{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:43:37Z","timestamp":1789771417875,"version":"4.0.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T00:00:00Z","timestamp":1431993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1038\/bjc.2015.172","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T20:04:23Z","timestamp":1432065863000},"page":"64-68","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Validation of histomolecular classification utilizing histological subtype, MUC1, and CDX2 for prognostication of resected ampullary adenocarcinoma"],"prefix":"10.1038","volume":"113","author":[{"given":"A","family":"Schueneman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Goggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ensor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Saka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Neishaboori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Maitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Varadhachary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Rezaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Wolfgang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Adsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Overman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,19]]},"reference":[{"key":"BFbjc2015172_CR1","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1002\/jso.21374","volume":"100","author":"J Albores-Saavedra","year":"2009","unstructured":"Albores-Saavedra J, Schwartz AM, Batich K, Henson DE (2009) Cancers of the ampulla of vater: demographics, morphology, and survival based on 5,625 cases from the SEER program. J Surg Oncol 100: 598\u2013605.","journal-title":"J Surg Oncol"},{"key":"BFbjc2015172_CR2","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1097\/PAS.0000000000000230","volume":"38","author":"DC Ang","year":"2014","unstructured":"Ang DC, Shia J, Tang LH, Katabi N, Klimstra DS (2014) The utility of immunohistochemistry in subtyping adenocarcinoma of the ampulla of vater. Am J Surg Pathol 38: 1371\u20131379.","journal-title":"Am J Surg Pathol"},{"key":"BFbjc2015172_CR3","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.ejso.2008.01.030","volume":"35","author":"PO Berberat","year":"2009","unstructured":"Berberat PO, Kunzli BM, Gulbinas A, Ramanauskas T, Kleeff J, Muller MW, Wagner M, Friess H, B\u00fcchler MW (2009) An audit of outcomes of a series of periampullary carcinomas. Eur J Surg Oncol 35: 187\u2013191.","journal-title":"Eur J Surg Oncol"},{"key":"BFbjc2015172_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0002-9610(00)00405-0","volume":"180","author":"M Bouvet","year":"2000","unstructured":"Bouvet M, Gamagami RA, Gilpin EA, Romeo O, Sasson A, Easter DW, Moossa AR (2000) Factors influencing survival after resection for periampullary neoplasms. Am J Surg 180: 13\u201317.","journal-title":"Am J Surg"},{"key":"BFbjc2015172_CR5","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1200\/JCO.2012.46.8868","volume":"31","author":"DK Chang","year":"2013","unstructured":"Chang DK, Jamieson NB, Johns AL, Scarlett CJ, Pajic M, Chou A, Pinese M, Humphris JL, Jones MD, Toon C, Nagrial AM, Chantrill LA, Chin VT, Pinho AV, Rooman I, Cowley MJ, Wu J, Mead RS, Colvin EK, Samra JS, Corbo V, Bassi C, Falconi M, Lawlor RT, Crippa S, Sperandio N, Bersani S, Dickson EJ, Mohamed MA, Oien KA, Foulis AK, Musgrove EA, Sutherland RL, Kench JG, Carter CR, Gill AJ, Scarpa A, McKay CJ, Biankin AV (2013) Histomolecular phenotypes and outcome in adenocarcinoma of the ampulla of vater. J Clin Oncol 31: 1348\u20131356.","journal-title":"J Clin Oncol"},{"key":"BFbjc2015172_CR6","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1440-1746.2006.04487.x","volume":"22","author":"YT Chang","year":"2007","unstructured":"Chang YT, Hsu C, Jeng YM, Chang MC, Wei SC, Wong JM (2007) Expression of the caudal-type homeodomain transcription factor CDX2 is related to clinical outcome in biliary tract carcinoma. J Gastroenterol Hepatol 22: 389\u2013394.","journal-title":"J Gastroenterol Hepatol"},{"key":"BFbjc2015172_CR7","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s11605-010-1156-4","volume":"14","author":"LB de Paiva Haddad","year":"2010","unstructured":"de Paiva Haddad LB, Patzina RA, Penteado S, Montagnini AL, da Cunha JE, Machado MC, Jukemura J (2010) Lymph node involvement and not the histophatologic subtype is correlated with outcome after resection of adenocarcinoma of the ampulla of vater. J Gastrointest Surg 14: 719\u2013728.","journal-title":"J Gastrointest Surg"},{"key":"BFbjc2015172_CR8","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1200\/JCO.2005.03.068","volume":"23","author":"DE Hansel","year":"2005","unstructured":"Hansel DE, Maitra A, Lin JW, Goggins M, Argani P, Yeo CJ, Piantadosi S, Leach SD, Biankin AV (2005) Expression of the caudal-type homeodomain transcription factors CDX 1\/2 and outcome in carcinomas of the ampulla of Vater. J Clin Oncol 23: 1811\u20131818.","journal-title":"J Clin Oncol"},{"key":"BFbjc2015172_CR9","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1245\/s10434-009-0883-9","volume":"17","author":"I Hatzaras","year":"2010","unstructured":"Hatzaras I, George N, Muscarella P, Melvin WS, Ellison EC, Bloomston M (2010) Predictors of survival in periampullary cancers following pancreaticoduodenectomy. Ann Surg Oncol 17: 991\u2013997.","journal-title":"Ann Surg Oncol"},{"key":"BFbjc2015172_CR10","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1038\/modpathol.2014.36","volume":"27","author":"SY Jun","year":"2014","unstructured":"Jun SY, Eom DW, Park H, Bae YK, Jang KT, Yu E, Hong SM (2014) Prognostic significance of CDX2 and mucin expression in small intestinal adenocarcinoma. Mod Pathol 27: 1364\u20131374.","journal-title":"Mod Pathol"},{"key":"BFbjc2015172_CR11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1349-7006.1994.tb02077.x","volume":"85","author":"W Kimura","year":"1994","unstructured":"Kimura W, Futakawa N, Yamagata S, Wada Y, Kuroda A, Muto T, Esaki Y (1994) Different clinicopathologic findings in two histologic types of carcinoma of papilla of Vater. Jpn J Cancer Res 85: 161\u2013166.","journal-title":"Jpn J Cancer Res"},{"key":"BFbjc2015172_CR12","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1111\/j.1349-7006.1996.tb00270.x","volume":"87","author":"H Kitamura","year":"1996","unstructured":"Kitamura H, Yonezawa S, Tanaka S, Kim YS, Sato E (1996) Expression of mucin carbohydrates and core proteins in carcinomas of the ampulla of Vater: their relationship to prognosis. Jpn J Cancer Res 87: 631\u2013640.","journal-title":"Jpn J Cancer Res"},{"key":"BFbjc2015172_CR13","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1177\/1066896911405654","volume":"19","author":"T Moriya","year":"2011","unstructured":"Moriya T, Kimura W, Hirai I, Takasu N, Mizutani M (2011) Expression of MUC1 and MUC2 in ampullary cancer. Int J Surg Pathol 19: 441\u2013447.","journal-title":"Int J Surg Pathol"},{"key":"BFbjc2015172_CR14","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1001\/jama.2012.7352","volume":"308","author":"JP Neoptolemos","year":"2012","unstructured":"Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Ol\u00e1h A, Rawcliffe CL, Verbeke CS, Campbell F, B\u00fcchler MW European Study Group for Pancreatic Cancer (2012) Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial. JAMA 308: 147\u2013156.","journal-title":"JAMA"},{"key":"BFbjc2015172_CR15","doi-asserted-by":"publisher","first-page":"1820","DOI":"10.1245\/s10434-008-9886-1","volume":"15","author":"JB O\u2019Connell","year":"2008","unstructured":"O\u2019Connell JB, Maggard MA, Manunga J Jr, Tomlinson JS, Reber HA, Ko CY, Hines OJ (2008) Survival after resection of ampullary carcinoma: a national population-based study. Ann Surg Oncol 15: 1820\u20131827.","journal-title":"Ann Surg Oncol"},{"key":"BFbjc2015172_CR16","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1097\/PAS.0b013e3181f8ff05","volume":"34","author":"N Ohike","year":"2010","unstructured":"Ohike N, Kim GE, Tajiri T, Krasinskas A, Basturk O, Coban I, Bandyopadhyay S, Morohoshi T, Goodman M, Kooby DA, Sarmiento JM, Adsay NV (2010) Intra-ampullary papillary-tubular neoplasm (IAPN): characterization of tumoral intraepithelial neoplasia occurring within the ampulla: a clinicopathologic analysis of 82 cases. Am J Surg Pathol 34: 1731\u20131748.","journal-title":"Am J Surg Pathol"},{"key":"BFbjc2015172_CR17","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1001\/jama.2012.13952","volume":"308","author":"M Overman","year":"2012","unstructured":"Overman M, Wang H, Varadhachary GR (2012) Adjuvant chemotherapy for resected periampullary adenocarcinoma. JAMA 308: 1855.","journal-title":"JAMA"},{"key":"BFbjc2015172_CR18","doi-asserted-by":"publisher","first-page":"e65144","DOI":"10.1371\/journal.pone.0065144","volume":"8","author":"MJ Overman","year":"2013","unstructured":"Overman MJ, Zhang J, Kopetz S, Davies M, Zhi-Qin J, Stemke-Hale K, R\u00fcmmele P, Pilarsky C, Gr\u00fctzmann R, Hamilton S, Hwang R, Abbruzzese JL, Varadhachary G, Broom B, Wang H (2013) Gene expression profiling of ampullary carcinomas classifies ampullary carcinomas into biliary-like and intestinal-like subtypes that are prognostic of outcome. PLoS One 8: e65144.","journal-title":"PLoS One"},{"key":"BFbjc2015172_CR19","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/35021093","volume":"406","author":"CM Perou","year":"2000","unstructured":"Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, L\u00f8nning PE, B\u00f8rresen-Dale AL, Brown PO, Botstein D (2000) Molecular portraits of human breast tumours. Nature 406: 747\u2013752.","journal-title":"Nature"},{"key":"BFbjc2015172_CR20","first-page":"1641","volume":"54","author":"YH Roh","year":"2007","unstructured":"Roh YH, Kim YH, Lee HW, Kim SJ, Roh MS, Jeong JS, Jung GJ (2007) The clinicopathologic and immunohistochemical characteristics of ampulla of Vater carcinoma: the intestinal type is associated with a better prognosis. Hepatogastroenterology 54: 1641\u20131644.","journal-title":"Hepatogastroenterology"},{"key":"BFbjc2015172_CR21","first-page":"769","volume":"21","author":"H Seno","year":"2002","unstructured":"Seno H, Oshima M, Taniguchi MA, Usami K, Ishikawa TO, Chiba T, Taketo MM (2002) CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: Prognostic implications. Int J Oncol 21: 769\u2013774.","journal-title":"Int J Oncol"},{"key":"BFbjc2015172_CR22","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s00428-007-0444-1","volume":"451","author":"F Sessa","year":"2007","unstructured":"Sessa F, Furlan D, Zampatti C, Carnevali I, Franzi F, Capella C (2007) Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability. Virchows Arch 451: 649\u2013657.","journal-title":"Virchows Arch"},{"key":"BFbjc2015172_CR23","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1053\/gast.2000.18142","volume":"119","author":"DG Silberg","year":"2000","unstructured":"Silberg DG, Swain GP, Suh ER, Traber PG (2000) Cdx1 and cdx2 expression during intestinal development. Gastroenterology 119: 961\u2013971.","journal-title":"Gastroenterology"},{"key":"BFbjc2015172_CR24","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1007\/s11605-008-0554-3","volume":"12","author":"RA Smith","year":"2008","unstructured":"Smith RA, Ghaneh P, Sutton R, Raraty M, Campbell F, Neoptolemos JP (2008) Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio. J Gastrointest Surg 12: 1422\u20131428.","journal-title":"J Gastrointest Surg"},{"key":"BFbjc2015172_CR25","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1056\/NEJMoa0908721","volume":"362","author":"J Valle","year":"2010","unstructured":"Valle J, Wasan H, Palmer DH, Cunningham D, Anthoney A, Maraveyas A, Madhusudan S, Iveson T, Hughes S, Pereira SP, Roughton M, Bridgewater J ABC-02 Trial Investigators (2010) Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. New Engl J Med 362: 1273\u20131281.","journal-title":"New Engl J Med"},{"key":"BFbjc2015172_CR26","doi-asserted-by":"publisher","first-page":"651","DOI":"10.4161\/cbt.3.7.919","volume":"3","author":"NT Van Heek","year":"2004","unstructured":"Van Heek NT, Maitra A, Koopmann J, Fedarko N, Jain A, Rahman A, Iacobuzio-Donahue CA, Adsay V, Ashfaq R, Yeo CJ, Cameron JL, Offerhaus JA, Hruban RH, Berg KD, Goggins M (2004) Gene expression profiling identifies markers of ampullary adenocarcinoma. Cancer Biol Ther 3: 651\u2013656.","journal-title":"Cancer Biol Ther"},{"key":"BFbjc2015172_CR27","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/1471-2407-8-170","volume":"8","author":"A Westgaard","year":"2008","unstructured":"Westgaard A, Tafjord S, Farstad IN, Cvancarova M, Eide TJ, Mathisen O, Clausen OP, Gladhaug IP (2008) Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. BMC Cancer 8: 170.","journal-title":"BMC Cancer"},{"key":"BFbjc2015172_CR28","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1097\/00000658-199806000-00005","volume":"227","author":"CJ Yeo","year":"1998","unstructured":"Yeo CJ, Sohn TA, Cameron JL, Hruban RH, Lillemoe KD, Pitt HA (1998) Periampullary adenocarcinoma: analysis of 5-year survivors. Ann Surg 227: 821\u2013831.","journal-title":"Ann Surg"},{"key":"BFbjc2015172_CR29","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/j.1440-1827.2011.02734.x","volume":"61","author":"S Yonezawa","year":"2011","unstructured":"Yonezawa S, Higashi M, Yamada N, Yokoyama S, Kitamoto S, Kitajima S, Goto M (2011) Mucins in human neoplasms: clinical pathology, gene expression and diagnostic application. Pathol Int 61: 697\u2013716.","journal-title":"Pathol Int"},{"key":"BFbjc2015172_CR30","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1097\/00000478-200407000-00005","volume":"28","author":"H Zhou","year":"2004","unstructured":"Zhou H, Schaefer N, Wolff M, Fischer HP (2004) Carcinoma of the ampulla of Vater: comparative histologic\/immunohistochemical classification and follow-up. Am J Surg Pathol 28: 875\u2013882.","journal-title":"Am J Surg Pathol"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bjc2015172.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2015172","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2015172.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:28:26Z","timestamp":1684416506000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bjc2015172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,19]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["BFbjc2015172"],"URL":"https:\/\/doi.org\/10.1038\/bjc.2015.172","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,19]]},"assertion":[{"value":"2 March 2015","order":1,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}