{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:43:43Z","timestamp":1791301423249,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T00:00:00Z","timestamp":1398384000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Blood Cancer Journal"],"DOI":"10.1038\/bcj.2014.25","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T13:35:52Z","timestamp":1398432952000},"page":"e205-e205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Sensitivity of MLL-rearranged AML cells to all-trans retinoic acid is associated with the level of H3K4me2 in the RAR\u03b1 promoter region"],"prefix":"10.1038","volume":"4","author":[{"given":"K","family":"Sakamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Fujiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Hirashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Hosoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,25]]},"reference":[{"key":"BFbcj201425_CR1","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1073\/pnas.77.5.2936","volume":"77","author":"TR Breitman","year":"1980","unstructured":"Breitman TR, Selonick SE, Collins SJ . Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc Natl Acad Sci USA 1980; 77: 2936\u20132940.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFbcj201425_CR2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood.V72.2.567.567","volume":"72","author":"ME Huang","year":"1988","unstructured":"Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L et al. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood 1988; 72: 567\u2013572.","journal-title":"Blood"},{"key":"BFbcj201425_CR3","doi-asserted-by":"publisher","first-page":"7186","DOI":"10.1038\/sj.onc.1204766","volume":"20","author":"A Zelent","year":"2001","unstructured":"Zelent A, Guidez F, Melnick A, Waxman S, Licht JD . Translocations of the RARalpha gene in acute promyelocytic leukemia. Oncogene 2001; 20: 7186\u20137203.","journal-title":"Oncogene"},{"key":"BFbcj201425_CR4","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.1182\/blood-2009-01-198911","volume":"113","author":"D Nowak","year":"2009","unstructured":"Nowak D, Stewart D, Koeffler HP . Differentiation therapy of leukemia: 3 decades of development. Blood 2009; 113: 3655\u20133665.","journal-title":"Blood"},{"key":"BFbcj201425_CR5","first-page":"939021","volume":"2012","author":"G Brown","year":"2012","unstructured":"Brown G, Hughes P . Retinoid differentiation therapy for common types of acute myeloid leukemia. Leuk Res Treatment 2012; 2012: 939021.","journal-title":"Leuk Res Treatment"},{"key":"BFbcj201425_CR6","doi-asserted-by":"publisher","first-page":"2374","DOI":"10.1182\/blood-2007-05-088344","volume":"111","author":"A Glasow","year":"2008","unstructured":"Glasow A, Barrett A, Petrie K, Gupta R, Boix-Chornet M, Zhou DC et al. DNA methylation-independent loss of RARA gene expression in acute myeloid leukemia. Blood 2008; 111: 2374\u20132377.","journal-title":"Blood"},{"key":"BFbcj201425_CR7","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1182\/blood-2004-03-1074","volume":"105","author":"A Glasow","year":"2005","unstructured":"Glasow A, Prodromou N, Xu K, von Lindern M, Zelent A . Retinoids and myelomonocytic growth factors cooperatively activate RARA and induce human myeloid leukemia cell differentiation via MAP kinase pathways. Blood 2005; 105: 341\u2013349.","journal-title":"Blood"},{"key":"BFbcj201425_CR8","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.bbrc.2012.09.131","volume":"428","author":"A Fujiki","year":"2012","unstructured":"Fujiki A, Imamura T, Sakamoto K, Kawashima S, Yoshida H, Hirashima Y et al. All-trans retinoic acid combined with 5-aza-2'-deoxycitidine induces C\/EBP\u03b1 expression and growth inhibition in MLL-AF9-positive leukemic cells. Biochem Biophys Res Commun 2012; 428: 216\u2013223.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFbcj201425_CR9","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1080\/1042819031000163887","volume":"45","author":"K Iijima","year":"2004","unstructured":"Iijima K, Honma Y, Niitsu N . Granulocytic differentiation of leukemic cells with t(9;11)(p22;q23) induced by all-trans-retinoic acid. Leuk Lymphoma 2004; 45: 1017\u20131024.","journal-title":"Leuk Lymphoma"},{"key":"BFbcj201425_CR10","doi-asserted-by":"publisher","first-page":"5289","DOI":"10.1182\/blood-2010-02-267963","volume":"116","author":"ZM Gu","year":"2010","unstructured":"Gu ZM, Wu YL, Zhou MY, Liu CX, Xu HZ, Yan H et al. Pharicin B stabilizes retinoic acid receptor-\u03b1 and presents synergistic differentiation induction with ATRA in myeloid leukemic cells. Blood 2010; 116: 5289\u20135297.","journal-title":"Blood"},{"key":"BFbcj201425_CR11","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/mc.20687","volume":"50","author":"Y Fang","year":"2011","unstructured":"Fang Y, Zhou X, Lin M, Ying M, Luo P, Zhu D et al. Inhibition of all-trans-retinoic acid-induced proteasome activation potentiates the differentiating effect of retinoid in acute myeloid leukemia cells. Mol Carcinog 2011; 50: 24\u201335.","journal-title":"Mol Carcinog"},{"key":"BFbcj201425_CR12","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1128\/MCB.00756-10","volume":"31","author":"B Cassinat","year":"2011","unstructured":"Cassinat B, Zassadowski F, Ferry C, Llopis L, Bruck N, Lainey E et al. New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1\/2 in histone modification and retinoic acid receptor \u03b1 recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation. Mol Cell Biol 2011; 31: 1409\u20131418.","journal-title":"Mol Cell Biol"},{"key":"BFbcj201425_CR13","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nm.2661","volume":"18","author":"T Schenk","year":"2012","unstructured":"Schenk T, Chen WC, G\u00f6llner S, Howell L, Jin L, Hebestreit K et al. Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med 2012; 18: 605\u2013611.","journal-title":"Nat Med"},{"key":"BFbcj201425_CR14","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.ccr.2012.03.014","volume":"21","author":"WJ Harris","year":"2012","unstructured":"Harris WJ, Huang X, Lynch JT, Spencer GJ, Hitchin JR, Li Y et al. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. Cancer Cell 2012; 21: 473\u2013487.","journal-title":"Cancer Cell"},{"key":"BFbcj201425_CR15","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1038\/leu.2013.135","volume":"27","author":"C Meyer","year":"2013","unstructured":"Meyer C, Hofmann J, Burmeister T, Gr\u00f6ger D, Park TS, Emerenciano M et al. The MLL recombinome of acute leukemias in 2013. Leukemia 2013; 27: 2165\u20132176.","journal-title":"Leukemia"},{"key":"BFbcj201425_CR16","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1182\/blood-2009-04-215152","volume":"114","author":"BV Balgobind","year":"2009","unstructured":"Balgobind BV, Raimondi SC, Harbott J, Zimmermann M, Alonzo TA, Auvrignon A et al. Novel prognostic subgroups in childhood 11q23\/MLL-rearranged acute myeloid leukemia: results of an international retrospective study. Blood 2009; 114: 2489\u20132496.","journal-title":"Blood"},{"key":"BFbcj201425_CR17","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1038\/leu.2011.90","volume":"25","author":"BV Balgobind","year":"2011","unstructured":"Balgobind BV, Zwaan CM, Pieters R, Van den Heuvel-Eibrink MM . The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia. Leukemia 2011; 25: 1239\u20131248.","journal-title":"Leukemia"},{"key":"BFbcj201425_CR18","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1200\/JCO.2009.25.6321","volume":"28","author":"C von Neuhoff","year":"2010","unstructured":"von Neuhoff C, Reinhardt D, Sander A, Zimmermann M, Bradtke J, Betts DR et al. Prognostic impact of specific chromosomal aberrations in a large group of pediatric patients with acute myeloid leukemia treated uniformly according to trial AML-BFM 98. J Clin Oncol 2010; 28: 2682\u20132689.","journal-title":"J Clin Oncol"},{"key":"BFbcj201425_CR19","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1182\/blood-2009-07-233049","volume":"115","author":"RW Stam","year":"2010","unstructured":"Stam RW, Schneider P, Hagelstein JA, van der Linden MH, Stumpel DJ, de Menezes RX et al. Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants. Blood 2010; 115: 2835\u20132844.","journal-title":"Blood"},{"key":"BFbcj201425_CR20","doi-asserted-by":"publisher","first-page":"5490","DOI":"10.1182\/blood-2009-06-227660","volume":"114","author":"DJ Stumpel","year":"2009","unstructured":"Stumpel DJ, Schneider P, van Roon EH, Boer JM, de Lorenzo P, Valsecchi MG et al. Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options. Blood 2009; 114: 5490\u20135498.","journal-title":"Blood"},{"key":"BFbcj201425_CR21","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1046\/j.1365-2141.2001.02523.x","volume":"112","author":"N Niitsu","year":"2001","unstructured":"Niitsu N, Hayashi Y, Sugita K, Honma Y . Sensitization by 5-aza-2'-deoxycytidine of leukaemia cells with MLL abnormalities to induction of differentiation by all-trans retinoic acid and 1alpha,25-dihydroxyvitamin D3. Br J Haematol 2001; 112: 315\u2013326.","journal-title":"Br J Haematol"},{"key":"BFbcj201425_CR22","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.leukres.2012.01.009","volume":"36","author":"H Yoshida","year":"2012","unstructured":"Yoshida H, Imamura T, Fujiki A, Hirashima Y, Miyachi M, Inukai T et al. Post-transcriptional modulation of C\/EBP\u03b1 prompts monocytic differentiation and apoptosis in acute myelomonocytic leukemia cells. Leuk Res 2012; 36: 735\u2013741.","journal-title":"Leuk Res"},{"key":"BFbcj201425_CR23","doi-asserted-by":"publisher","first-page":"10138","DOI":"10.1073\/pnas.88.22.10138","volume":"88","author":"P Leroy","year":"1991","unstructured":"Leroy P, Nakshatri H, Chambon P . Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element. Proc Natl Acad Sci USA. 1991; 88: 10138\u201310142.","journal-title":"Proc Natl Acad Sci USA."},{"key":"BFbcj201425_CR24","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1038\/sj.leu.2403937","volume":"19","author":"CS Chim","year":"2005","unstructured":"Chim CS, Wong SY, Pang A, Chu P, Lau JS, Wong KF et al. Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia. Leukemia 2005; 19: 2241\u20132246.","journal-title":"Leukemia"},{"key":"BFbcj201425_CR25","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.1128\/MCB.25.7.2832-2845.2005","volume":"25","author":"Y Okuno","year":"2005","unstructured":"Okuno Y, Huang G, Rosenbauer F, Evans EK, Radomska HS, Iwasaki H et al. Potential autoregulation of transcription factor PU.1 by an upstream regulatory element. Mol Cell Biol 2005; 25: 2832\u20132845.","journal-title":"Mol Cell Biol"},{"key":"BFbcj201425_CR26","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1002\/stem.507","volume":"28","author":"CE Ng","year":"2010","unstructured":"Ng CE, Yokomizo T, Yamashita N, Cirovic B, Jin H, Wen Z et al. A Runx1 intronic enhancer marks hemogenic endothelial cells and hematopoietic stem cells. Stem Cells 2010; 28: 1869\u20131881.","journal-title":"Stem Cells"},{"key":"BFbcj201425_CR27","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1073\/pnas.94.2.569","volume":"94","author":"DE Zhang","year":"1997","unstructured":"Zhang DE, Zhang P, Wang ND, Hetherington CJ, Darlington GJ, Tenen DG . Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci USA 1997; 94: 569\u2013574.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFbcj201425_CR28","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1182\/blood-2006-10-052175","volume":"110","author":"H Schepers","year":"2007","unstructured":"Schepers H, Wierenga AT, van Gosliga D, Eggen BJ, Vellenga E, Schuringa JJ . Reintroduction of C\/EBPalpha in leukemic CD34+ stem\/progenitor cells impairs self-renewal and partially restores myelopoiesis. Blood 2007; 110: 1317\u20131325.","journal-title":"Blood"},{"key":"BFbcj201425_CR29","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1189\/jlb.1202622","volume":"74","author":"T Kummalue","year":"2003","unstructured":"Kummalue T, Friedman AD . Cross-talk between regulators of myeloid development: C\/EBPalpha binds and activates the promoter of the PU.1 gene. J Leukoc Biol 2003; 74: 464\u2013470.","journal-title":"J Leukoc Biol"},{"key":"BFbcj201425_CR30","doi-asserted-by":"publisher","first-page":"6749","DOI":"10.1038\/onc.2008.285","volume":"27","author":"H Matsushita","year":"2008","unstructured":"Matsushita H, Nakajima H, Nakamura Y, Tsukamoto H, Tanaka Y, Jin G et al. C\/EBPalpha and C\/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene. Oncogene 2008; 27: 6749\u20136760.","journal-title":"Oncogene"},{"key":"BFbcj201425_CR31","doi-asserted-by":"publisher","first-page":"3265","DOI":"10.1182\/blood-2002-04-1039","volume":"101","author":"AF Gombart","year":"2003","unstructured":"Gombart AF, Kwok SH, Anderson KL, Yamaguchi Y, Torbett BE, Koeffler HP . Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C\/EBP epsilon and PU.1. Blood 2003; 101: 3265\u20133273.","journal-title":"Blood"},{"key":"BFbcj201425_CR32","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1172\/JCI2887","volume":"103","author":"DJ Park","year":"1999","unstructured":"Park DJ, Chumakov AM, Vuong PT, Chih DY, Gombart AF, Miller WH Jr et al. CCAAT\/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment. J Clin Invest 1999; 103: 1399\u20131408.","journal-title":"J Clin Invest"},{"key":"BFbcj201425_CR33","doi-asserted-by":"publisher","first-page":"4456","DOI":"10.1093\/emboj\/17.15.4456","volume":"17","author":"RP DeKoter","year":"1998","unstructured":"DeKoter RP, Walsh JC, Singh H . PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte\/macrophage progenitors. EMBO J 1998; 17: 4456\u20134468.","journal-title":"EMBO J"},{"key":"BFbcj201425_CR34","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1182\/blood.V94.7.2310.419k34_2310_2318","volume":"94","author":"KL Anderson","year":"1999","unstructured":"Anderson KL, Smith KA, Perkin H, Hermanson G, Anderson CG, Jolly DJ et al. PU.1 and the granulocyte- and macrophage colony-stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation. Blood 1999; 94: 2310\u20132318.","journal-title":"Blood"},{"key":"BFbcj201425_CR35","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1182\/blood.V110.11.868.868","volume":"110","author":"MP Martelli","year":"2007","unstructured":"Martelli MP, Pettirossi V, Manes N, Liso A, Mezzasoma M, Cecchetti F et al. Selective silencing of the NPM1 mutant protein and apoptosis induction upon ATRA in vitro treatment of AML cells carrying NPM1 mutations. Blood 2007; 110: 868.","journal-title":"Blood"},{"key":"BFbcj201425_CR36","doi-asserted-by":"publisher","first-page":"3096","DOI":"10.1182\/blood-2010-09-309674","volume":"118","author":"R Balusu","year":"2011","unstructured":"Balusu R, Fiskus W, Rao R, Chong DG, Nalluri S, Mudunuru U et al. Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1. Blood 2011; 118: 3096\u20133106.","journal-title":"Blood"},{"key":"BFbcj201425_CR37","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3324\/haematol.13378","volume":"94","author":"RF Schlenk","year":"2009","unstructured":"Schlenk RF, D\u00f6hner K, Kneba M, G\u00f6tze K, Hartmann F, Del Valle F et al. Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B. Haematologica 2009; 94: 54\u201360.","journal-title":"Haematologica"},{"key":"BFbcj201425_CR38","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1182\/blood-2009-08-236588","volume":"115","author":"AK Burnett","year":"2010","unstructured":"Burnett AK, Hills RK, Green C, Jenkinson S, Koo K, Patel Y et al. The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3, and CEBPA. Blood 2010; 115: 948\u2013956.","journal-title":"Blood"},{"key":"BFbcj201425_CR39","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3389\/fonc.2013.00218","volume":"3","author":"A Nazha","year":"2013","unstructured":"Nazha A, Bueso-Ramos C, Estey E, Faderl S, O'Brien S, Fernandez MH et al. The addition of all-trans retinoic acid to chemotherapy may not improve the outcome of patient with NPM1 mutated acute myeloid leukemia. Front Oncol 2013; 3: 218.","journal-title":"Front Oncol"},{"key":"BFbcj201425_CR40","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1038\/leu.2013.200","volume":"27","author":"CP Koh","year":"2013","unstructured":"Koh CP, Wang CQ, Ng CE, Ito Y, Araki M, Tergaonkar V et al. RUNX1 meets MLL: epigenetic regulation of hematopoiesis by two leukemia genes. Leukemia 2013; 27: 1793\u20131802.","journal-title":"Leukemia"},{"key":"BFbcj201425_CR41","doi-asserted-by":"publisher","first-page":"6544","DOI":"10.1182\/blood-2010-11-317909","volume":"118","author":"G Huang","year":"2011","unstructured":"Huang G, Zhao X, Wang L, Elf S, Xu H, Zhao X et al. The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS\/AML-associated RUNX1\/AML1 mutations. Blood 2011; 118: 6544\u20136552.","journal-title":"Blood"},{"key":"BFbcj201425_CR42","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/ng.2007.7","volume":"40","author":"G Huang","year":"2008","unstructured":"Huang G, Zhang P, Hirai H, Elf S, Yan X, Chen Z et al. PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis. Nat Genet 2008; 40: 51\u201360.","journal-title":"Nat Genet"},{"key":"BFbcj201425_CR43","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nm.2305","volume":"17","author":"M Rodr\u00edguez-Paredes","year":"2011","unstructured":"Rodr\u00edguez-Paredes M, Esteller M . Cancer epigenetics reaches mainstream oncology. Nat Med 2011; 17: 330\u2013339.","journal-title":"Nat Med"},{"key":"BFbcj201425_CR44","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ccr.2009.12.042","volume":"17","author":"JH Martens","year":"2010","unstructured":"Martens JH, Brinkman AB, Simmer F, Francoijs KJ, Nebbioso A, Ferrara F et al. PML-RARalpha\/RXR alters the epigenetic landscape in acute promyelocytic leukemia. Cancer Cell 2010; 17: 173\u2013185.","journal-title":"Cancer Cell"},{"key":"BFbcj201425_CR45","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.1182\/blood-2007-03-079921","volume":"111","author":"C Hoemme","year":"2008","unstructured":"Hoemme C, Peerzada A, Behre G, Wang Y, McClelland M, Nieselt K et al. Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip. Blood 2008; 111: 2887\u20132895.","journal-title":"Blood"},{"key":"BFbcj201425_CR46","first-page":"2","volume":"61","author":"FF Ferrara","year":"2001","unstructured":"Ferrara FF, Fazi F, Bianchini A, Padula F, Gelmetti V, Minucci S et al. Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia. Cancer Res 2001; 61: 2\u20137.","journal-title":"Cancer Res"},{"key":"BFbcj201425_CR47","doi-asserted-by":"publisher","first-page":"4432","DOI":"10.1182\/blood-2006-09-045781","volume":"109","author":"F Fazi","year":"2007","unstructured":"Fazi F, Zardo G, Gelmetti V, Travaglini L, Ciolfi A, Di Croce L et al. Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia. Blood 2007; 109: 4432\u20134440.","journal-title":"Blood"},{"key":"BFbcj201425_CR48","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","volume":"119","author":"Y Shi","year":"2004","unstructured":"Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004; 119: 941\u2013953.","journal-title":"Cell"},{"key":"BFbcj201425_CR49","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cell.2010.02.027","volume":"141","author":"SV Sharma","year":"2010","unstructured":"Sharma SV, Lee DY, Li B, Quinlan MP, Takahashi F, Maheswaran S et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell 2010; 141: 69\u201380.","journal-title":"Cell"},{"key":"BFbcj201425_CR50","first-page":"247","volume":"4","author":"J Hou","year":"2012","unstructured":"Hou J, Wu J, Dombkowski A, Zhang K, Holowatyj A, Boerner JL et al. Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer. Am J Transl Res 2012; 4: 247\u2013256.","journal-title":"Am J Transl Res"},{"key":"BFbcj201425_CR51","doi-asserted-by":"publisher","first-page":"17536","DOI":"10.1021\/ja907055q","volume":"131","author":"R Ueda","year":"2009","unstructured":"Ueda R, Suzuki T, Mino K, Tsumoto H, Nakagawa H, Hasegawa M et al. Identification of cell-active lysine specific demethylase 1-selective inhibitors. J Am Chem Soc 2009; 131: 17536\u201317537.","journal-title":"J Am Chem Soc"},{"key":"BFbcj201425_CR52","doi-asserted-by":"publisher","first-page":"7238","DOI":"10.1158\/0008-5472.CAN-11-0896","volume":"71","author":"J Wang","year":"2011","unstructured":"Wang J, Lu F, Ren Q, Sun H, Xu Z, Lan R et al. Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties. Cancer Res 2011; 71: 7238\u20137249.","journal-title":"Cancer Res"},{"key":"BFbcj201425_CR53","doi-asserted-by":"publisher","first-page":"8620","DOI":"10.1002\/anie.201303999","volume":"52","author":"D Ogasawara","year":"2013","unstructured":"Ogasawara D, Itoh Y, Tsumoto H, Kakizawa T, Mino K, Fukuhara K et al. Lysine-specific demethylase 1-selective inactivators: protein-targeted drug delivery mechanism. Angew Chem Int Ed Engl 2013; 52: 8620\u20138624.","journal-title":"Angew Chem Int Ed Engl"}],"container-title":["Blood Cancer Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bcj201425.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bcj201425","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bcj201425.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T22:50:33Z","timestamp":1672959033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bcj201425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,25]]},"references-count":53,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4]]}},"alternative-id":["BFbcj201425"],"URL":"https:\/\/doi.org\/10.1038\/bcj.2014.25","relation":{},"ISSN":["2044-5385"],"issn-type":[{"value":"2044-5385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,25]]},"assertion":[{"value":"18 March 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}