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The aim of this study was to determine the effect of oxytocin and AVP on peripheral tissues involved in ejaculation and to identify the receptor subtype(s) involved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental approach:<\/jats:title><jats:p>Standard tissue bath techniques were used to measure isometric tension from tissues involved in ejaculation and erection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results:<\/jats:title><jats:p>Oxytocin and AVP failed to elicit a tonic contractile response in rat and rabbit testes, vas deferens, epididymis, seminal vesicles and prostate. In contrast, oxytocin and AVP elicited large tonic contractions in erectile (corpus spongiosum and corpus cavernosum) and ejaculatory (prostatic urethra, bladder neck and ejaculatory duct) tissues in a concentration\u2010dependent manner. The selective oxytocin agonist, [Thr<jats:sup>4<\/jats:sup>,Gly<jats:sup>7<\/jats:sup>]\u2010oxytocin and the V<jats:sub>2<\/jats:sub>agonist, [deamino\u2010Cys<jats:sup>1<\/jats:sup>,Val<jats:sup>4<\/jats:sup>,D\u2010Arg<jats:sup>8<\/jats:sup>]\u2010vasopressin (dDAVP), failed to contract tissues. Oxytocin and AVP\u2010induced contractions were weakly antagonized by the selective oxytocin antagonist, L\u2010368899 but potently antagonized by the V<jats:sub>1A<\/jats:sub>antagonist, SR49059. The V<jats:sub>1B<\/jats:sub>antagonist SSR149415 failed to antagonize AVP contractions except in rabbit bladder neck. Neither L\u2010368899 nor SR49059 antagonized endothelin\u20101\u2010induced contractions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and implications:<\/jats:title><jats:p>The contractile effect of oxytocin on rat and rabbit ejaculatory and erectile tissues is mediated via V<jats:sub>1A<\/jats:sub>receptors. Endothelin\u20101\u2010induced contractions are not due to endogenous oxytocin or AVP release. V<jats:sub>1A<\/jats:sub>receptor antagonists may have a therapeutic role in both erectile dysfunction and premature ejaculation.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic>(2008)<jats:bold>155<\/jats:bold>, 118\u2013126; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/bjp.2008.226\">10.1038\/bjp.2008.226<\/jats:ext-link>; published online 16 June 2008<\/jats:p><\/jats:sec>","DOI":"10.1038\/bjp.2008.226","type":"journal-article","created":{"date-parts":[[2008,6,16]],"date-time":"2008-06-16T10:18:02Z","timestamp":1213611482000},"page":"118-126","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Oxytocin\u2010induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V<sub>1A<\/sub>receptors and not oxytocin 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