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Germinal center B-cell (GCB)-like diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and Burkitt\u2019s lymphoma (BL) each share molecular similarities with normal GCB cells. Recent next-generation sequencing studies have gained insight into the genetic etiology of these malignancies and revealed a high frequency of mutations within genes encoding proteins that modifying chromatin. These include activating and inactivating mutations of genes that perform post-translational modification of histones and organize chromatin structure. Here, we discuss the function of histone acetyltransferases (CREBBP, EP300), histone methyltransferases (KDM2C\/D, EZH2) and regulators of higher order chromatin structure (HIST1H1C\/D\/E, ARID1A and SMARCA4) that have been reported to be mutated in \u2a7e5% of DLBCL, FL or BL. Mutations of these genes are an emerging hallmark of lymphomas with GCB-cell origins, and likely represent the next generation of therapeutic targets for these malignancies.<\/jats:p>","DOI":"10.1038\/bcj.2015.89","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T09:22:20Z","timestamp":1444987340000},"page":"e361-e361","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas"],"prefix":"10.1038","volume":"5","author":[{"given":"M A","family":"Lunning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M R","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,16]]},"reference":[{"key":"BFbcj201589_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrc1589","volume":"5","author":"R Kuppers","year":"2005","unstructured":"Kuppers R . 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