{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:12:15Z","timestamp":1761894735808,"version":"3.35.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2008,6,16]],"date-time":"2008-06-16T00:00:00Z","timestamp":1213574400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,6,16]],"date-time":"2008-06-16T00:00:00Z","timestamp":1213574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1038\/bmt.2008.166","type":"journal-article","created":{"date-parts":[[2008,6,16]],"date-time":"2008-06-16T11:05:17Z","timestamp":1213614317000},"page":"259-264","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of additional cytoreduction following autologous SCT in multiple myeloma"],"prefix":"10.1038","volume":"42","author":[{"given":"S K","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Dingli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Dispenzieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Q","family":"Lacy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S R","family":"Hayman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F K","family":"Buadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S V","family":"Rajkumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R","family":"Litzow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Gertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,6,16]]},"reference":[{"key":"BFbmt2008166_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1056\/NEJM199607113350204","volume":"335","author":"M Attal","year":"1996","unstructured":"Attal M, Harousseau JL, Stoppa AM, Sotto JJ, Fuzibet JG, Rossi JF et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Francais du Myelome. N Engl J Med 1996; 335: 91\u201397.","journal-title":"N Engl J Med"},{"key":"BFbmt2008166_CR2","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1056\/NEJMoa022340","volume":"348","author":"JA Child","year":"2003","unstructured":"Child JA, Morgan GJ, Davies FE, Owen RG, Bell SE, Hawkins K et al. High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med 2003; 348: 1875\u20131883.","journal-title":"N Engl J Med"},{"key":"BFbmt2008166_CR3","doi-asserted-by":"publisher","first-page":"9227","DOI":"10.1200\/JCO.2005.03.0551","volume":"23","author":"JP Fermand","year":"2005","unstructured":"Fermand JP, Katsahian S, Divine M, Leblond V, Dreyfus F, Macro M et al. High-dose therapy and autologous blood stem-cell transplantation compared with conventional treatment in myeloma patients aged 55\u201365 years: long-term results of a randomized control trial from the Group Myelome-Autogreffe. J Clin Oncol 2005; 23: 9227\u20139233.","journal-title":"J Clin Oncol"},{"key":"BFbmt2008166_CR4","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1182\/blood.V92.9.3131","volume":"92","author":"JP Fermand","year":"1998","unstructured":"Fermand JP, Ravaud P, Chevret S, Divine M, Leblond V, Belanger C et al. High-dose therapy and autologous peripheral blood stem cell transplantation in multiple myeloma: up-front or rescue treatment? Results of a multicenter sequential randomized clinical trial. Blood 1998; 92: 3131\u20133136.","journal-title":"Blood"},{"key":"BFbmt2008166_CR5","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/sj.bmt.1701763","volume":"23","author":"P Moreau","year":"1999","unstructured":"Moreau P, Milpied N, Mahe B, Juge-Morineau N, Rapp MJ, Bataille R et al. Melphalan 220\u2009mg\/m2 followed by peripheral blood stem cell transplantation in 27 patients with advanced multiple myeloma. Bone Marrow Transplant 1999; 23: 1003\u20131006.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008166_CR6","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1046\/j.1365-2141.1996.d01-1932.x","volume":"95","author":"P Moreau","year":"1996","unstructured":"Moreau P, Kergueris MF, Milpied N, Le Tortorec S, Mahe B, Bulabois CE et al. A pilot study of 220\u2009mg\/m2 melphalan followed by autologous stem cell transplantation in patients with advanced haematological malignancies: pharmacokinetics and toxicity. Br J Haematol 1996; 95: 527\u2013530.","journal-title":"Br J Haematol"},{"key":"BFbmt2008166_CR7","doi-asserted-by":"publisher","first-page":"2684","DOI":"10.1182\/blood-2002-10-3250","volume":"102","author":"S Giralt","year":"2003","unstructured":"Giralt S, Bensinger W, Goodman M, Podoloff D, Eary J, Wendt R et al. 166Ho-DOTMP plus melphalan followed by peripheral blood stem cell transplantation in patients with multiple myeloma: results of two phase 1\/2 trials. Blood 2003; 102: 2684\u20132691.","journal-title":"Blood"},{"key":"BFbmt2008166_CR8","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1056\/NEJMoa032290","volume":"349","author":"M Attal","year":"2003","unstructured":"Attal M, Harousseau JL, Facon T, Guilhot F, Doyen C, Fuzibet JG et al. Single versus double autologous stem-cell transplantation for multiple myeloma. N Engl J Med 2003; 349: 2495\u20132502.","journal-title":"N Engl J Med"},{"key":"BFbmt2008166_CR9","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1200\/JCO.2005.04.5807","volume":"24","author":"B Barlogie","year":"2006","unstructured":"Barlogie B, Kyle RA, Anderson KC, Greipp PR, Lazarus HM, Hurd DD et al. Standard chemotherapy compared with high-dose chemoradiotherapy for multiple myeloma: final results of phase III US Intergroup Trial S9321. J Clin Oncol 2006; 24: 929\u2013936.","journal-title":"J Clin Oncol"},{"key":"BFbmt2008166_CR10","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1182\/blood.V81.12.3382.3382","volume":"81","author":"PR Greipp","year":"1993","unstructured":"Greipp PR, Lust JA, O'Fallon WM, Katzmann JA, Witzig TE, Kyle RA . Plasma cell labeling index and beta 2-microglobulin predict survival independent of thymidine kinase and C-reactive protein in multiple myeloma. Blood 1993; 81: 3382\u20133387.","journal-title":"Blood"},{"key":"BFbmt2008166_CR11","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1046\/j.1365-2141.1998.00930.x","volume":"102","author":"J Blade","year":"1998","unstructured":"Blade J, Samson D, Reece D, Apperley J, Bjorkstrand B, Gahrton G et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. Br J Haematol 1998; 102: 1115\u20131123.","journal-title":"Br J Haematol"},{"key":"BFbmt2008166_CR12","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","author":"E Kaplan","year":"1958","unstructured":"Kaplan E, Meier P . Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457\u2013481.","journal-title":"J Am Stat Assoc"},{"key":"BFbmt2008166_CR13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"D Cox","year":"1972","unstructured":"Cox D . Regression models and life tables. J R Stat Soc 1972; 34: 187\u2013202.","journal-title":"J R Stat Soc"},{"key":"BFbmt2008166_CR14","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3816\/CLM.2006.n.014","volume":"6","author":"D Dingli","year":"2006","unstructured":"Dingli D, Nowakowski GS, Dispenzieri A, Lacy MQ, Hayman S, Litzow MR et al. Cyclophosphamide mobilization does not improve outcome in patients receiving stem cell transplantation for multiple myeloma. Clin Lymphoma Myeloma 2006; 6: 384\u2013388.","journal-title":"Clin Lymphoma Myeloma"},{"key":"BFbmt2008166_CR15","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S0140-6736(83)90739-0","volume":"2","author":"TJ McElwain","year":"1983","unstructured":"McElwain TJ, Powles RL . High-dose intravenous melphalan for plasma-cell leukaemia and myeloma. Lancet 1983; 2: 822\u2013824.","journal-title":"Lancet"},{"key":"BFbmt2008166_CR16","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1182\/blood.V67.5.1298.1298","volume":"67","author":"B Barlogie","year":"1986","unstructured":"Barlogie B, Hall R, Zander A, Dicke K, Alexanian R . High-dose melphalan with autologous bone marrow transplantation for multiple myeloma. Blood 1986; 67: 1298\u20131301.","journal-title":"Blood"},{"issue":"Suppl 1989","key":"BFbmt2008166_CR17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-0609.1989.tb01509.x","volume":"51","author":"TJ McElwain","year":"1989","unstructured":"McElwain TJ, Selby PJ, Gore ME, Viner C, Meldrum M, Millar BC et al. High-dose chemotherapy and autologous bone marrow transplantation for myeloma. Eur J Haematol Suppl 1989; 51 (Suppl 1989): 152\u2013156.","journal-title":"Eur J Haematol Suppl"},{"key":"BFbmt2008166_CR18","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/sj.bmt.1703717","volume":"30","author":"S Singhal","year":"2002","unstructured":"Singhal S, Powles R, Sirohi B, Treleaven J, Kulkarni S, Mehta J . Response to induction chemotherapy is not essential to obtain survival benefit from high-dose melphalan and autotransplantation in myeloma. Bone Marrow Transplant 2002; 30: 673\u2013679.","journal-title":"Bone Marrow Transplant"},{"issue":"Suppl 2","key":"BFbmt2008166_CR19","first-page":"118","volume":"13","author":"R Alexanian","year":"1995","unstructured":"Alexanian R, Dimopoulos MA, Delasalle KB, Hester J, Champlin R . Myeloablative therapy for primary resistant multiple myeloma. Stem Cells 1995; 13 (Suppl 2): 118\u2013121.","journal-title":"Stem Cells"},{"key":"BFbmt2008166_CR20","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/sj.bmt.1704545","volume":"34","author":"S Kumar","year":"2004","unstructured":"Kumar S, Lacy MQ, Dispenzieri A, Rajkumar SV, Fonseca R, Geyer S et al. High-dose therapy and autologous stem cell transplantation for multiple myeloma poorly responsive to initial therapy. Bone Marrow Transplant 2004; 34: 161\u2013167.","journal-title":"Bone Marrow Transplant"},{"issue":"18 Suppl","key":"BFbmt2008166_CR21","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1200\/jco.2007.25.18_suppl.8021","volume":"25","author":"J Blade","year":"2007","unstructured":"Blade J, Rosinol L, Garcia-Sanz R, Lahuerta J, Hernandez M, Sureda A et al. A PETHEMA study of high-dose therapy\/stem cell support (HDT), including tandem transplant, in primary refractory multiple myeloma (MM): identification of two populations with different outcomes. J Clin Oncol (Meeting Abstracts) 2007; 25 (18 Suppl): 8021.","journal-title":"J Clin Oncol (Meeting Abstracts)"},{"key":"BFbmt2008166_CR22","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/sj.bmt.1702640","volume":"26","author":"SV Rajkumar","year":"2000","unstructured":"Rajkumar SV, Fonseca R, Dispenzieri A, Lacy MQ, Witzig TE, Lust JA et al. Effect of complete response on outcome following autologous stem cell transplantation for myeloma. Bone Marrow Transplant 2000; 26: 979\u2013983.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008166_CR23","first-page":"3077","volume":"108","author":"J-L Harousseau","year":"2006","unstructured":"Harousseau J-L, Attal M, Moreau P, Garban F, Facon T, Avet-Loiseau H . The prognostic impact of complete remission (CR) plus very good partial remission (VGPR) in a double-transplantation program for newly diagnosed multiple myeloma (MM). Combined results of the IFM 99 trials. ASH Annual Meeting Abstracts 2006; 108: 3077.","journal-title":"ASH Annual Meeting Abstracts"},{"key":"BFbmt2008166_CR24","doi-asserted-by":"publisher","first-page":"4933","DOI":"10.1200\/JCO.2007.11.7879","volume":"25","author":"D Dingli","year":"2007","unstructured":"Dingli D, Pacheco JM, Nowakowski GS, Kumar SK, Dispenzieri A, Hayman SR et al. Relationship between depth of response and outcome in multiple myeloma. J Clin Oncol 2007; 25: 4933\u20134937.","journal-title":"J Clin Oncol"},{"key":"BFbmt2008166_CR25","first-page":"1228","volume":"91","author":"S Lenhoff","year":"2006","unstructured":"Lenhoff S, Hjorth M, Turesson I, Westin J, Gimsing P, Wisloff F et al. Intensive therapy for multiple myeloma in patients younger than 60 years. Long-term results focusing on the effect of the degree of response on survival and relapse pattern after transplantation. Haematologica 2006; 91: 1228\u20131233.","journal-title":"Haematologica"},{"key":"BFbmt2008166_CR26","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/S0140-6736(07)61537-2","volume":"370","author":"T Facon","year":"2007","unstructured":"Facon T, Mary JY, Hulin C, Benboubker L, Attal M, Pegourie B et al. Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99\u201306): a randomised trial. Lancet 2007; 370: 1209\u20131218.","journal-title":"Lancet"},{"key":"BFbmt2008166_CR27","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1182\/blood.V99.3.731","volume":"99","author":"P Moreau","year":"2002","unstructured":"Moreau P, Facon T, Attal M, Hulin C, Michallet M, Maloisel F et al. Comparison of 200\u2009mg\/m(2) melphalan and 8\u2009Gy total body irradiation plus 140\u2009mg\/m(2) melphalan as conditioning regimens for peripheral blood stem cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the Intergroupe Francophone du Myelome 9502 randomized trial. Blood 2002; 99: 731\u2013735.","journal-title":"Blood"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bmt2008166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2008166","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2008166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T18:24:21Z","timestamp":1738261461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bmt2008166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,16]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["BFbmt2008166"],"URL":"https:\/\/doi.org\/10.1038\/bmt.2008.166","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"type":"print","value":"0268-3369"},{"type":"electronic","value":"1476-5365"}],"subject":[],"published":{"date-parts":[[2008,6,16]]},"assertion":[{"value":"23 August 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}