{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:27:22Z","timestamp":1762100842520},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,29]],"date-time":"2009-01-29T00:00:00Z","timestamp":1233187200000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>Identification of C\u2010polymodal nociceptors and the selective action of capsaicin on them by acting on a putative receptor, which has been cloned 11 years ago, initiated a burst of interest in pharmacology of nociceptors. Capsaicin receptor transient receptor potential vanilloid\u20101 (TRPV1) being a noxious heat\u2010gated cation channel gated also by several exogenous and endogenous substances serves as a nocisensor to generate graded receptor potentials in these sense organs. Impressive data on pathways involved in sensitization\/desensitization of the channel revealed in isolated cells should also validate at the level of nerve endings and lipid raft around TRPV1 could modify the channel gating. Capsaicin\u2010sensitive nociceptors subserve dual sensory\u2010efferent functions: tachykinins and calcitonin gene\u2010related peptide released from them elicit local tissue responses as neurogenic inflammation and release of somatostatin evokes systemic anti\u2010inflammatory and antihyperalgesic effects. TRPV1 gene\u2010deleted mice show subtle changes in physiological regulations, therefore TRPV1 is a promising but challenging target for drug research.<\/jats:p><jats:p><jats:italic>British Journal of Pharmacology<\/jats:italic> (2008) <jats:bold>155<\/jats:bold>, 1142\u20131144; doi:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"doi\" xlink:href=\"fn1\">fn1<\/jats:ext-link>; published online 10 November 2008<\/jats:p>","DOI":"10.1038\/bjp.2008.374","type":"journal-article","created":{"date-parts":[[2008,11,10]],"date-time":"2008-11-10T10:44:54Z","timestamp":1226313894000},"page":"1142-1144","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Hot target on nociceptors: perspectives, caveats and unique features"],"prefix":"10.1111","volume":"155","author":[{"given":"J","family":"Szolcs\u00e1nyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,29]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1969.32.6.1025"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00446.2006"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.351"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.05.027"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.012"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61079-1"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.087874"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)61097-3"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780203219973.ch28"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702144"},{"key":"e_1_2_4_12_1","first-page":"113","volume-title":"Hyperalgesia: Molecular Mechanisms and Clinical Implications","author":"Szolcs\u00e1nyi J","year":"2004"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.05.015"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Fbjp.2008.374","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/bjp.2008.374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T11:25:10Z","timestamp":1697109910000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1038\/bjp.2008.374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["10.1038\/bjp.2008.374"],"URL":"https:\/\/doi.org\/10.1038\/bjp.2008.374","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12]]},"assertion":[{"value":"2009-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}