{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:25:29Z","timestamp":1776209129303,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T00:00:00Z","timestamp":1349740800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1038\/bjc.2012.459","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T21:11:57Z","timestamp":1349817117000},"page":"1702-1713","source":"Crossref","is-referenced-by-count":37,"title":["Vascular endothelial growth factor signals through platelet-derived growth factor receptor \u03b2 in meningiomas in vitro"],"prefix":"10.1038","volume":"107","author":[{"given":"C","family":"Pfister","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Pfrommer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M S","family":"Tatagiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Roser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,10,9]]},"reference":[{"issue":"5","key":"BFbjc2012459_CR1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1440-1789.2010.01105.x","volume":"30","author":"V Barresi","year":"2010","unstructured":"Barresi V, Tuccari G (2010) Increased ratio of vascular endothelial growth factor to semaphorin3A is a negative prognostic factor in human meningiomas. Neuropathology 30 (5): 537\u2013546","journal-title":"Neuropathology"},{"key":"BFbjc2012459_CR2","doi-asserted-by":"publisher","first-page":"R100","DOI":"10.1186\/gb-2006-7-10-r100","volume":"7","author":"AE Carpenter","year":"2006","unstructured":"Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, Guertin DA, Chang JH, Lindquist RA, Moffat J, Golland P, Sabatini DM (2006) CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol 7: R100","journal-title":"Genome Biol"},{"issue":"1","key":"BFbjc2012459_CR3","first-page":"46","volume":"11","author":"Y Cheng","year":"2008","unstructured":"Cheng Y, Paz K (2008) Tandutinib, an oral, small-molecule inhibitor of FLT3 for the treatment of AML and other cancer indications. IDrugs 11 (1): 46\u201356","journal-title":"IDrugs"},{"key":"BFbjc2012459_CR4","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1007\/s004010051102","volume":"98","author":"C Christov","year":"1999","unstructured":"Christov C, Lechapt-Zalcman E, Adle-Biassette H, Nachev S, Gherardi R (1999) Vascular permeability factor\/vascular endothelial growth factor (VPF\/VEGF) and its receptor flt-1 in microcystic meningiomas. Acta Neuropathol 98: 414\u2013420","journal-title":"Acta Neuropathol"},{"key":"BFbjc2012459_CR5","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/S0968-0004(03)00193-2","volume":"28","author":"M Cross","year":"2003","unstructured":"Cross M, Dixelius J, Matsumoto T, Claesson-Welsh L (2003) VEGF receptor signal transduction. Trends Biochem Sci 28: 488\u2013494","journal-title":"Trends Biochem Sci"},{"issue":"9","key":"BFbjc2012459_CR6","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1038\/labinvest.3700659","volume":"87","author":"HS Erickson","year":"2007","unstructured":"Erickson HS, Albert PS, Gillespie JW, Wallis BS, Rodriguez-Canales J, Linehan WM, Gonzalez S, Velasco A, Chuaqui RF, Emmert-Buck MR (2007) Assessment of normalization strategies for quantitative RT-PCR using microdissected tissue samples. Lab Invest 87 (9): 951\u2013962","journal-title":"Lab Invest"},{"issue":"6","key":"BFbjc2012459_CR7","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/nm0603-669","volume":"9","author":"N Ferrara","year":"2003","unstructured":"Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9 (6): 669\u2013676","journal-title":"Nat Med"},{"issue":"5","key":"BFbjc2012459_CR8","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1365-2990.1994.tb00994.x","volume":"20","author":"D Figarella\u2013Branger","year":"1994","unstructured":"Figarella\u2013Branger D, Vagner\u2013Capodano AM, Bouillot P, Graziani N, Gambarelli D, Devictor B, Zattara\u2013Cannoni H, Bianco N, Grisoli F, Pellissier JF (1994) Platelet-derived growth factor (PDGF) and receptor (PDGFR) expression in human meningiomas: correlations with clinicopathological features and cytogenetic analysis. Neuropathol Appl Neurobiol 20 (5): 439\u2013447","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"10","key":"BFbjc2012459_CR9","doi-asserted-by":"publisher","first-page":"3298","DOI":"10.1158\/1535-7163.MCT-08-0212","volume":"7","author":"H Gu","year":"2008","unstructured":"Gu H, Wang X, Rao S, Wang J, Zhao J, Ren FL, Mu R, Yang Y, Qi Q, Liu W, Lu N, Ling H, You Q, Guo Q (2008) Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells. Mol Cancer Ther 7 (10): 3298\u20133305","journal-title":"Mol Cancer Ther"},{"key":"BFbjc2012459_CR10","first-page":"368","volume":"146","author":"E Hatva","year":"1995","unstructured":"Hatva E, Kaipainen A, Mentula P, Jaaskelainen J, Paetau A, Haltia M, Alitalo K (1995) Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors. Am J Pathol 146: 368\u2013378","journal-title":"Am J Pathol"},{"key":"BFbjc2012459_CR11","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/gb-2005-6-2-209","volume":"6","author":"DI Holmes","year":"2005","unstructured":"Holmes DI, Zachary I (2005) The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. Genome Biol 6: 209\u2013219","journal-title":"Genome Biol"},{"key":"BFbjc2012459_CR12","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1179\/016164105X39833","volume":"27","author":"H Huang","year":"2005","unstructured":"Huang H, Held-Feindt J, Buhl R, Mehdor nH, Mentlein R (2005) Expression of VEGF and its receptors in different brain tumors. Neurol Res 27: 371\u2013377","journal-title":"Neurol Res"},{"issue":"5","key":"BFbjc2012459_CR13","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/0090-3019(86)90259-4","volume":"26","author":"J J\u00e4\u00e4skel\u00e4inen","year":"1986","unstructured":"J\u00e4\u00e4skel\u00e4inen J (1986) Seemingly complete removal of histologically benign intracranial meningioma: Late recurrence rate and factors predicting recurrence in 657 patients. A multivariate analysis. Surg Neurol 26 (5): 461\u2013469","journal-title":"Surg Neurol"},{"issue":"34","key":"BFbjc2012459_CR14","doi-asserted-by":"publisher","first-page":"12095","DOI":"10.1073\/pnas.0406731102","volume":"102","author":"S Kasibhatla","year":"2005","unstructured":"Kasibhatla S, Jessen KA, Maliartchouk S, Wang JY, English NM, Drewe J, Qiu L, Archer SP, Ponce AE, Sirisoma N, Jiang S, Zhang H-Z, Gehlsen KR, Cai SX, Green DR, Tseng B (2005) A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid. Proc Natl Acad Sci USA 102 (34): 12095\u201312100","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"BFbjc2012459_CR15","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S1535-6108(02)00070-3","volume":"1","author":"LM Kelly","year":"2002","unstructured":"Kelly LM, Yu J-C, Boulton CL, Apatira M, Li J, Sullivan CM, Williams I, Amaral SM, Curley DP, Duclos N, Neuberg D, Scarborough RM, Pandey A, Hollenbach S, Abe K, Lokker NA, Gilliland DG, Giese NA (2002) CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell 1 (5): 421\u2013432","journal-title":"Cancer Cell"},{"issue":"3","key":"BFbjc2012459_CR16","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/BF01808629","volume":"131","author":"JI Kuratsu","year":"1994","unstructured":"Kuratsu JI, Seto H, Kochi M, Ushio Y (1994) Expression of PDGF, PDGF-receptor, EGF-receptor and sex hormone receptors on meningioma. Acta Neurochir (Wien) 131 (3): 289\u2013293","journal-title":"Acta Neurochir (Wien)"},{"key":"BFbjc2012459_CR17","first-page":"938","volume":"46","author":"K Lamszuz","year":"2000","unstructured":"Lamszuz K, Lengler U, Schmidt NO, Stavrou D, Ergun S, Westphal M (2000) Vascular endothelial growth factor, hepatocyte growth factor\/scatter factor, basic fibroblast growth factor, and placenta growth factor in human meningiomas and their relation to angiogenesis and malignancy. Neurosurgery 46: 938\u2013947","journal-title":"Neurosurgery"},{"issue":"9","key":"BFbjc2012459_CR18","doi-asserted-by":"publisher","first-page":"901","DOI":"10.5551\/jat.3491","volume":"17","author":"Y Liu","year":"2010","unstructured":"Liu Y, Li W, Ye C, Lin Y, Cheang T-Y, Wang M, Zhang H, Wang S, Zhang L, Wang S (2010) Gambogic acid induces G0\/G1 cell cycle arrest and cell migration inhibition via suppressing PDGF receptor \u03b2 tyrosine phosphorylation and Rac1 activity in rat aortic smooth muscle cells. J Atheroscler Thromb 17 (9): 901\u2013913","journal-title":"J Atheroscler Thromb"},{"issue":"2","key":"BFbjc2012459_CR19","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","volume":"114","author":"D Louis","year":"2007","unstructured":"Louis D, Ohgaki H, Wiestler O, Cavenee W, Burger P, Jouvet A, Scheithauer B, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114 (2): 97\u2013109","journal-title":"Acta Neuropathol"},{"issue":"6","key":"BFbjc2012459_CR20","first-page":"955","volume":"33","author":"A Mahmood","year":"1993","unstructured":"Mahmood A, Caccamo DV, Tomecek FJ, Malik GM (1993) Atypical and malignant meningiomas: a clinicopathological review. Neurosurgery 33 (6): 955\u2013963","journal-title":"Neurosurgery"},{"issue":"2","key":"BFbjc2012459_CR21","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0022-510X(95)00106-C","volume":"131","author":"A Mauro","year":"1995","unstructured":"Mauro A, Di Sapio A, Mocellini C, Schiffer D (1995) Control of meningioma cell growth by platelet-derived growth factor (PDGF). J Neurol Sci 131 (2): 135\u2013143","journal-title":"J Neurol Sci"},{"issue":"6","key":"BFbjc2012459_CR22","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s11864-004-0038-y","volume":"5","author":"KP McMullen","year":"2004","unstructured":"McMullen KP, Stieber VW (2004) Meningioma: current treatment options and future directions. Curr Treat Options Oncol 5 (6): 499\u2013509","journal-title":"Curr Treat Options Oncol"},{"issue":"1","key":"BFbjc2012459_CR23","first-page":"327","volume":"9","author":"DB Mendel","year":"2003","unstructured":"Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar J\u00d6, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM (2003) In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors. Clin Cancer Res 9 (1): 327\u2013337","journal-title":"Clin Cancer Res"},{"issue":"5","key":"BFbjc2012459_CR24","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1517\/13543784.15.5.553","volume":"15","author":"RJ Motzer","year":"2006","unstructured":"Motzer RJ, Hoosen S, Bello CL, Christensen JG (2006) Sunitinib malate for the treatment of solid tumours: a review of current clinical data. Expert Opin Investig Drugs 15 (5): 553\u2013561","journal-title":"Expert Opin Investig Drugs"},{"issue":"2","key":"BFbjc2012459_CR25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10014-009-0251-2","volume":"26","author":"S Nakasu","year":"2009","unstructured":"Nakasu S, Fukami T, Jito J, Nozaki K (2009) Recurrence and regrowth of benign meningiomas. Brain Tumor Pathol 26 (2): 69\u201372","journal-title":"Brain Tumor Pathol"},{"key":"BFbjc2012459_CR26","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s004010050919","volume":"96","author":"R Nishikawa","year":"1998","unstructured":"Nishikawa R, Cheng S, Nagashima R, Huang H, Cavenee W, Matsutani M (1998) Expression of vascular endothelial growth factor in human brain tumors. Acta Neuropathol 96: 453\u2013462","journal-title":"Acta Neuropathol"},{"issue":"3","key":"BFbjc2012459_CR27","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s11060-004-9164-4","volume":"70","author":"S Otsuka","year":"2004","unstructured":"Otsuka S, Tamiya T, Ono Y, Michiue H, Kurozumi K, Daido S, Kambara H, Date I, Ohmoto T (2004) The relationship between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in intracranial meningiomas. J Neurooncol 70 (3): 349\u2013357","journal-title":"J Neurooncol"},{"key":"BFbjc2012459_CR28","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0304-3940(00)00904-6","volume":"283","author":"K Park","year":"2000","unstructured":"Park K, Kim JH, Nam DH, Lee JI, Kim JS, Hong SC, Shin HJ, Eoh W, Park K (2000) Vascular endothelial growth factor expression under ischemic stress in human meninigiomas. Neurosci Lett 283: 45\u201348","journal-title":"Neurosci Lett"},{"key":"BFbjc2012459_CR29","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/1756-0500-4-275","volume":"4","author":"C Pfister","year":"2011","unstructured":"Pfister C, Tatagiba MS, Roser F (2011) Selection of suitable reference genes for quantitative real-time polymerase chain reaction in human meningiomas and arachnoidea. BMC Res Notes 4: 275","journal-title":"BMC Res Notes"},{"key":"BFbjc2012459_CR30","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s004010050591","volume":"93","author":"T Pietsch","year":"1997","unstructured":"Pietsch T, Valter MM, Wolf HK, von Deimling A, Huang HJ, Cavenee WK, Wiestler OD (1997) Expression and distribution of vascular endothelial growth factor protein in human brain tumors. Acta Neuropathol 93: 109\u2013117","journal-title":"Acta Neuropathol"},{"key":"BFbjc2012459_CR31","doi-asserted-by":"publisher","first-page":"352","DOI":"10.5414\/NP300488","volume":"31","author":"M Preusser","year":"2012","unstructured":"Preusser M, Hassler M, Birner P, Rudas M, Acker T, Plate KH, Widhalm G, Knosp E, Breitschopf H, Berger J, Marosi C (2012) Microvascularization and expression of VEGF and its receptors in recurring meningiomas: pathobiological data in favor of anti-angiogenic therapy approaches. Clin Neuropathol 31: 352\u2013360","journal-title":"Clin Neuropathol"},{"key":"BFbjc2012459_CR32","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1097\/00006123-199705000-00027","volume":"40","author":"J Provias","year":"1997","unstructured":"Provias J, Claffey K, delAguila L, Lau N, Feldkamp M, Guha A (1997) Meningiomas: role of vascular endothelial growth factor\/vascular permeability factor in angiogenesis and peritumoral edema. Neurosurgery 40: 1016\u20131026","journal-title":"Neurosurgery"},{"issue":"5","key":"BFbjc2012459_CR33","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.bcp.2007.10.033","volume":"75","author":"L Qiang","year":"2008","unstructured":"Qiang L, Yang Y, You Q-D, Ma Y-J, Yang L, Nie F-F, Gu H-Y, Zhao L, Lu N, Qi Q, Liu W, Wang X-T, Guo Q-L (2008) Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study. Biochem Pharmacol 75 (5): 1083\u20131092","journal-title":"Biochem Pharmacol"},{"issue":"12","key":"BFbjc2012459_CR34","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/S1474-4422(06)70625-1","volume":"5","author":"MJ Riemenschneider","year":"2006","unstructured":"Riemenschneider MJ, Perry A, Reifenberger G (2006) Histological classification and molecular genetics of meningiomas. Lancet Neurol 5 (12): 1045\u20131054","journal-title":"Lancet Neurol"},{"key":"BFbjc2012459_CR35","first-page":"1189","volume":"55","author":"K Samoto","year":"1995","unstructured":"Samoto K, Ikezaki K, Ono M, Shono T, Kohno K, Kuwano M, Fukui M (1995) Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors. Cancer Res 55: 1189\u20131193","journal-title":"Cancer Res"},{"issue":"5","key":"BFbjc2012459_CR36","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/j.1365-2990.2006.00761.x","volume":"32","author":"J Schittenhelm","year":"2006","unstructured":"Schittenhelm J, Mittelbronn M, Roser F, Tatagiba M, Mawrin C, Bornemann A (2006) Patterns of SPARC expression and basement membrane intactness at the tumour-brain border of invasive meningiomas. Neuropathol Appl Neurobiol 32 (5): 525\u2013531","journal-title":"Neuropathol Appl Neurobiol"},{"key":"BFbjc2012459_CR37","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s11060-007-9336-0","volume":"83","author":"T Uesaka","year":"2007","unstructured":"Uesaka T, Shono T, Suzuki SO, Nakamizo A, Niiro H, Mizoguchi M, Iwaki T, Sasaki T (2007) Expression of VEGF and its receptor genes in intracranial schwannomas. J Neurooncol 83: 259\u2013266","journal-title":"J Neurooncol"},{"key":"BFbjc2012459_CR38","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1002\/ijc.2910460504","volume":"46","author":"J Wang","year":"1990","unstructured":"Wang J, Nister M, Hermansson M, Westermark B, Ponten J (1990) Expression of PDGF beta-receptors in human meningioma cells. Int J Cancer 46: 772\u2013778","journal-title":"Int J Cancer"},{"key":"BFbjc2012459_CR39","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1002\/1097-0142(20000901)89:5<1102::AID-CNCR20>3.0.CO;2-L","volume":"89","author":"F Yamasaki","year":"2000","unstructured":"Yamasaki F (2000) Recurrence of meningiomas. Cancer 89: 1102\u20131110","journal-title":"Cancer"},{"key":"BFbjc2012459_CR40","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s11030-006-9027-3","volume":"10","author":"Y Yamazaki","year":"2006","unstructured":"Yamazaki Y, Morita T (2006) Molecular and functional diversity of vascular endothelial growth factors. Mol Divers 10: 515\u2013527","journal-title":"Mol Divers"},{"key":"BFbjc2012459_CR41","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/35025215","volume":"407","author":"GD Yancopoulos","year":"2000","unstructured":"Yancopoulos GD, Davis S, Gale N, Rudge J, Wiegand S, Holash J (2000) Vascular specific growth factors and blood vessel formation. Nature 407: 242\u2013248","journal-title":"Nature"},{"issue":"4","key":"BFbjc2012459_CR42","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1054\/jocn.2001.0877","volume":"8","author":"S Yang","year":"2001","unstructured":"Yang S (2001) Expression of PDGF and its receptor as well as their relationship to proliferating activity and apoptosis of meningiomas in human meningiomas. J Clin Neurosci 8 (4): 49\u201353","journal-title":"J Clin Neurosci"},{"key":"BFbjc2012459_CR43","first-page":"49","volume":"36","author":"J Yu","year":"2003","unstructured":"Yu J, Ustach C, Kim H (2003) Platelet-derived growth factor signaling and human cancer. J Biochem Mol Biol 36: 49\u201359","journal-title":"J Biochem Mol Biol"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bjc2012459.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2012459","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2012459.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T04:52:28Z","timestamp":1714452748000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bjc2012459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,9]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["BFbjc2012459"],"URL":"https:\/\/doi.org\/10.1038\/bjc.2012.459","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,9]]}}}