{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:59:39Z","timestamp":1790967579754,"version":"4.1.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T00:00:00Z","timestamp":1346371200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Blood Cancer Journal"],"DOI":"10.1038\/bcj.2012.29","type":"journal-article","created":{"date-parts":[[2012,8,31]],"date-time":"2012-08-31T14:38:31Z","timestamp":1346423911000},"page":"e84-e84","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Epstein-Barr nuclear antigen 1 induces expression of the cellular microRNA hsa-miR-127 and impairing B-cell differentiation in EBV-infected memory B cells. New insights into the pathogenesis of Burkitt lymphoma"],"prefix":"10.1038","volume":"2","author":[{"given":"A","family":"Onnis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Navari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Antonicelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Morettini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Mannucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"De Falco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Vigorito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Leoncini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,31]]},"reference":[{"key":"BFbcj201229_CR1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1128\/mr.59.3.387-405.1995","volume":"59","author":"R Khanna","year":"1995","unstructured":"Khanna R, Burrows SR, Moss DJ . Immune regulation in Epstein-Barr virus-associated diseases. Microbiol Rev 1995; 59: 387\u2013405.","journal-title":"Microbiol Rev"},{"key":"BFbcj201229_CR2","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/nrc1452","volume":"4","author":"LS Young","year":"2004","unstructured":"Young LS, Rickinson A . Epstein-Barr virus: 40 years on. Nat Rev Cancer 2004; 4: 757\u2013768.","journal-title":"Nat Rev Cancer"},{"key":"BFbcj201229_CR3","first-page":"33","volume":"110","author":"J Joncas","year":"1974","unstructured":"Joncas J, Boucher J, Granger-Julien M, Filion C . Epstein-Barr virus infection in the neonatal period and in childhood. Can Med Assoc J 1974; 110: 33\u201337.","journal-title":"Can Med Assoc J"},{"key":"BFbcj201229_CR4","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/nrmicro928","volume":"2","author":"LO Bakaletz","year":"2004","unstructured":"Bakaletz LO . Developing animal models for polymicrobial diseases. Nat Rev Microbiol 2004; 2: 552\u2013568.","journal-title":"Nat Rev Microbiol"},{"key":"BFbcj201229_CR5","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/nrmicro2015","volume":"6","author":"DA Thorley-Lawson","year":"2008","unstructured":"Thorley-Lawson DA, Allday MJ . The curious case of the tumour virus: 50 years of Burkitt's lymphoma. Nat Rev Microbiol 2008; 6: 913\u2013924.","journal-title":"Nat Rev Microbiol"},{"key":"BFbcj201229_CR6","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.semcancer.2009.07.002","volume":"19","author":"GW Bornkamm","year":"2009","unstructured":"Bornkamm GW . Epstein-Barr virus and its role in the pathogenesis of Burkitt's lymphoma: an unresolved issue. Semin Cancer Biol 2009; 19: 351\u2013365.","journal-title":"Semin Cancer Biol"},{"key":"BFbcj201229_CR7","unstructured":"Swerdlow SH, Campo E, Harris NL, Jaffe E, Pileri S, Stein H . WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, (ed) IARC: Lyon, France, 2008."},{"key":"BFbcj201229_CR8","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.semcancer.2009.07.007","volume":"19","author":"MJ Allday","year":"2009","unstructured":"Allday MJ . How does Epstein-Barr virus (EBV) complement the activation of Myc in the pathogenesis of Burkitt's lymphoma? Semin Cancer Biol 2009; 19: 366\u2013376.","journal-title":"Semin Cancer Biol"},{"key":"BFbcj201229_CR9","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1073\/pnas.2237267100","volume":"101","author":"D Hochberg","year":"2004","unstructured":"Hochberg D, Middeldorp JM, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA . Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo. Proc Natl Acad Sci USA 2004; 101: 239\u2013244.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFbcj201229_CR10","doi-asserted-by":"publisher","first-page":"14269","DOI":"10.1073\/pnas.2336099100","volume":"100","author":"G Kennedy","year":"2003","unstructured":"Kennedy G, Komano J, Sugden B . Epstein-Barr virus provides a survival factor to Burkitt\u2019s lymphomas. Proc Natl Acad Sci USA 2003; 100: 14269\u201314274.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFbcj201229_CR11","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1182\/blood-2005-01-0168","volume":"106","author":"C Bellan","year":"2005","unstructured":"Bellan C, Lazzi S, Hummel M, Palummo N, De Santi M, Amato T et al. Immunoglobulin gene analysis reveals 2 distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomas. Blood 2005; 106: 1031\u20131036.","journal-title":"Blood"},{"key":"BFbcj201229_CR12","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/ijc.24655","volume":"126","author":"E Leucci","year":"2009","unstructured":"Leucci E, Onnis A, Cocco M, De Falco G, Imperatore F, Antonicelli G et al. B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-altered expression. Int J Cancer 2009; 126: 1316\u20131326.","journal-title":"Int J Cancer"},{"key":"BFbcj201229_CR13","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel DP . MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281\u2013297.","journal-title":"Cell"},{"key":"BFbcj201229_CR14","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/nrg1379","volume":"5","author":"L He","year":"2004","unstructured":"He L, Hannon GJ . MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004; 5: 522\u2013531.","journal-title":"Nat Rev Genet"},{"key":"BFbcj201229_CR15","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","volume":"115","author":"BP Lewis","year":"2003","unstructured":"Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB . Prediction of mammalian microRNA targets. Cell 2003; 115: 787\u2013798.","journal-title":"Cell"},{"key":"BFbcj201229_CR16","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1146\/annurev.pathol.4.110807.092222","volume":"4","author":"YS Lee","year":"2009","unstructured":"Lee YS, Dutta A . MicroRNAs in cancer. Annu Rev Pathol Mech Dis 2009; 4: 199\u2013227.","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"BFbcj201229_CR17","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.chom.2008.05.002","volume":"3","author":"E Gottwein","year":"2008","unstructured":"Gottwein E, Cullen BR . Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe 2008; 3: 375\u2013387.","journal-title":"Cell Host Microbe"},{"key":"BFbcj201229_CR18","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1126\/science.1108784","volume":"308","author":"CH Lecellier","year":"2005","unstructured":"Lecellier CH, Dunoyer P, Arar K, Lehmann-Che J, Eyquem S, Himber C et al. A cellular microRNA mediates antiviral defense in human cells. Science 2005; 308: 557\u2013560.","journal-title":"Science"},{"key":"BFbcj201229_CR19","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1742-4690-3-68","volume":"3","author":"V Scaria","year":"2006","unstructured":"Scaria V, Hariharan M, Maiti S, Pillai B, Brahmachari SK . Host-virus interaction: a new role for microRNAs. Retrovirology 2006; 3: 68.","journal-title":"Retrovirology"},{"key":"BFbcj201229_CR20","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1111\/j.1462-5822.2007.01050.x","volume":"9","author":"V Scaria","year":"2007","unstructured":"Scaria V, Hariharan M, Pillai B, Maiti S, Brahmachari SK . Host-virus genome interactions: macro roles for microRNAs. Cell Microbiol 2007; 9: 2784\u20132794.","journal-title":"Cell Microbiol"},{"key":"BFbcj201229_CR21","doi-asserted-by":"publisher","first-page":"131","DOI":"10.4161\/rna.4.3.5206","volume":"4","author":"N Motsch","year":"2007","unstructured":"Motsch N, Pfuhl T, Mrazek J, Barth S, Grasser FA . Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induces the expression of the cellular microRNA miR-146a. RNA Biol 2007; 4: 131\u2013137.","journal-title":"RNA Biol"},{"key":"BFbcj201229_CR22","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1128\/JVI.02136-07","volume":"82","author":"JE Cameron","year":"2008","unstructured":"Cameron JE, Yin Q, Fewell C, Lacey M, McBride J, Wang X et al. Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J Virol 2008; 82: 1946\u20131958.","journal-title":"J Virol"},{"key":"BFbcj201229_CR23","first-page":"372","volume":"60","author":"PP Claudio","year":"2000","unstructured":"Claudio PP, Howard CM, Pacilio C, Cinti C, Romano G, Minimo C et al. Mutations in the retinoblastoma-related gene RB2\/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer. Cancer Res 2000; 60: 372\u2013382.","journal-title":"Cancer Res"},{"key":"BFbcj201229_CR24","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD . Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001; 25: 402\u2013408.","journal-title":"Methods"},{"key":"BFbcj201229_CR25","doi-asserted-by":"publisher","first-page":"5727","DOI":"10.1093\/nar\/gkn567","volume":"36","author":"G Song","year":"2008","unstructured":"Song G, Wang L . Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma. Nucleic Acids Res 2008; 36: 5727\u20135735.","journal-title":"Nucleic Acids Res"},{"key":"BFbcj201229_CR26","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1002\/ijc.24223","volume":"124","author":"GW Bornkamm","year":"2009","unstructured":"Bornkamm GW . Epstein-Barr virus and the pathogenesis of Burkitt's lymphoma: more questions than answers. Int J Cancer 2009; 124: 1745\u20131755.","journal-title":"Int J Cancer"},{"key":"BFbcj201229_CR27","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1056\/NEJMra032015","volume":"350","author":"DA Thorley-Lawson","year":"2004","unstructured":"Thorley-Lawson DA, Gross A . Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N Eng J Med 2004; 350: 1328\u20131337.","journal-title":"N Eng J Med"},{"key":"BFbcj201229_CR28","doi-asserted-by":"publisher","first-page":"3153","DOI":"10.4049\/jimmunol.179.5.3153","volume":"179","author":"TA Souza","year":"2007","unstructured":"Souza TA, Stollar BD, Sullivan JL, Luzuriaga K, Thorley-Lawson DA . Influence of EBV on the peripheral blood memory B cell compartment. J Immunol 2007; 179: 3153\u20133160.","journal-title":"J Immunol"},{"key":"BFbcj201229_CR29","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.semcancer.2009.07.003","volume":"19","author":"G De Falco","year":"2009","unstructured":"De Falco G, Antonicelli G, Onnis A, Lazzi S, Bellan C, Leoncini L . Role of EBV in microRNA dysregulation in Burkitt lymphoma. Semin Cancer Biol 2009; 19: 401\u2013406.","journal-title":"Semin Cancer Biol"},{"key":"BFbcj201229_CR30","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1182\/blood-2010-08-301556","volume":"117","author":"PP Piccaluga","year":"2011","unstructured":"Piccaluga PP, De Falco G, Kustagi M, Gazzola A, Agostinelli C, Tripodo C et al. Gene expression analysis uncovers similarity and differences among Burkitt lymphoma subtypes. Blood 2011; 117: 3596\u20133608.","journal-title":"Blood"},{"key":"BFbcj201229_CR31","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1038\/leu.2011.156","volume":"25","author":"D Lenze","year":"2011","unstructured":"Lenze D, Leoncini L, Hummel M, Volinia S, Liu CG, Amato T et al. The different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma. Leukemia 2011; 25: 1869\u20131876.","journal-title":"Leukemia"},{"key":"BFbcj201229_CR32","first-page":"2313","volume":"106","author":"SA Kamranvar","year":"2008","unstructured":"Kamranvar SA, Gastaldello S, Masucci MG . The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species. Proc Natl Acad Sci USA 2008; 106: 2313\u20132318.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFbcj201229_CR33","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/leu.2011.35","volume":"25","author":"SA Kamranvar","year":"2011","unstructured":"Kamranvar SA, Masucci MG . The Epstein-Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress. Leukemia 2011; 25: 1017\u20131025.","journal-title":"Leukemia"},{"key":"BFbcj201229_CR34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.molcel.2005.02.029","volume":"18","author":"V Saridakis","year":"2005","unstructured":"Saridakis V, Sheng Y, Sarkari F, Holowaty MN, Shire K, Nguyen T et al. Structure of the p53 binding domain of HAUSP\/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization. Mol Cell 2005; 18: 25\u201336.","journal-title":"Mol Cell"},{"key":"BFbcj201229_CR35","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1038\/leu.2009.92","volume":"23","author":"B Renouf","year":"2009","unstructured":"Renouf B, Hollville E, Pujals A, Tetaud C, Garibal J, Wiels J . Activation of p53 by MDM2 antagonists has differential apoptotic effects on Epstein-Barr virus (EBV)-positive and EBV-negative Burkitt's lymphoma cells. Leukemia 2009; 23: 1557\u20131563.","journal-title":"Leukemia"},{"key":"BFbcj201229_CR36","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1038\/ni.1814","volume":"10","author":"I Dogan","year":"2009","unstructured":"Dogan I, Bertocci B, Vilmont V, Delbos F, Megret J, Storck S et al. Multiple layers of B cell memory with different effector functions. Nat Immunol 2009; 10: 1292\u20131299.","journal-title":"Nat Immunol"},{"key":"BFbcj201229_CR37","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.0105-2896.2006.00403.x","volume":"211","author":"A Lanzavecchia","year":"2006","unstructured":"Lanzavecchia A, Bernasconi N, Traggiai E, Ruprecht CR, Corti D, Sallusto F . Understanding and making use of human memory B cells. Immunol Rev 2006; 211: 303\u2013309.","journal-title":"Immunol Rev"},{"key":"BFbcj201229_CR38","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1084\/jem.20071006","volume":"204","author":"RJ Bende","year":"2007","unstructured":"Bende RJ, van Maldegem F, Triesscheijn M, Wormhoudt TA, Guijt R, van Noesel CJ . Germinal centers in human lymph nodes contain reactivated memory B cells. J Exp Med 2007; 204: 2655\u20132665.","journal-title":"J Exp Med"},{"key":"BFbcj201229_CR39","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1097\/QCO.0b013e328349ac4f","volume":"24","author":"AM Moormann","year":"2011","unstructured":"Moormann AM, Snider CJ, Chelimo K . The company malaria keeps: how co-infection with Epstein-Barr virus leads to endemic Burkitt lymphoma. Curr Opin Infect Dis 2011; 24: 435\u2013441.","journal-title":"Curr Opin Infect Dis"},{"key":"BFbcj201229_CR40","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/j.1365-2141.2011.09013.x","volume":"156","author":"I Magrath","year":"2012","unstructured":"Magrath I . Epidemiology: clues to the pathogenesis of Burkitt lymphoma. Br J Haematol 2012; 156: 744\u2013756.","journal-title":"Br J Haematol"},{"key":"BFbcj201229_CR41","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.coi.2005.03.003","volume":"17","author":"S Peng","year":"2005","unstructured":"Peng S . Signaling in B cells via Toll-like receptors. Curr Opin Immunol 2005; 17: 230\u2013236.","journal-title":"Curr Opin Immunol"},{"key":"BFbcj201229_CR42","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature04495","volume":"440","author":"AR Ramiro","year":"2006","unstructured":"Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM et al. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 2006; 440: 105\u2013109.","journal-title":"Nature"},{"key":"BFbcj201229_CR43","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1146\/annurev.immunol.20.100301.064842","volume":"20","author":"AM Krieg","year":"2002","unstructured":"Krieg AM . CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002; 20: 709\u2013760.","journal-title":"Annu Rev Immunol"}],"container-title":["Blood Cancer Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bcj201229.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bcj201229","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bcj201229.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T20:56:48Z","timestamp":1714337808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bcj201229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,31]]},"references-count":43,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2012,8]]}},"alternative-id":["BFbcj201229"],"URL":"https:\/\/doi.org\/10.1038\/bcj.2012.29","relation":{},"ISSN":["2044-5385"],"issn-type":[{"value":"2044-5385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,31]]},"assertion":[{"value":"14 February 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}