{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:45:44Z","timestamp":1780393544563,"version":"3.54.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T00:00:00Z","timestamp":1476921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1038\/bjc.2016.324","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T22:50:14Z","timestamp":1477003814000},"page":"1421-1429","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Risk factors cannot explain the higher prevalence rates of precancerous colorectal lesions in men"],"prefix":"10.1038","volume":"115","author":[{"given":"Elisabeth","family":"Waldmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Heinze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnulf","family":"Ferlitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"GessI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Sallinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Jeschek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Britto-Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Salzl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Fasching","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Jilma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kundi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Trauner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Ferlitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"issue":"3","key":"BFbjc2016324_CR1","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1097\/01.mcg.0000247988.96838.60","volume":"41","author":"JC Anderson","year":"2007","unstructured":"Anderson JC, Messina CR, Dakhllalah F, Abraham B, Alpern Z, Martin C, Hubbard PM, Grimson R, Shaw RD (2007) Body mass index: a marker for significant colorectal neoplasia in a screening population. J Clin Gastroenterol 41 (3): 285\u2013290.","journal-title":"J Clin Gastroenterol"},{"issue":"12","key":"BFbjc2016324_CR2","doi-asserted-by":"publisher","first-page":"3616","DOI":"10.1007\/s10620-011-1814-8","volume":"56","author":"JC Anderson","year":"2011","unstructured":"Anderson JC, Moezardalan K, Messina CR, Latreille M, Shaw RD (2011) Smoking and the association of advanced colorectal neoplasia in an asymptomatic average risk population: analysis of exposure and anatomical location in men and women. Dig Dis Sci 56 (12): 3616\u20133623.","journal-title":"Dig Dis Sci"},{"key":"BFbjc2016324_CR3","unstructured":"Babor TF, Higgins-Biddle JC, Saunders JB, Monteiro MG (2001) AUDIT. The Alcohol Use Disorders Identification Test. In Guidelines for Use in Primary Care, 2nd edn. World Health Organization: Geneva. Available at \n                    http:\/\/apps.who.int\/iris\/bitstream\/10665\/67205\/1\/WHO_MSD_MSB_01.6a.pdf\n                    \n                  ."},{"issue":"1","key":"BFbjc2016324_CR4","doi-asserted-by":"publisher","first-page":"450","DOI":"10.3390\/cancers7010450","volume":"7","author":"LF Baccaro","year":"2015","unstructured":"Baccaro LF, Conde DM, Costa-Paiva L, de Souza Santos Machado V, Pinto-Neto AM (2015) Cancer in women over 50 years of age: a focus on smoking. Cancers 7 (1): 450\u2013459.","journal-title":"Cancers"},{"issue":"12","key":"BFbjc2016324_CR5","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1038\/ajg.2012.347","volume":"107","author":"C Bannert","year":"2012","unstructured":"Bannert C, Reinhart K, Dunkler D, Trauner M, Renner F, Knoflach P, Ferlitsch A, Weiss W, Ferlitsch M (2012) Sedation in screening colonoscopy: impact on quality indicators and complications. Am J Gastroenterol 107 (12): 1837\u20131848.","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"BFbjc2016324_CR6","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1053\/j.gastro.2011.12.050","volume":"142","author":"Q Ben","year":"2012","unstructured":"Ben Q, An W, Jiang Y, Zhan X, Du Y, Cai QC, Gao J, Li Z (2012) Body mass index increases risk for colorectal adenomas based on meta-analysis. Gastroenterology 142 (4): 762\u2013772.","journal-title":"Gastroenterology"},{"issue":"8","key":"BFbjc2016324_CR7","doi-asserted-by":"publisher","first-page":"603","DOI":"10.7326\/0003-4819-140-8-200404200-00007","volume":"140","author":"E Cho","year":"2004","unstructured":"Cho E, Smith-Warner SA, Ritz J, van den Brandt PA, Colditz GA, Folsom AR, Freudenheim JL, Giovannucci E, Goldbohm RA, Graham S, Holmberg L, Kim DH, Malila N, Miller AB, Pietinen P, Rohan TE, Sellers TA, Speizer FE, Willett WC, Wolk A, Hunter DJ (2004) Alcohol intake and colorectal cancer: a pooled analysis of 8 cohort studies. Ann Intern Med 140 (8): 603\u2013613.","journal-title":"Ann Intern Med"},{"issue":"6","key":"BFbjc2016324_CR8","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1023\/A:1008984432272","volume":"11","author":"GA Colditz","year":"2000","unstructured":"Colditz GA, Atwood KA, Emmons K, Monson RR, Willett WC, Trichopoulos D, Hunter DJ (2000) Harvard report on cancer prevention volume 4: Harvard Cancer Risk Index. Risk Index Working Group, Harvard Center for Cancer Prevention. Cancer Causes Control 11 (6): 477\u2013488.","journal-title":"Cancer Causes Control"},{"issue":"12","key":"BFbjc2016324_CR9","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1001\/jama.2011.1362","volume":"306","author":"M Ferlitsch","year":"2011","unstructured":"Ferlitsch M, Reinhart K, Pramhas S, Wiener C, Gal O, Bannert C, Hassler M, Kozbial K, Dunkler D, Trauner M, Weiss W (2011) Sex-specific prevalence of adenomas, advanced adenomas, and colorectal cancer in individuals undergoing screening colonoscopy. JAMA 306 (12): 1352\u20131358.","journal-title":"JAMA"},{"issue":"5","key":"BFbjc2016324_CR10","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1200\/JCO.2008.17.4797","volume":"27","author":"AN Freedman","year":"2009","unstructured":"Freedman AN, Slattery ML, Ballard-Barbash R, Willis G, Cann BJ, Pee D, Gail MH, Pfeiffer RM (2009) Colorectal cancer risk prediction tool for white men and women without known susceptibility. J Clin Oncol 27 (5): 686\u2013693.","journal-title":"J Clin Oncol"},{"issue":"8","key":"BFbjc2016324_CR11","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1007\/s10552-009-9366-3","volume":"20","author":"S Hermann","year":"2009","unstructured":"Hermann S, Rohrmann S, Linseisen J (2009) Lifestyle factors, obesity and the risk of colorectal adenomas in EPIC-Heidelberg. Cancer Causes Control 20 (8): 1397\u20131408.","journal-title":"Cancer Causes Control"},{"issue":"10","key":"BFbjc2016324_CR12","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.cgh.2010.07.004","volume":"8","author":"M Hoffmeister","year":"2010","unstructured":"Hoffmeister M, Schmitz S, Karmrodt E, Stegmaier C, Haug U, Arndt V, Brenner H (2010) Male sex and smoking have a larger impact on the prevalence of colorectal neoplasia than family history of colorectal cancer. Clin Gastroenterol Hepatol 8 (10): 870\u2013876.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"BFbjc2016324_CR13","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/CEJ.0b013e328351c775","volume":"21","author":"S Hong","year":"2012","unstructured":"Hong S, Cai Q, Chen D, Zhu W, Huang W, Li Z (2012) Abdominal obesity and the risk of colorectal adenoma: a meta-analysis of observational studies. Eur J Cancer Prev 21 (6): 523\u2013531.","journal-title":"Eur J Cancer Prev"},{"issue":"3","key":"BFbjc2016324_CR14","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/j.1440-1746.2009.06117.x","volume":"25","author":"ST Hwang","year":"2010","unstructured":"Hwang ST, Cho YK, Park JH, Kim HJ, Park DI, Sohn CI, Jeon WK, Kim BI, Won KH, Jin W (2010) Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps. J Gastroenterol Hepatol 25 (3): 562\u2013567.","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"BFbjc2016324_CR15","first-page":"187","volume":"371","author":"TF Imeriale","year":"2014","unstructured":"Imeriale TF, Ranshoff DF, Itzkowitz SH (2014) Multitarget stool DNA testing for colorectal-cancer screening. N Engl J Med 371 (2): 187\u2013188.","journal-title":"N Engl J Med"},{"issue":"7","key":"BFbjc2016324_CR16","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1136\/gutjnl-2013-304965","volume":"63","author":"MF Kaminski","year":"2014","unstructured":"Kaminski MF, Polkowski M, Kraszewska E, Rupinski M, Butruk E, Regula J (2014) A score to estimate the likelihood of detecting advanced colorectal neoplasia at colonoscopy. Gut 63 (7): 1112\u20131119.","journal-title":"Gut"},{"issue":"3","key":"BFbjc2016324_CR17","first-page":"207","volume":"47","author":"K Kozbial","year":"2014","unstructured":"Kozbial K, Reinhart K, Heinze G, Zwatz C, Bannert C, Salzl P, Waldmann E, Britto-Arias M, Ferlitsch A, Trauner M, Weiss W, Ferlitsch M (2014) High quality of screening colonoscopy in Austria is not dependent on endoscopist specialty or setting. Endoscopy 47 (3): 207\u2013216.","journal-title":"Endoscopy"},{"issue":"22","key":"BFbjc2016324_CR18","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1093\/jnci\/dji375","volume":"97","author":"SC Larsson","year":"2005","unstructured":"Larsson SC, Orsini N, Wolk A (2005) Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J Natl Cancer Inst 97 (22): 1679\u20131687.","journal-title":"J Natl Cancer Inst"},{"issue":"3","key":"BFbjc2016324_CR19","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1093\/ajcn\/86.3.556","volume":"86","author":"SC Larsson","year":"2007","unstructured":"Larsson SC, Wolk A (2007) Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies. Am J Clin Nutr 86 (3): 556\u2013565.","journal-title":"Am J Clin Nutr"},{"issue":"22","key":"BFbjc2016324_CR20","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1001\/jama.290.22.2959","volume":"290","author":"DA Lieberman","year":"2003","unstructured":"Lieberman DA, Prindiville S, Weiss DG, Willett W VA Cooperative Study Group 380 (2003) Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals. JAMA 290 (22): 2959\u20132967.","journal-title":"JAMA"},{"issue":"7","key":"BFbjc2016324_CR21","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.1111\/j.1572-0241.2000.02172.x","volume":"95","author":"RM Ness","year":"2000","unstructured":"Ness RM, Holmes AM, Klein R, Dittus R (2000) Cost-utility of one-time colonoscopic screening for colorectal cancer at various ages. Am J Gastroenterol 95 (7): 1800\u20131811.","journal-title":"Am J Gastroenterol"},{"key":"BFbjc2016324_CR22","unstructured":"New Zealand Primary Care Handbook 2012 (updated 2013) Cardiovascular Disease Risk Assessment. Available at \n                    http:\/\/www.health.govt.nz\/system\/files\/documents\/publications\/cardiovascular-disease-risk-assessment-updated-2013-dec13.pdf\n                    \n                  ."},{"issue":"6","key":"BFbjc2016324_CR23","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.cgh.2009.01.008","volume":"7","author":"SP Nguyen","year":"2009","unstructured":"Nguyen SP, Bent S, Chen YH, Terdiman JP (2009) Gender as a risk factor for advanced neoplasia and colorectal cancer: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 7 (6): 676\u201381 e1\u20133.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"BFbjc2016324_CR24","unstructured":"NHLBI Obesity Education Initiative (2000) The Practical Guide. Identification, Evaluation and Treatment of Overweight and Obesity in Adults."},{"issue":"5","key":"BFbjc2016324_CR25","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1200\/JCO.2008.17.4813","volume":"27","author":"Y Park","year":"2009","unstructured":"Park Y, Freedman AN, Gail MH, Pee D, Hollenbeck A, Schatzkin A, Pfeiffer RM (2009) Validation of a colorectal cancer risk prediction model among white patients age 50 years and older. J Clin Oncol 27 (5): 694\u2013698.","journal-title":"J Clin Oncol"},{"issue":"1","key":"BFbjc2016324_CR26","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1053\/j.gastro.2014.03.006","volume":"147","author":"S Rampal","year":"2014","unstructured":"Rampal S, Yang MH, Sung J, Son HJ, Choi YH, Lee JH, Kim YH, Chang DK, Rhee PL, Rhee JC, Guallar E, Cho J (2014) Association between markers of glucose metabolism and risk of colorectal adenoma. Gastroenterology 147 (1): 78\u201387 e3.","journal-title":"Gastroenterology"},{"issue":"18","key":"BFbjc2016324_CR27","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1056\/NEJMoa054967","volume":"355","author":"J Regula","year":"2006","unstructured":"Regula J, Rupinski M, Kraszewska E, Polkowski M, Pachlewski J, Orlowska J, Nowacki MP, Butruk E (2006) Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia. N Engl J Med 355 (18): 1863\u20131872.","journal-title":"N Engl J Med"},{"issue":"5","key":"BFbjc2016324_CR28","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1055\/s-0032-1326348","volume":"45","author":"K Reinhart","year":"2013","unstructured":"Reinhart K, Bannert C, Dunkler D, Salzl P, Trauner M, Renner F, Knoflach P, Ferlitsch A, Weiss W, Ferlitsch M (2013) Prevalence of flat lesions in a large screening population and their role in colonoscopy quality improvement. Endoscopy 45 (5): 350\u2013356.","journal-title":"Endoscopy"},{"issue":"4","key":"BFbjc2016324_CR29","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1111\/j.1572-0241.2006.00673.x","volume":"101","author":"DK Rex","year":"2006","unstructured":"Rex DK, Petrini JL, Baron TH, Chak A, Cohen J, Deal SE, Hoffman B, Jacobson BC, Mergener K, Petersen BT, Safdi MA, Faigel DO, Pike IM ASGE\/ACG Taskforce on Quality in Endoscopy (2006) Quality indicators for colonoscopy. Am J Gastroenterol 101 (4): 873\u2013885.","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"BFbjc2016324_CR30","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/ajg.2014.385","volume":"110","author":"DK Rex","year":"2015","unstructured":"Rex DK, Schoenfeld PS, Cohen J, Pike IM, Adler DG, Fennerty MB, Lieb JG 2nd, Park WG, Rizk MK, Sawhney MS, Shaheen NJ, Wani S, Weinberg DS (2015) Quality indicators for colonoscopy. Am J Gastroenterol 110 (1): 72\u201390.","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"BFbjc2016324_CR31","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1055\/s-2008-1027726","volume":"46","author":"W Schmiegel","year":"2008","unstructured":"Schmiegel W, Reinacher-Schick A, Arnold D, Graeven U, Heinemann V, Porschen R, Riemann J, R\u00f6del C, Sauer R, Wieser M, Schmitt W, Schmoll HJ, Seufferlein T, Kopp I, Pox C (2008) [Update S3-guideline \"colorectal cancer\" 2008]. Z Gastroenterol 46 (8): 799\u2013840.","journal-title":"Z Gastroenterol"},{"key":"BFbjc2016324_CR32","unstructured":"Segnan N, Patnick J, von Karsa L (2010) European guidelines for quality assurance in colorectal cancer screening and diagnosis. Luxembourg: Publications Office of the European Union: European Commission."},{"issue":"1","key":"BFbjc2016324_CR33","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3322\/caac.21166","volume":"63","author":"R Siegel","year":"2013","unstructured":"Siegel R, Naishadham D, Jemal A (2013) Cancer statistics, 2013. CA Cancer J Clin 63 (1): 11\u201330.","journal-title":"CA Cancer J Clin"},{"issue":"10","key":"BFbjc2016324_CR34","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.1007\/s10620-009-1113-9","volume":"55","author":"B Stein","year":"2010","unstructured":"Stein B, Anderson JC, Rajapakse R, Alpern ZA, Messina CR, Walker G (2010) Body mass index as a predictor of colorectal neoplasia in ethnically diverse screening population. Dig Dis Sci 55 (10): 2945\u20132952.","journal-title":"Dig Dis Sci"},{"issue":"21","key":"BFbjc2016324_CR35","first-page":"5771","volume":"47","author":"DB Thomas","year":"1987","unstructured":"Thomas DB, Karagas MR (1987) Cancer in first and second generation Americans. Cancer Res 47 (21): 5771\u20135776.","journal-title":"Cancer Res"},{"issue":"2","key":"BFbjc2016324_CR36","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1007\/s00464-014-3688-2","volume":"29","author":"E Waldmann","year":"2015","unstructured":"Waldmann E, Britto-Arias M, Gessl I, Heinze G, Salzl P, Sallinger D, Trauner M, Weiss W, Ferlitsch A, Ferlitsch M (2015) Endoscopists with low adenoma detection rates benefit from high-definition endoscopy. Surg Endosc 29 (2): 466\u2013473.","journal-title":"Surg Endosc"},{"key":"BFbjc2016324_CR37","unstructured":"Waldmann E, Gessl I, Sallinger D, Jeschek P, Britto-Arias M, Heinze G, Fasching E, Weiss W, Gschwantler M, Trauner M, Ferlitsch M (2016) Trends in quality of screening colonoscopy in Austria. Endoscopy e-pub ahead of print 30 August 2016."}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bjc2016324.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2016324","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2016324.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:34:33Z","timestamp":1684416873000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bjc2016324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,20]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["BFbjc2016324"],"URL":"https:\/\/doi.org\/10.1038\/bjc.2016.324","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,20]]},"assertion":[{"value":"4 February 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 September 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Data on screening colonoscopy stem from the \u2018Quality certificate for CRC prevention\u2019 founded by the Austrian Society for Gastroenterology and Hepatology, the Federation of the Statutory Insurance Institutions and the Austrian Cancer Aid. This study was further supported by the Skoda Award of the Austrian Society of Internal Medicine (to MF).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}