{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:51:11Z","timestamp":1790387471703,"version":"4.1.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1038\/bjc.2014.379","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T22:45:45Z","timestamp":1407451545000},"page":"903-908","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Functional identity of receptors for proteolysis-inducing factor on human and murine skeletal muscle"],"prefix":"10.1038","volume":"111","author":[{"given":"K A","family":"Mirza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Tisdale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"BFbjc2014379_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/S0014-5793(02)03053-3","volume":"524","author":"A Berna","year":"2002","unstructured":"Berna A, Bernier F, Scott K, Stuhlm\u00fcller B (2002) Ring up the curtain on DING proteins. FEBS Lett 524: 6\u201310.","journal-title":"FEBS Lett"},{"key":"BFbjc2014379_CR2","doi-asserted-by":"publisher","first-page":"7087","DOI":"10.1074\/jbc.M610378200","volume":"282","author":"HL Eley","year":"2007","unstructured":"Eley HL, Tisdale MJ (2007) Skeletal muscle atrophy, a link between depression of protein synthesis and increase in degradation. J Biol Chem 282: 7087\u20137097.","journal-title":"J Biol Chem"},{"key":"BFbjc2014379_CR3","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cellsig.2010.01.002","volume":"22","author":"HL Eley","year":"2010","unstructured":"Eley HL, Russell ST, Tisdale MJ (2010) Mechanism of activation of dsRNA-dependent protein kinase (PKR) in muscle atrophy. Cell Sig 22: 783\u2013790.","journal-title":"Cell Sig"},{"key":"BFbjc2014379_CR4","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1079\/PNS19920036","volume":"51","author":"KC Fearon","year":"1992","unstructured":"Fearon KC (1992) The mechanisms and treatment of weight loss in cancer. Proc Nutr Soc 51: 251\u2013265.","journal-title":"Proc Nutr Soc"},{"key":"BFbjc2014379_CR5","doi-asserted-by":"publisher","first-page":"227S","DOI":"10.1093\/jn\/129.1.227S","volume":"129","author":"SH Lecker","year":"1999","unstructured":"Lecker SH, Solomon V, Mitch WE, Goldberg AL (1999) Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. J Nutr 129: 227S\u2013237S.","journal-title":"J Nutr"},{"key":"BFbjc2014379_CR6","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/bjc.1997.504","volume":"76","author":"MJ Lorite","year":"1997","unstructured":"Lorite MJ, Cariuk P, Tisdale MJ (1997) Induction of muscle protein degradation by a tumour factor. Br J Cancer 76: 1035\u20131040.","journal-title":"Br J Cancer"},{"key":"BFbjc2014379_CR7","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1038\/sj.bjc.6603148","volume":"94","author":"AG Lowrie","year":"2006","unstructured":"Lowrie AG, Wigmore SJ, Wright DJ, Waddell ID, Ross JA (2006) Dermcidin expression in hepatic cells improves survival without N-glycosylation, but requires asparagine residues. Br J Cancer 94: 1663\u20131671.","journal-title":"Br J Cancer"},{"key":"BFbjc2014379_CR8","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/bjc.2011.216","volume":"105","author":"KA Mirza","year":"2011","unstructured":"Mirza KA, Wyke SM, Tisdale MJ (2011) Attenuation of muscle atrophy by an N-terminal peptide to the receptor for proteolysis-inducing factor (PIF). Br J Cancer 105: 83\u201388.","journal-title":"Br J Cancer"},{"key":"BFbjc2014379_CR9","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1016\/j.cellsig.2012.07.016","volume":"24","author":"KA Mirza","year":"2012","unstructured":"Mirza KA, Tisdale MJ (2012) Role of Ca2+ in proteolysis-inducing factor (PIF)-induced atrophy of skeletal muscle. Cell Sig 24: 2118\u20132122.","journal-title":"Cell Sig"},{"key":"BFbjc2014379_CR10","unstructured":"Tisdale MJ, Todorov P, Wyke SM (2008) Antibodies to proteolysis inducing factor (PIF) receptor and methods of use thereof. PCT W02008\/071934."},{"key":"BFbjc2014379_CR11","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/379739a0","volume":"379","author":"PT Todorov","year":"1996","unstructured":"Todorov PT, Cariuk P, McDevitt T, Coles B, Fearon K, Tisdale M (1996) Characterisation of a cancer cachectic factor. Nature 379: 739\u2013742.","journal-title":"Nature"},{"key":"BFbjc2014379_CR12","doi-asserted-by":"publisher","first-page":"12279","DOI":"10.1074\/jbc.272.19.12279","volume":"272","author":"PT Todorov","year":"1997","unstructured":"Todorov PT, Deacon M, Tisdale MJ (1997) Structural analysis of a tumor-produced sulphated glycoprotein capable of initiating muscle protein degradation. J Biol Chem 272: 12279\u201312288.","journal-title":"J Biol Chem"},{"key":"BFbjc2014379_CR13","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1038\/sj.bjc.6690590","volume":"80","author":"PT Todorov","year":"1999","unstructured":"Todorov PT, Field WN, Tisdale MJ (1999) Role of a proteolysis-inducing factor (PIF) in cachexia induced by a human melanoma (G361). Br J Cancer 80: 1734\u20131737.","journal-title":"Br J Cancer"},{"key":"BFbjc2014379_CR14","doi-asserted-by":"publisher","first-page":"11419","DOI":"10.1158\/0008-5472.CAN-07-2602","volume":"67","author":"PT Todorov","year":"2007","unstructured":"Todorov PT, Wyke SM, Tisdale MJ (2007) Identification and characterization of a membrane receptor for proteolysis-inducing factor on skeletal muscle. Cancer Res 67: 11419\u201311427.","journal-title":"Cancer Res"},{"key":"BFbjc2014379_CR15","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3816\/CLC.2010.n.044","volume":"11","author":"Q Wang","year":"2010","unstructured":"Wang Q, Lu J-B, Wu B, Hao L-Y (2010) Expression and clinicopathologic significance of proteolysis-inducing factor in non-small-cell lung cancer: an immunohistochemical analysis. Clin Lung Cancer 11: 346\u2013351.","journal-title":"Clin Lung Cancer"},{"key":"BFbjc2014379_CR16","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1038\/sj.bjc.6601132","volume":"89","author":"AS Whitehouse","year":"2003","unstructured":"Whitehouse AS, Tisdale MJ (2003) Increased expression of the ubiquitin-proteasome pathway in murine myotubes by proteolysis-inducing factor (PIF) is associated with activation of the transcription factor NF-\u03baB. Br J Cancer 89: 1116\u20131122.","journal-title":"Br J Cancer"},{"key":"BFbjc2014379_CR17","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/bjc.1997.17","volume":"75","author":"SJ Wigmore","year":"1997","unstructured":"Wigmore SJ, Plester CE, Richardson RA, Fearon KC (1997) Changes in nutritional status associated with unresectable pancreatic cancer. Br J Cancer 75: 106\u2013109.","journal-title":"Br J Cancer"},{"key":"BFbjc2014379_CR18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1046\/j.1365-2168.2000.01317.x","volume":"87","author":"SJ Wigmore","year":"2000","unstructured":"Wigmore SJ, Todorov PT, Barber MD, Ross JA, Tisdale MJ, Fearon KC (2000) Characteristics of patients with pancreatic cancer expressing a novel cancer cachectic factor. Br J Surg 87: 53\u201358.","journal-title":"Br J Surg"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bjc2014379.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2014379","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2014379.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:24:43Z","timestamp":1684416283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bjc2014379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["BFbjc2014379"],"URL":"https:\/\/doi.org\/10.1038\/bjc.2014.379","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"1 April 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}