{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T08:58:56Z","timestamp":1772787536651,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1038\/bjc.2012.570","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T21:11:16Z","timestamp":1358284276000},"page":"402-408","source":"Crossref","is-referenced-by-count":14,"title":["Lacking hypoxia-mediated downregulation of E-cadherin in cancers of the uterine cervix"],"prefix":"10.1038","volume":"108","author":[{"given":"A","family":"Mayer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"H\u00f6ckel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Schlischewsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Schmidberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L-C","family":"Horn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Vaupel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,1,15]]},"reference":[{"key":"BFbjc2012570_CR1","first-page":"413","volume":"50","author":"E Ancuta","year":"2009","unstructured":"Ancuta E, Ancuta C, Cozma LG, Iordache C, Anghelache-Lupascu I, Anton E, Carasevici E, Chirieac R (2009) Tumor biomarkers in cervical cancer: focus on Ki-67 proliferation factor and E-cadherin expression. Rom J Morphol Embryol 50: 413\u2013418","journal-title":"Rom J Morphol Embryol"},{"key":"BFbjc2012570_CR2","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1046\/j.0022-3042.2001.00756.x","volume":"80","author":"RJ Boado","year":"2002","unstructured":"Boado RJ, Pardridge WM (2002) Glucose deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis-acting regulatory element. J Neurochem 80: 552\u2013554","journal-title":"J Neurochem"},{"key":"BFbjc2012570_CR3","first-page":"941","volume":"56","author":"DM Brizel","year":"1996","unstructured":"Brizel DM, Scully SP, Harrelson JM, Layfield LJ, Bean JM, Prosnitz LR, Dewhirst MW (1996) Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56: 941\u2013943","journal-title":"Cancer Res"},{"key":"BFbjc2012570_CR4","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1093\/carcin\/bgn145","volume":"29","author":"JH Caberg","year":"2008","unstructured":"Caberg JH, Hubert PM, Begon DY, Herfs MF, Roncarati PJ, Boniver JJ, Delvenne PO (2008) Silencing of E7 oncogene restores functional E-cadherin expression in human papillomavirus 16-transformed keratinocytes. Carcinogenesis 29: 1441\u20131447","journal-title":"Carcinogenesis"},{"key":"BFbjc2012570_CR5","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1046\/j.1365-2559.2003.01629.x","volume":"42","author":"CG Colpaert","year":"2003","unstructured":"Colpaert CG, Vermeulen PB, van Beest P, Soubry A, Goovaerts G, Dirix LY, Harris AL, van Marck EA (2003) Cutaneous breast cancer deposits show distinct growth patterns with different degrees of angiogenesis, hypoxia and fibrin deposition. Histopathology 42: 530\u2013540","journal-title":"Histopathology"},{"key":"BFbjc2012570_CR6","first-page":"625","volume":"4","author":"DR Coman","year":"1944","unstructured":"Coman DR (1944) Decreased mutual adhesiveness, a property of cells from squamous cell carcinomas. Cancer Res 4: 625\u2013629","journal-title":"Cancer Res"},{"key":"BFbjc2012570_CR7","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0002-9440(10)65146-2","volume":"155","author":"CJ de Boer","year":"1999","unstructured":"de Boer CJ, van Dorst E, van Krieken H, Jansen-van Rhijn CM, Warnaar SO, Fleuren GJ, Litvinov SV (1999) Changing roles of cadherins and catenins during progression of squamous intraepithelial lesions in the uterine cervix. Am J Pathol 155: 505\u2013515","journal-title":"Am J Pathol"},{"key":"BFbjc2012570_CR8","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1667\/RR1926.1","volume":"172","author":"MW Dewhirst","year":"2009","unstructured":"Dewhirst MW (2009) Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. Radiat Res 172: 653\u2013665","journal-title":"Radiat Res"},{"key":"BFbjc2012570_CR9","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/j.1525-1438.2007.00876.x","volume":"17","author":"P Dursun","year":"2007","unstructured":"Dursun P, Yuce K, Usubutun A, Ayhan A (2007) Loss of epithelium cadherin expression is associated with reduced overall survival and disease-free survival in early-stage squamous cell cervical carcinoma. Int J Gynecol Cancer 17: 843\u2013850","journal-title":"Int J Gynecol Cancer"},{"key":"BFbjc2012570_CR10","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/nature04695","volume":"440","author":"JT Erler","year":"2006","unstructured":"Erler JT, Bennewith KL, Nicolau M, Dornh\u00f6fer N, Kong C, Le QT, Chi JT, Jeffrey SS, Giaccia AJ (2006) Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440: 1222\u20131226","journal-title":"Nature"},{"key":"BFbjc2012570_CR11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1159\/000081729","volume":"71","author":"C Faleiro-Rodrigues","year":"2004","unstructured":"Faleiro-Rodrigues C, Lopes C (2004) E-cadherin, CD44 and CD44v6 in squamous intraepithelial lesions and invasive carcinomas of the uterine cervix: an immunohistochemical study. Pathobiology 71: 329\u2013336","journal-title":"Pathobiology"},{"key":"BFbjc2012570_CR12","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/cdd.2008.10","volume":"15","author":"GH Fong","year":"2008","unstructured":"Fong GH, Takeda K (2008) Role and regulation of prolyl hydroxylase domain proteins. Cell Death Differ 15: 635\u2013641","journal-title":"Cell Death Differ"},{"key":"BFbjc2012570_CR13","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/nrc1075","volume":"3","author":"P Friedl","year":"2003","unstructured":"Friedl P, Wolf K (2003) Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3: 362\u2013374","journal-title":"Nat Rev Cancer"},{"key":"BFbjc2012570_CR14","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1038\/ncb1658","volume":"9","author":"C Gaggioli","year":"2007","unstructured":"Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E (2007) Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol 9: 1392\u20131400","journal-title":"Nat Cell Biol"},{"key":"BFbjc2012570_CR15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0167-8140(93)90025-4","volume":"26","author":"M H\u00f6ckel","year":"1993","unstructured":"H\u00f6ckel M, Knoop C, Schlenger K, Vorndran B, Baussmann E, Mitze M, Knapstein PG, Vaupel P (1993) Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol 26: 45\u201350","journal-title":"Radiother Oncol"},{"key":"BFbjc2012570_CR16","first-page":"4509","volume":"56","author":"M H\u00f6ckel","year":"1996","unstructured":"H\u00f6ckel M, Schlenger K, Aral B, Mitze M, Sch\u00e4ffer U, Vaupel P (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56: 4509\u20134515","journal-title":"Cancer Res"},{"key":"BFbjc2012570_CR17","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/(SICI)1097-0215(19980821)79:4<365::AID-IJC10>3.0.CO;2-4","volume":"79","author":"M H\u00f6ckel","year":"1998","unstructured":"H\u00f6ckel M, Schlenger K, H\u00f6ckel S, Aral B, Sch\u00e4ffer U, Vaupel P (1998) Tumor hypoxia in pelvic recurrences of cervical cancer. Int J Cancer 79: 365\u2013369","journal-title":"Int J Cancer"},{"key":"BFbjc2012570_CR18","first-page":"6098","volume":"51","author":"M H\u00f6ckel","year":"1991","unstructured":"H\u00f6ckel M, Schlenger K, Knoop C, Vaupel P (1991) Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements. Cancer Res 51: 6098\u20136102","journal-title":"Cancer Res"},{"key":"BFbjc2012570_CR19","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1038\/labinvest.3700680","volume":"87","author":"VV Iakovlev","year":"2007","unstructured":"Iakovlev VV, Pintilie M, Morrison A, Fyles AW, Hill RP, Hedley DW (2007) Effect of distributional heterogeneity on the analysis of tumor hypoxia based on carbonic anhydrase IX. Lab Invest 87: 1206\u20131217","journal-title":"Lab Invest"},{"key":"BFbjc2012570_CR20","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/S0002-9440(10)63501-8","volume":"163","author":"T Imai","year":"2003","unstructured":"Imai T, Horiuchi A, Wang C, Oka K, Ohira S, Nikaido T, Konishi I (2003) Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am J Pathol 163: 1437\u20131447","journal-title":"Am J Pathol"},{"key":"BFbjc2012570_CR21","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1006\/gyno.1996.4578","volume":"64","author":"MD Jeffers","year":"1997","unstructured":"Jeffers MD, Paxton J, Bolger B, Richmond JA, Kennedy JH, McNicol AM (1997) E-cadherin and integrin cell adhesion molecule expression in invasive and in situ carcinoma of the cervix. Gynecol Oncol 64: 481\u2013486","journal-title":"Gynecol Oncol"},{"key":"BFbjc2012570_CR22","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/S0360-3016(99)00342-9","volume":"46","author":"WT Jenkins","year":"2000","unstructured":"Jenkins WT, Evans SM, Koch CJ (2000) Hypoxia and necrosis in rat 9\u2009L glioma and Morris 7777 hepatoma tumors: comparative measurements using EF5 binding and the Eppendorf needle electrode. Int J Radiat Oncol Biol Phys 46: 1005\u20131017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFbjc2012570_CR23","first-page":"4469","volume":"62","author":"S Kaluz","year":"2002","unstructured":"Kaluz S, Kaluzova M, Chrastina A, Olive PL, Pastorekova S, Pastorek J, Lerman MI, Stanbridge EJ (2002) Lowered oxygen tension induces expression of the hypoxia marker MN\/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1\u03b1 stabilization: a role for phosphatidylinositol 3'-kinase. Cancer Res 62: 4469\u20134477","journal-title":"Cancer Res"},{"key":"BFbjc2012570_CR24","doi-asserted-by":"publisher","first-page":"4694","DOI":"10.1158\/1078-0432.CCR-04-2530","volume":"11","author":"SJ Kwon","year":"2005","unstructured":"Kwon SJ, Lee YJ (2005) Effect of low glutamine\/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1\u03b1 in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells. Clin Cancer Res 11: 4694\u20134670","journal-title":"Clin Cancer Res"},{"key":"BFbjc2012570_CR25","doi-asserted-by":"publisher","first-page":"4743","DOI":"10.1158\/1078-0432.CCR-08-0234","volume":"14","author":"MY Lee","year":"2008","unstructured":"Lee MY, Chou CY, Tang MJ, Shen MR (2008) Epithelial-mesenchymal transition in cervical cancer: correlation with tumor progression, epidermal growth factor receptor overexpression, and snail up-regulation. Clin Cancer Res 14: 4743\u20134750","journal-title":"Clin Cancer Res"},{"key":"BFbjc2012570_CR26","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0167-8140(97)01920-8","volume":"44","author":"H Lyng","year":"1997","unstructured":"Lyng H, Sundfor K, Rofstad EK (1997) Oxygen tension in human tumours measured with polarographic needle electrodes and its relationship to vascular density, necrosis and hypoxia. Radiother Oncol 44: 163\u2013169","journal-title":"Radiother Oncol"},{"key":"BFbjc2012570_CR27","first-page":"145","volume":"38","author":"A Mayer","year":"2011","unstructured":"Mayer A, H\u00f6ckel M, Horn LC, Schmidberger H, Vaupel P (2011) GLUT-1 staining of squamous cell carcinomas of the uterine cervix identifies a novel element of invasion. Int J Oncol 38: 145\u2013150","journal-title":"Int J Oncol"},{"key":"BFbjc2012570_CR28","doi-asserted-by":"publisher","first-page":"7220","DOI":"10.1158\/1078-0432.CCR-05-0869","volume":"11","author":"A Mayer","year":"2005","unstructured":"Mayer A, H\u00f6ckel M, Vaupel P (2005a) Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix. Clin Cancer Res 11: 7220\u20137225","journal-title":"Clin Cancer Res"},{"key":"BFbjc2012570_CR29","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00066-006-1525-9","volume":"182","author":"A Mayer","year":"2006","unstructured":"Mayer A, H\u00f6ckel M, Vaupel P (2006) Endogenous hypoxia markers in locally advanced cancers of the uterine cervix: reality or wishful thinking? Strahlenther Onkol 182: 501\u2013510","journal-title":"Strahlenther Onkol"},{"key":"BFbjc2012570_CR30","doi-asserted-by":"publisher","first-page":"4719","DOI":"10.1158\/0008-5472.CAN-07-6339","volume":"68","author":"A Mayer","year":"2008","unstructured":"Mayer A, H\u00f6ckel M, Wree A, Leo C, Horn LC, Vaupel P (2008) Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia. Cancer Res 68: 4719\u20134726","journal-title":"Cancer Res"},{"key":"BFbjc2012570_CR31","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1158\/1078-0432.CCR-04-2344","volume":"11","author":"A Mayer","year":"2005","unstructured":"Mayer A, H\u00f6ckel M, Wree A, Vaupel P (2005b) Microregional expression of glucose transporter-1 and oxygenation status: lack of correlation in locally advanced cervical cancers. Clin Cancer Res 11: 2768\u20132773","journal-title":"Clin Cancer Res"},{"key":"BFbjc2012570_CR32","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/ncb1144","volume":"6","author":"K Mekhail","year":"2004","unstructured":"Mekhail K, Gunaratnam L, Bonicalzi ME, Lee S (2004) HIF activation by pH-dependent nucleolar sequestration of VHL. Nat Cell Biol 6: 642\u2013647","journal-title":"Nat Cell Biol"},{"key":"BFbjc2012570_CR33","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1476-4598-2-24","volume":"2","author":"G Narayan","year":"2003","unstructured":"Narayan G, Arias-Pulido H, Koul S, Vargas H, Zhang FF, Villella J, Schneider A, Terry MB, Mansukhani M, Murty VV (2003) Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome. Mol Cancer 2: 24","journal-title":"Mol Cancer"},{"key":"BFbjc2012570_CR34","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.radonc.2005.06.038","volume":"77","author":"M Nordsmark","year":"2005","unstructured":"Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, Becker A, Adam M, Molls M, Dunst J, Terris DJ, Overgaard J (2005) Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 77: 18\u201324","journal-title":"Radiother Oncol"},{"key":"BFbjc2012570_CR35","doi-asserted-by":"publisher","first-page":"21797","DOI":"10.1074\/jbc.C000023200","volume":"275","author":"RC Osthus","year":"2000","unstructured":"Osthus RC, Shim H, Kim S, Li Q, Reddy R, Mukherjee M, Xu Y, Wonsey D, Lee LA, Dang CV (2000) Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem 275: 21797\u201321800","journal-title":"J Biol Chem"},{"key":"BFbjc2012570_CR36","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/S0092-8674(03)00108-9","volume":"112","author":"M Perez-Moreno","year":"2003","unstructured":"Perez-Moreno M, Jamora C, Fuchs E (2003) Sticky business: orchestrating cellular signals at adherens junctions. Cell 112: 535\u2013548","journal-title":"Cell"},{"key":"BFbjc2012570_CR37","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.ygyno.2004.12.062","volume":"97","author":"MA Rodriguez-Sastre","year":"2005","unstructured":"Rodriguez-Sastre MA, Gonzalez-Maya L, Delgado R, Lizano M, Tsubaki G, Mohar A, Garcia-Carranca A (2005) Abnormal distribution of E-cadherin and \u00df-catenin in different histologic types of cancer of the uterine cervix. Gynecol Oncol 97: 330\u2013336","journal-title":"Gynecol Oncol"},{"key":"BFbjc2012570_CR38","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.tips.2012.01.005","volume":"33","author":"GL Semenza","year":"2012","unstructured":"Semenza GL (2012) Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci 33: 207\u2013214","journal-title":"Trends Pharmacol Sci"},{"key":"BFbjc2012570_CR39","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.ygyno.2004.05.046","volume":"94","author":"G van de Putte","year":"2004","unstructured":"van de Putte G, Kristensen GB, Baekelandt M, Lie AK, Holm R (2004) E-cadherin and catenins in early squamous cervical carcinoma. Gynecol Oncol 94: 521\u2013527","journal-title":"Gynecol Oncol"},{"key":"BFbjc2012570_CR40","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s10555-007-9055-1","volume":"26","author":"P Vaupel","year":"2007","unstructured":"Vaupel P, Mayer A (2007) Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 26: 225\u2013239","journal-title":"Cancer Metastasis Rev"},{"key":"BFbjc2012570_CR41","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0076-6879(04)81023-1","volume":"381","author":"P Vaupel","year":"2004","unstructured":"Vaupel P, Mayer A, H\u00f6ckel M (2004) Tumor hypoxia and malignant progression. Methods Enzymol 381: 335\u2013354","journal-title":"Methods Enzymol"},{"key":"BFbjc2012570_CR42","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1002\/path.1711760208","volume":"176","author":"CJ Vessey","year":"1995","unstructured":"Vessey CJ, Wilding J, Folarin N, Hirano S, Takeichi M, Soutter P, Stamp GW, Pignatelli M (1995) Altered expression and function of E-cadherin in cervical intraepithelial neoplasia and invasive squamous cell carcinoma. J Pathol 176: 151\u2013159","journal-title":"J Pathol"},{"key":"BFbjc2012570_CR43","doi-asserted-by":"publisher","first-page":"5510","DOI":"10.1073\/pnas.92.12.5510","volume":"92","author":"GL Wang","year":"1995","unstructured":"Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92: 5510\u20135514","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFbjc2012570_CR44","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1096\/fj.01-0944rev","volume":"16","author":"RH Wenger","year":"2002","unstructured":"Wenger RH (2002) Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J 16: 1151\u20131162","journal-title":"FASEB J"},{"key":"BFbjc2012570_CR45","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ccr.2006.03.010","volume":"9","author":"A Wicki","year":"2006","unstructured":"Wicki A, Lehembre F, Wick N, Hantusch B, Kerjaschki D, Christofori G (2006) Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell 9: 261\u2013272","journal-title":"Cancer Cell"},{"key":"BFbjc2012570_CR46","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/ncb1691","volume":"10","author":"MH Yang","year":"2008","unstructured":"Yang MH, Wu MZ, Chiou SH, Chen PM, Chang SY, Liu CJ, Teng SC, Wu KJ (2008) Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 10: 295\u2013305","journal-title":"Nat Cell Biol"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bjc2012570.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2012570","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2012570.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:12:31Z","timestamp":1684415551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bjc2012570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,15]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["BFbjc2012570"],"URL":"https:\/\/doi.org\/10.1038\/bjc.2012.570","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,15]]}}}