{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:08:08Z","timestamp":1790417288372,"version":"4.1.0"},"reference-count":156,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>The vasoconstrictor substance named serotonin was identified as 5\u2010hydroxytryptamine (5\u2010HT) by Maurice Rapport in 1949. In 1951, Rapport gave Gaddum samples of 5\u2010HT substance allowing him to develop a bioassay to both detect and measure the amine. Gaddum and colleagues rapidly identified 5\u2010HT in brain and showed that lysergic acid diethylamide (LSD) antagonized its action in peripheral tissues. Gaddum accordingly postulated that 5\u2010HT might have a role in mood regulation. This review examines the role of UK scientists in the first 20 years following these major discoveries, discussing their role in developing assays for 5\u2010HT in the CNS, identifying the enzymes involved in the synthesis and metabolism of 5\u2010HT and investigating the effect of drugs on brain 5\u2010HT. It reviews studies on the effects of LSD in humans, including Gaddum's self\u2010administration experiments. It outlines investigations on the role of 5\u2010HT in psychiatric disorders, including studies on the effect of antidepressant drugs on the 5\u2010HT concentration in rodent and human brain, and the attempts to examine 5\u2010HT biochemistry in the brains of patients with depressive illness. It is clear that a rather small group of both preclinical scientists and psychiatrists in the UK made major advances in our understanding of the role of 5\u2010HT in the brain, paving the way for much of the knowledge now taken for granted when discussing ways that 5\u2010HT might be involved in the control of mood and the idea that therapeutic drugs used to alleviate psychiatric illness might alter the function of cerebral 5\u2010HT.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(2008)<jats:bold>154<\/jats:bold>, 1583\u20131599; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/bjp.2008.207\">10.1038\/bjp.2008.207<\/jats:ext-link>; published online 26 May 2008<\/jats:p>","DOI":"10.1038\/bjp.2008.207","type":"journal-article","created":{"date-parts":[[2008,6,2]],"date-time":"2008-06-02T10:15:03Z","timestamp":1212401703000},"page":"1583-1599","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Gaddum and LSD: the birth and growth of experimental and clinical neuropharmacology research on 5\u2010HT in the UK"],"prefix":"10.1111","volume":"154","author":[{"given":"A 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