{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:02:28Z","timestamp":1761541348090},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Blood Cancer Journal"],"DOI":"10.1038\/bcj.2016.113","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T14:20:53Z","timestamp":1479478853000},"page":"e501-e501","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Plasma immunoprofiling of patients with high-risk diffuse large B-cell lymphoma: a Nordic Lymphoma Group study"],"prefix":"10.1038","volume":"6","author":[{"given":"F","family":"Pauly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Fjord\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Lepp\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Holte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bj\u00f6rkholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8","family":"Fluge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"M\u00f8ller Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Isinger-Ekstrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A K","family":"Borrebaeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Jerkeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Wingren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,18]]},"reference":[{"key":"BFbcj2016113_CR1","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.leukres.2014.03.010","volume":"38","author":"F Pauly","year":"2014","unstructured":"Pauly F, Smedby KE, Jerkeman M, Hjalgrim H, Ohlsson M, Rosenquist R et al. Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays. Leuk Res 2014; 38: 682\u2013690.","journal-title":"Leuk Res"},{"key":"BFbcj2016113_CR2","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1093\/annonc\/mds621","volume":"24","author":"H Holte","year":"2013","unstructured":"Holte H, Leppa S, Bjorkholm M, Fluge O, Jyrkkio S, Delabie J et al. Dose-densified chemoimmunotherapy followed by systemic central nervous system prophylaxis for younger high-risk diffuse large B-cell\/follicular grade 3 lymphoma patients: results of a phase II Nordic Lymphoma Group study. Ann Oncol 2013; 24: 1385\u20131392.","journal-title":"Ann Oncol"},{"key":"BFbcj2016113_CR3","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/978-1-62703-992-5_36","volume":"1131","author":"CA Borrebaeck","year":"2014","unstructured":"Borrebaeck CA, Wingren C . Antibody array generation and use. Methods Mol Biol 2014; 1131: 563\u2013571.","journal-title":"Methods Mol Biol"},{"key":"BFbcj2016113_CR4","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1158\/0008-5472.CAN-11-2883","volume":"72","author":"C Wingren","year":"2012","unstructured":"Wingren C, Sandstrom A, Segersvard R, Carlsson A, Andersson R, Lohr M et al. Identification of serum biomarker signatures associated with pancreatic cancer. Cancer Res 2012; 72: 2481\u20132490.","journal-title":"Cancer Res"},{"key":"BFbcj2016113_CR5","doi-asserted-by":"publisher","first-page":"M110 005033","DOI":"10.1074\/mcp.M110.005033","volume":"10","author":"A Carlsson","year":"2011","unstructured":"Carlsson A, Wuttge DM, Ingvarsson J, Bengtsson AA, Sturfelt G, Borrebaeck CA et al. Serum protein profiling of systemic lupus erythematosus and systemic sclerosis using recombinant antibody microarrays. Mol Cell Proteomics 2011; 10: M110 005033.","journal-title":"Mol Cell Proteomics"},{"key":"BFbcj2016113_CR6","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.cyto.2012.08.028","volume":"60","author":"B Charbonneau","year":"2012","unstructured":"Charbonneau B, Maurer MJ, Ansell SM, Slager SL, Fredericksen ZS, Ziesmer SC et al. Pretreatment circulating serum cytokines associated with follicular and diffuse large B-cell lymphoma: a clinic-based case-control study. Cytokine 2012; 60: 882\u2013889.","journal-title":"Cytokine"},{"key":"BFbcj2016113_CR7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/nrd3937","volume":"12","author":"RM Young","year":"2013","unstructured":"Young RM, Staudt LM . Targeting pathological B cell receptor signalling in lymphoid malignancies. Nat Rev Drug Discov 2013; 12: 229\u2013243.","journal-title":"Nat Rev Drug Discov"},{"key":"BFbcj2016113_CR8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s10238-010-0093-6","volume":"10","author":"T Valkovic","year":"2010","unstructured":"Valkovic T, Duletic-Nacinovic A, Stifter S, Hasan M, Hadzisejdic I, Zombori D et al. Macrophage chemotactic protein-1 mRNA levels in non-Hodgkin lymphoma. Clin Exp Med 2010; 10: 229\u2013235.","journal-title":"Clin Exp Med"},{"key":"BFbcj2016113_CR9","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/j.1365-2141.2006.06093.x","volume":"133","author":"O Al-Assar","year":"2006","unstructured":"Al-Assar O, Rees-Unwin KS, Menasce LP, Hough RE, Goepel JR, Hammond DW et al. Transformed diffuse large B-cell lymphomas with gains of the discontinuous 12q12-14 amplicon display concurrent deregulation of CDK2, CDK4 and GADD153 genes. Br J Haematol 2006; 133: 612\u2013621.","journal-title":"Br J Haematol"},{"key":"BFbcj2016113_CR10","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.pharmthera.2013.12.010","volume":"142","author":"TM Pitts","year":"2014","unstructured":"Pitts TM, Davis SL, Eckhardt SG, Bradshaw-Pierce EL . Targeting nuclear kinases in cancer: development of cell cycle kinase inhibitors. Pharmacol Therap 2014; 142: 258\u2013269.","journal-title":"Pharmacol Therap"},{"key":"BFbcj2016113_CR11","doi-asserted-by":"publisher","first-page":"411","DOI":"10.3109\/10428194.2011.621566","volume":"53","author":"M Giachelia","year":"2012","unstructured":"Giachelia M, Voso MT, Tisi MC, Martini M, Bozzoli V, Massini G et al. Interleukin-6 plasma levels are modulated by a polymorphism in the NF-kappaB1 gene and are associated with outcome following rituximab-combined chemotherapy in diffuse large B-cell non-Hodgkin lymphoma. Leuk Lymphoma 2012; 53: 411\u2013416.","journal-title":"Leuk Lymphoma"},{"key":"BFbcj2016113_CR12","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","volume":"19","author":"KW Moore","year":"2001","unstructured":"Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A . Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19: 683\u2013765.","journal-title":"Annu Rev Immunol"},{"key":"BFbcj2016113_CR13","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/sj.bjc.6605530","volume":"102","author":"Y Wu","year":"2010","unstructured":"Wu Y, Zhou BP . TNF-alpha\/NF-kappaB\/Snail pathway in cancer cell migration and invasion. Br J Cancer 2010; 102: 639\u2013644.","journal-title":"Br J Cancer"},{"key":"BFbcj2016113_CR14","doi-asserted-by":"publisher","first-page":"2844","DOI":"10.1182\/blood-2011-10-388538","volume":"119","author":"M Gupta","year":"2012","unstructured":"Gupta M, Han JJ, Stenson M, Maurer M, Wellik L, Hu G et al. Elevated serum IL-10 levels in diffuse large B-cell lymphoma: a mechanism of aberrant JAK2 activation. Blood 2012; 119: 2844\u20132853.","journal-title":"Blood"},{"key":"BFbcj2016113_CR15","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00005-010-0066-1","volume":"58","author":"E Lech-Maranda","year":"2010","unstructured":"Lech-Maranda E, Bienvenu J, Broussais-Guillaumot F, Warzocha K, Michallet AS, Robak T et al. Plasma TNF-alpha and IL-10 level-based prognostic model predicts outcome of patients with diffuse large B-cell lymphoma in different risk groups defined by the International Prognostic Index. Arch Immunol Therap Exp 2010; 58: 131\u2013141.","journal-title":"Arch Immunol Therap Exp"}],"container-title":["Blood Cancer Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bcj2016113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bcj2016113","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bcj2016113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T08:52:27Z","timestamp":1672822347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bcj2016113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,18]]},"references-count":15,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11]]}},"alternative-id":["BFbcj2016113"],"URL":"https:\/\/doi.org\/10.1038\/bcj.2016.113","relation":{},"ISSN":["2044-5385"],"issn-type":[{"value":"2044-5385","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,18]]},"assertion":[{"value":"18 November 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}