{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:02:31Z","timestamp":1790330551814,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T00:00:00Z","timestamp":1321920000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1038\/bjc.2011.510","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T21:09:06Z","timestamp":1321996146000},"page":"189-198","source":"Crossref","is-referenced-by-count":69,"title":["Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients"],"prefix":"10.1038","volume":"106","author":[{"given":"G","family":"Goebel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Strasak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Egle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"M\u00fcller-Holzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Rainer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Presul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Parson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Widschwendter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Fiegl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,11,22]]},"reference":[{"key":"BFbjc2011510_CR1","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1111\/j.1349-7006.2010.01491.x","volume":"101","author":"R Berger","year":"2010","unstructured":"Berger R, Fiegl H, Goebel G, Obexer P, Ausserlechner M, Doppler W, Hauser-Kronberger C, Reitsamer R, Egle D, Reimer D, M\u00fcller-Holzner E, Jones A, Widschwendter M (2010) Toll-like receptor 9 expression in breast- and ovarian-cancer is associated with poorly differentiated tumors. Cancer Sci 101: 1059\u20131066","journal-title":"Cancer Sci"},{"key":"BFbjc2011510_CR2","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/clinchem\/45.8.1148","volume":"45","author":"I Bi\u00e8che","year":"1999","unstructured":"Bi\u00e8che I, Onody P, Laurendeau I, Olivi M, Vidaud D, Lidereau R, Vidaud M (1999) Real-time reverse-transcription-PCR assay for future management of ERBB2-based clinical applications. Clin Chem 45: 1148\u20131156","journal-title":"Clin Chem"},{"key":"BFbjc2011510_CR3","doi-asserted-by":"publisher","first-page":"6626","DOI":"10.1038\/sj.onc.1208804","volume":"24","author":"M Buchholz","year":"2005","unstructured":"Buchholz M, Braun M, Heidenblut A, Kestler HA, Kl\u00f6ppel G, Schmiege, W, Hahn SA, L\u00fcttges J, Gress TM (2005) Transcriptome analysis of microdissected pancreatic intraepithelial neoplastic lesions. Oncogene 24: 6626\u20136636","journal-title":"Oncogene"},{"key":"BFbjc2011510_CR4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/carcin\/23.1.123","volume":"23","author":"X Chen","year":"2001","unstructured":"Chen X, Ding Y, Liu CG, Mikhail S, Yang CS (2001) Overexpression of glucose-regulated protein 94 (Grp94) in esophageal-adenocarcinomas of a rat surgical model and humans. Carcinogenesis 23: 123\u2013130","journal-title":"Carcinogenesis"},{"key":"BFbjc2011510_CR5","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1002\/ijc.25516","volume":"127","author":"J Ferlay","year":"2010","unstructured":"Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893\u20132917","journal-title":"Int J Cancer"},{"key":"BFbjc2011510_CR6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1023\/A:1006332011207","volume":"59","author":"PM Fernandez","year":"2000","unstructured":"Fernandez PM, Tabbara SO, Jacobs LK, Manning FC, Tsangaris TN, Schwartz AM, Kennedy KA, Patierno SR (2000) Overexpression of the glucose-regulated stress-gene GRP78 in malignant but not benign human breast lesions. Breast Cancer Res Treat 59: 15\u201326","journal-title":"Breast Cancer Res Treat"},{"key":"BFbjc2011510_CR7","doi-asserted-by":"publisher","first-page":"12741","DOI":"10.1073\/pnas.0605457103","volume":"103","author":"PS Gargalovic","year":"2006","unstructured":"Gargalovic PS, Imura M, Zhang B, Gharavi NM, Clark MJ, Pagnon J, Yang WP, He A, Truong A, Patel S, Nelson SF, Horvath S, Berliner JA, Kirchgessner TG, Lusis AJ (2006) Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci USA 103: 12741\u201312746","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFbjc2011510_CR8","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1023\/B:CANC.0000031768.89246.d7","volume":"23","author":"QT Le","year":"2004","unstructured":"Le QT, Denko NC, Giaccia AJ (2004) Hypoxic gene expression and metastasis. Cancer Metastasis Rev 23: 293\u2013310","journal-title":"Cancer Metastasis Rev"},{"key":"BFbjc2011510_CR9","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nprot.2007.30","volume":"2","author":"CC Liang","year":"2007","unstructured":"Liang CC, Park AY, Guan JL (2007) In-vitro scratch-assay: a convenient and inexpensive method for analysis of cell-migration in-vitro. Nat Protoc 2: 329\u2013333","journal-title":"Nat Protoc"},{"key":"BFbjc2011510_CR10","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/nrc1505","volume":"4","author":"Y Ma","year":"2004","unstructured":"Ma Y, Hendershot LM (2004) The role of the unfolded protein response in tumour development: friend or foe? Nat Rev Cancer 4: 966\u2013977","journal-title":"Nat Rev Cancer"},{"key":"BFbjc2011510_CR11","first-page":"3818","volume":"57","author":"C Marth","year":"1997","unstructured":"Marth C, Zeimet AG, Widschwendter M, Ludescher C, Kaern J, Trop\u00e9 C, Gastl G, Daxenbichler G, Dapunt O (1997) Paclitaxel- and docetaxel-dependent activation of CA-125 expression in human ovarian carcinoma-cells. Cancer Res 57: 3818\u20133822","journal-title":"Cancer Res"},{"key":"BFbjc2011510_CR12","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1093\/jnci\/dji237","volume":"97","author":"LM McShane","year":"2005","unstructured":"McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM (2005) Reporting recommendations for tumor marker prognostic studies (REMARK). J Natl Cancer Inst 97: 1180\u20131184","journal-title":"J Natl Cancer Inst"},{"key":"BFbjc2011510_CR13","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1038\/sj.bjc.6601392","volume":"89","author":"HM Mueller","year":"2003","unstructured":"Mueller HM, Fiegl H, Goebel G, Hubalek MM, Widschwendter A, M\u00fcller-Holzner E, Marth C, Widschwendter M (2003) MeCP2 and MBD2 expression in human neoplastic and non-neoplastic breast-tissue and its association with oestrogen-receptor-status. Br J Cancer 89: 1934\u20131939","journal-title":"Br J Cancer"},{"key":"BFbjc2011510_CR14","doi-asserted-by":"publisher","first-page":"466","DOI":"10.4049\/jimmunol.182.1.466","volume":"182","author":"IN Mungrue","year":"2009","unstructured":"Mungrue IN, Pagnon J, Kohannim O, Gargalovic PS, Lusis AJ. (2009) CHAC1\/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade. J Immunol 182: 466\u2013476","journal-title":"J Immunol"},{"key":"BFbjc2011510_CR15","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1096\/fj.04-3062fje","volume":"19","author":"W Parson","year":"2005","unstructured":"Parson W, Kirchebner R, M\u00fchlmann R, Renner K, Kofler A, Schmidt S, Kofler R. (2005) Cancer cell-line identification by short tandem repeat profiling: power and limitations. FASEB J 19: 434\u2013436","journal-title":"FASEB J"},{"key":"BFbjc2011510_CR16","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s00109-006-0150-5","volume":"85","author":"P Scriven","year":"2007","unstructured":"Scriven P, Brown NJ, Pockley AG, Wyld L (2007) The unfolded protein response and cancer: a brighter future unfolding? J Mol Med 85: 331\u2013341","journal-title":"J Mol Med"},{"key":"BFbjc2011510_CR17","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1038\/sj.bjc.6605365","volume":"101","author":"P Scriven","year":"2009","unstructured":"Scriven P, Coulson S, Haines R, Balasubramanian S, Cross S, Wyld L (2009) Activation and clinical significance of the unfolded protein response in breast-cancer. Br J Cancer 101: 1692\u20131698","journal-title":"Br J Cancer"},{"key":"BFbjc2011510_CR18","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/S0168-8278(03)00029-1","volume":"38","author":"M Shuda","year":"2003","unstructured":"Shuda M, Kondoh N, Imazeki N, Tanaka K, Okada T, Mori K, Hada A, Arai M, Wakatsuki T, Matsubara O, Yamamoto N, Yamamoto M (2003) Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular-carcinoma: a possible involvement of the ER-stress pathway in hepatocarcinogenesis. J Hepatol 38: 605\u2013614","journal-title":"J Hepatol"},{"key":"BFbjc2011510_CR19","unstructured":"Song MS, Park YK, Lee JH, Park K (2001) Cancer Res 61: 8322\u20138330"},{"key":"BFbjc2011510_CR20","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/nsmb.2050","volume":"18","author":"Y Stelzer","year":"2011","unstructured":"Stelzer Y, Yanuka O, Benvenisty N (2011) Global analysis of parental imprinting in human parthenogenetic induced pluripotent stem-cells. Nat Struct Mol Biol 18: 735\u2013741","journal-title":"Nat Struct Mol Biol"},{"key":"BFbjc2011510_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.annepidem.2008.08.009","volume":"19","author":"AM Strasak","year":"2009","unstructured":"Strasak AM, Lang S, Kneib T, Brant LJ, Klenk J, Hilbe W, Oberaigner W, Ruttmann E, Kaltenbach L, Concin H, Diem G, Pfeiffer KP, Ulmer H (2009) Use of penalized-splines in extended cox-type additive hazard regression to flexibly estimate the effect of time-varying serum uric acid on risk of cancer incidence: a prospective, population-based study in 78\u2009850 men. Ann Epidemiol 19: 15\u201324","journal-title":"Ann Epidemiol"},{"key":"BFbjc2011510_CR22","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1093\/jnci\/92.10.826","volume":"92","author":"M Widschwendter","year":"2000","unstructured":"Widschwendter M, Berger J, Hermann M, M\u00fcller HM, Amberger A, Zeschnigk M, Widschwendter A, Abendstein B, Zeimet AG, Daxenbichler G, Marth C (2000) Methylation and silencing of the retinoic-acid receptor-beta2 gene in breast-cancer. J Natl Cancer Inst 92: 826\u2013832","journal-title":"J Natl Cancer Inst"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bjc2011510.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2011510","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2011510.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:05:21Z","timestamp":1684415121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bjc2011510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,22]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["BFbjc2011510"],"URL":"https:\/\/doi.org\/10.1038\/bjc.2011.510","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,22]]}}}