{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T04:48:35Z","timestamp":1755838115951},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:sec><jats:title>Background and purpose:<\/jats:title><jats:p>VGX\u20101027 is a novel, low molecular weight, immunomodulatory compound that has shown efficacy against a variety of immuno\u2010inflammatory disease models in animals including autoimmune diabetes in NOD mice, collagen\u2010induced arthritis and chemically induced inflammatory colitis. Here, we have studied the effects of VGX\u20101027 on the development of endotoxin\u2010induced uveitis (EIU) in male Lewis rats, as a model of inflammatory ocular diseases in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental approach:<\/jats:title><jats:p>EIU was induced by a single footpad injection of 200\u2003\u03bcg lipopolysaccharide (LPS). Groups of rats were treated with either VGX\u20101027 (25\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) or its vehicle at different time points (30\u2003min, 6\u2003h or 12\u2003h) after the challenge with LPS or, as positive control, with dexamethasone. The rats were killed within 16\u2003h after LPS challenge, and the eyes and aqueous humor were collected to study serological, immunological and histological signs of EIU.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results:<\/jats:title><jats:p>The rats treated with VGX\u20101027 within 6\u2003h after LPS challenge exhibited milder clinical, histological and laboratory signs of EIU than those treated with vehicle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and implications:<\/jats:title><jats:p>This study provides the first evidence that systemic treatment with VGX\u20101027 counteracts the uveitis\u2010inducing effect of LPS in rats and suggests that this drug may have potential in the treatment of immuno\u2010inflammatory conditions of the eye in humans.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2008) <jats:bold>155<\/jats:bold>, 722\u2013730; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" 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