{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:51:29Z","timestamp":1790869889144,"version":"4.1.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Br J Cancer"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1038\/bjc.2017.385","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T23:47:38Z","timestamp":1510271258000},"page":"233-247","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["BPIFB1 (LPLUNC1) inhibits migration and invasion of nasopharyngeal carcinoma by interacting with VTN and VIM"],"prefix":"10.1038","volume":"118","author":[{"given":"Fang","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojian","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiayu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"BFbjc2017385_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/jss.400140106","volume":"14","author":"D Barnes","year":"1980","unstructured":"Barnes D, Wolfe R, Serrero G, McClure D, Sato G (1980) Effects of a serum spreading factor on growth and morphology of cells in serum-free medium. J Supramol Struct 14: 47\u201363.","journal-title":"J Supramol Struct"},{"key":"BFbjc2017385_CR2","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1042\/bst0310806","volume":"31","author":"CD Bingle","year":"2003","unstructured":"Bingle CD, Craven CJ (2003) Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families. Biochem Soc Trans 31: 806\u2013809.","journal-title":"Biochem Soc Trans"},{"key":"BFbjc2017385_CR3","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1042\/BST0390977","volume":"39","author":"CD Bingle","year":"2011","unstructured":"Bingle CD, Seal RL, Craven CJ (2011) Systematic nomenclature for the PLUNC\/PSP\/BSP30\/SMGB proteins as a subfamily of the BPI fold-containing superfamily. Biochem Soc Trans 39: 977\u2013983.","journal-title":"Biochem Soc Trans"},{"key":"BFbjc2017385_CR4","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/35094059","volume":"1","author":"MJ Bissell","year":"2001","unstructured":"Bissell MJ, Radisky D (2001) Putting tumours in context. Nat Rev Cancer 1: 46\u201354.","journal-title":"Nat Rev Cancer"},{"key":"BFbjc2017385_CR5","doi-asserted-by":"publisher","first-page":"20404","DOI":"10.18632\/oncotarget.4057","volume":"6","author":"H Bo","year":"2015","unstructured":"Bo H, Gong Z, Zhang W, Li X, Zeng Y, Liao Q, Chen P, Shi L, Lian Y, Jing Y, Tang K, Li Z, Zhou Y, Zhou M, Xiang B, Li X, Yang J, Xiong W, Li G, Zeng Z (2015) Upregulated long non-coding RNA AFAP1-AS1 expression is associated with progression and poor prognosis of nasopharyngeal carcinoma. Oncotarget 6: 20404\u201320418.","journal-title":"Oncotarget"},{"key":"BFbjc2017385_CR6","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/nrc2967","volume":"10","author":"S Cabodi","year":"2010","unstructured":"Cabodi S, del Pilar Camacho-Leal M, Di Stefano P, Defilippi P (2010) Integrin signalling adaptors: not only figurants in the cancer story. Nat Rev Cancer 10: 858\u2013870.","journal-title":"Nat Rev Cancer"},{"key":"BFbjc2017385_CR7","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.it.2008.07.012","volume":"29","author":"G Canny","year":"2008","unstructured":"Canny G, Levy O (2008) Bactericidal\/permeability-increasing protein (BPI) and BPI homologs at mucosal sites. Trends Immunol 29: 541\u2013547.","journal-title":"Trends Immunol"},{"key":"BFbjc2017385_CR8","doi-asserted-by":"publisher","first-page":"e56929","DOI":"10.1371\/journal.pone.0056929","volume":"8","author":"P Chen","year":"2013","unstructured":"Chen P, Guo X, Zhou H, Zhang W, Zeng Z, Liao Q, Li X, Xiang B, Yang J, Ma J, Zhou M, Peng S, Xiang J, Li X, Le CW, Xiong W, McCarthy JB, Li G (2013) SPLUNC1 regulates cell progression and apoptosis through the miR-141-PTEN\/p27 pathway, but is hindered by LMP1. PLoS One 8: e56929.","journal-title":"PLoS One"},{"key":"BFbjc2017385_CR9","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/S0140-6736(15)00055-0","volume":"387","author":"ML Chua","year":"2016","unstructured":"Chua ML, Wee JT, Hui EP, Chan AT, Lo KW, Huang DP (2016) Nasopharyngeal carcinoma. Lancet 387: 1012\u20131024.","journal-title":"Lancet"},{"key":"BFbjc2017385_CR10","doi-asserted-by":"publisher","first-page":"30720","DOI":"10.1074\/jbc.M113.512467","volume":"288","author":"JM Dave","year":"2013","unstructured":"Dave JM, Kang H, Abbey CA, Maxwell SA, Bayless KJ (2013) Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). J Biol Chem 288: 30720\u201330733.","journal-title":"J Biol Chem"},{"key":"BFbjc2017385_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/nrc2748","volume":"10","author":"JS Desgrosellier","year":"2010","unstructured":"Desgrosellier JS, Cheresh DA (2010) Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 10: 9\u201322.","journal-title":"Nat Rev Cancer"},{"key":"BFbjc2017385_CR12","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1432-0436.1982.tb01266.x","volume":"23","author":"WW Franke","year":"1982","unstructured":"Franke WW, Grund C, Kuhn C, Jackson BW, Illmensee K (1982) Formation of cytoskeletal elements during mouse embryogenesis. III. Primary mesenchymal cells and the first appearance of vimentin filaments. Differentiation 23: 43\u201359.","journal-title":"Differentiation"},{"key":"BFbjc2017385_CR13","doi-asserted-by":"publisher","first-page":"R42","DOI":"10.1186\/bcr1524","volume":"8","author":"AJ Galliher","year":"2006","unstructured":"Galliher AJ, Schiemann WP (2006) Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial\u2013mesenchymal transition in mammary epithelial cells. Breast Cancer Res 8: R42.","journal-title":"Breast Cancer Res"},{"key":"BFbjc2017385_CR14","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.1007\/s13277-015-4156-x","volume":"37","author":"Z Gong","year":"2016","unstructured":"Gong Z, Yang Q, Zeng Z, Zhang W, Li X, Zu X, Deng H, Chen P, Liao Q, Xiang B, Zhou M, Li X, Li Y, Xiong W, Li G (2016) An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma. Tumour Biol 37: 3683\u20133695.","journal-title":"Tumour Biol"},{"key":"BFbjc2017385_CR15","doi-asserted-by":"publisher","first-page":"e2353","DOI":"10.1038\/cddis.2016.253","volume":"7","author":"B He","year":"2016","unstructured":"He B, Li W, Wu Y, Wei F, Gong Z, Bo H, Wang Y, Li X, Xiang B, Guo C, Liao Q, Chen P, Zu X, Zhou M, Ma J, Li X, Li Y, Li G, Xiong W, Zeng Z (2016) Epstein-Barr virus-encoded miR-BART6-3p inhibits cancer cell metastasis and invasion by targeting long non-coding RNA LOC553103. Cell Death Dis 7: e2353.","journal-title":"Cell Death Dis"},{"key":"BFbjc2017385_CR16","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1242\/jcs.111.18.2717","volume":"111","author":"SM Homan","year":"1998","unstructured":"Homan SM, Mercurio AM, LaFlamme SE (1998) Endothelial cells assemble two distinct alpha6beta4-containing vimentin-associated structures: roles for ligand binding and the beta4 cytoplasmic tail. J Cell Sci 111: 2717\u20132728.","journal-title":"J Cell Sci"},{"key":"BFbjc2017385_CR17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nrc727","volume":"2","author":"JD Hood","year":"2002","unstructured":"Hood JD, Cheresh DA (2002) Role of integrins in cell invasion and migration. Nat Rev Cancer 2: 91\u2013100.","journal-title":"Nat Rev Cancer"},{"key":"BFbjc2017385_CR18","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1038\/bjc.2011.38","volume":"104","author":"T Horikawa","year":"2011","unstructured":"Horikawa T, Yoshizaki T, Kondo S, Furukawa M, Kaizaki Y, Pagano JS (2011) Epstein\u2013Barr Virus latent membrane protein 1 induces Snail and epithelial\u2013mesenchymal transition in metastatic nasopharyngeal carcinoma. Br J Cancer 104: 1160\u20131167.","journal-title":"Br J Cancer"},{"key":"BFbjc2017385_CR19","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1172\/JCI39104","volume":"119","author":"R Kalluri","year":"2009","unstructured":"Kalluri R, Weinberg RA (2009) The basics of epithelial\u2013mesenchymal transition. J Clin Invest 119: 1420\u20131428.","journal-title":"J Clin Invest"},{"key":"BFbjc2017385_CR20","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1177\/154405910308201202","volume":"82","author":"EE LeClair","year":"2003","unstructured":"LeClair EE (2003) Four reasons to consider a novel class of innate immune molecules in the oral epithelium. J Dent Res 82: 944\u2013950.","journal-title":"J Dent Res"},{"key":"BFbjc2017385_CR21","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.3892\/ijo.2016.3599","volume":"49","author":"F Liang","year":"2016","unstructured":"Liang F, Li Q, Li X, Li Z, Gong Z, Deng H, Xiang B, Zhou M, Li X, Li G, Zeng Z, Xiong W (2016) TSC22D2 interacts with PKM2 and inhibits cell growth in colorectal cancer. Int J Oncol 49: 1046\u20131056.","journal-title":"Int J Oncol"},{"key":"BFbjc2017385_CR22","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1038\/onc.2013.161","volume":"33","author":"Q Liao","year":"2013","unstructured":"Liao Q, Zeng Z, Guo X, Li X, Wei F, Zhang W, Li X, Chen P, Liang F, Xiang B, Ma J, Wu M, Tang H, Deng M, Zeng X, Tang K, Xiong W, Li G (2013) LPLUNC1 suppresses IL-6-induced nasopharyngeal carcinoma cell proliferation via inhibiting the Stat3 activation. Oncogene 33: 2098\u20132109.","journal-title":"Oncogene"},{"key":"BFbjc2017385_CR23","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/35077241","volume":"411","author":"LA Liotta","year":"2001","unstructured":"Liotta LA, Kohn EC (2001) The microenvironment of the tumour\u2013host interface. Nature 411: 375\u2013379.","journal-title":"Nature"},{"key":"BFbjc2017385_CR24","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S1535-6108(04)00119-9","volume":"5","author":"KW Lo","year":"2004","unstructured":"Lo KW, To KF, Huang DP (2004) Focus on nasopharyngeal carcinoma. Cancer Cell 5: 423\u2013428.","journal-title":"Cancer Cell"},{"key":"BFbjc2017385_CR25","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/bjc.2013.751","volume":"110","author":"J Lu","year":"2013","unstructured":"Lu J, Xu X, Liu X, Peng Y, Zhang B, Wang L, Luo H, Peng X, Li G, Tian W, He M, Li X (2013) Predictive value of miR-9 as a potential biomarker for nasopharyngeal carcinoma metastasis. Br J Cancer 110: 392\u2013398.","journal-title":"Br J Cancer"},{"key":"BFbjc2017385_CR26","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1096\/fj.09-151639","volume":"24","author":"MG Mendez","year":"2010","unstructured":"Mendez MG, Kojima SI, Goldman RD (2010) Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J 24: 1838\u20131851.","journal-title":"FASEB J"},{"key":"BFbjc2017385_CR27","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/bjc.1998.86","volume":"77","author":"T Meyer","year":"1998","unstructured":"Meyer T, Marshall JF, Hart IR (1998) Expression of alphav integrins and vitronectin receptor identity in breast cancer cells. Br J Cancer 77: 530\u2013536.","journal-title":"Br J Cancer"},{"key":"BFbjc2017385_CR28","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.3892\/or.2015.3913","volume":"33","author":"C Ou","year":"2015","unstructured":"Ou C, Sun Z, Zhang HAN, Xiong WEI, Ma J, Zhou M, Lu J, Zeng Z, Bo X, Chen PAN, Li G, Li X, Li X (2015) SPLUNC1 reduces the inflammatory response of nasopharyngeal carcinoma cells infected with the EB virus by inhibiting the TLR9\/NF-\u03baB pathway. Oncol Rep 33: 2779\u20132788.","journal-title":"Oncol Rep"},{"key":"BFbjc2017385_CR29","doi-asserted-by":"publisher","first-page":"20500","DOI":"10.1038\/srep20500","volume":"6","author":"C Peng","year":"2016","unstructured":"Peng C, Li Z, Niu Z, Niu W, Xu Z, Gao H, Niu W, Wang J, He Z, Gao C, Lin P, Agrez M, Zhang Z, Niu J (2016) Norcantharidin suppresses colon cancer cell epithelial-mesenchymal transition by inhibiting the \u03b1v\u03b26-ERK-Ets1 signaling pathway. Sci Rep 6: 20500.","journal-title":"Sci Rep"},{"key":"BFbjc2017385_CR30","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.1182\/blood-2012-08-451187","volume":"121","author":"V Pirazzoli","year":"2013","unstructured":"Pirazzoli V, Ferraris GM, Sidenius N (2013) Direct evidence of the importance of vitronectin and its interaction with the urokinase receptor in tumor growth. Blood 121: 2316\u20132323.","journal-title":"Blood"},{"key":"BFbjc2017385_CR31","doi-asserted-by":"publisher","first-page":"7529","DOI":"10.1074\/jbc.M109675200","volume":"277","author":"TJ Podor","year":"2001","unstructured":"Podor TJ, Singh D, Chindemi P, Foulon DM, McKelvie R, Weitz JI, Austin R, Boudreau G, Davies R (2001) Vimentin exposed on activated platelets and platelet microparticles localizes vitronectin and plasminogen activator inhibitor complexes on their surface. J Biol Chem 277: 7529\u20137539.","journal-title":"J Biol Chem"},{"key":"BFbjc2017385_CR32","doi-asserted-by":"publisher","first-page":"4571","DOI":"10.1158\/0008-5472.CAN-13-0218","volume":"73","author":"C Pola","year":"2013","unstructured":"Pola C, Formenti SC, Schneider RJ (2013) Vitronectin-alphavbeta3 integrin engagement directs hypoxia-resistant mTOR activity and sustained protein synthesis linked to invasion by breast cancer cells. Cancer Res 73: 4571\u20134578.","journal-title":"Cancer Res"},{"key":"BFbjc2017385_CR33","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1016\/j.ejca.2010.04.004","volume":"46","author":"ARA Razak","year":"2010","unstructured":"Razak ARA, Siu LL, Liu FF, Ito E, O\u2019Sullivan B, Chan K (2010) Nasopharyngeal carcinoma: the next challenges. Eur J Cancer 46: 1967\u20131978.","journal-title":"Eur J Cancer"},{"key":"BFbjc2017385_CR34","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1002\/jcb.23111","volume":"112","author":"U Reuning","year":"2011","unstructured":"Reuning U (2011) Integrin \u03b1v\u03b23 promotes vitronectin gene expression in human ovarian cancer cells by implicating rel transcription factors. J Cell Biochem 112: 1909\u20131919.","journal-title":"J Cell Biochem"},{"key":"BFbjc2017385_CR35","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1038\/sj.onc.1210422","volume":"26","author":"PJ Roberts","year":"2007","unstructured":"Roberts PJ, Der CJ (2007) Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 26: 3291\u20133310.","journal-title":"Oncogene"},{"key":"BFbjc2017385_CR36","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1126\/science.2821619","volume":"238","author":"E Ruoslahti","year":"1987","unstructured":"Ruoslahti E, Pierschbacher MD, Liotta LA, Kohn EC, Barnes D, Wolfe R, Serrero G, McClure D, Sato G (1987) New perspectives in cell adhesion: RGD and integrins. Science 238: 491\u2013497.","journal-title":"Science"},{"key":"BFbjc2017385_CR37","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1007\/s00018-011-0735-1","volume":"68","author":"A Satelli","year":"2011","unstructured":"Satelli A, Li S (2011) Vimentin in cancer and its potential as a molecular target for cancer therapy. Cell Mol Life Sci 68: 3033\u20133046.","journal-title":"Cell Mol Life Sci"},{"key":"BFbjc2017385_CR38","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/bjc.2015.358","volume":"113","author":"C Siret","year":"2015","unstructured":"Siret C, Terciolo C, Dobric A, Habib MC, Germain S, Bonnier R, Lombardo D, Rigot V, Andre F (2015) Interplay between cadherins and alpha2beta1 integrin differentially regulates melanoma cell invasion. Br J Cancer 113: 1445\u20131453.","journal-title":"Br J Cancer"},{"key":"BFbjc2017385_CR39","doi-asserted-by":"publisher","first-page":"4153","DOI":"10.1073\/pnas.1703931114","volume":"114","author":"ES Sokol","year":"2017","unstructured":"Sokol ES, Feng Y-X, Jin DX, Tizabi MD, Miller DH, Cohen MA, Sanduja S, Reinhardt F, Pandey J, Superville DA, Jaenisch R, Gupta PB (2017) SMARCE1 is required for the invasive progression of in situ cancers. Proc Natl Acad Sci USA 114: 4153\u20134158.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFbjc2017385_CR40","doi-asserted-by":"crossref","first-page":"36783","DOI":"10.18632\/oncotarget.9170","volume":"7","author":"Y Song","year":"2016","unstructured":"Song Y, Li X, Zeng Z, Li Q, Gong Z, Liao Q, Li X, Chen P, Xiang B, Zhang W, Xiong F, Zhou Y, Zhou M, Ma J, Li Y, Chen X, Li G, Xiong W (2016) Epstein\u2013Barr virus encoded miR-BART11 promotes inflammation-induced carcinogenesis by targeting FOXP1. Oncotarget 7: 36783\u201336799.","journal-title":"Oncotarget"},{"key":"BFbjc2017385_CR41","doi-asserted-by":"crossref","first-page":"39001","DOI":"10.18632\/oncotarget.16545","volume":"8","author":"Y Tang","year":"2017","unstructured":"Tang Y, He Y, Shi L, Yang L, Wang J, Lian Y, Fan C, Zhang P, Guo C, Zhang S, Gong Z, Li X, Xiong F, Li X, Li Y, Li G, Xiong W, Zeng Z (2017) Co-expression of AFAP1-AS1 and PD-1 predicts poor prognosis in nasopharyngeal carcinoma. Oncotarget 8: 39001\u201339011.","journal-title":"Oncotarget"},{"key":"BFbjc2017385_CR42","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","volume":"139","author":"JP Thiery","year":"2009","unstructured":"Thiery JP, Acloque H, Huang RYJ, Nieto MA (2009) Epithelial\u2013mesenchymal transitions in development and disease. Cell 139: 871\u2013890.","journal-title":"Cell"},{"key":"BFbjc2017385_CR43","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/bjc.2013.715","volume":"110","author":"YM Tian","year":"2013","unstructured":"Tian YM, Tian YH, Zeng L, Liu S, Guan Y, Lu TX, Han F (2013) Prognostic model for survival of local recurrent nasopharyngeal carcinoma with intensity-modulated radiotherapy. Br J Cancer 110: 297\u2013303.","journal-title":"Br J Cancer"},{"key":"BFbjc2017385_CR44","doi-asserted-by":"publisher","first-page":"e00301","DOI":"10.1128\/JVI.00301-17","volume":"91","author":"C Tu","year":"2017","unstructured":"Tu C, Zeng Z, Qi P, Li X, Yu Z, Guo C, Xiong F, Xiang B, Zhou M, Gong Z, Liao Q, Yu J, He Y, Zhang W, Li X, Li Y, Li G, Xiong W, Sandri-Goldin RM (2017) Genome-wide analysis of 18 Epstein\u2013Barr viruses isolated from primary nasopharyngeal carcinoma biopsy specimens. J Virol 91: e00301\u2013e00317.","journal-title":"J Virol"},{"key":"BFbjc2017385_CR45","first-page":"1587","volume":"5","author":"JH Uhm","year":"1999","unstructured":"Uhm JH, Dooley NP, Kyritsis AP, Rao JS, Gladson CL (1999) Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death. Clin Cancer Res 5: 1587\u20131594.","journal-title":"Clin Cancer Res"},{"key":"BFbjc2017385_CR46","doi-asserted-by":"publisher","first-page":"761","DOI":"10.7150\/jca.17648","volume":"8","author":"M Wang","year":"2017","unstructured":"Wang M, Zhao J, Zhang L, Wei F, Lian Y, Wu Y, Gong Z, Zhang S, Zhou J, Cao K, Li X, Xiong W, Li G, Zeng Z, Guo C (2017) Role of tumor microenvironment in tumorigenesis. J Cancer 8: 761\u2013773.","journal-title":"J Cancer"},{"key":"BFbjc2017385_CR47","first-page":"24","volume":"41","author":"F Wei","year":"2014","unstructured":"Wei F, Li XL, Li XY, Zhang WL, Liao QJ, Zeng Y, Gong ZJ, Zhou M, Ma J, Xiong W, Shen SR, Zeng Z (2014) The effect and mechanism of PLUNC protein family against inflammation and carcinogenesis of nasopharyngeal carcinoma. Prog Biochem Biophys 41: 24\u201331.","journal-title":"Prog Biochem Biophys"},{"key":"BFbjc2017385_CR48","doi-asserted-by":"publisher","first-page":"13698","DOI":"10.1074\/jbc.274.19.13698","volume":"274","author":"WM Weston","year":"1999","unstructured":"Weston WM, LeClair EE, Trzyna W, McHugh KM, Nugent P, Lafferty CM, Ma L, Tuan RS, Greene RM (1999) Differential display identification of plunc, a novel gene expressed in embryonic palate, nasal epithelium, and adult lung. J Biol Chem 274: 13698\u201313703.","journal-title":"J Biol Chem"},{"key":"BFbjc2017385_CR49","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1158\/0008-5472.CAN-03-3253","volume":"64","author":"W Xiong","year":"2004","unstructured":"Xiong W, Zeng ZY, Xia JH, Xia K, Shen SR, Li XL, Hu DX, Tan C, Xiang JJ, Zhou J, Deng H, Fan SQ, Li WF, Wang R, Zhou M, Zhu SG, Lu HB, Qian J, Zhang BC, Wang JR, Ma J, Xiao BY, Huang H, Zhang QH, Zhou YH, Luo XM, Zhou HD, Yang YX, Dai HP, Feng GY, Pan Q, Wu LQ, He L, Li GY, Chua ML, Wee JT, Hui EP, Chan AT, Lo KW, Huang DP, Zeng Z, Huang H, Zhang W, Xiang B, Zhou M, Zhou Y, Ma J, Yi M, Li X, Li X, Xiong W, Li G, Lo KW, To KF, Huang DP (2004) A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma Nasopharyngeal carcinoma. Cancer Res 64: 1972\u20131974.","journal-title":"Cancer Res"},{"key":"BFbjc2017385_CR50","doi-asserted-by":"crossref","first-page":"41766","DOI":"10.18632\/oncotarget.6155","volume":"6","author":"QJ Yan","year":"2015","unstructured":"Yan QJ, Zeng ZY, Gong ZJ, Zhang WL, Li XY, He BY, Song YL, Li Q, Zeng Y, Liao Q, Chen P, Shi L, Fan S, Xiang B, Ma J, Zhou M, Li X, Yang J, Xiong W, Li G (2015) EBV-miR-BART10-3p facilitates epithelial\u2013mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC. Oncotarget 6: 41766\u201341782.","journal-title":"Oncotarget"},{"key":"BFbjc2017385_CR51","doi-asserted-by":"publisher","first-page":"e62869","DOI":"10.1371\/journal.pone.0062869","volume":"8","author":"Y Yang","year":"2013","unstructured":"Yang Y, Liao Q, Wei F, Li X, Zhang W, Fan S, Shi L, Li X, Gong Z, Ma J, Zhou M, Xiang J, Peng S, Xiang B, Deng H, Yang Y, Li Y, Xiong W, Zeng Z, Li G (2013) LPLUNC1 inhibits nasopharyngeal carcinoma cell growth via down-regulation of the MAP kinase and cyclin D1\/E2F pathways. PLoS One 8: e62869.","journal-title":"PLoS One"},{"key":"BFbjc2017385_CR52","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s12094-015-1354-3","volume":"18","author":"Z Zeng","year":"2015","unstructured":"Zeng Z, Fan S, Zhang X, Li S, Zhou M, Xiong W, Tan M, Zhang W, Li G (2015) Epstein\u2013Barr virus-encoded small RNA 1 (EBER-1) could predict good prognosis in nasopharyngeal carcinoma. Clin Transl Oncol 18: 206\u2013211.","journal-title":"Clin Transl Oncol"},{"key":"BFbjc2017385_CR53","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s11427-013-4577-y","volume":"57","author":"Z Zeng","year":"2014","unstructured":"Zeng Z, Huang H, Huang L, Sun M, Yan Q, Song Y, Wei F, Bo H, Gong Z, Zeng Y, Li Q, Zhang W, Li X, Xiang B, Li X, Li Y, Xiong W, Li G (2014) Regulation network and expression profiles of Epstein\u2013Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomas. Sci China Life Sci 57: 315\u2013326.","journal-title":"Sci China Life Sci"},{"key":"BFbjc2017385_CR54","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1007\/s11427-011-4223-5","volume":"54","author":"Z Zeng","year":"2011","unstructured":"Zeng Z, Huang H, Zhang W, Xiang B, Zhou M, Zhou Y, Ma J, Yi M, Li X, Li X, Xiong W, Li G (2011) Nasopharyngeal carcinoma: advances in genomics and molecular genetics. Sci China Life Sci 54: 966\u2013975.","journal-title":"Sci China Life Sci"},{"key":"BFbjc2017385_CR55","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1002\/gcc.10247","volume":"38","author":"B Zhang","year":"2003","unstructured":"Zhang B, Nie X, Xiao B, Xiang J, Shen S, Gong J, Zhou M, Zhu S, Zhou J, Qian J, Lu H, He X, Li X, Hu G, Li G (2003) Identification of tissue-specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray. Genes Chromosomes Cancer 38: 80\u201390.","journal-title":"Genes Chromosomes Cancer"},{"key":"BFbjc2017385_CR56","doi-asserted-by":"publisher","first-page":"4815","DOI":"10.1111\/febs.13020","volume":"281","author":"W Zhang","year":"2014","unstructured":"Zhang W, Zeng Z, Wei F, Chen P, Schmitt DC, Fan S, Guo X, Liang F, Shi L, Liu Z, Zhang Z, Xiang B, Zhou M, Huang D, Tang K, Li X, Xiong W, Tan M, Li G, Li X (2014) SPLUNC1 is associated with nasopharyngeal carcinoma prognosis and plays an important role in all-trans-retinoic acid-induced growth inhibition and differentiation in nasopharyngeal cancer cells. FEBS J 281: 4815\u20134829.","journal-title":"FEBS J"},{"key":"BFbjc2017385_CR57","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00418-005-0070-4","volume":"125","author":"HD Zhou","year":"2005","unstructured":"Zhou HD, Fan SQ, Zhao J, Huang DH, Zhou M, Liu HY, Zeng ZY, Yang YX, Huang H, Li XL, Shen SR, Li G-Y (2005) Tissue distribution of the secretory protein, SPLUNC1, in the human fetus. Histochem Cell Biol 125: 315\u2013324.","journal-title":"Histochem Cell Biol"},{"key":"BFbjc2017385_CR58","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s11010-007-9659-3","volume":"309","author":"HD Zhou","year":"2007","unstructured":"Zhou HD, Li XL, Li GY, Zhou M, Liu HY, Yang YX, Deng T, Ma J, Sheng SR (2007) Effect of SPLUNC1 protein on the pseudomonas aeruginosa and Epstein\u2013Barr virus. Mol Cell Biochem 309: 191\u2013197.","journal-title":"Mol Cell Biochem"},{"key":"BFbjc2017385_CR59","doi-asserted-by":"publisher","first-page":"367","DOI":"10.7150\/jca.13695","volume":"7","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Liao Q, Li X, Wang H, Wei F, Chen J, Yang J, Zeng Z, Guo X, Chen P, Zhang W, Tang K, Li X, Xiong W, Li G (2016) HYOU1, regulated by LPLUNC1, is up-regulated in nasopharyngeal carcinoma and associated with poor prognosis. J Cancer 7: 367\u2013376.","journal-title":"J Cancer"}],"container-title":["British Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/bjc2017385.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2017385","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/bjc.2017.385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/bjc2017385.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:40:14Z","timestamp":1684417214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bjc2017385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,9]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["BFbjc2017385"],"URL":"https:\/\/doi.org\/10.1038\/bjc.2017.385","relation":{},"ISSN":["0007-0920","1532-1827"],"issn-type":[{"value":"0007-0920","type":"print"},{"value":"1532-1827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,9]]},"assertion":[{"value":"24 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}