{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:09:16Z","timestamp":1787170156579,"version":"build-2736575974"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1038\/bjc.2012.496","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T05:54:25Z","timestamp":1353477265000},"page":"1969-1977","source":"Crossref","is-referenced-by-count":28,"title":["High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma"],"prefix":"10.1038","volume":"107","author":[{"given":"K","family":"Niimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Shinjo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kotani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Umezu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kajiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Ino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Kikkawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,20]]},"reference":[{"key":"BFbjc2012496_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1385\/ENDO:19:1:13","volume":"19","author":"MU Baumann","year":"2002","unstructured":"Baumann MU, Deborde S, Illsley NP (2002) Placental glucose transfer and fetal growth. Endocrine 19: 13\u201322","journal-title":"Endocrine"},{"key":"BFbjc2012496_CR2","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/1477-7827-8-102","volume":"8","author":"LA Cole","year":"2010","unstructured":"Cole LA (2010) Biological functions of hCG and hCG-related molecules. Reprod Biol Endocrinol 8: 102","journal-title":"Reprod Biol Endocrinol"},{"key":"BFbjc2012496_CR3","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/0006-291X(85)90610-2","volume":"126","author":"LA Cole","year":"1985","unstructured":"Cole LA, Birken S, Perini F (1985) The structures of the serine-linked sugar chains on human chorionic gonadotropin. Biochem Biophys Res Commun 126: 333\u2013339","journal-title":"Biochem Biophys Res Commun"},{"key":"BFbjc2012496_CR4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ygyno.2005.12.047","volume":"102","author":"LA Cole","year":"2006","unstructured":"Cole LA, Dai D, Butler SA, Leslie KK, Kohorn EI (2006) Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG. Gynecol Oncol 102: 145\u2013150","journal-title":"Gynecol Oncol"},{"key":"BFbjc2012496_CR5","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1016\/0006-291X(84)91228-2","volume":"122","author":"LA Cole","year":"1984","unstructured":"Cole LA, Perini F, Birken S, Ruddon RW (1984) An oligosaccharide of the O-linked type distinguishes the free from the combined form of hCG alpha subunit. Biochem Biophys Res Commun 122: 1260\u20131267","journal-title":"Biochem Biophys Res Commun"},{"key":"BFbjc2012496_CR6","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1172\/JCI115565","volume":"89","author":"CH Damsky","year":"1992","unstructured":"Damsky CH, Fitzgerald ML, Fisher SJ (1992) Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo. J Clin Invest 89: 210\u2013222","journal-title":"J Clin Invest"},{"key":"BFbjc2012496_CR7","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1242\/dev.120.12.3657","volume":"120","author":"CH Damsky","year":"1994","unstructured":"Damsky CH, Librach C, Lim KH, Fitzgerald ML, McMaster MT, Janatpour M, Zhou Y, Logan SK, Fisher SJ (1994) Integrin switching regulates normal trophoblast invasion. Development 120: 3657\u20133566","journal-title":"Development"},{"key":"BFbjc2012496_CR8","first-page":"5242","volume":"47","author":"T Endo","year":"1987","unstructured":"Endo T, Nishimura R, Kawano T, Mochizuki M, Kobata A (1987) Structural differences found in the asparagine-linked sugar chains of human chorionic gonadotropins purified from the urine of patients with invasive mole and with choriocarcinoma. Cancer Res 47: 5242\u20135245","journal-title":"Cancer Res"},{"key":"BFbjc2012496_CR9","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s10719-012-9414-1","volume":"29","author":"J Fan","year":"2012","unstructured":"Fan J, Wang S, Yu S, He J, Zheng W, Zhang J (2012) N-acetylglucosaminyltransferase IVa regulates metastatic potential of mouse hepatocarcinoma cells through glycosylation of CD147. Glycoconj J 29: 323\u2013334","journal-title":"Glycoconj J"},{"key":"BFbjc2012496_CR10","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1006\/gyno.1993.1028","volume":"48","author":"S Goto","year":"1993","unstructured":"Goto S, Yamada A, Ishizuka T, Tomoda Y (1993) Development of postmolar trophoblastic disease after partial molar pregnancy. Gynecol Oncol 48: 165\u2013170","journal-title":"Gynecol Oncol"},{"key":"BFbjc2012496_CR11","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1006\/excr.1993.1139","volume":"206","author":"CH Graham","year":"1993","unstructured":"Graham CH, Hawley TS, Hawley RG, MacDougall JR, Kerbel RS, Khoo N, Lala PK (1993) Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Exp Cell Res 206: 204\u2013211","journal-title":"Exp Cell Res"},{"key":"BFbjc2012496_CR12","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1248\/bpb.32.780","volume":"32","author":"J Gu","year":"2009","unstructured":"Gu J, Isaji T, Sato Y, Kariya Y, Fukuda T (2009) Importance of N-glycosylation on alpha5beta1 integrin for its biological functions. Biol Pharm Bull 32: 780\u2013785","journal-title":"Biol Pharm Bull"},{"key":"BFbjc2012496_CR13","doi-asserted-by":"publisher","first-page":"E240","DOI":"10.1210\/jc.2010-0138","volume":"95","author":"J Guibourdenche","year":"2010","unstructured":"Guibourdenche J, Handschuh K, Tsatsaris V, Gerbaud P, Leguy MC, Muller F, Brion DE, Fournier T (2010) Hyperglycosylated hCG is a marker of early human trophoblast invasion. J Clin Endocrinol Metab 95: E240\u2013E244","journal-title":"J Clin Endocrinol Metab"},{"key":"BFbjc2012496_CR14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0065-230X(08)60215-8","volume":"52","author":"S Hakomori","year":"1989","unstructured":"Hakomori S (1989) Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv Cancer Res 52: 257\u2013331","journal-title":"Adv Cancer Res"},{"key":"BFbjc2012496_CR15","doi-asserted-by":"publisher","first-page":"5011","DOI":"10.1210\/en.2007-0286","volume":"148","author":"K Handschuh","year":"2007","unstructured":"Handschuh K, Guibourdenche J, Tsatsaris V, Guesnon M, Laurendeau I, Evain-Brion D, Fournier T (2007) Human chorionic gonadotropin produced by the invasive trophoblast but not the villous trophoblast promotes cell invasion and is down-regulated by peroxisome proliferator-activated receptor-gamma. Endocrinology 148: 5011\u20135019","journal-title":"Endocrinology"},{"key":"BFbjc2012496_CR16","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.febslet.2005.12.089","volume":"580","author":"K Inamori","year":"2006","unstructured":"Inamori K, Gu J, Ohira M, Kawasaki A, Nakamura Y, Nakagawa T, Kondo A, Miyoshi E, Nakagawara A, Taniguchi N (2006) High expression of N-acetylglucosaminyltransferase V in favorable neuroblastomas: involvement of its effect on apoptosis. FEBS Lett 580: 627\u2013632","journal-title":"FEBS Lett"},{"key":"BFbjc2012496_CR17","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/BF02221328","volume":"3","author":"K Ino","year":"1991","unstructured":"Ino K, Goto S, Kosaki A, Nomura S, Asada E, Misawa T, Furuhashi Y, Mizutani S, Tomoda Y (1991) Growth inhibitory effect of bestatin on choriocarcinoma cell lines in vitro. Biotherapy 3: 351\u2013357","journal-title":"Biotherapy"},{"key":"BFbjc2012496_CR18","doi-asserted-by":"publisher","first-page":"19747","DOI":"10.1074\/jbc.M311627200","volume":"279","author":"T Isaji","year":"2004","unstructured":"Isaji T, Gu J, Nishiuchi R, Zhao Y, Takahashi M, Miyoshi E, Honke K, Sekiguchi K, Taniguchi N (2004) Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration. J Biol Chem 279: 19747\u201319754","journal-title":"J Biol Chem"},{"key":"BFbjc2012496_CR19","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/268633a0","volume":"268","author":"T Kajii","year":"1977","unstructured":"Kajii T, Ohama K (1977) Androgenetic origin of hydatidiform mole. Nature 268: 633\u2013634","journal-title":"Nature"},{"key":"BFbjc2012496_CR20","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1038\/sj.bjc.6601422","volume":"89","author":"F Khan","year":"2003","unstructured":"Khan F, Everard J, Ahmed S, Coleman RE, Aitken M, Hancock BW (2003) Low-risk persistent gestational trophoblastic disease treated with low-dose methotrexate: efficacy, acute and long-term effects. Br J Cancer 89: 2197\u20132201","journal-title":"Br J Cancer"},{"key":"BFbjc2012496_CR21","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/S0925-4439(99)00060-5","volume":"1455","author":"A Kobata","year":"1999","unstructured":"Kobata A, Takeuchi M (1999) Structure, pathology and function of the N-linked sugar chains of human chorionic gonadotropin. Biochim Biophys Acta 1455: 315\u2013326","journal-title":"Biochim Biophys Acta"},{"key":"BFbjc2012496_CR22","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.ajog.2010.06.073","volume":"203","author":"JR Lurain","year":"2010","unstructured":"Lurain JR (2010) Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol 203: 531\u2013539","journal-title":"Am J Obstet Gynecol"},{"key":"BFbjc2012496_CR23","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1159\/000229021","volume":"68","author":"Y Mano","year":"2009","unstructured":"Mano Y, Shibata K, Sumigama S, Hayakawa H, Ino K, Yamamoto E, Kajiyama H, Nawa A, Kikkawa F (2009) Tocilizumab inhibits interleukin-6-mediated matrix metalloproteinase-2 and -9 secretions from human amnion cells in preterm premature rupture of membranes. Gynecol Obstet Invest 68: 145\u2013153","journal-title":"Gynecol Obstet Invest"},{"key":"BFbjc2012496_CR24","doi-asserted-by":"crossref","first-page":"14126","DOI":"10.1016\/S0021-9258(17)43832-4","volume":"258","author":"T Mizuochi","year":"1983","unstructured":"Mizuochi T, Nishimura R, Derappe C, Taniguchi T, Hamamoto T, Mochizuki M, Kobata A (1983) Structures of the asparagine-linked sugar chains of human chorionic gonadotropin produced in choriocarcinoma. Appearance of triantennary sugar chains and unique biantennary sugar chains. J Biol Chem 258: 14126\u201314129","journal-title":"J Biol Chem"},{"key":"BFbjc2012496_CR25","doi-asserted-by":"publisher","first-page":"S182","DOI":"10.1016\/j.placenta.2011.01.009","volume":"32","author":"W Norris","year":"2011","unstructured":"Norris W, Nevers T, Sharma S, Kalkunte S (2011) Review: hCG, preeclampsia and regulatory T cells. Placenta 32: S182\u2013S185","journal-title":"Placenta"},{"key":"BFbjc2012496_CR26","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/j.cell.2005.09.041","volume":"123","author":"K Ohtsubo","year":"2005","unstructured":"Ohtsubo K, Takamatsu S, Minowa MT, Yoshida A, Takeuchi M, Marth JD (2005) Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes. Cell 123: 1307\u20131321","journal-title":"Cell"},{"key":"BFbjc2012496_CR27","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0076-6879(89)79138-2","volume":"1989","author":"H Schachter","year":"1989","unstructured":"Schachter H, Brockhausen I, Hull E (1989) High-performance liquid chromatography assays for N-acetylglucosaminyltransferases involved in N- and O-glycan synthesis. Methods Enzymol 1989: 351\u2013397","journal-title":"Methods Enzymol"},{"key":"BFbjc2012496_CR28","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/S0140-6736(09)60618-8","volume":"374","author":"P Schmid","year":"2009","unstructured":"Schmid P, Nagai Y, Agarwal R, Hancock B, Savage PM, Sebire NJ, Lindsay I, Wells M, Fisher RA, Short D, Newlands ES, Wischnewsky MB, Seckl MJ (2009) Prognostic markers and long-term outcome of placental-site trophoblastic tumours: a retrospective observational study. Lancet 374: 48\u201355","journal-title":"Lancet"},{"key":"BFbjc2012496_CR29","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1097\/00000478-199811000-00010","volume":"22","author":"IM Shih","year":"1998","unstructured":"Shih IM, Kurman RJ (1998) Epithelioid trophoblastic tumor: a neoplasm distinct from choriocarcinoma and placental site trophoblastic tumor simulating carcinoma. Am J Surg Pathol 22: 1393\u20131403","journal-title":"Am J Surg Pathol"},{"key":"BFbjc2012496_CR30","first-page":"197","volume":"57","author":"M Singh","year":"2012","unstructured":"Singh M, Kindelberger D, Nagymanyoki Z, Ng SW, Quick CM, Yamamoto H, Fichorova R, Fulop V, Berkowitz RS (2012) Vascular endothelial growth factors and their receptors and regulators in gestational trophoblastic diseases and normal placenta. J Reprod Med 57: 197\u2013203","journal-title":"J Reprod Med"},{"key":"BFbjc2012496_CR31","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1097\/01.AOG.0000224697.31138.a1","volume":"108","author":"JT Soper","year":"2006","unstructured":"Soper JT (2006) Gestational trophoblastic disease. Obstet Gynecol 108: 176\u2013187","journal-title":"Obstet Gynecol"},{"key":"BFbjc2012496_CR32","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1023\/B:GLYC.0000038293.37376.9f","volume":"20","author":"S Takamatsu","year":"2004","unstructured":"Takamatsu S, Katsumata T, Inoue N, Watanabe T, Fujibayashi Y, Takeuchi M (2004) Abnormal biantennary sugar chains are expressed in human chorionic gonadotropin produced in the choriocarcinoma cell line, JEG-3. Glycoconj J 20: 473\u2013481","journal-title":"Glycoconj J"},{"key":"BFbjc2012496_CR33","first-page":"3949","volume":"59","author":"S Takamatsu","year":"1999","unstructured":"Takamatsu S, Oguri S, Minowa MT, Yoshida A, Nakamura K, Takeuchi M, Kobata A (1999) Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain. Cancer Res 59: 3949\u20133953","journal-title":"Cancer Res"},{"key":"BFbjc2012496_CR34","unstructured":"World Health Organization (1983) Gestational Trophoblastic Diseases: Report of a WHO Scientific Group pp. 7\u201342. World Health Organization: Geneva"},{"key":"BFbjc2012496_CR35","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1210\/en.2008-1005","volume":"150","author":"E Yamamoto","year":"2009","unstructured":"Yamamoto E, Ino K, Miyoshi E, Inamori K, Abe A, Sumigama S, Iwase A, Kajiyama H, Shibata K, Nawa A, Kikkawa F (2009) N-acetylglucosaminyltransferase V regulates extravillous trophoblast invasion through glycosylation of alpha5beta1 integrin. Endocrinology 150: 990\u2013999","journal-title":"Endocrinology"},{"key":"BFbjc2012496_CR36","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1038\/sj.bjc.6604044","volume":"97","author":"E Yamamoto","year":"2007","unstructured":"Yamamoto E, Ino K, Miyoshi E, Shibata K, Takahashi N, Kajiyama H, Nawa A, Nomura S, Nagasaka T, Kikkawa F (2007) Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis. Br J Cancer 97: 1538\u20131544","journal-title":"Br J Cancer"},{"key":"BFbjc2012496_CR37","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1093\/molehr\/gah239","volume":"11","author":"E Yamamoto","year":"2005","unstructured":"Yamamoto E, Ito T, Abe A, Sido F, Ino K, Itakura A, Mizutani S, Dovat S, Nomura S, Kikkawa F (2005) Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion. Mol Hum Reprod 11: 825\u2013831","journal-title":"Mol Hum Reprod"},{"key":"BFbjc2012496_CR38","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1093\/oxfordjournals.jbchem.a122736","volume":"105","author":"K Yamashita","year":"1989","unstructured":"Yamashita K, Totani K, Iwaki Y, Takamisawa I, Tateishi N, Higashi T, Sakamoto Y, Kobata A (1989) Comparative study of the sugar chains of gamma-glutamyltranspeptidases purified from human hepatocellular carcinoma and from human liver. J Biochem 105: 728\u2013735","journal-title":"J Biochem"},{"key":"BFbjc2012496_CR39","first-page":"3451","volume":"47","author":"K Yamashita","year":"1987","unstructured":"Yamashita K, Totani K, Kuroki M, Matsuoka Y, Ueda I, Kobata A (1987) Structural studies of the carbohydrate moieties of carcinoembryonic antigens. Cancer Res 47: 3451\u20133459","journal-title":"Cancer Res"},{"key":"BFbjc2012496_CR40","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/glycob\/9.3.303","volume":"9","author":"A Yoshida","year":"1999","unstructured":"Yoshida A, Minowa MT, Takamatsu S, Hara T, Oguri S, Ikenaga H, Takeuchi M (1999) Tissue specific expression and chromosomal mapping of a human UDP-N-acetylglucosamine: alpha1,3-d-mannoside beta1, 4-N-acetylglucosaminyltransferase. Glycobiology 9: 303\u2013310","journal-title":"Glycobiology"},{"key":"BFbjc2012496_CR41","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1111\/j.1349-7006.2008.00839.x","volume":"99","author":"YY Zhao","year":"2008","unstructured":"Zhao YY, Takahashi M, Gu JG, Miyoshi E, Matsumoto A, Kitazume S, Taniguchi N (2008) Functional roles of N-glycans in cell signaling and cell adhesion in cancer. Cancer Sci 99: 1304\u20131310","journal-title":"Cancer Sci"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bjc2012496.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2012496","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2012496.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T09:11:41Z","timestamp":1684401101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bjc2012496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,20]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["BFbjc2012496"],"URL":"https:\/\/doi.org\/10.1038\/bjc.2012.496","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,20]]}}}