{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:34:45Z","timestamp":1791228885057,"version":"4.1.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T00:00:00Z","timestamp":1460073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Blood Cancer Journal"],"DOI":"10.1038\/bcj.2016.11","type":"journal-article","created":{"date-parts":[[2016,4,8]],"date-time":"2016-04-08T17:39:01Z","timestamp":1460137141000},"page":"e412-e412","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic lymphoma with ETV6\u2013LYN gene fusion"],"prefix":"10.1038","volume":"6","author":[{"given":"N","family":"Telford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O J","family":"McGinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K M","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bloor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,8]]},"reference":[{"key":"BFbcj201611_CR1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"SH Swerdlow","year":"2008","unstructured":"Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pilieri SA, Stein H et al. (eds). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edn. IARC: Lyon, France, 2008."},{"key":"BFbcj201611_CR2","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1038\/leu.2014.35","volume":"28","author":"A Tefferi","year":"2014","unstructured":"Tefferi A, Thiele J, Vannucchi AM, Barbui T . An overview on CALR and CSF3R mutations and a proposal for revision of WHO diagnostic criteria for myeloproliferative neoplasms. Leukemia 2014; 28: 1407\u20131413.","journal-title":"Leukemia"},{"key":"BFbcj201611_CR3","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/j.1582-4934.2008.00559.x","volume":"13","author":"A Tefferi","year":"2009","unstructured":"Tefferi A . Molecular drug targets in myeloproliferative neoplasms: mutant ABL1, JAK2, MPL, KIT, PDGFRA, PDGFRB and FGFR1. J Cell Mol Med 2009; 13: 215\u2013237.","journal-title":"J Cell Mol Med"},{"key":"BFbcj201611_CR4","volume-title":"WHO Classification of tumours of haematopoietic and lymphoid tissues","author":"BJ Bain","year":"2008","unstructured":"Bain BJ, Gilliland DG, Horny H-P, Vardiman JW . Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pilieri SA, Stein H et al. (eds). WHO Classification of tumours of haematopoietic and lymphoid tissues, 4th edn, IARC: Lyon, France, 2008."},{"key":"BFbcj201611_CR5","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1158\/1078-0432.CCR-07-4022","volume":"14","author":"S Strehl","year":"2008","unstructured":"Strehl S, Nebral K, Konig M, Harbott J, Strobl H, Ratei R et al. ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations. Clin Cancer Res 2008; 14: 977\u2013983.","journal-title":"Clin Cancer Res"},{"key":"BFbcj201611_CR6","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1111\/j.1365-2141.2011.08663.x","volume":"153","author":"Y Takeda","year":"2011","unstructured":"Takeda Y, Nakaseko C, Tanaka H, Takeuchi M, Yui M, Saraya A et al. Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis. Br J Haematol 2011; 153: 589\u2013598.","journal-title":"Br J Haematol"},{"key":"BFbcj201611_CR7","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.bbrc.2004.06.040","volume":"320","author":"A Abe","year":"2004","unstructured":"Abe A, Emi N, Kanie T, Imagama S, Kuno Y, Takahashi M et al. Expression cloning of oligomerization-activated genes with cell-proliferating potency by pseudotype retrovirus vector. Biochem Biophys Res Commun 2004; 320: 920\u2013926.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFbcj201611_CR8","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/leu.2009.167","volume":"24","author":"H Tanaka","year":"2009","unstructured":"Tanaka H, Takeuchi M, Takeda Y, Sakai S, Abe D, Ohwada C et al. Identification of a novel TEL-Lyn fusion gene in primary myelofibrosis. Leukemia 2009; 24: 197\u2013200.","journal-title":"Leukemia"},{"key":"BFbcj201611_CR9","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/sj.leu.2404942","volume":"22","author":"L Shvidel","year":"2008","unstructured":"Shvidel L, Sigler E, Vorst E, Feldberg E, Voskoboinic N, Shtalrid M et al. A novel cytogenetic aberration found in stem cell leukemia\/lymphoma syndrome. Leukemia 2008; 22: 644\u2013646.","journal-title":"Leukemia"},{"key":"BFbcj201611_CR10","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.semcancer.2005.01.008","volume":"15","author":"SK Bohlander","year":"2005","unstructured":"Bohlander SK . ETV6: A versatile player in leukemogenesis. Semin Cancer Biol 2005; 15: 162\u2013174.","journal-title":"Semin Cancer Biol"},{"key":"BFbcj201611_CR11","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.leukres.2012.04.010","volume":"36","author":"E De Braekeleer","year":"2012","unstructured":"De Braekeleer E, Douet-Guilbert N, Fdr Morel, Le Bris M-Je, Basinko A, De Braekeleer M . ETV6 fusion genes in hematological malignancies: a review. Leuk Res 2012; 36: 945\u2013961.","journal-title":"Leuk Res"},{"key":"BFbcj201611_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1478-811X-10-21","volume":"10","author":"E Ingley","year":"2012","unstructured":"Ingley E . Functions of the Lyn tyrosine kinase in health and disease. Cell Commun Signal 2012; 10: 21.","journal-title":"Cell Commun Signal"},{"key":"BFbcj201611_CR13","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1182\/blood-2007-04-082099","volume":"111","author":"C Dos Santos","year":"2008","unstructured":"Dos Santos C, Demur C, Bardet V, Prade-Houdellier N, Payrastre B, Recher C . A critical role for Lyn in acute myeloid leukemia. Blood 2008; 111: 2269\u20132279.","journal-title":"Blood"},{"issue":"7","key":"BFbcj201611_CR14","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.1182\/blood-2007-08-109330","volume":"111","author":"J. Wu","year":"2008","unstructured":"Wu J, Meng F, Lu H, Kong L, Bornmann W, Peng Z et al. Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. Blood. 2008; 111: 3821\u20133829.","journal-title":"Blood"},{"key":"BFbcj201611_CR15","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1182\/blood-2012-11-466425","volume":"122","author":"C Dos Santos","year":"2013","unstructured":"Dos Santos C, McDonald T, Ho YW, Liu H, Lin A, Forman SJ et al. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Blood 2013; 122: 1900\u20131913.","journal-title":"Blood"}],"container-title":["Blood Cancer Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bcj201611.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bcj201611","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bcj201611.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T09:06:09Z","timestamp":1672823169000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bcj201611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,8]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2016,4]]}},"alternative-id":["BFbcj201611"],"URL":"https:\/\/doi.org\/10.1038\/bcj.2016.11","relation":{},"ISSN":["2044-5385"],"issn-type":[{"value":"2044-5385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,8]]},"assertion":[{"value":"8 April 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}