{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T08:19:23Z","timestamp":1791533963046,"version":"4.3.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T00:00:00Z","timestamp":1415059200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1038\/bjc.2014.557","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T23:47:33Z","timestamp":1414712853000},"page":"290-295","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplification"],"prefix":"10.1038","volume":"112","author":[{"given":"R","family":"Defferrari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Mazzocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I M","family":"Ambros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P F","family":"Ambros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bedwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Beiske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"B\u00e9nard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A P","family":"Berbegall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Bown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Combaret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Couturier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Erminio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Gambini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Garaventa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Haupt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Kohler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Jeison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Lunec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Martinsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Noguera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Parodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Schleiermacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Tweddle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Valent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Van Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Vicha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Villamon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G P","family":"Tonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,4]]},"reference":[{"issue":"4","key":"BFbjc2014557_CR1","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1158\/1078-0432.CCR-10-0830","volume":"17","author":"IM Ambros","year":"2011","unstructured":"Ambros IM, Brunner B, Aigner G, Bedwell C, Beiske K, B\u00e9nard J, Bown N, Combaret V, Couturier J, Defferrari R, Gross N, Jeison M, Lunec J, Marques B, Martinsson T, Mazzocco K, Noguera R, Schleiermacher G, Speleman F, Stallings R, Tonini GP, Tweddle DA, Valent A, Vicha A, Roy NV, Villamon E, Ziegler A, Preuner S, Drobics M, Ladenstein R, Amann G, Schuit RJ, P\u00f6tschger U, Ambros PF (2011) A multilocus technique for risk evaluation of patients with neuroblastoma. Clin Cancer Res 17 (4): 792\u2013804.","journal-title":"Clin Cancer Res"},{"issue":"6","key":"BFbjc2014557_CR2","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/mpo.1242","volume":"37","author":"PF Ambros","year":"2001","unstructured":"Ambros PF, Ambros IM SIOP Europe Neuroblastoma Pathology, Biology and Bone Marrow Group (2001) Pathology and biology guidelines for resectable and unresectable neuroblastic tumors and bone marrow examination guidelines. Med Pediatr Oncol 37 (6): 492\u2013504.","journal-title":"Med Pediatr Oncol"},{"issue":"9","key":"BFbjc2014557_CR3","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1038\/sj.bjc.6605014","volume":"100","author":"PF Ambros","year":"2009","unstructured":"Ambros PF, Ambros IM, Brodeur GM, Haber M, Khan J, Nakagawara A, Schleiermacher G, Speleman F, Spitz R, London WB, Cohn SL, Pearson AD, Maris JM (2009) International consensus for neuroblastoma molecular diagnostic: report from the International Neuroblastoma Risk Group (INRG) Biology Committee. Br J Cancer 100 (9): 1471\u20131482.","journal-title":"Br J Cancer"},{"issue":"12","key":"BFbjc2014557_CR4","first-page":"2098","volume":"31","author":"N Breslow","year":"1971","unstructured":"Breslow N, McCann B (1971) Statistical estimation of prognosis for children with neuroblastoma. Cancer Res 31 (12): 2098\u20132103.","journal-title":"Cancer Res"},{"issue":"4653","key":"BFbjc2014557_CR5","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1126\/science.6719137","volume":"224","author":"GM Brodeur","year":"1984","unstructured":"Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM (1984) Amplification of N-MYC in untreated human neuroblastomas correlates with advanced disease stage. Science 224 (4653): 1121\u20131124.","journal-title":"Science"},{"issue":"9","key":"BFbjc2014557_CR6","doi-asserted-by":"publisher","first-page":"4323","DOI":"10.1073\/pnas.0910684107","volume":"107","author":"H Car\u00e9n","year":"2010","unstructured":"Car\u00e9n H, Kryh H, Nethander M, Sj\u00f6berg RM, Tr\u00e4ger C, Nilsson S, Abrahamsson J, Kogner P, Martinsson T (2010) High-risk neuroblastoma tumours with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset. Proc Natl Acad Sci USA 107 (9): 4323\u20134328.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"BFbjc2014557_CR7","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/ijc.27432","volume":"131","author":"S Coco","year":"2012","unstructured":"Coco S, Theissen J, Scaruffi P, Stigliani S, Moretti S, Oberthuer A, Valdora F, Fischer M, Gallo F, Hero B, Bonassi S, Berthold F, Tonini GP (2012) Age-dependent accumulation of genomic aberrations and deregulation of cell cycle and telomerase genes in metastatic neuroblastoma. Int J Cancer 131 (7): 1591\u20131600.","journal-title":"Int J Cancer"},{"issue":"3","key":"BFbjc2014557_CR8","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.cancergen.2011.03.001","volume":"204","author":"RJ Deyell","year":"2011","unstructured":"Deyell RJ, Attiyeh EF (2011) Advances in the understanding of constitutional and somatic genomic alterations in neuroblastoma. Cancer Genet 204 (3): 113\u2013121.","journal-title":"Cancer Genet"},{"issue":"6","key":"BFbjc2014557_CR9","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/onc.2009.390","volume":"29","author":"M Fisher","year":"2010","unstructured":"Fisher M, Bauer T, Oberthur A, Hero B, Theissen J, Ehrich M, Spitz R, Eils R, Westermann F, Brors B, K\u00f6nig R, Berthold F (2010) Integrated genomic profiling identifies two distinct molecular subtypes with divergent outcome in neuroblastoma with loss of chromosome 11. Oncogene 29 (6): 865\u2013875.","journal-title":"Oncogene"},{"issue":"7","key":"BFbjc2014557_CR10","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1200\/JCO.2008.16.0630","volume":"27","author":"I Janoueix-Lerosey","year":"2009","unstructured":"Janoueix-Lerosey I, Schleiermacher G, Michels E, Mosseri V, Ribeiro A, Lequin D, Vermeulen J, Couturier J, Peuchmaur M, Valent A, Plantaz D, Rubie H, Valteau-Couanet D, Thomas C, Combaret V, Rousseau R, Eggert A, Michon J, Speleman F, Delattre O (2009) Overall genomic pattern is a predictor of outcome in neuroblastoma. J Clin Oncol 27 (7): 1026\u20131033.","journal-title":"J Clin Oncol"},{"issue":"11","key":"BFbjc2014557_CR11","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1038\/onc.2009.518","volume":"29","author":"I Janoueix-Lerosey","year":"2010","unstructured":"Janoueix-Lerosey I, Schleiermacher G, Delattre O (2010) Molecular pathogenesis of peripheral neuroblastic tumours. Oncogene 29 (11): 1566\u20131579.","journal-title":"Oncogene"},{"key":"BFbjc2014557_CR12","volume-title":"The Statistical Analysis of Failure Time Data","author":"JD Kalbfleisch","year":"1980","unstructured":"Kalbfleisch JD, Prentice RL (1980) The Statistical Analysis of Failure Time Data. John Wiley & Sons: New York."},{"issue":"17","key":"BFbjc2014557_CR13","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.1016\/j.ejca.2013.07.002","volume":"49","author":"JA Kohler","year":"2013","unstructured":"Kohler JA, Rubie H, Castel V, Beiske K, Holmes K, Gambini C, Casale F, Munzer C, Erminio G, Parodi S, Navarro S, Marquez C, Peuchmaur M, Cullinane C, Brock P, Valteau-Couanet D, Garaventa A, Haupt R (2013) Treatment of children over the age of one year with unresectable localised neuroblastoma without MYCN amplification: results of the SIOPEN study. Eur J Cancer 49 (17): 3671\u20133679.","journal-title":"Eur J Cancer"},{"issue":"27","key":"BFbjc2014557_CR14","doi-asserted-by":"publisher","first-page":"6459","DOI":"10.1200\/JCO.2005.05.571","volume":"23","author":"WB London","year":"2005","unstructured":"London WB, Castleberry RP, Matthay KK, Look AT, Seeger RC, Shimada H, Thorner P, Brodeur G, Maris JM, Reynolds CP, Cohn SL (2005a) Evidence for an age cut off greater than 365 days for neuroblastoma risk group stratification in the Children\u2019s Oncology Group. J Clin Oncol 23 (27): 6459\u20136465.","journal-title":"J Clin Oncol"},{"issue":"1-2","key":"BFbjc2014557_CR15","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.canlet.2004.12.054","volume":"228","author":"WB London","year":"2005","unstructured":"London WB, Boni L, Simon T, Berthold F, Twist C, Schmidt ML, Castleberry RP, Matthay KK, Cohn SL, De Bernardi B (2005b) The role of age in neuroblastoma risk stratification: the German, Italian and Children\u2019s Oncology Group perspectives. Cancer Lett 228 (1-2): 257\u2013266.","journal-title":"Cancer Lett"},{"issue":"12","key":"BFbjc2014557_CR16","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1002\/gcc.20496","volume":"46","author":"E Michels","year":"2007","unstructured":"Michels E, Vandesompele J, De Preter K, Hoebeeck J, Vermeulen J, Schramm A, Molenaar JJ, Menten B, Marques B, Stallings RL, Combaret V, Devalck C, De Paepe A, Versteeg R, Eggert A, Laureys G, Van Roy N, Speleman F (2007) ArrayCGH-based classification of neuroblastoma into genomic subgroups. Genes Chromosomes Cancer 46 (12): 1098\u20131108.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFbjc2014557_CR17","unstructured":"Mitelman F, Johansson B, Mertens F Mitelman Database of Chromosome Aberrations in Cancer. Available at \n                    http:\/\/cgap.nci.nih.gov\/Chromosome\/Mitelman\n                    \n                  ."},{"issue":"2","key":"BFbjc2014557_CR18","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0165-4608(91)90216-H","volume":"54","author":"R Sansone","year":"1991","unstructured":"Sansone R, Strigini P, Badiali M, Dominici C, Fontana V, Iolascon A, De Bernardi B, Tonini GP (1991) Age-dependent prognostic significance of N-myc amplification in neuroblastoma. The Italian experience. Cancer Genet Cytogenet 54 (2): 253\u2013257.","journal-title":"Cancer Genet Cytogenet"},{"issue":"19","key":"BFbjc2014557_CR19","doi-asserted-by":"publisher","first-page":"3122","DOI":"10.1200\/JCO.2009.26.7955","volume":"28","author":"G Schleiermacher","year":"2010","unstructured":"Schleiermacher G, Janoueix-Lerosey I, Ribeiro A, Klijanienko J, Couturier J, Pierron G, Mosseri V, Valent A, Auger N, Plantaz D, Rubie H, Valteau-Couanet D, Bourdeaut F, Combaret V, Bergeron C, Michon J, Delattre O (2010) Accumulation of segmental alterations determines progression in neuroblastoma. J Clin Oncol 28 (19): 3122\u20133130.","journal-title":"J Clin Oncol"},{"issue":"12","key":"BFbjc2014557_CR20","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1038\/bjc.2011.472","volume":"105","author":"G Schleiermacher","year":"2011","unstructured":"Schleiermacher G, Michon J, Ribeiro A, Pierron G, Mosseri V, Rubie H, Munzer C, B\u00e9nard J, Auger N, Combaret V, Janoueix-Lerosey I, Pearson A, Tweddle DA, Bown N, Gerrard M, Wheeler K, Noguera R, Villamon E, Ca\u00f1ete A, Castel V, Marques B, de Lacerda A, Tonini GP, Mazzocco K, Defferrari R, De Bernardi B, di Cataldo A, van Roy N, Brichard B, Ladenstein R, Ambros I, Ambros P, Beiske K, Delattre O, Couturier J (2011) Segmental chromosomal alterations lead to a high risk of relapse in infants with MYCN-non amplified localised unresectable\/disseminated neuroblastoma (a SIOPEN collaborative study). Br J Cancer 105 (12): 1940\u20131948.","journal-title":"Br J Cancer"},{"issue":"18","key":"BFbjc2014557_CR21","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1056\/NEJM198510313131802","volume":"313","author":"RC Seeger","year":"1985","unstructured":"Seeger RC, Brodeur GM, Sather H, Dalton A, Siegel SE, Wong KY, Hammond D (1985) Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 313 (18): 1111\u20131116.","journal-title":"N Engl J Med"},{"issue":"2","key":"BFbjc2014557_CR22","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/(SICI)1097-0142(19990715)86:2<349::AID-CNCR20>3.0.CO;2-Y","volume":"86","author":"H Shimada","year":"1999","unstructured":"Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B (1999) Terminology and morphologic criteria of neuroblastic tumours: recommendations by the International Neuroblastoma Pathology Committee. Cancer 86 (2): 349\u2013363.","journal-title":"Cancer"},{"issue":"7","key":"BFbjc2014557_CR23","doi-asserted-by":"publisher","first-page":"3673","DOI":"10.1158\/0008-5472.CAN-05-4154","volume":"66","author":"RL Stallings","year":"2006","unstructured":"Stallings RL, Nair P, Maris JM, Catchpoole D, McDermott M, O'Meara A, Breatnach F (2006) High-resolution analysis of chromosomal breakpoints and genomic instability identifies PTPRD as a candidate tumor suppressor gene in neuroblastoma. Cancer Res 66 (7): 3673\u20133680.","journal-title":"Cancer Res"},{"issue":"9","key":"BFbjc2014557_CR24","first-page":"823","volume":"14","author":"S Stigliani","year":"2012","unstructured":"Stigliani S, Coco S, Moretti S, Oberthuer A, Fischer M, Theissen J, Gallo F, Garaventa A, Berthold F, Bonassi S, Tonini GP, Scaruffi P (2012) High genomic instability predicts survival in metastatic high-risk neuroblastoma. Neoplasia 2012 14 (9): 823\u2013832.","journal-title":"Neoplasia 2012"},{"issue":"1","key":"BFbjc2014557_CR25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1200\/JCO.1997.15.1.85","volume":"15","author":"GP Tonini","year":"1997","unstructured":"Tonini GP, Boni L, Pession A, Rogers D, Iolascon A, Basso G, Cordero di Montezemolo L, Casale F, Pession A, Perri P, Mazzocco K, Scaruffi P, Lo Cunsolo C, Marchese N, Milanaccio C, Conte M, Bruzzi P, De Bernardi B (1997) MYCN oncogene amplification in neuroblastoma is associated with worse prognosis, except in stage 4s: the Italian experience with 295 children. J Clin Oncol 15 (1): 85\u201393.","journal-title":"J Clin Oncol"},{"issue":"2","key":"BFbjc2014557_CR26","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.canlet.2012.08.017","volume":"326","author":"GP Tonini","year":"2012","unstructured":"Tonini GP, Nakagawara A, Berthold F (2012) Towards a turning point of neuroblastoma therapy. Cancer Lett 326 (2): 128\u2013134.","journal-title":"Cancer Lett"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bjc2014557.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2014557","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2014557.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:26:23Z","timestamp":1684416383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bjc2014557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,4]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["BFbjc2014557"],"URL":"https:\/\/doi.org\/10.1038\/bjc.2014.557","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,4]]},"assertion":[{"value":"26 May 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}