{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:51:14Z","timestamp":1765885874595},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1038\/bjc.2013.202","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T20:02:05Z","timestamp":1368561725000},"page":"2241-2249","source":"Crossref","is-referenced-by-count":12,"title":["Individually tailored screening of breast cancer with genes, tumour phenotypes, clinical attributes, and conventional risk factors"],"prefix":"10.1038","volume":"108","author":[{"given":"Y-Y","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M-F","family":"Yen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C-P","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-H","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,5,14]]},"reference":[{"key":"BFbjc2013202_CR1","doi-asserted-by":"publisher","first-page":"397","DOI":"10.7326\/0003-4819-144-6-200603210-00006","volume":"144","author":"K Anderson","year":"2006","unstructured":"Anderson K, Jacobson JS, Heitjan DF, Zivin JG, Hershman D, Neugut AI, Grann VR (2006) Cost-effectiveness of preventive strategies for women with a BRCA1 or a BRCA2 mutation. Ann Intern Med 144: 397\u2013406","journal-title":"Ann Intern Med"},{"key":"BFbjc2013202_CR2","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1001\/jama.299.18.2151","volume":"299","author":"WA Berg","year":"2008","unstructured":"Berg WA, Blume JD, Cormack JB, Mendelson EB, Lehrer D, Bohm-Velez M, Pisano ED, Jong RA, Evans WP, Morton MJ, Mahoney MC, Larsen LH, Barr RG, Farria DM, Marques HS, Boparai K (2008) Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer. JAMA 299: 2151\u20132163","journal-title":"JAMA"},{"key":"BFbjc2013202_CR3","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1056\/NEJMoa062790","volume":"356","author":"NF Boyd","year":"2007","unstructured":"Boyd NF, Guo H, Martin LJ, Sun L, Stone J, Fishell E, Jong RA, Hislop G, Chiarelli A, Minkin S, Yaffe MJ (2007) Mammographic density and the risk and detection of breast cancer. N Engl J Med 356: 227\u2013236","journal-title":"N Engl J Med"},{"key":"BFbjc2013202_CR4","first-page":"271","volume-title":"Statistical Inference","author":"G Casella","year":"2001","unstructured":"Casella G, Berger RL (2001) Statistical Inference 2nd edn, pp 271\u2013300. Duxbury Press: California"},{"key":"BFbjc2013202_CR5","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1002\/cncr.20171","volume":"100","author":"TH Chen","year":"2004","unstructured":"Chen TH, Chiu YH, Luh DL, Yen MF, Wu HM, Chen LS, Tung TH, Huang CC, Chan CC, Shiu MN, Yeh YP, Liou HH, Liao CS, Lai HC, Chiang CP, Peng HL, Tseng CD, Yen MS, Hsu WC, Chen CH (2004) Community-based multiple screening model: design, implementation, and analysis of 42,387 participants. Cancer 100: 1734\u20131743","journal-title":"Cancer"},{"key":"BFbjc2013202_CR6","first-page":"9","volume":"2","author":"THH Chen","year":"1997","unstructured":"Chen THH, Duffy SW, Day NE (1997a) Markov chain models for progression of breast cancer. Part I: tumor attributes and the preclinical screen-detectable phase. J Epidemiol Biostat 2: 9\u201323","journal-title":"J Epidemiol Biostat"},{"key":"BFbjc2013202_CR7","first-page":"25","volume":"2","author":"THH Chen","year":"1997","unstructured":"Chen THH, Duffy SW, Tabar L, Day NE (1997b) Markov chain models for progression of breast cancer. Part II: prediction of outcomes for different screening regimes. J Epidemiol Biostat 2: 25\u201335","journal-title":"J Epidemiol Biostat"},{"key":"BFbjc2013202_CR8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1111\/j.0006-341X.2000.00167.x","volume":"56","author":"THH Chen","year":"2000","unstructured":"Chen THH, Kuo HS, Yen MF, Lai MS, Tabar L, Duffy SW (2000) Estimation of sojourn time in chronic disease screening without data on interval cases. Biometrics 56: 167\u2013172","journal-title":"Biometrics"},{"key":"BFbjc2013202_CR9","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1200\/JCO.2006.09.1066","volume":"25","author":"SN Chen","year":"2007","unstructured":"Chen SN, Parmigiani G (2007) Meta-analysis of BRCA1 and BRCA2 penetrance. J Clin Oncol 25: 1329\u20131333","journal-title":"J Clin Oncol"},{"key":"BFbjc2013202_CR10","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/ng1981","volume":"39","author":"A Cox","year":"2007","unstructured":"Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MW, Pooley KA, Scollen S, Baynes C, Ponder BA, Chanock S, Lissowska J, Brinton L, Peplonska B, Southey MC, Hopper JL, McCredie MR, Giles GG, Fletcher O, Johnson N, dos Santos Silva I, Gibson L, Bojesen SE, Nordestgaard BG, Axelsson CK, Torres D, Hamann U, Justenhoven C, Brauch H, Chang-Claude J, Kropp S, Risch A, Wang-Gohrke S, Schurmann P, Bogdanova N, Dork T, Fagerholm R, Aaltonen K, Blomqvist C, Nevanlinna H, Seal S, Renwick A, Stratton MR, Rahman N, Sangrajrang S, Hughes D, Odefrey F, Brennan P, Spurdle AB, Chenevix-Trench G, Beesley J, Mannermaa A, Hartikainen J, Kataja V, Kosma VM, Couch FJ, Olson JE, Goode EL, Broeks A, Schmidt MK, Hogervorst FB, Van't Veer LJ, Kang D, Yoo KY, Noh DY, Ahn SH, Wedren S, Hall P, Low YL, Liu J, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Sigurdson AJ, Stredrick DL, Alexander BH, Struewing JP, Pharoah PD, Easton DF (2007) A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet 39: 352\u2013358","journal-title":"Nat Genet"},{"key":"BFbjc2013202_CR11","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/jnci\/djp018","volume":"101","author":"SR Cummings","year":"2009","unstructured":"Cummings SR, Tice JA, Bauer S, Browner WS, Cuzick J, Ziv E, Vogel V, Shepherd J, Vachon C, Smith-Bindman R, Kerlikowske K (2009) Prevention of breast cancer in postmenopausal women: approaches to estimating and reducing risk. J Natl Cancer Inst 101: 384\u2013398","journal-title":"J Natl Cancer Inst"},{"key":"BFbjc2013202_CR12","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1126\/science.1125948","volume":"312","author":"WS Dalton","year":"2006","unstructured":"Dalton WS, Friend SH (2006) Cancer biomarkers--an invitation to the table. Science 312: 1165\u20131168","journal-title":"Science"},{"key":"BFbjc2013202_CR13","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.2214\/AJR.06.0619","volume":"188","author":"MG del Carmen","year":"2007","unstructured":"del Carmen MG, Halpern EF, Kopans DB, Moy B, Moore RH, Goss PE, Hughes KS (2007) Mammographic breast density and race. Am J Roentgenol 188: 1147\u20131150","journal-title":"Am J Roentgenol"},{"key":"BFbjc2013202_CR14","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1158\/1055-9965.EPI-08-0201","volume":"17","author":"W Dong","year":"2008","unstructured":"Dong W, Berry DA, Bevers TB, Kau SW, Hsu L, Theriault RL, Shen Y (2008) Prognostic role of detection method and its relationship with tumor biomarkers in breast cancer: the university of Texas M.D. Anderson Cancer Center experience. Cancer Epidemiol Biomarkers Prev 17: 1096\u20131103","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFbjc2013202_CR15","doi-asserted-by":"publisher","first-page":"8019","DOI":"10.1158\/1078-0432.CCR-08-0974","volume":"14","author":"M Dowsett","year":"2008","unstructured":"Dowsett M, Dunbier AK (2008) Emerging biomarkers and new understanding of traditional markers in personalized therapy for breast cancer. Clin Cancer Res 14: 8019\u20138026","journal-title":"Clin Cancer Res"},{"key":"BFbjc2013202_CR16","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1002\/sim.4780141404","volume":"14","author":"SW Duffy","year":"1995","unstructured":"Duffy SW, Chen HH, Tabar L, Day NE (1995) Estimation of mean sojourn time in breast cancer screening using a Markov chain model of both entry to and exit from the preclinical detectable phase. Stat Med 14: 1531\u20131543","journal-title":"Stat Med"},{"key":"BFbjc2013202_CR17","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S0140-6736(09)61082-5","volume":"375","author":"VJ Dzau","year":"2010","unstructured":"Dzau VJ, Ackerly DC, Sutton-Wallace P, Merson MH, Williams RS, Krishnan KR, Taber RC, Califf RM (2010) The role of academic health science systems in the transformation of medicine. Lancet 375: 949\u2013953","journal-title":"Lancet"},{"key":"BFbjc2013202_CR18","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1038\/nature05887","volume":"447","author":"DF Easton","year":"2007","unstructured":"Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG, Struewing JP, Morrison J, Field H, Luben R, Wareham N, Ahmed S, Healey CS, Bowman R, Meyer KB, Haiman CA, Kolonel LK, Henderson BE, Le Marchand L, Brennan P, Sangrajrang S, Gaborieau V, Odefrey F, Shen CY, Wu PE, Wang HC, Eccles D, Evans DG, Peto J, Fletcher O, Johnson N, Seal S, Stratton MR, Rahman N, Chenevix-Trench G, Bojesen SE, Nordestgaard BG, Axelsson CK, Garcia-Closas M, Brinton L, Chanock S, Lissowska J, Peplonska B, Nevanlinna H, Fagerholm R, Eerola H, Kang D, Yoo KY, Noh DY, Ahn SH, Hunter DJ, Hankinson SE, Cox DG, Hall P, Wedren S, Liu J, Low YL, Bogdanova N, Schurmann P, Dork T, Tollenaar RA, Jacobi CE, Devilee P, Klijn JG, Sigurdson AJ, Doody MM, Alexander BH, Zhang J, Cox A, Brock IW, MacPherson G, Reed MW, Couch FJ, Goode EL, Olson JE, Meijers-Heijboer H, van den Ouweland A, Uitterlinden A, Rivadeneira F, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Hopper JL, McCredie M, Southey M, Giles GG, Schroen C, Justenhoven C, Brauch H, Hamann U, Ko YD, Spurdle AB, Beesley J, Chen X, Mannermaa A, Kosma VM, Kataja V, Hartikainen J, Day NE, Cox DR, Ponder BA (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447: 1087\u20131093","journal-title":"Nature"},{"key":"BFbjc2013202_CR19","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1001\/jama.2009.1498","volume":"302","author":"L Esserman","year":"2009","unstructured":"Esserman L, Shieh Y, Thompson I (2009) Rethinking screening for breast cancer and prostate cancer. JAMA 302: 1685\u20131692","journal-title":"JAMA"},{"key":"BFbjc2013202_CR20","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1002\/sim.1277","volume":"21","author":"HJ Hsieh","year":"2002","unstructured":"Hsieh HJ, Chen THH, Chang SH (2002) Assessing chronic disease progression using non-homogeneous exponential regression Markov models: an illustration using a selective breast cancer screening in Taiwan. Stat Med 21: 3369\u20133382","journal-title":"Stat Med"},{"key":"BFbjc2013202_CR21","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1524-4733.2008.00418.x","volume":"12","author":"ML Holland","year":"2009","unstructured":"Holland ML, Huston A, Noyes K (2009) Cost-effectiveness of testing for breast cancer susceptibility genes. Value Health 12: 207\u2013216","journal-title":"Value Health"},{"key":"BFbjc2013202_CR22","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/ng2075","volume":"39","author":"DJ Hunter","year":"2007","unstructured":"Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, Chatterjee N, Orr N, Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF Jr., Hoover RN, Thomas G, Chanock SJ (2007) A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 39: 870\u2013874","journal-title":"Nat Genet"},{"key":"BFbjc2013202_CR23","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1200\/JCO.2009.23.0839","volume":"28","author":"C Kuhl","year":"2010","unstructured":"Kuhl C, Weigel S, Schrading S, Arand B, Bieling H, Konig R, Tombach B, Leutner C, Rieber-Brambs A, Nordhoff D, Heindel W, Reiser M, Schild HH (2010) Prospective multicenter cohort study to refine management recommendations for women at elevated familial risk of breast cancer: the EVA trial. J Clin Oncol 28: 1450\u20131457","journal-title":"J Clin Oncol"},{"key":"BFbjc2013202_CR24","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1056\/NEJMoa031759","volume":"351","author":"M Kriege","year":"2004","unstructured":"Kriege M, Brekelmans CT, Boetes C, Besnard PE, Zonderland HM, Obdeijn IM, Manoliu RA, Kok T, Peterse H, Tilanus-Linthorst MM, Muller SH, Meijer S, Oosterwijk JC, Beex LV, Tollenaar RA, de Koning HJ, Rutgers EJ, Klijn JG (2004) Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med 351: 427\u2013437","journal-title":"N Engl J Med"},{"key":"BFbjc2013202_CR25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/(SICI)1097-0215(19980925)78:1<21::AID-IJC5>3.0.CO;2-Z","volume":"78","author":"MS Lai","year":"1998","unstructured":"Lai MS, Yen MF, Kuo HS, Koong SL, Chen TH, Duffy SW (1998) Efficacy of breast-cancer screening for female relatives of breast-cancer-index cases: Taiwan multicentre cancer screening (TAMCAS). Int J Cancer 78: 21\u201326","journal-title":"Int J Cancer"},{"key":"BFbjc2013202_CR26","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/bcr1831","volume":"10","author":"LJ Martin","year":"2008","unstructured":"Martin LJ, Boyd NF (2008) Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence. Breast Cancer Res 10: 201","journal-title":"Breast Cancer Res"},{"key":"BFbjc2013202_CR27","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1093\/oxfordjournals.aje.a112046","volume":"100","author":"S Shapiro","year":"1974","unstructured":"Shapiro S, Goldberg JD, Hutchison GB (1974) Lead time in breast cancer detection and implications for periodicity of screening. Am J Epidemiol 100: 357\u2013366","journal-title":"Am J Epidemiol"},{"key":"BFbjc2013202_CR28","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/ng2064","volume":"39","author":"SN Stacey","year":"2007","unstructured":"Stacey SN, Manolescu A, Sulem P, Rafnar T, Gudmundsson J, Gudjonsson SA, Masson G, Jakobsdottir M, Thorlacius S, Helgason A, Aben KK, Strobbe LJ, Albers-Akkers MT, Swinkels DW, Henderson BE, Kolonel LN, Le Marchand L, Millastre E, Andres R, Godino J, Garcia-Prats MD, Polo E, Tres A, Mouy M, Saemundsdottir J, Backman VM, Gudmundsson L, Kristjansson K, Bergthorsson JT, Kostic J, Frigge ML, Geller F, Gudbjartsson D, Sigurdsson H, Jonsdottir T, Hrafnkelsson J, Johannsson J, Sveinsson T, Myrdal G, Grimsson HN, Jonsson T, von Holst S, Werelius B, Margolin S, Lindblom A, Mayordomo JI, Haiman CA, Kiemeney LA, Johannsson OT, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K (2007) Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 39: 865\u2013869","journal-title":"Nat Genet"},{"key":"BFbjc2013202_CR29","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/35021093","volume":"406","author":"CM Perou","year":"2000","unstructured":"Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D (2000) Molecular portraits of human breast tumours. Nature 406: 747\u2013752","journal-title":"Nature"},{"key":"BFbjc2013202_CR30","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1093\/jnci\/91.11.943","volume":"91","author":"J Peto","year":"1999","unstructured":"Peto J, Collins N, Barfoot R, Seal S, Warren W, Rahman N, Easton DF, Evans C, Deacon J, Stratton MR (1999) Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst 91: 943\u2013949","journal-title":"J Natl Cancer Inst"},{"key":"BFbjc2013202_CR31","doi-asserted-by":"publisher","first-page":"2796","DOI":"10.1056\/NEJMsa0708739","volume":"358","author":"PD Pharoah","year":"2008","unstructured":"Pharoah PD, Antoniou AC, Easton DF, Ponder BA (2008) Polygenes, risk prediction, and targeted prevention of breast cancer. N Engl J Med 358: 2796\u20132803","journal-title":"N Engl J Med"},{"key":"BFbjc2013202_CR32","doi-asserted-by":"publisher","first-page":"460","DOI":"10.2307\/1426139","volume":"8","author":"P Prorok","year":"1976","unstructured":"Prorok P (1976) The theory of periodic screening II: doubly bounded recurrence times and mean lead time and detection probability estimation. Adv Appl Probab 8: 460\u2013476","journal-title":"Adv Appl Probab"},{"key":"BFbjc2013202_CR33","unstructured":"Taiwan Cancer Registry Annual Report (2009) Taiwan: Department of Health, Executive Yuan. \n                    http:\/\/crs.cph.ntu.edu.tw"},{"key":"BFbjc2013202_CR34","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1093\/oxfordjournals.aje.a113705","volume":"118","author":"SD Walter","year":"1983","unstructured":"Walter SD, Day NE (1983) Estimation of the duration of a pre-clinical disease state using screening data. Am J Epidemiol 118: 865\u2013886","journal-title":"Am J Epidemiol"},{"key":"BFbjc2013202_CR35","first-page":"211","volume":"299","author":"SH Woolf","year":"2008","unstructured":"Woolf SH (2008) The meaning of translational research and why it matters. JAMA 299: 211\u2013213","journal-title":"JAMA"},{"key":"BFbjc2013202_CR36","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1111\/j.1541-0420.2007.00979.x","volume":"64","author":"GH Wu","year":"2008","unstructured":"Wu GH, Chang SH, Hsiu-Hsi Chen T (2008) A bayesian random-effects markov model for tumor progression in women with a family history of breast cancer. Biometrics 64: 1231\u20131237","journal-title":"Biometrics"},{"key":"BFbjc2013202_CR37","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/ijc.2910460211","volume":"46","author":"GJ van Oortmarssen","year":"1990","unstructured":"van Oortmarssen GJ, Habbema JD, Lubbe JT, van der Maas PJ (1990) A model-based analysis of the HIP project for breast cancer screening. Int J Cancer 46: 207\u2013213","journal-title":"Int J Cancer"},{"key":"BFbjc2013202_CR38","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/1471-2407-7-153","volume":"7","author":"GA Viani","year":"2007","unstructured":"Viani GA, Afonso SL, Stefano EJ, De Fendi LI, Soares FV (2007) Adjuvant trastuzumab in the treatment of her-2-positive early breast cancer: a meta-analysis of published randomized trials. BMC Cancer 7: 153","journal-title":"BMC Cancer"},{"key":"BFbjc2013202_CR39","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1056\/NEJMsb053723","volume":"353","author":"EA Zerhouni","year":"2005","unstructured":"Zerhouni EA (2005) Translational and clinical science--time for a new vision. N Engl J Med 353: 1621\u20131623","journal-title":"N Engl J Med"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bjc2013202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2013202","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2013202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:14:21Z","timestamp":1684415661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bjc2013202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,14]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["BFbjc2013202"],"URL":"https:\/\/doi.org\/10.1038\/bjc.2013.202","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,14]]}}}