{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T10:21:06Z","timestamp":1784974866711,"version":"3.55.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1038\/bjc.2017.177","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T20:01:46Z","timestamp":1497988906000},"page":"306-314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Infradiaphragmatic irradiation and high procarbazine doses increase colorectal cancer risk in Hodgkin lymphoma survivors"],"prefix":"10.1038","volume":"117","author":[{"given":"Anna M","family":"van Eggermond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schaapveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile PM","family":"Janus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Paul","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustinus DG","family":"Krol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9e M","family":"Zijlstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard WM","family":"van der Maazen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontien C","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique E","family":"van Leerdam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke WJ","family":"Louwman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie L","family":"De Bruin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthe MP","family":"Aleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora E","family":"van Leeuwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,20]]},"reference":[{"key":"BFbjc2017177_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0360-3016(96)00489-0","volume":"37","author":"SH Birdwell","year":"1997","unstructured":"Birdwell SH, Hancock SL, Varghese A, Cox RS, Hoppe RT (1997) Gastrointestinal cancer after treatment of Hodgkin's disease. Int J Rad Oncol Biol Phys 37: 67\u2013673.","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"BFbjc2017177_CR2","first-page":"1","volume":"82","author":"NE Breslow","year":"1987","unstructured":"Breslow NE, Day NE (1987) Statistical methods in cancer research. Volume II\u2014The design and analysis of cohort studies. IARC Sci Publ 82: 1\u2013406.","journal-title":"IARC Sci Publ"},{"issue":"1","key":"BFbjc2017177_CR3","first-page":"19","volume":"29","author":"M Casparie","year":"2007","unstructured":"Casparie M, Tiebosch ATMG, Burger G, Blauwgeers H, Van de Pol A, van Krieken JHJ, Meijer GA (2007) Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive. Cell Oncol 29 (1): 19\u201324.","journal-title":"Cell Oncol"},{"issue":"16","key":"BFbjc2017177_CR4","doi-asserted-by":"publisher","first-page":"3679","DOI":"10.1182\/blood-2008-10-184705","volume":"113","author":"ML De Bruin","year":"2009","unstructured":"De Bruin ML, Burgers JA, Baas P, van't Veer MB, Noordijk EM, Louwman MW, Zijlstra JM, van den Berg H, Aleman BM, van Leeuwen FE (2009) Malignant mesothelioma after radiation treatment for Hodgkin lymphoma. Blood 113 (16): 3679\u20133681.","journal-title":"Blood"},{"issue":"26","key":"BFbjc2017177_CR5","doi-asserted-by":"publisher","first-page":"4229","DOI":"10.1200\/JCO.2008.19.9174","volume":"27","author":"ML De Bruin","year":"2009","unstructured":"De Bruin ML, Sparidans J, van 't Veer MB, Noordijk E, Louwman MW, Zijlstra JM, van den Berg H, Russell N, Broeks A, Baaijens MH, Aleman BM, van Leeuwen FE (2009) Breast cancer risk in female survivors of Hodgkin's lymphoma; lower risk after smaller radiation volumes. J Clin Oncol 27 (26): 4229\u20134231.","journal-title":"J Clin Oncol"},{"key":"BFbjc2017177_CR6","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1093\/annonc\/mdu287","volume":"25","author":"GM Dores","year":"2014","unstructured":"Dores GM, Curtis RE, van Leeuwen FE, Stovall M, Hall P, Lynch CF, Smith SA, Weathers RE, Storm HH, Hodgson DC, Kleinerman RA, Joensuu H, Johannesen TB, Andersson M, Holowaty EJ, Kaijser M, Pukkala E, Vaalavirta L, Fossa SD, Langmark F, Travis LB, Fraumeni JF, Aleman BM, Morton LM, Gilbert ES (2014) Pancreatic cancer risk after treatment for Hodgkin lymphoma. Ann Oncol 25: 2073\u20132079.","journal-title":"Ann Oncol"},{"key":"BFbjc2017177_CR7","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1200\/JCO.2002.09.038","volume":"20","author":"GM Dores","year":"2002","unstructured":"Dores GM, Metayer C, Curtis RE, Lynch CF, Clarke EA, Glimelius B, Storm H, Pukkala E, van Leeuwen FE, Holowaty EJ, Andersson M, Wiklund T, Joensuu T, van\/'t Veer MB, Stovall M, Gospodarowicz M, Travis LB (2002) Second malignant neoplasms among long-term survivors of Hodgkin's disease: a population-based evaluation over 25 years. J Clin Oncol 20: 3484\u20133494.","journal-title":"J Clin Oncol"},{"issue":"8","key":"BFbjc2017177_CR8","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1002\/cncr.24178","volume":"115","author":"O Favier","year":"2009","unstructured":"Favier O, Heutte N, Stamatoullas-Bastard A, Carde P, Van't Veer MB, Aleman BM, Noordijk EM, Thomas J, Ferme C, Henry-Amar M European Organization for R, Treatment of Cancer Lymphoma G the Groupe d'Etudes des Lymphomes de lA (2009) Survival after Hodgkin lymphoma: causes of death and excess mortality in patients treated in 8 consecutive trials. Cancer 115 (8): 1680\u20131691.","journal-title":"Cancer"},{"key":"BFbjc2017177_CR9","unstructured":"Children\u2019s Oncology Group (2008) Children's Oncology Group Long-Term Follow-up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers. Children's Oncology Group: Arcadia, CA, USA."},{"issue":"11","key":"BFbjc2017177_CR10","doi-asserted-by":"publisher","first-page":"757","DOI":"10.7326\/0003-4819-156-11-201206050-00002","volume":"156","author":"TOOK Henderson","year":"2012","unstructured":"Henderson TO OK, Whitton J, Leisenring W, Neglia J, Meadows A, Crotty C, Rubin DT, Diller L, Inskip P, Smith SA, Stovall M, Constine LS, Hammond S, Armstrong GT, Robison LL, Nathan PC (2012) Secondary gastrointestinal cancer in childhood cancer survivors: a cohort study. Ann Intern Med 156 (11): 757\u2013766.","journal-title":"Ann Intern Med"},{"key":"BFbjc2017177_CR11","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1200\/JCO.2006.09.0936","volume":"25","author":"DC Hodgson","year":"2007","unstructured":"Hodgson DC, Gilbert ES, Dores GM, Schonfeld SJ, Lynch CF, Storm H, Hall P, Langmark F, Pukkala E, Andersson M, Kaijser M, Joensuu H, Fossa SD, Travis LB (2007) Long-term solid cancer risk among 5-year survivors of Hodgkin's lymphoma. J Clin Oncol 25: 1489\u20131497.","journal-title":"J Clin Oncol"},{"key":"BFbjc2017177_CR12","unstructured":"IKNL (2012) Netherlands Comprehensive Cancer Organisation (IKNL); Dutch Cancer Figures. Available at: \n                    http:\/\/cijfersoverkanker.nl\n                    \n                  ."},{"key":"BFbjc2017177_CR13","first-page":"347","volume-title":"Radiation Carcinogenesis","author":"CE Land","year":"1986","unstructured":"Land CE (1986) Carcinogenic effects of radiation on the human digestive tract and other organs. In Radiation CarcinogenesisAC Upton, RE Albert, F Burns, RE Shore, (eds) Vol. 373, pp 347\u2013378. Elsevier: New York, NY, USA."},{"issue":"6","key":"BFbjc2017177_CR14","doi-asserted-by":"publisher","first-page":"784","DOI":"10.3109\/02841861003733713","volume":"49","author":"V Lemmens","year":"2010","unstructured":"Lemmens V, Steenbergen Lv, Janssen-Heijnen M, Martijn H, Rutten H, Coebergh JW (2010) Trends in colorectal cancer in the south of the Netherlands 1975\u20132007: rectal cancer survival levels with colon cancer survival. Acta Oncol 49 (6): 784\u2013796.","journal-title":"Acta Oncol"},{"issue":"27","key":"BFbjc2017177_CR15","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1200\/JCO.2013.50.6832","volume":"31","author":"LM Morton","year":"2013","unstructured":"Morton LM, Dores GM, Curtis RE, Lynch CF, Stovall M, Hall P, Gilbert ES, Hodgson DC, Storm HH, Johannesen TB, Smith SA, Weathers RE, Andersson M, Fossa SD, Hauptmann M, Holowaty EJ, Joensuu H, Kaijser M, Kleinerman RA, Langmark F, Pukkala E, Vaalavirta L, van den Belt-Dusebout AW, Fraumeni JF, Travis LB, Aleman BM, van Leeuwen FE (2013) Stomach cancer risk after treatment for Hodgkin Lymphoma. J Clin Oncol 31 (27): 3369\u20133377.","journal-title":"J Clin Oncol"},{"issue":"11","key":"BFbjc2017177_CR16","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1111\/j.1349-7006.2006.00312.x","volume":"97","author":"K Nakachi","year":"2006","unstructured":"Nakachi K, Harris CC, Tahara E (2006) Japan\u2013US Cooperative Cancer Research Seminar on molecular epidemiological characteristics of lung and colon cancer development among atomic\u2013bomb survivors, Bethesda, USA, February 23\u201324, 2006. Cancer Sci 97 (11): 1279\u20131282.","journal-title":"Cancer Sci"},{"issue":"4","key":"BFbjc2017177_CR17","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1269\/jrr.33.342","volume":"33","author":"H Nakatsuka","year":"1992","unstructured":"Nakatsuka H, Shimizu Y, Yamamoto T, Sekine I, Ezaki H, Tahara E, Takahashi M, Shimoyama T, Mochinaga N, Tomita M (1992) Colorectal cancer incidence among atomic bomb survivors, 1950-80. J Radiat Res 33 (4): 342\u2013361.","journal-title":"J Radiat Res"},{"key":"BFbjc2017177_CR18","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nature11252","volume":"Vol. 487","author":"Network","year":"2012","unstructured":"Network (2012) The Cancer Genome Network. Comprehensive molecular characterization of human colon and rectal cancer. In Nature Vol. 487, pp 330\u2013337.","journal-title":"Nature"},{"issue":"6","key":"BFbjc2017177_CR19","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1182\/blood-2002-02-0634","volume":"100","author":"AK Ng","year":"2002","unstructured":"Ng AK, Bernardo MV, Weller E, Backstrand K, Silver B, Marcus KC, Tarbell NJ, Stevenson MA, Friedberg JW, Mauch PM (2002) Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors. Blood 100 (6): 1989\u20131996.","journal-title":"Blood"},{"issue":"20","key":"BFbjc2017177_CR20","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1200\/JCO.2011.37.8760","volume":"30","author":"K Nottage","year":"2012","unstructured":"Nottage K, McFarlane J, Krasin MJ, Li C, Srivastava D, Robison LL, Hudson MM (2012) Secondary colorectal carcinoma after childhood cancer. J Clin Oncol 30 (20): 2552\u20132558.","journal-title":"J Clin Oncol"},{"issue":"1","key":"BFbjc2017177_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1667\/RR0763.1","volume":"168","author":"DL Preston","year":"2007","unstructured":"Preston DL, Ron E, Tokuoka S, Funamoto S, Nishi N, Soda M, Mabuchi K, Kodama K (2007) Solid cancer incidence in atomic bomb survivors: 1958-1998. Radiat Res 168 (1): 1\u201364.","journal-title":"Radiat Res"},{"issue":"22","key":"BFbjc2017177_CR22","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1001\/jama.2011.747","volume":"305","author":"RC Reulen","year":"2011","unstructured":"Reulen RC, Frobisher C, Winter DL, Kelly J, Lancashire ER, Stiller CA, Pritchard-Jones K, Jenkinson HC, Hawkins MM British Childhood Cancer Survivor Study Steering Group (2011) Long-term risks of subsequent primary neoplasms among survivors of childhood cancer. JAMA 305 (22): 2311\u20132319.","journal-title":"JAMA"},{"issue":"1","key":"BFbjc2017177_CR23","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1186\/s12885-016-2880-2","volume":"16","author":"LS Rigter","year":"2016","unstructured":"Rigter LS, Kallenberg FG, Bastiaansen B, van Os TA, van Leeuwen FE, van Leerdam ME, Dekker E (2016) A case series of intestinal adenomatous polyposis of unidentified etiology; a late effect of irradiation? BMC Cancer 16 (1): 862.","journal-title":"BMC Cancer"},{"issue":"1","key":"BFbjc2017177_CR24","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s12885-017-3089-8","volume":"17","author":"LS Rigter","year":"2017","unstructured":"Rigter LS, Spaander MC, Moons LM, Bisseling TM, Aleman BM, de Boer JP, Lugtenburg PJ, Janus CP, Petersen EJ, Roesink JM, Raemaekers JM, van der Maazen RW, Cats A, Bleiker EM, Snaebjornsson P, Carvalho B, Lansdorp-Vogelaar I, J\u00f3\u017awiak K, Te Riele H, Meijer GA, van Leeuwen FE, van Leerdam ME (2017) Colorectal cancer surveillance in Hodgkin lymphoma survivors at increased risk of therapy-related colorectal cancer: study design. BMC Cancer 17 (1): 112.","journal-title":"BMC Cancer"},{"issue":"26","key":"BFbjc2017177_CR25","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1056\/NEJMoa1505949","volume":"373","author":"M Schaapveld","year":"2015","unstructured":"Schaapveld M, Aleman BMP, van Eggermond AM, Janus CPM, Krol ADG, van der Maazen RWM, Roesink J, Raemaekers JMM, de Boer JP, Zijlstra JM, van Imhoff GW, Petersen EJ, Poortmans PMP, Beijert M, Lybeert ML, Mulder I, Visser O, Louwman MWJ, Krul IM, Lugtenburg PJ, van Leeuwen FE (2015) Second cancer risk up to 40 years after treatment for hodgkin\u2019s lymphoma. N Eng J Med 373 (26): 2499\u20132511.","journal-title":"N Eng J Med"},{"key":"BFbjc2017177_CR26","first-page":"703","volume-title":"Cancer Epidemiology and Prevention","author":"D Schottenfeld","year":"1982","unstructured":"Schottenfeld D, Winawer SJ (1982) Large intestine. In Cancer Epidemiology and PreventionD Schottenfeld, JFJ Fraumeni, (eds), pp 703\u2013727. W.B. Saunders: Philadelphia, PA, USA."},{"issue":"6","key":"BFbjc2017177_CR27","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1093\/ije\/23.6.1111","volume":"23","author":"LJ Schouten","year":"1994","unstructured":"Schouten LJ, Straatman H, Kiemeney LA, Gimbr\u00e8re CH, Verbeek AL (1994) The capture-recapture method for estimation of cancer registry completeness: a useful tool? Int J Epidemiol 23 (6): 1111\u20131116.","journal-title":"Int J Epidemiol"},{"issue":"3","key":"BFbjc2017177_CR28","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1200\/JCO.2000.18.3.498","volume":"18","author":"AJ Swerdlow","year":"2000","unstructured":"Swerdlow AJ, Barber JA, Hudson GV, Cunningham D, Gupta RK, Hancock BW, Horwich A, Lister TA, Linch DC (2000) Risk of second malignancy after Hodgkin's disease in a collaborative British cohort: the relation to age at treatment. J Clin Oncol 18 (3): 498\u2013509.","journal-title":"J Clin Oncol"},{"issue":"22","key":"BFbjc2017177_CR29","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1200\/JCO.2011.38.8835","volume":"30","author":"AJ Swerdlow","year":"2012","unstructured":"Swerdlow AJ, Cooke R, Bates A, Cunningham D, Falk SJ, Gilson D, Hancock BW, Harris SJ, Horwich A, Hoskin PJ, Linch DC, Lister TA, Lucraft HH, Radford JA, Stevens AM, Syndikus I, Williams MV (2012) Breast cancer risk after supradiaphragmatic radiotherapy for Hodgkin's lymphoma in England and Wales: A National Cohort Study. J Clin Oncol 30 (22): 2745\u20132752.","journal-title":"J Clin Oncol"},{"issue":"31","key":"BFbjc2017177_CR30","doi-asserted-by":"publisher","first-page":"4096","DOI":"10.1200\/JCO.2011.34.8268","volume":"29","author":"AJ Swerdlow","year":"2011","unstructured":"Swerdlow AJ, Higgins CD, Smith P, Cunningham D, Hancock BW, Horwich A, Hoskin PJ, Lister TA, Radford JA, Rohatiner AZS, Linch DC (2011) Second cancer risk after chemotherapy for hodgkin's lymphoma: A Collaborative British Cohort Study. J Clin Oncol 29 (31): 4096\u20134104.","journal-title":"J Clin Oncol"},{"issue":"6","key":"BFbjc2017177_CR31","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1200\/JCO.2001.19.6.1610","volume":"19","author":"AJ Swerdlow","year":"2001","unstructured":"Swerdlow AJ, Schoemaker MJ, Allerton R, Horwich A, Barber JA, Cunningham D, Lister TA, Rohatiner AZ, Vaughan Hudson G, Williams MV, Linch DC (2001) Lung cancer after Hodgkin's disease: a nested case-control study of the relation to treatment. J Clin Oncol 19 (6): 1610\u20131618.","journal-title":"J Clin Oncol"},{"issue":"3","key":"BFbjc2017177_CR32","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/jnci\/94.3.182","volume":"94","author":"LB Travis","year":"2002","unstructured":"Travis LB, Gospodarowicz M, Curtis RE, Clarke EA, Andersson M, Glimelius B, Joensuu T, Lynch CF, van Leeuwen FE, Holowaty E, Storm H, Glimelius I, Pukkala E, Stovall M, Fraumeni JF Jr, Boice JD Jr, Gilbert E (2002) Lung cancer following chemotherapy and radiotherapy for Hodgkin's disease. J Natl Cancer Inst 94 (3): 182\u2013192.","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"BFbjc2017177_CR33","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1001\/jama.290.4.465","volume":"290","author":"LB Travis","year":"2003","unstructured":"Travis LB, Hill DA, Dores GM, Gospodarowicz M, van Leeuwen FE, Holowaty E, Glimelius B, Andersson M, Wiklund T, Lynch CF, van't Veer MB, Glimelius I, Storm H, Pukkala E, Stovall M, Curtis R, Boice JD Jr., Gilbert E (2003) Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin's disease. JAMA 290 (4): 465\u2013475.","journal-title":"JAMA"},{"issue":"5","key":"BFbjc2017177_CR34","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1016\/j.ijrobp.2009.01.073","volume":"75","author":"AW van den Belt-Dusebout","year":"2009","unstructured":"van den Belt-Dusebout AW, Aleman BM, Besseling G, de Bruin ML, Hauptmann M, van 't Veer MB, de Wit R, Ribot JG, Noordijk EM, Kerst JM, Gietema JA, van Leeuwen FE (2009) Roles of radiation dose and chemotherapy in the etiology of stomach cancer as a second malignancy. Int J Rad Oncol Biol Phys 75 (5): 1420\u20131429.","journal-title":"Int J Rad Oncol Biol Phys"},{"issue":"3","key":"BFbjc2017177_CR35","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1200\/JCO.2000.18.3.487","volume":"18","author":"FE van Leeuwen","year":"2000","unstructured":"van Leeuwen FE, Klokman WJ, van 't Veer MB, Hagenbeek A, Krol AD, Vetter UA, Schaapveld M, van Heerde P, Burgers JM, Somers R, Aleman BM (2000) Long-term risk of second malignancy in survivors of Hodgkin's disease treated during adolescence or young adulthood. J Clin Oncol 18 (3): 487\u2013497.","journal-title":"J Clin Oncol"},{"key":"BFbjc2017177_CR36","unstructured":"WHO (2000) World Health Organization. International Classification of Diseases for Oncology. Organization WH (eds) 3rd edn. WHO, Geneva, Switzerland."}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bjc2017177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2017177","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/bjc.2017.177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2017177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:38:11Z","timestamp":1684417091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bjc2017177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,20]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["BFbjc2017177"],"URL":"https:\/\/doi.org\/10.1038\/bjc.2017.177","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,20]]},"assertion":[{"value":"28 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}