi R, Mehta S, Narayan RK. Prolonged cyclooxygenase-2 induction in neurons and glia following traumatic brain injury in the rat. J Neurotrauma 2000; 17: 695\u2013711.","journal-title":"J Neurotrauma"},{"key":"116_CR14","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1089\/neu.2000.17.69","volume":"17","author":"PK Dash","year":"2000","unstructured":"Dash PK, Mach SA, Moore AN. Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury. J Neurotrauma 2000; 17: 69\u201381.","journal-title":"J Neurotrauma"},{"key":"116_CR15","first-page":"H1207","volume":"277","author":"F Domoki","year":"1999","unstructured":"Domoki F, Veltkamp R, Thrikawala N, Robins G, Bari F, Louis TM, et al. Ischemia-reperfusion rapidly increases COX-2 expression in piglet cerebral arteries. Am J Physiol 1999; 277: H1207\u201314.","journal-title":"Am J Physiol"},{"key":"116_CR16","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0165-3806(98)00022-4","volume":"107","author":"R D\u00e9g\u00ec","year":"1998","unstructured":"D\u00e9g\u00ec R, Bari F, Thrikawala N, Beasley TC, Thore C, Louis TM, et al. Effects of anoxic stress on prostaglandin H synthase isoforms in piglet brain. Dev Brain Res 1998; 107: 265\u201376.","journal-title":"Dev Brain Res"},{"key":"116_CR17","doi-asserted-by":"publisher","first-page":"12013","DOI":"10.1073\/pnas.91.25.12013","volume":"91","author":"K Seibert","year":"1994","unstructured":"Seibert K, Zhang Y, Leahy K, Hauser S, Masferrer J, Perkins W, et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci U S A 1994; 91: 12013\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"116_CR18","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.tips.2009.01.002","volume":"30","author":"SH Choi","year":"2009","unstructured":"Choi SH, Aid S, Bosetti F. The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research. Trends Pharmacol Sci 2009; 30: 174\u201381.","journal-title":"Trends Pharmacol Sci"},{"key":"116_CR19","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1097\/CCM.0b013e3181cb1158","volume":"38","author":"N Fathali","year":"2010","unstructured":"Fathali N, Ostrowski RP, Lekic T, Jadhav V, Tong W, Tang J, et al. Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury. Crit Care Med 2010; 38: 572\u20138.","journal-title":"Crit Care Med"},{"key":"116_CR20","first-page":"245","volume":"33","author":"DFC Toti P","year":"2001","unstructured":"Toti P DFC, Sch\u00fcrfeld K, Stumpo M, Bartolommei S, Lombardi A, Petraglia E, Buonocore G. Cyclooxygenase-2 immunoreactivity in the ischemic neonatal human brain. An autopsy study. J Submicrosc Cytol Pathol 2001; 33: 245\u20139.","journal-title":"J Submicrosc Cytol Pathol"},{"key":"116_CR21","doi-asserted-by":"crossref","unstructured":"Dobbing J, Sands J. Comparative aspects of the brain growth spurt. Early HumDev 1979; 3: 79\u201383.","DOI":"10.1016\/0378-3782(79)90022-7"},{"key":"116_CR22","doi-asserted-by":"crossref","unstructured":"Olah O, Nemeth I, Toth-Szuki V, Bari F, Domoki F. Regional differences in the neuronal expression of cyclooxygenase-2 (COX-2) in the newborn pig brain. Acta Histochem Cytochem 2012; 45: 187\u201392.","DOI":"10.1267\/ahc.11056"},{"key":"116_CR23","first-page":"677","volume":"67","author":"J Nemeth","year":"2016","unstructured":"Nemeth J, Toth-Szuki V, Varga V, Kovacs V, Remzso G, Domoki F. Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic encephalopathy. J Physiol Pharmacol 2016; 67: 677\u201389.","journal-title":"J Physiol Pharmacol"},{"key":"116_CR24","first-page":"387","volume":"68","author":"F Domoki","year":"2010","unstructured":"Domoki F, Olah O, Zimmermann A, Nemeth I, Toth-Szuki V, Hugyecz M, et al. Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs. Pediatr Res 2010; 68: 387\u201392.","journal-title":"Pediatr Res"},{"key":"116_CR25","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/nm1577","volume":"13","author":"I Ohsawa","year":"2007","unstructured":"Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 2007; 13: 688\u201394.","journal-title":"Nat Med"},{"key":"116_CR26","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.brainres.2008.11.048","volume":"1256","author":"J Cai","year":"2009","unstructured":"Cai J, Kang Z, Liu K, Liu W, Li R, Zhang JH, et al. Neuroprotective effects of hydrogen saline in neonatal hypoxia\u2013ischemia rat model. Brain Res 2009; 1256: 129\u201337.","journal-title":"Brain Res"},{"key":"116_CR27","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.neulet.2008.05.077","volume":"441","author":"J Cai","year":"2008","unstructured":"Cai J, Kang Z, Liu WW, Luo X, Qiang S, Zhang JH, et al. Hydrogen therapy reduces apoptosis in neonatal hypoxia\u2013ischemia rat model. Neurosci Lett 2008; 441: 167\u201372.","journal-title":"Neurosci Lett"},{"key":"116_CR28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.neulet.2009.02.016","volume":"453","author":"Y Fu","year":"2009","unstructured":"Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, et al. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett 2009; 453: 81\u20135.","journal-title":"Neurosci Lett"},{"key":"116_CR29","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/aps.2011.190","volume":"33","author":"J Qu","year":"2012","unstructured":"Qu J, Gan YN, Xie KL, Liu WB, Wang YF, Hei RY, et al. Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils. Acta Pharmacol Sin 2012; 33: 445\u201351.","journal-title":"Acta Pharmacol Sin"},{"key":"116_CR30","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/npp.2008.95","volume":"34","author":"K Nagata","year":"2008","unstructured":"Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice. Neuropsychopharmacology 2008; 34: 501\u20138.","journal-title":"Neuropsychopharmacology"},{"key":"116_CR31","doi-asserted-by":"publisher","first-page":"324","DOI":"10.2174\/1570159X14666160607205417","volume":"15","author":"M Iketani","year":"2017","unstructured":"Iketani M, Ohsawa I. Molecular hydrogen as a neuroprotective agent. Curr Neuropharmacol 2017; 15: 324\u201331.","journal-title":"Curr Neuropharmacol"},{"key":"116_CR32","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000348445","volume":"104","author":"O Olah","year":"2013","unstructured":"Olah O, Toth-Szuki V, Temesvari P, Bari F, Domoki F. Delayed neurovascular dysfunction is alleviated by hydrogen in asphyxiated newborn pigs. Neonatology 2013; 104: 79\u201386.","journal-title":"Neonatology"},{"key":"116_CR33","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/ana.22387","volume":"70","author":"S Faulkner","year":"2011","unstructured":"Faulkner S, Bainbridge A, Kato T, Chandrasekaran M, Kapetanakis AB, Hristova M, et al. Xenon augmented hypothermia reduces early lactate\/N-acetylaspartate and cell death in perinatal asphyxia. Ann Neurol 2011; 70: 133\u201350.","journal-title":"Ann Neurol"},{"key":"116_CR34","first-page":"141","volume":"35","author":"GCB Randall","year":"1971","unstructured":"Randall GCB. The relationship of arterial blood pH and pCO2 to the viability of the newborn piglet. Can J Comp Med 1971; 35: 141\u20136.","journal-title":"Can J Comp Med"},{"key":"116_CR35","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1523\/JNEUROSCI.20-02-00763.2000","volume":"20","author":"K Niwa","year":"2000","unstructured":"Niwa K, Araki E, Morham SG, Ross ME, Iadecola C. Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex. J Neurosci 2000; 20: 763\u201370.","journal-title":"J Neurosci"},{"key":"116_CR36","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-2199-3-16","volume":"3","author":"B Kaltschmidt","year":"2002","unstructured":"Kaltschmidt B, Linker RA, Deng J, Kaltschmidt C. Cyclooxygenase-2 is a neuronal target gene of NF-kappaB. BMC Mol Biol 2002; 3: 16.","journal-title":"BMC Mol Biol"},{"key":"116_CR37","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0304-3940(96)12799-3","volume":"212","author":"YN Hou","year":"1996","unstructured":"Hou YN, Vlaskovska M, Cebers G, Kasakov L, Liljequist S, Terenius L. A \u03bc-receptor opioid agonist induces AP-1 and NF-\u03baB transcription factor activity in primary cultures of rat cortical neurons. Neurosci Lett 1996; 212: 159\u201362.","journal-title":"Neurosci Lett"},{"key":"116_CR38","doi-asserted-by":"publisher","first-page":"3176","DOI":"10.2741\/1471","volume":"9","author":"P Cadet","year":"2004","unstructured":"Cadet P, Rasmussen M, Zhu W, Tonnesen E, Mantione KJ, Stefano GB. Endogenous morphinergic signaling and tumor growth. Front Biosci 2004; 9: 3176\u201386.","journal-title":"Front Biosci"},{"key":"116_CR39","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.bbagrm.2010.05.004","volume":"1799","author":"SC Gupta","year":"2010","unstructured":"Gupta SC, Sundaram C, Reuter S, Aggarwal BB. Inhibiting NF-\u03baB activation by small molecules as a therapeutic strategy. Biochim Biophys Acta, Gene Regul Mech 2010; 1799: 775\u201387.","journal-title":"Biochim Biophys Acta, Gene Regul Mech"},{"key":"116_CR40","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1651-2227.2011.02480.x","volume":"101","author":"A Roka","year":"2012","unstructured":"Roka A, Kelen D, Halasz J, Beko G, Azzopardi D, Szabo M. Serum S100B and neuron-specific enolase levels in normothermic and hypothermic infants after perinatal asphyxia. Acta Paediatr 2012; 101: 319\u201323.","journal-title":"Acta Paediatr"},{"key":"116_CR41","doi-asserted-by":"publisher","first-page":"F262","DOI":"10.1136\/adc.2003.044305","volume":"90","author":"J Tooley","year":"2005","unstructured":"Tooley J, Eagle R, Satas S, Thoresen M. Significant head cooling can be achieved while maintaining normothermia in the newborn piglet. Arch Dis Child Fetal Neonatal Ed 2005; 90: F262\u2013F6.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"116_CR42","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1097\/WNR.0000000000000824","volume":"28","author":"Y Xin","year":"2017","unstructured":"Xin Y, Liu H, Zhang P, Chang L, Xie K. Molecular hydrogen inhalation attenuates postoperative cognitive impairment in rats. NeuroReport 2017; 28: 694\u2013700.","journal-title":"NeuroReport"},{"key":"116_CR43","doi-asserted-by":"crossref","unstructured":"Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, et al. H2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc 2012; 1: e003459. doi: 10.1161\/JAHA.112.003459.","DOI":"10.1161\/JAHA.112.003459"},{"key":"116_CR44","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/0165-3806(91)90115-Y","volume":"61","author":"TS Park","year":"1991","unstructured":"Park TS, Gidday JM, Gonzales E. Local cerebral blood flow response to locally infused 2-chloroadenosine during hypotension in piglets. Dev Brain Res 1991; 61: 73\u20137.","journal-title":"Dev Brain Res"},{"key":"116_CR45","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/jcbfm.1992.90","volume":"12","author":"JM Gidday","year":"1992","unstructured":"Gidday JM, Park TS. Effect of 2-chloroadenosine on cerebrovascular reactivity to hypercapnia in newborn pig. J Cereb Blood Flow Metab 1992; 12: 656\u201363.","journal-title":"J Cereb Blood Flow Metab"},{"key":"116_CR46","doi-asserted-by":"publisher","first-page":"H1762","DOI":"10.1152\/ajpheart.1993.265.5.H1762","volume":"265","author":"VJ Ruth","year":"1993","unstructured":"Ruth VJ, Park TS, Gonzales ER, Gidday JM. Adenosine and cerebrovascular hyperemia during insulin-induced hypoglycemia in newborn piglet. Am J Physiol, Heart Circ Physiol 1993; 265: H1762\u2013H8.","journal-title":"Am J Physiol, Heart Circ Physiol"},{"key":"116_CR47","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/2045-9912-2-21","volume":"2","author":"H Ono","year":"2012","unstructured":"Ono H, Nishijima Y, Adachi N, Sakamoto M, Kudo Y, Kaneko K, et al. A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. Med Gas Res 2012; 2: 21.","journal-title":"Med Gas Res"},{"key":"116_CR48","doi-asserted-by":"publisher","first-page":"500","DOI":"10.3109\/15376516.2013.785625","volume":"23","author":"VS Anjana Vaman","year":"2013","unstructured":"Anjana Vaman VS, Tinu SK, Geetha CS, Lissy KK, Mohanan PV. Effect of fibrin glue on antioxidant defense mechanism, oxidative DNA damage and chromosomal aberrations. Toxicol Mech Methods 2013; 23: 500\u20138.","journal-title":"Toxicol Mech Methods"},{"key":"116_CR49","doi-asserted-by":"publisher","first-page":"973","DOI":"10.3109\/10715762.2015.1025388","volume":"49","author":"D Villa\u00f1o","year":"2015","unstructured":"Villa\u00f1o D, Vilaplana C, Medina S, Cejuela-Anta R, Mart\u00ednez-Sanz JM, Gil P, et al. Effect of elite physical exercise by triathletes on seven catabolites of DNA oxidation. Free Radic Res 2015; 49: 973\u201383.","journal-title":"Free Radic Res"},{"key":"116_CR50","first-page":"1497","volume":"36","author":"HR Hintsala","year":"2016","unstructured":"Hintsala HR, Jokinen E, Haapasaari KM, Moza M, Ristim\u00c4Ki ARI, Soini Y, et al. Nrf2\/Keap1 pathway and expression of oxidative stress lesions 8-hydroxy-2\u2032-deoxyguanosine and nitrotyrosine in melanoma. Anticancer Res 2016; 36: 1497\u2013506.","journal-title":"Anticancer Res"},{"key":"116_CR51","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s12640-012-9331-x","volume":"22","author":"A Nunomura","year":"2012","unstructured":"Nunomura A, Moreira PI, Castellani RJ, Lee HG, Zhu X, Smith MA, et al. Oxidative damage to RNA in aging and neurodegenerative disorders. Neurotox Res 2012; 22: 231\u201348.","journal-title":"Neurotox Res"},{"key":"116_CR52","first-page":"8847","volume":"9","author":"Q Huang","year":"2016","unstructured":"Huang Q, Chen Z, Yang Y, Wang B, Li F, Zhan M. Content change and clinical significance of oxidation damage products 8-OHdG, 4-HNE and NTY in hemangioma tissue. Int J Clin Exp Pathol 2016; 9: 8847\u201357.","journal-title":"Int J Clin Exp Pathol"},{"key":"116_CR53","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s11010-008-9707-7","volume":"311","author":"GM Campo","year":"2008","unstructured":"Campo GM, Avenoso A, Campo S, D'Ascola A, Traina P, Sam\u00e0 D, et al. The antioxidant effect exerted by TGF-1\u03b2-stimulated hyaluronan production reduced NF-kB activation and apoptosis in human fibroblasts exposed to FeSo4 plus ascorbate. Mol Cell Biochem 2008; 311: 167\u201377.","journal-title":"Mol Cell Biochem"},{"key":"116_CR54","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1126\/science.1071914","volume":"298","author":"A Hoffmann","year":"2002","unstructured":"Hoffmann A, Levchenko A, Scott ML, Baltimore D. The I\u03baB-NF-\u03baB signaling module: temporal control and selective gene activation. Science 2002; 298: 1241\u20135.","journal-title":"Science"},{"key":"116_CR55","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/S0166-2236(96)01035-1","volume":"20","author":"LAJ O'Neill","year":"1997","unstructured":"O'Neill LAJ, Kaltschmidt C. NF-kB: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci 1997; 20: 252\u20138.","journal-title":"Trends Neurosci"},{"key":"116_CR56","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1006\/bbrc.1995.2060","volume":"212","author":"A Salminen","year":"1995","unstructured":"Salminen A, Liu PK, Hsu CY. Alteration of transcription factor binding activities in the ischemic rat-brain. Biochem Biophys Res Commun 1995; 212: 939\u201344.","journal-title":"Biochem Biophys Res Commun"},{"key":"116_CR57","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1097\/WNR.0000000000000899","volume":"28","author":"Y Shi","year":"2017","unstructured":"Shi Y, Wang G, Li J, Yu W. Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats. Neuroreport 2017; 28: 1170\u20135.","journal-title":"Neuroreport"},{"key":"116_CR58","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/0165-5728(94)90151-1","volume":"55","author":"C Kaltschmidt","year":"1994","unstructured":"Kaltschmidt C, Kaltschmidt B, Lannes-Vieira J, Kreutzberg GW, Wekerle H, Baeuerle PA, et al. Transcription factor NF-\u03baB is activated in microglia during experimental autoimmune encephalomyelitis. J Neuroimmunol 1994; 55: 99\u2013106.","journal-title":"J Neuroimmunol"},{"key":"116_CR59","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.mito.2006.11.026","volume":"7","author":"HP Indo","year":"2007","unstructured":"Indo HP, Davidson M, Yen HC, Suenaga S, Tomita K, Nishii T, et al. Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion 2007; 7: 106\u201318.","journal-title":"Mitochondrion"},{"key":"116_CR60","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s12291-014-0446-0","volume":"30","author":"A Phaniendra","year":"2015","unstructured":"Phaniendra A, Jestadi DB, Periyasamy L. Free radicals: properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem 2015; 30: 11\u201326.","journal-title":"Indian J Clin Biochem"},{"key":"116_CR61","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nrn2038","volume":"8","author":"ML Block","year":"2007","unstructured":"Block ML, Zecca L, Hong JS. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 2007; 8: 57\u201369.","journal-title":"Nat Rev Neurosci"},{"key":"116_CR62","doi-asserted-by":"publisher","first-page":"4065","DOI":"10.1097\/00001756-200112210-00041","volume":"12","author":"F Domoki","year":"2001","unstructured":"Domoki F, Perciaccante JV, Puskar M, Bari F, Busija DW. Cyclooxygenase-2 inhibitor NS398 preserves neuronal function after hypoxia\/ischemia in piglets. Neuroreport 2001; 12: 4065\u20138.","journal-title":"Neuroreport"}],"container-title":["Acta Pharmacologica Sinica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/aps2017148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/aps2017148","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/aps.2017.148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/aps2017148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:35:41Z","timestamp":1684413341000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/aps2017148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,22]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["116"],"URL":"https:\/\/doi.org\/10.1038\/aps.2017.148","relation":{},"ISSN":["1671-4083","1745-7254"],"issn-type":[{"value":"1671-4083","type":"print"},{"value":"1745-7254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,22]]},"assertion":[{"value":"3 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}