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In this report, we describe the pharmacological characteristics of MDA7 (1\u2010[(3\u2010benzyl\u20103\u2010methyl\u20102,3\u2010dihydro\u20101\u2010benzofuran\u20106\u2010yl)carbonyl]piperidine), a novel CB<jats:sub>2<\/jats:sub> receptor agonist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental approach:<\/jats:title><jats:p>We characterized the pharmacological profile of MDA7 by using radioligand\u2010binding assays and <jats:italic>in vitro<\/jats:italic> functional assays at human cannabinoid type 1 (CB<jats:sub>1<\/jats:sub>) and CB<jats:sub>2<\/jats:sub> receptors. <jats:italic>In vitro<\/jats:italic> functional assays were performed at rat CB<jats:sub>1<\/jats:sub> and CB<jats:sub>2<\/jats:sub> receptors. The effects of MDA7 in reversing neuropathic pain were assessed in spinal nerve ligation and paclitaxel\u2010induced neuropathy models in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results:<\/jats:title><jats:p>MDA7 exhibited selectivity and agonist affinity at human and rat CB<jats:sub>2<\/jats:sub> receptors. MDA7 treatment attenuated tactile allodynia produced by spinal nerve ligation or by paclitaxel in a dose\u2010related manner. These effects were selectively antagonized by a CB<jats:sub>2<\/jats:sub> receptor antagonist but not by CB<jats:sub>1<\/jats:sub> or opioid receptor antagonists. MDA7 did not affect rat locomotor activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and implications:<\/jats:title><jats:p>MDA7, a novel selective CB<jats:sub>2<\/jats:sub> agonist, was effective in suppressing neuropathic nociception in two rat models without affecting locomotor behaviour. These results confirm the potential for CB<jats:sub>2<\/jats:sub> agonists in the treatment of neuropathic pain.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2008) <jats:bold>155<\/jats:bold>, 1104\u20131116; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1038\/bjp.2008.340\">10.1038\/bjp.2008.340<\/jats:ext-link>; published online 1 September 2008<\/jats:p><\/jats:sec>","DOI":"10.1038\/bjp.2008.340","type":"journal-article","created":{"date-parts":[[2008,8,25]],"date-time":"2008-08-25T10:37:44Z","timestamp":1219660664000},"page":"1104-1116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["MDA7: a novel selective agonist for CB<sub>2<\/sub> receptors that prevents allodynia in rat neuropathic pain 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