{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:49:05Z","timestamp":1783493345489,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>The failure of the cholesterol ester transfer protein (CETP) inhibitor, torcetrapib, has led to questions regarding whether the molecule itself or the mechanism of CETP inhibition was responsible for the adverse cardiovascular outcomes. Given the association with increases in blood pressure and plasma aldosterone levels, torcetrapib has been postulated to have adverse \u2018off\u2010target\u2019 effects. In this issue of British Journal of Pharmacology, Forrest and co\u2010workers have elegantly investigated these effects, demonstrating two salient points\u2014(1) the pressor effect of torcetrapib is independent of CETP inhibition and (2) although associated with hyperaldosteronism, the pressor effect is likely not mediated by hyperaldosteronism. Anacetrapib, by contrast, did not demonstrate any pressor or off\u2010target effects. Despite these findings, it remains to be proven whether the adverse cardiovascular outcomes from torcetrapib were indeed related to the pressor effects and whether CETP inhibition by other agents will result in beneficial clinical outcomes. Yet, the studies of Forrest and co\u2010workers do bring us closer to unravelling the reasons behind the failure of torcetrapib.<\/jats:p><jats:p> <jats:italic>British Journal of Pharmacology<\/jats:italic> (2008) <jats:bold>154<\/jats:bold>, 1379\u20131381; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"fn1\">fn1<\/jats:ext-link>; published online 9 June 2008<\/jats:p>","DOI":"10.1038\/bjp.2008.248","type":"journal-article","created":{"date-parts":[[2008,6,9]],"date-time":"2008-06-09T10:28:59Z","timestamp":1213007339000},"page":"1379-1381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The failure of torcetrapib: what have we learned?"],"prefix":"10.1111","volume":"154","author":[{"given":"T R","family":"Joy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Hegele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706628"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61088-5"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.229"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011013231803"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2489"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071359"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61813-3"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.12.064"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070635"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/35018119"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000256728.60226.77"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fbjp.2008.248","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fbjp.2008.248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/bjp.2008.248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:09:11Z","timestamp":1694563751000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/bjp.2008.248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["10.1038\/bjp.2008.248"],"URL":"https:\/\/doi.org\/10.1038\/bjp.2008.248","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"2009-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}