{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:15:54Z","timestamp":1788999354355,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":212,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:sec><jats:title>Background and purpose:<\/jats:title><jats:p>Recently, we reported that 12(<jats:italic>S<\/jats:italic>)\u2010HPETE (12(<jats:italic>S<\/jats:italic>)\u2010hydroperoxyeicosa\u20105Z,8Z,10E,14Z\u2010tetraenoic acid) induces scratching in ICR mice. We hypothesized that 12(<jats:italic>S<\/jats:italic>)\u2010HPETE might act as an agonist of the low\u2010affinity leukotriene B<jats:sub>4<\/jats:sub> receptor BLT<jats:sub>2<\/jats:sub>. To confirm the involvement of the BLT<jats:sub>2<\/jats:sub> receptor in 12(<jats:italic>S<\/jats:italic>)\u2010HPETE\u2010induced scratching, we studied the scratch response using the BLT<jats:sub>2<\/jats:sub> receptor agonists compound A (4\u2032\u2010{[pentanoyl (phenyl) amino]methyl}\u20101,1\u2032\u2010biphenyl\u20102\u2010carboxylic acid) and 12(<jats:italic>S<\/jats:italic>)\u2010HETE (12(<jats:italic>S<\/jats:italic>)\u2010hydroxyeicosa\u20105Z,8Z,10E,14Z\u2010tetraenoic acid).<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental approach:<\/jats:title><jats:p>A video recording was used to determine whether the BLT<jats:sub>2<\/jats:sub> receptor agonists caused itch\u2010associated scratching in ICR mice. Selective antagonists and several chemicals were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results:<\/jats:title><jats:p>Both 12(<jats:italic>S<\/jats:italic>)\u2010HETE and compound A dose dependently induced scratching in the ICR mice. The dose\u2013response curve for compound A showed peaks at around 0.005\u20130.015\u2003nmol per site. Compound A\u2010 and 12(<jats:italic>S<\/jats:italic>)\u2010HETE\u2010induced scratching was suppressed by capsaicin and naltrexon. We examined the suppressive effects of U75302 (6\u2010[6\u2010(3\u2010hydroxy\u20101E,5Z\u2010undecadienyl)\u20102\u2010pyridinyl]\u20101,5\u2010hexanediol, the BLT<jats:sub>1<\/jats:sub> receptor antagonist) and LY255283 (1\u2010[5\u2010ethyl\u20102\u2010hydroxy\u20104\u2010[[6\u2010methyl\u20106\u2010(1<jats:italic>H<\/jats:italic>\u2010tetrazol\u20105\u2010yl)heptyl]oxy]phenyl]\u2010ethanone, the BLT<jats:sub>2<\/jats:sub> receptor antagonist) on the BLT<jats:sub>2<\/jats:sub> agonist\u2010induced scratching. LY255283 suppressed compound A\u2010 and 12(S)\u2010HETE\u2010induced scratching, but U75302 did not. LY255283 required a higher dose to suppress the compound A\u2010induced scratching than it did to suppress the 12(<jats:italic>S<\/jats:italic>)\u2010HETE\u2010induced scratching. One of the BLT<jats:sub>2<\/jats:sub> receptor agonists, 12(<jats:italic>R<\/jats:italic>)\u2010HETE (12(<jats:italic>R<\/jats:italic>)\u2010hydroxyeicosa\u20105Z,8Z,10E,14Z\u2010tetraenoic acid), also induced scratching in the ICR mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and implications:<\/jats:title><jats:p>Our present results corroborate the hypothesis that the BLT<jats:sub>2<\/jats:sub> receptor is involved in 12(<jats:italic>S<\/jats:italic>)\u2010lipoxygenase\u2010product\u2010induced scratching in ICR mice. We also confirmed that this animal model could be a valuable means of evaluating the effects of BLT<jats:sub>2<\/jats:sub> receptor antagonists.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2008) <jats:bold>154<\/jats:bold>, 1073\u20131078; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/bjp.2008.220\">10.1038\/bjp.2008.220<\/jats:ext-link>; published online 9 June 2008<\/jats:p><\/jats:sec>","DOI":"10.1038\/bjp.2008.220","type":"journal-article","created":{"date-parts":[[2008,6,9]],"date-time":"2008-06-09T10:28:59Z","timestamp":1213007339000},"page":"1073-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Involvement of the BLT<sub>2<\/sub> receptor in the itch\u2010associated scratching induced by 12\u2010(<i>S<\/i>)\u2010lipoxygenase products in ICR mice"],"prefix":"10.1111","volume":"154","author":[{"given":"H 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