{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:43:03Z","timestamp":1760550183728},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1038\/bjc.2016.424","type":"journal-article","created":{"date-parts":[[2017,1,10]],"date-time":"2017-01-10T21:03:45Z","timestamp":1484082225000},"page":"335-343","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Antitumour activity of trabectedin in myelodysplastic\/myeloproliferative neoplasms"],"prefix":"10.1038","volume":"116","author":[{"given":"Michela","family":"Romano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo Giovanni","family":"Della Porta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gall\u00ec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00f2","family":"Panini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta Andrea","family":"Licandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezia","family":"Bello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Craparotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Rosti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Bonetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Tancredi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Mannarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Marchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Porcu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos M","family":"Galmarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Zambelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Zecca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Cazzola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Biondi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Rambaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Allavena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Erba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"D'Incalci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,1,10]]},"reference":[{"key":"BFbjc2016424_CR1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1365-2249.2011.04515.x","volume":"167","author":"P Allavena","year":"2012","unstructured":"Allavena P, Mantovani A ( 2012 ) Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment . Clin Exp Immunol 167 : 195 \u2013 205 .","journal-title":"Clin Exp Immunol"},{"key":"BFbjc2016424_CR2","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1158\/0008-5472.CAN-04-4037","volume":"65","author":"P Allavena","year":"2005","unstructured":"Allavena P, Signorelli M, Chieppa M, Erba E, Bianchi G, Marchesi F, Olimpio CO, Bonardi C, Garbi A, Lissoni A, de Braud F, Jimeno J, D'Incalci M ( 2005 ) Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production . Cancer Res 65 : 2964 \u2013 2971 .","journal-title":"Cancer Res"},{"key":"BFbjc2016424_CR3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/349117a0","volume":"349","author":"HR Bourne","year":"1991","unstructured":"Bourne HR, Sanders DA, McCormick F ( 1991 ) The GTPase superfamily: conserved structure and molecular mechanism . Nature 349 : 117 \u2013 127 .","journal-title":"Nature"},{"key":"BFbjc2016424_CR4","doi-asserted-by":"publisher","first-page":"4114","DOI":"10.1158\/1078-0432.CCR-13-0360","volume":"19","author":"E Calura","year":"2013","unstructured":"Calura E, Fruscio R, Paracchini L, Bignotti E, Ravaggi A, Martini P, Sales G, Beltrame L, Clivio L, Ceppi L, Di Marino M, Fuso Nerini I, Zanotti L, Cavalieri D, Cattoretti G, Perego P, Milani R, Katsaros D, Tognon G, Sartori E, Pecorelli S, Mangioni C, D'Incalci M, Romualdi C, Marchini S ( 2013 ) MiRNA landscape in stage I epithelial ovarian cancer defines the histotype specificities . Clin Cancer Res 19 : 4114 \u2013 4123 .","journal-title":"Clin Cancer Res"},{"key":"BFbjc2016424_CR5","doi-asserted-by":"publisher","first-page":"4021","DOI":"10.1182\/blood-2013-09-381665","volume":"122","author":"M Cazzola","year":"2013","unstructured":"Cazzola M, Della Porta MG, Malcovati L ( 2013 ) The genetic basis of myelodysplasia and its clinical relevance . Blood 122 : 4021 \u2013 4034 .","journal-title":"Blood"},{"key":"BFbjc2016424_CR6","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.4155\/bio.15.117","volume":"7","author":"L Ceriani","year":"2015","unstructured":"Ceriani L, Ferrari M, Zangarini M, Licandro SA, Bello E, Frapolli R, Falcetta F, D'Incalci M, Libener R, Grosso F, Aviles P, Zucchetti M ( 2015 ) HPLC-MS\/MS method to measure trabectedin in tumors: preliminary PK study in a mesothelioma xenograft model . Bioanalysis 7 : 1831 \u2013 1842 .","journal-title":"Bioanalysis"},{"key":"BFbjc2016424_CR7","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1158\/1535-7163.MCT-10-0263","volume":"9","author":"M D'Incalci","year":"2010","unstructured":"D'Incalci M, Galmarini CM ( 2010 ) A review of trabectedin (ET-743): a unique mechanism of action . Mol Cancer Ther 9 : 2157 \u2013 2163 .","journal-title":"Mol Cancer Ther"},{"key":"BFbjc2016424_CR8","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/bjc.2014.149","volume":"111","author":"M D'Incalci","year":"2014","unstructured":"D'Incalci M, Badri N, Galmarini CM, Allavena P ( 2014 ) Trabectedin, a drug acting on both cancer cells and the tumour microenvironment . Br J Cancer 111 : 646 \u2013 650 .","journal-title":"Br J Cancer"},{"key":"BFbjc2016424_CR9","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1002\/ijc.1221","volume":"92","author":"G Damia","year":"2001","unstructured":"Damia G, Silvestri S, Carrassa L, Filiberti L, Faircloth GT, Liberi G, Foiani M, D'Incalci M ( 2001 ) Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways . Int J Cancer 92 : 583 \u2013 588 .","journal-title":"Int J Cancer"},{"key":"BFbjc2016424_CR10","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3324\/haematol.2009.016865","volume":"95","author":"AC de Vries","year":"2010","unstructured":"de Vries AC, Zwaan CM, van den Heuvel-Eibrink MM ( 2010 ) Molecular basis of juvenile myelomonocytic leukemia . Haematologica 95 : 179 \u2013 182 .","journal-title":"Haematologica"},{"key":"BFbjc2016424_CR11","doi-asserted-by":"publisher","first-page":"4188","DOI":"10.1200\/JCO.2008.21.0088","volume":"27","author":"GD Demetri","year":"2009","unstructured":"Demetri GD, Chawla SP, von Mehren M, Ritch P, Baker LH, Blay JY, Hande KR, Keohan ML, Samuels BL, Schuetze S, Lebedinsky C, Elsayed YA, Izquierdo MA, Gomez J, Park YC, Le Cesne A ( 2009 ) Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules . J Clin Oncol 27 : 4188 \u2013 4196 .","journal-title":"J Clin Oncol"},{"key":"BFbjc2016424_CR12","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1200\/JCO.2015.62.4734","volume":"34","author":"GD Demetri","year":"2016","unstructured":"Demetri GD, von Mehren M, Jones RL, Hensley ML, Schuetze SM, Staddon A, Milhem M, Elias A, Ganjoo K, Tawbi H, Van Tine BA, Spira A, Dean A, Khokhar NZ, Park YC, Knoblauch RE, Parekh TV, Maki RG, Patel SR ( 2016 ) Efficacy and safety of trabectedin or dacarbazine for metastatic liposarcoma or leiomyosarcoma after failure of conventional chemotherapy: results of a Phase III Randomized Multicenter Clinical Trial . J Clin Oncol 34 : 786 \u2013 793 .","journal-title":"J Clin Oncol"},{"key":"BFbjc2016424_CR13","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ccr.2009.06.018","volume":"16","author":"DG DeNardo","year":"2009","unstructured":"DeNardo DG, Barreto JB, Andreu P, Vasquez L, Tawfik D, Kolhatkar N, Coussens LM ( 2009 ) CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages . Cancer Cell 16 : 91 \u2013 102 .","journal-title":"Cancer Cell"},{"key":"BFbjc2016424_CR14","doi-asserted-by":"publisher","first-page":"5201","DOI":"10.1038\/onc.2013.462","volume":"33","author":"S Di Giandomenico","year":"2014","unstructured":"Di Giandomenico S, Frapolli R, Bello E, Uboldi S, Licandro SA, Marchini S, Beltrame L, Brich S, Mauro V, Tamborini E, Pilotti S, Casali PG, Grosso F, Sanfilippo R, Gronchi A, Mantovani R, Gatta R, Galmarini CM, Sousa-Faro JM, D'Incalci M ( 2014 ) Mode of action of trabectedin in myxoid liposarcomas . Oncogene 33 : 5201 \u2013 5210 .","journal-title":"Oncogene"},{"key":"BFbjc2016424_CR15","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/sj.leu.2403236","volume":"18","author":"HG Drexler","year":"2004","unstructured":"Drexler HG, Quentmeier H, MacLeod RA ( 2004 ) Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations . Leukemia 18 : 227 \u2013 232 .","journal-title":"Leukemia"},{"key":"BFbjc2016424_CR16","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/leu.2008.162","volume":"22","author":"PD Emanuel","year":"2008","unstructured":"Emanuel PD ( 2008 ) Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia . Leukemia 22 : 1335 \u2013 1342 .","journal-title":"Leukemia"},{"key":"BFbjc2016424_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0959-8049(00)00357-9","volume":"37","author":"E Erba","year":"2001","unstructured":"Erba E, Bergamaschi D, Bassano L, Damia G, Ronzoni S, Faircloth GT, D'Incalci M ( 2001 ) Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action . Eur J Cancer 37 : 97 \u2013 105 .","journal-title":"Eur J Cancer"},{"key":"BFbjc2016424_CR18","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nature01148","volume":"420","author":"S Etienne-Manneville","year":"2002","unstructured":"Etienne-Manneville S, Hall A ( 2002 ) Rho GTPases in cell biology . Nature 420 : 629 \u2013 635 .","journal-title":"Nature"},{"key":"BFbjc2016424_CR19","first-page":"3377","volume":"62","author":"D Friedman","year":"2002","unstructured":"Friedman D, Hu Z, Kolb EA, Gorfajn B, Scotto KW ( 2002 ) Ecteinascidin-743 inhibits activated but not constitutive transcription . Cancer Res 62 : 3377 \u2013 3381 .","journal-title":"Cancer Res"},{"key":"BFbjc2016424_CR20","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.ccr.2013.01.008","volume":"23","author":"G Germano","year":"2013","unstructured":"Germano G, Frapolli R, Belgiovine C, Anselmo A, Pesce S, Liguori M, Erba E, Uboldi S, Zucchetti M, Pasqualini F, Nebuloni M, van Rooijen N, Mortarini R, Beltrame L, Marchini S, Fuso Nerini I, Sanfilippo R, Casali PG, Pilotti S, Galmarini CM, Anichini A, Mantovani A, D'Incalci M, Allavena P ( 2013 ) Role of macrophage targeting in the antitumor activity of trabectedin . Cancer Cell 23 : 249 \u2013 262 .","journal-title":"Cancer Cell"},{"key":"BFbjc2016424_CR21","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1158\/0008-5472.CAN-09-2335","volume":"70","author":"G Germano","year":"2010","unstructured":"Germano G, Frapolli R, Simone M, Tavecchio M, Erba E, Pesce S, Pasqualini F, Grosso F, Sanfilippo R, Casali PG, Gronchi A, Virdis E, Tarantino E, Pilotti S, Greco A, Nebuloni M, Galmarini CM, Tercero JC, Mantovani A, D'Incalci M, Allavena P ( 2010 ) Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells . Cancer Res 70 : 2235 \u2013 2244 .","journal-title":"Cancer Res"},{"key":"BFbjc2016424_CR22","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/S1470-2045(07)70175-4","volume":"8","author":"F Grosso","year":"2007","unstructured":"Grosso F, Jones RL, Demetri GD, Judson IR, Blay JY, Le Cesne A, Sanfilippo R, Casieri P, Collini P, Dileo P, Spreafico C, Stacchiotti S, Tamborini E, Tercero JC, Jimeno J, D'Incalci M, Gronchi A, Fletcher JA, Pilotti S, Casali PG ( 2007 ) Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study . Lancet Oncol 8 : 595 \u2013 602 .","journal-title":"Lancet Oncol"},{"key":"BFbjc2016424_CR23","doi-asserted-by":"publisher","first-page":"2428","DOI":"10.1200\/JCO.2012.47.3314","volume":"31","author":"R Itzykson","year":"2013","unstructured":"Itzykson R, Kosmider O, Renneville A, Gelsi-Boyer V, Meggendorfer M, Morabito M, Berthon C, Ades L, Fenaux P, Beyne-Rauzy O, Vey N, Braun T, Haferlach T, Dreyfus F, Cross NC, Preudhomme C, Bernard OA, Fontenay M, Vainchenker W, Schnittger S, Birnbaum D, Droin N, Solary E ( 2013 ) Prognostic score including gene mutations in chronic myelomonocytic leukemia . J Clin Oncol 31 : 2428 \u2013 2436 .","journal-title":"J Clin Oncol"},{"key":"BFbjc2016424_CR24","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1038\/leu.2013.100","volume":"27","author":"R Itzykson","year":"2013","unstructured":"Itzykson R, Solary E ( 2013 ) An evolutionary perspective on chronic myelomonocytic leukemia . Leukemia 27 : 1441 \u2013 1450 .","journal-title":"Leukemia"},{"key":"BFbjc2016424_CR25","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1073\/pnas.040569197","volume":"97","author":"PJ Kourlas","year":"2000","unstructured":"Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS, Krahe R, Ruutu T, Knuutila S, Bloomfield CD, Caligiuri MA ( 2000 ) Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia . Proc Natl Acad Sci USA 97 : 2145 \u2013 2150 .","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFbjc2016424_CR26","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1182\/blood.V70.1.192.192","volume":"70","author":"B Lange","year":"1987","unstructured":"Lange B, Valtieri M, Santoli D, Caracciolo D, Mavilio F, Gemperlein I, Griffin C, Emanuel B, Finan J, Nowell P ( 1987 ) Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines . Blood 70 : 192 \u2013 199 .","journal-title":"Blood"},{"key":"BFbjc2016424_CR27","doi-asserted-by":"publisher","first-page":"41662","DOI":"10.18632\/oncotarget.9340","volume":"7","author":"M Liguori","year":"2016","unstructured":"Liguori M, Buracchi C, Pasqualini F, Bergomas F, Pesce S, Sironi M, Grizzi F, Mantovani A, Belgiovine C, Allavena P ( 2016 ) Functional TRAIL receptors in monocytes and tumor-associated macrophages: a possible targeting pathway in the tumor microenvironment . Oncotarget 7 : 41662 \u2013 41676 .","journal-title":"Oncotarget"},{"key":"BFbjc2016424_CR28","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1182\/blood-2014-08-550483","volume":"125","author":"F Locatelli","year":"2015","unstructured":"Locatelli F, Niemeyer CM ( 2015 ) How I treat juvenile myelomonocytic leukemia . Blood 125 : 1083 \u2013 1090 .","journal-title":"Blood"},{"key":"BFbjc2016424_CR29","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1182\/blood-2004-05-1944","volume":"105","author":"F Locatelli","year":"2005","unstructured":"Locatelli F, Nollke P, Zecca M, Korthof E, Lanino E, Peters C, Pession A, Kabisch H, Uderzo C, Bonfim CS, Bader P, Dilloo D, Stary J, Fischer A, Revesz T, Fuhrer M, Hasle H, Trebo M, van den Heuvel-Eibrink MM, Fenu S, Strahm B, Giorgiani G, Bonora MR, Duffner U, Niemeyer CM ( 2005 ) Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS\/EBMT trial . Blood 105 : 410 \u2013 419 .","journal-title":"Blood"},{"key":"BFbjc2016424_CR30","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1182\/asheducation-2010.1.357","volume":"2010","author":"ML Loh","year":"2010","unstructured":"Loh ML ( 2010 ) Childhood myelodysplastic syndrome: focus on the approach to diagnosis and treatment of juvenile myelomonocytic leukemia . Hematol Am Soc Hematol Educ Program 2010 : 357 \u2013 362 .","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"BFbjc2016424_CR31","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/j.1365-2141.2010.08525.x","volume":"152","author":"ML Loh","year":"2011","unstructured":"Loh ML ( 2011 ) Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia . Br J Haematol 152 : 677 \u2013 687 .","journal-title":"Br J Haematol"},{"key":"BFbjc2016424_CR32","doi-asserted-by":"publisher","first-page":"6780","DOI":"10.1073\/pnas.97.12.6780","volume":"97","author":"M Minuzzo","year":"2000","unstructured":"Minuzzo M, Marchini S, Broggini M, Faircloth G, D'Incalci M, Mantovani R ( 2000 ) Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743 . Proc Natl Acad Sci USA 97 : 6780 \u2013 6784 .","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFbjc2016424_CR33","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.1200\/JCO.2009.25.4037","volume":"28","author":"BJ Monk","year":"2010","unstructured":"Monk BJ, Herzog TJ, Kaye SB, Krasner CN, Vermorken JB, Muggia FM, Pujade-Lauraine E, Lisyanskaya AS, Makhson AN, Rolski J, Gorbounova VA, Ghatage P, Bidzinski M, Shen K, Ngan HY, Vergote IB, Nam JH, Park YC, Lebedinsky CA, Poveda AM ( 2010 ) Trabectedin plus pegylated liposomal Doxorubicin in recurrent ovarian cancer . J Clin Oncol 28 : 3107 \u2013 3114 .","journal-title":"J Clin Oncol"},{"key":"BFbjc2016424_CR34","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1182\/blood-2009-09-198127","volume":"115","author":"JC Mulloy","year":"2010","unstructured":"Mulloy JC, Cancelas JA, Filippi MD, Kalfa TA, Guo F, Zheng Y ( 2010 ) Rho GTPases in hematopoiesis and hemopathies . Blood 115 : 936 \u2013 947 .","journal-title":"Blood"},{"key":"BFbjc2016424_CR35","doi-asserted-by":"publisher","first-page":"5068","DOI":"10.1182\/blood-2012-10-460170","volume":"121","author":"E Padron","year":"2013","unstructured":"Padron E, Painter JS, Kunigal S, Mailloux AW, McGraw K, McDaniel JM, Kim E, Bebbington C, Baer M, Yarranton G, Lancet J, Komrokji RS, Abdel-Wahab O, List AF, Epling-Burnette PK ( 2013 ) GM-CSF-dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia . Blood 121 : 5068 \u2013 5077 .","journal-title":"Blood"},{"key":"BFbjc2016424_CR36","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/bjh.12756","volume":"165","author":"MM Patnaik","year":"2014","unstructured":"Patnaik MM, Parikh SA, Hanson CA, Tefferi A ( 2014 ) Chronic myelomonocytic leukaemia: a concise clinical and pathophysiological review . Br J Haematol 165 : 273 \u2013 286 .","journal-title":"Br J Haematol"},{"key":"BFbjc2016424_CR37","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.mayocp.2015.11.011","volume":"91","author":"MM Patnaik","year":"2016","unstructured":"Patnaik MM, Tefferi A ( 2016 ) Chronic myelomonocytic leukemia: focus on clinical practice . Mayo Clin Proc 91 : 259 \u2013 272 .","journal-title":"Mayo Clin Proc"},{"key":"BFbjc2016424_CR38","doi-asserted-by":"publisher","first-page":"867","DOI":"10.2165\/00003088-200746100-00005","volume":"46","author":"JJ Perez-Ruixo","year":"2007","unstructured":"Perez-Ruixo JJ, Zannikos P, Hirankarn S, Stuyckens K, Ludwig EA, Soto-Matos A, Lopez-Lazaro L, Owen JS ( 2007 ) Population pharmacokinetic meta-analysis of trabectedin (ET-743, Yondelis) in cancer patients . Clin Pharmacokinet 46 : 867 \u2013 884 .","journal-title":"Clin Pharmacokinet"},{"key":"BFbjc2016424_CR39","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/sj.leu.2404235","volume":"20","author":"FG Rucker","year":"2006","unstructured":"Rucker FG, Sander S, Dohner K, Dohner H, Pollack JR, Bullinger L ( 2006 ) Molecular profiling reveals myeloid leukemia cell lines to be faithful model systems characterized by distinct genomic aberrations . Leukemia 20 : 994 \u2013 1001 .","journal-title":"Leukemia"},{"key":"BFbjc2016424_CR40","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1016\/j.ejca.2009.04.002","volume":"45","author":"C Sessa","year":"2009","unstructured":"Sessa C, Cresta S, Noberasco C, Capri G, Gallerani E, De Braud F, Zucchetti M, D'Incalci M, Locatelli A, Marsoni S, Corradino I, Minoia C, Zintl P, Gianni L ( 2009 a) Phase I clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours . Eur J Cancer 45 : 2116 \u2013 2122 .","journal-title":"Eur J Cancer"},{"key":"BFbjc2016424_CR41","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/j.ejca.2008.11.019","volume":"45","author":"C Sessa","year":"2009","unstructured":"Sessa C, Perotti A, Noberasco C, De Braud F, Gallerani E, Cresta S, Zucchetti M, Vigano L, Locatelli A, Jimeno J, Feilchenfeldt JW, D'Incalci M, Capri G, Ielmini N, Gianni L ( 2009 b) Phase I clinical and pharmacokinetic study of trabectedin and doxorubicin in advanced soft tissue sarcoma and breast cancer . Eur J Cancer 45 : 1153 \u2013 1161 .","journal-title":"Eur J Cancer"},{"key":"BFbjc2016424_CR42","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.bcp.2005.04.013","volume":"70","author":"DG Soares","year":"2005","unstructured":"Soares DG, Poletto NP, Bonatto D, Salvador M, Schwartsmann G, Henriques JA ( 2005 ) Low cytotoxicity of ecteinascidin 743 in yeast lacking the major endonucleolytic enzymes of base and nucleotide excision repair pathways . Biochem Pharmacol 70 : 59 \u2013 69 .","journal-title":"Biochem Pharmacol"},{"key":"BFbjc2016424_CR43","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1056\/NEJMoa0905680","volume":"362","author":"C Steidl","year":"2010","unstructured":"Steidl C, Lee T, Shah SP, Farinha P, Han G, Nayar T, Delaney A, Jones SJ, Iqbal J, Weisenburger DD, Bast MA, Rosenwald A, Muller-Hermelink HK, Rimsza LM, Campo E, Delabie J, Braziel RM, Cook JR, Tubbs RR, Jaffe ES, Lenz G, Connors JM, Staudt LM, Chan WC, Gascoyne RD ( 2010 ) Tumor-associated macrophages and survival in classic Hodgkin's lymphoma . N Engl J Med 362 : 875 \u2013 885 .","journal-title":"N Engl J Med"},{"key":"BFbjc2016424_CR44","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.1038\/ng.3400","volume":"47","author":"E Stieglitz","year":"2015","unstructured":"Stieglitz E, Taylor-Weiner AN, Chang TY, Gelston LC, Wang YD, Mazor T, Esquivel E, Yu A, Seepo S, Olsen SR, Rosenberg M, Archambeault SL, Abusin G, Beckman K, Brown PA, Briones M, Carcamo B, Cooper T, Dahl GV, Emanuel PD, Fluchel MN, Goyal RK, Hayashi RJ, Hitzler J, Hugge C, Liu YL, Messinger YH, Mahoney DH Jr ., Monteleone P, Nemecek ER, Roehrs PA, Schore RJ, Stine KC, Takemoto CM, Toretsky JA, Costello JF, Olshen AB, Stewart C, Li Y, Ma J, Gerbing RB, Alonzo TA, Getz G, Gruber TA, Golub TR, Stegmaier K, Loh ML ( 2015 ) The genomic landscape of juvenile myelomonocytic leukemia . Nat Genet 47 : 1326 \u2013 1333 .","journal-title":"Nat Genet"},{"key":"BFbjc2016424_CR45","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/bjh.13576","volume":"171","author":"A Symeonidis","year":"2015","unstructured":"Symeonidis A, van Biezen A, de Wreede L, Piciocchi A, Finke J, Beelen D, Bornhauser M, Cornelissen J, Volin L, Mufti G, Chalandon Y, Ganser A, Bruno B, Niederwieser D, Kobbe G, Schwerdtfeger R, de Witte T, Robin M, Kroger N ( 2015 ) Achievement of complete remission predicts outcome of allogeneic haematopoietic stem cell transplantation in patients with chronic myelomonocytic leukaemia. A study of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation . Br J Haematol 171 : 239 \u2013 246 .","journal-title":"Br J Haematol"},{"key":"BFbjc2016424_CR46","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1111\/j.1365-2184.2007.00469.x","volume":"40","author":"M Tavecchio","year":"2007","unstructured":"Tavecchio M, Natoli C, Ubezio P, Erba E, D'Incalci M ( 2007 ) Dynamics of cell cycle phase perturbations by trabectedin (ET-743) in nucleotide excision repair (NER)-deficient and NER-proficient cells, unravelled by a novel mathematical simulation approach . Cell Prolif 40 : 885 \u2013 904 .","journal-title":"Cell Prolif"},{"key":"BFbjc2016424_CR47","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.ejca.2008.01.003","volume":"44","author":"M Tavecchio","year":"2008","unstructured":"Tavecchio M, Simone M, Erba E, Chiolo I, Liberi G, Foiani M, D'Incalci M, Damia G ( 2008 ) Role of homologous recombination in trabectedin-induced DNA damage . Eur J Cancer 44 : 609 \u2013 618 .","journal-title":"Eur J Cancer"},{"key":"BFbjc2016424_CR48","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1016\/j.yexcr.2013.07.002","volume":"319","author":"A Troeger","year":"2013","unstructured":"Troeger A, Williams DA ( 2013 ) Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders . Exp Cell Res 319 : 2375 \u2013 2383 .","journal-title":"Exp Cell Res"},{"key":"BFbjc2016424_CR49","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1182\/blood-2009-03-209262","volume":"114","author":"JW Vardiman","year":"2009","unstructured":"Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellstrom-Lindberg E, Tefferi A, Bloomfield CD ( 2009 ) The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes . Blood 114 : 937 \u2013 951 .","journal-title":"Blood"},{"key":"BFbjc2016424_CR50","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1200\/JCO.2004.05.210","volume":"22","author":"A Yovine","year":"2004","unstructured":"Yovine A, Riofrio M, Blay JY, Brain E, Alexandre J, Kahatt C, Taamma A, Jimeno J, Martin C, Salhi Y, Cvitkovic E, Misset JL ( 2004 ) Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients . J Clin Oncol 22 : 890 \u2013 899 .","journal-title":"J Clin Oncol"},{"key":"BFbjc2016424_CR51","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1021\/jm990241l","volume":"42","author":"M Zewail-Foote","year":"1999","unstructured":"Zewail-Foote M, Hurley LH ( 1999 ) Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove . J Med Chem 42 : 2493 \u2013 2497 .","journal-title":"J Med Chem"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bjc2016424.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2016424","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2016424.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:35:58Z","timestamp":1684416958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bjc2016424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["BFbjc2016424"],"URL":"https:\/\/doi.org\/10.1038\/bjc.2016.424","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"27 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Maurizio D\u2019Incalci has received honorarium to participate in a scientific board of PhamaMar. Carlos M Galmarini is an employee of PharmaMar, which produces trabectedin.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}