{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:58:30Z","timestamp":1792605510473,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Dent J"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1038\/bdj.2007.1065","type":"journal-article","created":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T16:33:40Z","timestamp":1197045220000},"page":"641-644","source":"Crossref","is-referenced-by-count":31,"title":["Bisphosphonate osteonecrosis of the jaws; an increasing problem for the dental practitioner"],"prefix":"10.1038","volume":"203","author":[{"given":"N. M. H.","family":"McLeod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J. B.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,12,8]]},"reference":[{"key":"BFbdj20071065_CR1","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1210\/edrv.19.1.0325","volume":"19","author":"H Fleisch","year":"2002","unstructured":"Fleisch H . Bisphosphonates: mechanisms of Action. Endocr Rev 2002; 19: 80\u2013100.","journal-title":"Endocr Rev"},{"key":"BFbdj20071065_CR2","doi-asserted-by":"publisher","first-page":"753","DOI":"10.7326\/0003-4819-144-10-200605160-00009","volume":"144","author":"S Woo","year":"2006","unstructured":"Woo S, Hellstein J W, Kalmar J R . Systematic review. bisphosphonates and osteonecrosis of the jaws. Ann Intern Med 2006; 144: 753\u2013761.","journal-title":"Ann Intern Med"},{"key":"BFbdj20071065_CR3","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1124\/jpet.102.035295","volume":"302","author":"J Wood","year":"2002","unstructured":"Wood J, Bonjean K, Reutz S et al. Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid. J Pharmacol Exp Ther 2002; 302: 1055\u20131061.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFbdj20071065_CR4","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1093\/annonc\/mdg401","volume":"14","author":"D Santini","year":"2003","unstructured":"Santini D, Vespasiani Gentilucci U, Vincenzi B et al. The antineoplastic role of bisphosphonates: from basic research to clinical evidence. Ann Oncol 2003; 14: 1468\u20131476.","journal-title":"Ann Oncol"},{"key":"BFbdj20071065_CR5","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1359\/JBMR.040326","volume":"19","author":"KE Ensrud","year":"2004","unstructured":"Ensrud K E, Barrett-Connor E L, Schwartz A et al. Randomized trial of effect of aledronate continuation versus discontinuation in women with low BMD: results from the Fracture Intervention Trial long term extension. J Bone Miner Res 2004; 19: 1259\u20131269.","journal-title":"J Bone Miner Res"},{"key":"BFbdj20071065_CR6","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1056\/NEJMoa011807","volume":"346","author":"IR Reis","year":"2002","unstructured":"Reis I R, Brown J P, Burckhardt P et al. Intravenous zoledronic acid in postmenopausal women with low bone mineral density. N Engl J Med 2002; 346: 653\u2013661.","journal-title":"N Engl J Med"},{"key":"BFbdj20071065_CR7","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.joms.2005.01.010","volume":"63","author":"JW Hellstein","year":"2005","unstructured":"Hellstein J W, Marek C L . Bisphosphonate osteochemonecrosis (bis-phossy jaw): is this phossy jaw of the 21st century? J Oral Maxillofac Surg 2005; 63: 682\u2013689.","journal-title":"J Oral Maxillofac Surg"},{"key":"BFbdj20071065_CR8","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1259\/dmfr\/27458726","volume":"35","author":"S Chiandussi","year":"2006","unstructured":"Chiandussi S, Biasotto M, Dore F et al. Clinical and diagnostic imaging of bisphosphonate-associated osteonecrosis of the jaws. Dentomaxillofac Radiol 2006; 35: 236\u2013243.","journal-title":"Dentomaxillofac Radiol"},{"key":"BFbdj20071065_CR9","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s100670050116","volume":"18","author":"N Demerjian","year":"1999","unstructured":"Demerjian N, Bolla G, Spreux A . Severe oral ulceration induced by aledronate. Clin Rheumatol 1999; 18: 349\u2013350.","journal-title":"Clin Rheumatol"},{"key":"BFbdj20071065_CR10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0278-2391(03)00720-1","volume":"61","author":"RE Marx","year":"2003","unstructured":"Marx R E . Pamidronate (Aredia) and Zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 2003; 61: 115\u2013118.","journal-title":"J Oral Maxillofac Surg"},{"key":"BFbdj20071065_CR11","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.tripleo.2005.10.045","volume":"102","author":"AF Leite","year":"2006","unstructured":"Leite A F, Figuieredo P T, Melo N S et al. Bisphosphonate-associated osteonecrosis of the jaws. Report of a case and literature review Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102: 14\u201321.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"BFbdj20071065_CR12","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","volume":"63","author":"RE Marx","year":"2005","unstructured":"Marx R E, Sawatari Y, Fortin M, Broumand V . Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: risk factors, recognition, prevention and treatment. J Oral Maxillofac Surg 2005; 63: 1567\u20131575.","journal-title":"J Oral Maxillofac Surg"},{"key":"BFbdj20071065_CR13","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.tripleo.2006.06.004","volume":"102","author":"SL Ruggiero","year":"2006","unstructured":"Ruggiero S L, Fantasia J, Carlson E . Bisphosphonate-related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102: 433\u2013441.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"BFbdj20071065_CR14","doi-asserted-by":"publisher","first-page":"8580","DOI":"10.1200\/JCO.2005.02.8670","volume":"23","author":"A Bamias","year":"2005","unstructured":"Bamias A, Kastritis E, Bamia C et al. Osteonecrosis of the jaw in cancer after bisphosphonates: incidence and risk factors. J Clin Oncol 2005; 23: 8580\u20138587.","journal-title":"J Clin Oncol"},{"key":"BFbdj20071065_CR15","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1200\/JCO.2005.04.2465","volume":"24","author":"A Badros","year":"2006","unstructured":"Badros A, Weikel D, Salama A et al. Osteonecrosis of the jaws in Multiple Myeloma patients: clinical features and risk factors. J Clin Oncol 2006; 24: 945\u2013952.","journal-title":"J Clin Oncol"},{"key":"BFbdj20071065_CR16","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","volume":"62","author":"SL Ruggiero","year":"2004","unstructured":"Ruggiero S L, Mehrotra B, Rosenberg T J, Engroff S L . Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg 2004; 62: 527\u2013534.","journal-title":"J Oral Maxillofac Surg"},{"key":"BFbdj20071065_CR17","doi-asserted-by":"crossref","unstructured":"American Dental Association council on Scientific Affairs. Dental management of patients receiving oral bisphosphonate therapy. J Am Dent Assoc 2006; 137: 1144\u20131150.","DOI":"10.14219\/jada.archive.2006.0355"},{"key":"BFbdj20071065_CR18","first-page":"801","volume":"35","author":"P Sambrook","year":"2006","unstructured":"Sambrook P, Olver I, Goss A . Bisphosphonates and osteonecrosis of the jaws. Aust Fam Physician 2006; 35: 801\u2013803.","journal-title":"Aust Fam Physician"},{"key":"BFbdj20071065_CR19","unstructured":"http:\/\/www.mhra.gov.uk\n                    \n                  . Accessed January 2007."},{"issue":"Suppl","key":"BFbdj20071065_CR20","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1111\/j.1834-7819.2005.tb00384.x","volume":"50","author":"A Cheng","year":"2005","unstructured":"Cheng A, Mavrokokki A, Carter G et al. The dental implications of bisphosphonates and bone disease. Aust Dent J 2005; 50(Suppl) 2: S4\u2013S13.","journal-title":"Aust Dent J"},{"key":"BFbdj20071065_CR21","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/ar2050","volume":"8","author":"F Capsoni","year":"2006","unstructured":"Capsoni F, Longhi M, Weinstein R . Bisphosphonate-associated osteonecrosis of the jaw: the rheumatologist's role. Arthritis Res Ther 2006; 8: 219.","journal-title":"Arthritis Res Ther"},{"key":"BFbdj20071065_CR22","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.4065\/81.8.1047","volume":"81","author":"MQ Lacy","year":"2006","unstructured":"Lacy M Q, Dispenzieri A, Gertz M A et al. Mayo Clinic consensus statement for the use of bisphosphonates in multiple myeloma. Mayo Clin Proc 2006; 81: 1047\u20131053.","journal-title":"Mayo Clin Proc"}],"container-title":["British Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bdj.2007.1065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bdj.2007.1065","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bdj.2007.1065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:39:08Z","timestamp":1684413548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bdj.2007.1065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["BFbdj20071065"],"URL":"https:\/\/doi.org\/10.1038\/bdj.2007.1065","relation":{},"ISSN":["0007-0610","1476-5373"],"issn-type":[{"value":"0007-0610","type":"print"},{"value":"1476-5373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}