{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:07:21Z","timestamp":1773259641554,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2011,12,9]],"date-time":"2011-12-09T00:00:00Z","timestamp":1323388800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Blood Cancer Journal"],"DOI":"10.1038\/bcj.2011.33","type":"journal-article","created":{"date-parts":[[2011,12,9]],"date-time":"2011-12-09T15:47:25Z","timestamp":1323445645000},"page":"e48-e48","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins"],"prefix":"10.1038","volume":"1","author":[{"given":"C","family":"Nishioka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Ikezoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Udaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,12,9]]},"reference":[{"key":"BFbcj201133_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1101\/gad.947102","volume":"16","author":"A Bird","year":"2002","unstructured":"Bird A . DNA methylation patterns and epigenetic memory. Genes Dev 2002; 16: 6\u201321.","journal-title":"Genes Dev"},{"key":"BFbcj201133_CR2","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/ng1089","volume":"33","author":"R Jaenisch","year":"2003","unstructured":"Jaenisch R, Bird A . Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003; 33: 245\u2013254.","journal-title":"Nat Genet"},{"key":"BFbcj201133_CR3","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1101\/gad.1035902","volume":"16","author":"A Kuzmichev","year":"2002","unstructured":"Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D . Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev 2002; 16: 2893\u20132905.","journal-title":"Genes Dev"},{"key":"BFbcj201133_CR4","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1126\/science.1076997","volume":"298","author":"R Cao","year":"2002","unstructured":"Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002; 298: 1039\u20131043.","journal-title":"Science"},{"key":"BFbcj201133_CR5","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.gde.2004.02.001","volume":"14","author":"R Cao","year":"2004","unstructured":"Cao R, Zhang Y . The functions of E(Z)\/EZH2-mediated methylation of lysine 27 in histone H3. Curr Opin Genet Dev 2004; 14: 155\u2013164.","journal-title":"Curr Opin Genet Dev"},{"key":"BFbcj201133_CR6","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.molcel.2005.12.002","volume":"20","author":"R Cao","year":"2005","unstructured":"Cao R, Tsukada Y, Zhang Y . Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell 2005; 20: 845\u2013854.","journal-title":"Mol Cell"},{"key":"BFbcj201133_CR7","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S1097-2765(04)00185-6","volume":"14","author":"A Kuzmichev","year":"2004","unstructured":"Kuzmichev A, Jenuwein T, Tempst P, Reinberg D . Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell 2004; 14: 183\u2013193.","journal-title":"Mol Cell"},{"key":"BFbcj201133_CR8","doi-asserted-by":"publisher","first-page":"788","DOI":"10.4161\/cbt.10.8.12913","volume":"10","author":"S Hu","year":"2010","unstructured":"Hu S, Yu L, Li Z, Shen Y, Wang J, Cai J et al. Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo. Cancer Biol Ther 2010; 10: 788\u2013795.","journal-title":"Cancer Biol Ther"},{"key":"BFbcj201133_CR9","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/ng1950","volume":"39","author":"Y Schlesinger","year":"2007","unstructured":"Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J et al. Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet 2007; 39: 232\u2013236.","journal-title":"Nat Genet"},{"key":"BFbcj201133_CR10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S1535-6108(02)00234-9","volume":"3","author":"KE Bachman","year":"2003","unstructured":"Bachman KE, Park BH, Rhee I, Rajagopalan H, Herman JG, Baylin SB et al. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell 2003; 3: 89\u201395.","journal-title":"Cancer Cell"},{"key":"BFbcj201133_CR11","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/71750","volume":"24","author":"F Fuks","year":"2000","unstructured":"Fuks F, Burgers WA, Brehm A, Hughes-Davies L, Kouzarides T . DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet 2000; 24: 88\u201391.","journal-title":"Nat Genet"},{"key":"BFbcj201133_CR12","doi-asserted-by":"publisher","first-page":"2536","DOI":"10.1093\/emboj\/20.10.2536","volume":"20","author":"F Fuks","year":"2001","unstructured":"Fuks F, Burgers WA, Godin N, Kasai M, Kouzarides T . Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J 2001; 20: 2536\u20132544.","journal-title":"EMBO J"},{"key":"BFbcj201133_CR13","doi-asserted-by":"publisher","first-page":"5594","DOI":"10.1128\/MCB.23.16.5594-5605.2003","volume":"23","author":"T Chen","year":"2003","unstructured":"Chen T, Ueda Y, Dodge JE, Wang Z, Li E . Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol Cell Biol 2003; 23: 5594\u20135605.","journal-title":"Mol Cell Biol"},{"key":"BFbcj201133_CR14","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nature04431","volume":"439","author":"E Vir\u00e9","year":"2006","unstructured":"Vir\u00e9 E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature 2006; 439: 871\u2013874.","journal-title":"Nature"},{"key":"BFbcj201133_CR15","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1056\/NEJMoa011573","volume":"346","author":"H Kantarjian","year":"2002","unstructured":"Kantarjian H, Sawyers C, Hochhaus A, Guilhot F, Schiffer C, Gambacorti-Passerini C et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 2002; 346: 645\u2013652.","journal-title":"N Engl J Med"},{"key":"BFbcj201133_CR16","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1056\/NEJMoa022457","volume":"348","author":"SG O\u2019Brien","year":"2003","unstructured":"O\u2019Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F et al. Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003; 348: 994\u20131004.","journal-title":"N Engl J Med"},{"key":"BFbcj201133_CR17","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.ceb.2004.03.010","volume":"16","author":"AH Lund","year":"2004","unstructured":"Lund AH, van Lohuizen M . Polycomb complexes and silencing mechanisms. Curr Opin Cell Biol 2004; 16: 239\u2013246.","journal-title":"Curr Opin Cell Biol"},{"key":"BFbcj201133_CR18","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1182\/blood-2006-02-004325","volume":"108","author":"HM Kantarjian","year":"2006","unstructured":"Kantarjian HM, Talpaz M, O\u2019Brien S, Jones D, Giles F, Garcia-Manero G et al. Survival benefit with imatinib mesylate versus interferon-alpha-based regimens in newly diagnosed chronic-phase chronic myelogenous leukemia. Blood 2006; 108: 1835\u20131840.","journal-title":"Blood"},{"key":"BFbcj201133_CR19","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1056\/NEJMoa020150","volume":"347","author":"JF Apperley","year":"2002","unstructured":"Apperley JF, Gardembas M, Melo JV, Russell-Jones R, Bain BJ, Baxter EJ et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N Engl J Med 2002; 347: 481\u2013487.","journal-title":"N Engl J Med"},{"key":"BFbcj201133_CR20","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1111\/j.1365-2141.2008.07033.x","volume":"141","author":"G Helbig","year":"2008","unstructured":"Helbig G, Stella-Ho\u0142owiecka B, Majewski M, Ca\u0142becka M, Gajkowska J, Klimkiewicz R et al. A single weekly dose of imatinib is sufficient to induce and maintain remission of chronic eosinophilic leukaemia in FIP1L1-PDGFR\u03b1-expressing patients. Br J Haematol 2008; 141: 200\u2013204.","journal-title":"Br J Haematol"},{"key":"BFbcj201133_CR21","doi-asserted-by":"publisher","first-page":"4635","DOI":"10.1182\/blood-2006-10-050054","volume":"109","author":"JV Jovanovic","year":"2007","unstructured":"Jovanovic JV, Score J, Waghorn K, Cilloni D, Gottardi E, Metzgeroth G et al. Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in FIP1L1-PDGFR\u03b1-positive chronic eosinophilic leukemia. Blood 2007; 109: 4635\u20134640.","journal-title":"Blood"},{"key":"BFbcj201133_CR22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.drup.2005.04.005","volume":"8","author":"J Cools","year":"2005","unstructured":"Cools J, Maertens C, Marynen P . Resistance to tyrosine kinase inhibitors: calling on extra forces. Drug Resist Updat 2005; 8: 119\u2013129.","journal-title":"Drug Resist Updat"},{"key":"BFbcj201133_CR23","doi-asserted-by":"publisher","first-page":"e200","DOI":"10.1016\/j.leukres.2010.02.024","volume":"34","author":"T Ikezoe","year":"2010","unstructured":"Ikezoe T, Togitani K, Tasaka T, Nishioka C, Yokoyama A . Successful treatment of imatinib-resistant hypereosinophilic syndrome with nilotinib. Leuk Res 2010; 34: e200\u2013e201.","journal-title":"Leuk Res"},{"key":"BFbcj201133_CR24","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1038\/leu.2010.145","volume":"24","author":"C Nishioka","year":"2010","unstructured":"Nishioka C, Ikezoe T, Yang J, Yokoyama A . Long-term exposure of leukemia cells to multi-targeted tyrosine kinase inhibitor induces activations of AKT, ERK and STAT5 signaling via epigenetic silencing of the PTEN gene. Leukemia 2010; 24: 1631\u20131640.","journal-title":"Leukemia"},{"key":"BFbcj201133_CR25","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1038\/sj.leu.2404622","volume":"21","author":"C Nishioka","year":"2007","unstructured":"Nishioka C, Ikezoe T, Yang J, Koeffler HP, Taguchi H . Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-kappaB signal pathway. Leukemia 2007; 21: 1044\u20131049.","journal-title":"Leukemia"},{"key":"BFbcj201133_CR26","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.leukres.2005.12.008","volume":"30","author":"T Ikezoe","year":"2006","unstructured":"Ikezoe T, Bandobashi K, Yang Y, Takeuchi S, Sekiguchi N, Sakai S et al. HIV-1 protease inhibitor ritonavir potentiates the effect of 1,25-dihydroxyvitamin D3 to induce growth arrest and differentiation of human myeloid leukemia cells via down-regulation of CYP24. Leuk Res 2006; 30: 1005\u20131011.","journal-title":"Leuk Res"},{"key":"BFbcj201133_CR27","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cell.2010.02.027","volume":"141","author":"SV Sharma","year":"2010","unstructured":"Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 2010; 141: 69\u201380.","journal-title":"Cell"}],"container-title":["Blood Cancer Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bcj201133.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bcj201133","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bcj201133.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T22:31:54Z","timestamp":1672957914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bcj201133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,9]]},"references-count":27,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12]]}},"alternative-id":["BFbcj201133"],"URL":"https:\/\/doi.org\/10.1038\/bcj.2011.33","relation":{},"ISSN":["2044-5385"],"issn-type":[{"value":"2044-5385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,9]]},"assertion":[{"value":"6 June 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}