{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:02:37Z","timestamp":1761512557545},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2008,6,30]],"date-time":"2008-06-30T00:00:00Z","timestamp":1214784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,6,30]],"date-time":"2008-06-30T00:00:00Z","timestamp":1214784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1038\/bmt.2008.186","type":"journal-article","created":{"date-parts":[[2008,6,30]],"date-time":"2008-06-30T11:13:54Z","timestamp":1214824434000},"page":"449-454","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Risk factors for hepatic veno-occlusive disease: a retrospective unicentric study in 116 children autografted after a high-dose BU-thiotepa regimen"],"prefix":"10.1038","volume":"42","author":[{"given":"A","family":"Cacchione","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"LeMaitre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D Valteau","family":"Couanet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Benhamou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Amoroso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Simonnard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,6,30]]},"reference":[{"key":"BFbmt2008186_CR1","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1016\/j.transproceed.2007.01.075","volume":"39","author":"GT Sucak","year":"2007","unstructured":"Sucak GT, Aki ZS, Yagci M, Yegin ZA, Ozkurt ZN, Haznedar R . Treatment of sinusoidal obstruction syndrome with defibrotide: a single-center experience. Transplant Proc 2007; 39: 1558\u20131563.","journal-title":"Transplant Proc"},{"key":"BFbmt2008186_CR2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1055\/s-2002-23204","volume":"22","author":"LD DeLeve","year":"2002","unstructured":"DeLeve LD, Shulman HM, McDonald GB . Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis 2002; 22: 27\u201342.","journal-title":"Semin Liver Dis"},{"key":"BFbmt2008186_CR3","first-page":"53","volume":"3","author":"L Brugieres","year":"1988","unstructured":"Brugieres L, Hartmann O, Benhamou E, Zafrani ES, Caillaud JM, Patte C et al. Veno-occlusive disease of the liver following high-dose chemotherapy and autologous bone marrow transplantation in children with solid tumors: incidence, clinical course and outcome. Bone Marrow Transplant 1988; 3: 53\u201358.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR4","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1097\/00043426-200212000-00013","volume":"24","author":"U Reiss","year":"2002","unstructured":"Reiss U, Cowan M, MCMillan A, Horn B . Hepatic veno-occlusive disease in blood and bone marrow transplantation in children and young adults: incidence, risk factors, and outcome in a cohort of 241 patients. J Pediatr Hematol Oncol 2002; 24: 746\u2013750.","journal-title":"J Pediatr Hematol Oncol"},{"key":"BFbmt2008186_CR5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/sj.bmt.1704069","volume":"32","author":"CC Barker","year":"2003","unstructured":"Barker CC, Butzner JD, Anderson RA, Brant R, Sauve RS . Incidence, survival and risk factors for the development of veno-occlusive disease in paediatric haematopoietic stem cell transplant recipients. Bone Marrow Transplant 2003; 32: 79\u201387.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR6","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/hep.1840040121","volume":"4","author":"GB McDonald","year":"1984","unstructured":"McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED . Veno-occlusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology 1984; 4: 116\u2013122.","journal-title":"Hepatology"},{"key":"BFbmt2008186_CR7","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/sj.bmt.1701737","volume":"23","author":"O Hartmann","year":"1999","unstructured":"Hartmann O, Valteau\u2013Couanet D, Vassal G, Lapierre V, Brugieres L, Delgado R et al. Prognostic factors in metastatic neuroblastoma in patients over 1 year of age treated with high-dose chemotherapy and stem cell transplantation: a multivariate analysis in 218 patients treated in a single institution. Bone Marrow Transplant 1999; 23: 789\u2013795.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR8","first-page":"135","volume":"10","author":"V Meresse","year":"1992","unstructured":"Meresse V, Hartmann O, Vassal G, Benhamou E, Valteau-Couanet D, Brugieres L et al. Risk factors for hepatic veno-occlusive disease after high-dose busulfan-containing regimens followed by autologous bone marrow transplantation: a study in 136 children. Bone Marrow Transplant 1992; 10: 135\u2013141.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR9","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1182\/blood.V85.11.3005.bloodjournal85113005","volume":"85","author":"SI Bearman","year":"1995","unstructured":"Bearman SI . The syndrome of hepatic veno-occlusive disease after marrow transplantation. Blood 1995; 85: 3005\u20133020.","journal-title":"Blood"},{"key":"BFbmt2008186_CR10","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/sj.bmt.1705162","volume":"36","author":"D Valteau-Couanet","year":"2005","unstructured":"Valteau-Couanet D, Fillipini B, Benhamou E, Grill J, Kalifa C, Couanet D et al. High-dose busulfan and thiotepa followed by autologous stem cell transplantation (ASCT) in previously irradiated medulloblastoma patients: high toxicity and lack of efficacy. Bone Marrow Transplant 2005; 36: 939\u2013945.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR11","first-page":"419","volume":"10","author":"A Garaventa","year":"1992","unstructured":"Garaventa A, Porta F, Rondelli R, Dini G, Meloni G, Bonetti F et al. Early deaths in children after BMT. Bone Marrow Transplant 1992; 10: 419\u2013423.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR12","first-page":"736","volume":"49","author":"RL Heideman","year":"1989","unstructured":"Heideman RL, Cole DE, Balis F, Sato J, Reaman GH, Packer RJ et al. Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid and plasma of pediatrics patients: evidence for dose dependent plasma clearance of thiotepa. Cancer Res 1989; 49: 736\u2013741.","journal-title":"Cancer Res"},{"key":"BFbmt2008186_CR13","first-page":"227","volume":"9","author":"C Kalifa","year":"1992","unstructured":"Kalifa C, Hartmann O, Demeocq F, Vassal G, Couanet D, Terrier-Lacombe MJ et al. High-dose busulfan and thiotepa with autologous bone marrow transplantation in childhood malignant brain tumors: a phase II study. Bone Marrow Transplant 1992; 9: 227\u2013233.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR14","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/BF00146088","volume":"27","author":"S Dupuis-Girod","year":"1996","unstructured":"Dupuis-Girod S, Hartmann O, Benhamou E, Doz F, Mechinaud F, Bouffet E et al. Will high-dose chemotherapy followed by autologous bone marrow transplantation supplant cranio-spinal irradiation in young children treated for medulloblastoma? J Neurooncol 1996; 27: 87\u201398.","journal-title":"J Neurooncol"},{"key":"BFbmt2008186_CR15","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/cncr.22761","volume":"110","author":"V Ridola","year":"2007","unstructured":"Ridola V, Grill J, Doz F, Gentet JC, Frappaz D, Raquin MA et al. High-dose chemotherapy with autologous stem cell rescue followed by posterior fossa irradiation for local medulloblastoma recurrence or progression after conventional chemotherapy. Cancer 2007; 110: 156\u2013163.","journal-title":"Cancer"},{"key":"BFbmt2008186_CR16","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/sj.bmt.1702376","volume":"25","author":"D Valteau-Couanet","year":"2000","unstructured":"Valteau-Couanet D, Benhamou E, Vassal G, Stambouli F, LaPierre V, Couanet D et al. Consolidation with busulfan-containing regimen followed by stem cell transplantation in infants with poor prognosis stage 4 neuroblastoma. Bone Marrow Transplant 2000; 25: 937\u2013942.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR17","doi-asserted-by":"publisher","first-page":"255","DOI":"10.7326\/0003-4819-118-4-199302150-00003","volume":"118","author":"GB Mc Donald","year":"1993","unstructured":"Mc Donald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Ann Intern Med 1993; 118: 255\u2013267.","journal-title":"Ann Intern Med"},{"key":"BFbmt2008186_CR18","first-page":"171","volume":"18","author":"MJ Styler","year":"1996","unstructured":"Styler MJ, Crilley P, Biggs J, Moul J, Copelan E, Topolsky D et al. Hepatic dysfunction following busulfan and cyclophoshamide myeloablation: a retrospective, multicenter analysis. Bone Marrow Transplant 1996; 18: 171\u2013176.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR19","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1200\/JCO.2000.18.5.981","volume":"18","author":"T Girinsky","year":"2000","unstructured":"Girinsky T, Benhamou E, Bourhis JH, Dhermain F, Guillot-Valls D, Ganansia V et al. A prospective randomized comparison of single dose versus hyperfractionated total-body irradiation in patients with hematologic malignancies. J Clin Oncol 2000; 18: 981\u2013986.","journal-title":"J Clin Oncol"},{"key":"BFbmt2008186_CR20","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1034\/j.1600-0609.2000.9r200.x","volume":"64","author":"E Carreras","year":"2000","unstructured":"Carreras E . Veno-occlusive disease of the liver after hemopoietic cell transplantation. Eur J Haematol 2000; 64: 281\u2013291.","journal-title":"Eur J Haematol"},{"key":"BFbmt2008186_CR21","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/sj.bmt.1703393","volume":"29","author":"B Horn","year":"2002","unstructured":"Horn B, Reiss U, Matthay K, McMillan A, Cowan M . Veno-occlusive disease of the liver in children with solid tumors undergoing autologous hematopoietic progenitor cell transplantation: a high incidence in patients with neuroblastoma. Bone Marrow Transplant 2002; 29: 409\u2013415.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR22","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1097\/01.tp.0000167758.63247.f4","volume":"80","author":"V LaPierre","year":"2005","unstructured":"LaPierre V, Mahe C, Auperin A, Stambouli F, Oubouzar N, Tramalloni D et al. Platelet transfusion containing ABO-incompatible plasma and hepatic veno-occlusive disease after hematopoietic transplantation in young children. Transplantation 2005; 80: 314\u2013319.","journal-title":"Transplantation"},{"key":"BFbmt2008186_CR23","first-page":"1396","volume":"90","author":"S Cesaro","year":"2005","unstructured":"Cesaro S, Pillon M, Talenti E, Toffolutti T, Calore E, Tridello G et al. A prospective survey on incidence, risk factors and therapy of hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation. Hematologica 2005; 90: 1396\u20131404.","journal-title":"Hematologica"},{"key":"BFbmt2008186_CR24","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/sj.bmt.1704329","volume":"33","author":"S Corbacioglu","year":"2004","unstructured":"Corbacioglu S, Greil J, Peters C, Wulffraat N, Laws HJ, Dilloo D et al. Defibrotide in the treatment of the children with veno-occlusive disease (VOD): a retrospective multicentre study demonstrates therapeutic efficacy upon early intervention. Bone Marrow Transplant 2004; 33: 189\u2013195.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR25","doi-asserted-by":"publisher","first-page":"267","DOI":"10.3109\/10428199809059219","volume":"31","author":"P Richardson","year":"1998","unstructured":"Richardson P, Bearman SI . Prevention and treatment of hepatic veno-occlusive disease after high-dose cytoreductive therapy. Leuk Lymphoma 1998; 31: 267.","journal-title":"Leuk Lymphoma"},{"key":"BFbmt2008186_CR26","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1097\/00007890-199604150-00014","volume":"61","author":"R Or","year":"1996","unstructured":"Or R, Nagler A, Shpilberg O, Elad S, Naparstek E, Kapelushnik J et al. Low molecular weight heparin for the prevention of veno-occlusive disease of the liver in bone marrow transplantation patients. Transplantation 1996; 61: 1067\u20131671.","journal-title":"Transplantation"},{"key":"BFbmt2008186_CR27","doi-asserted-by":"publisher","first-page":"975","DOI":"10.7326\/0003-4819-128-12_Part_1-199806150-00002","volume":"128","author":"JH Essell","year":"1998","unstructured":"Essell JH, Schroeder MT, Harman GS, Halvorson R, Lew V, Callander N et al. Ursodiol prophylaxis against hepatic complications of allogeneic bone marrow transplantation. A randomized, double blind, placebo-controlled trial. Ann Intern Med 1998; 128: 975\u2013981.","journal-title":"Ann Intern Med"},{"key":"BFbmt2008186_CR28","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1182\/blood-2001-12-0159","volume":"100","author":"T Ruutu","year":"2002","unstructured":"Ruutu T, Eriksson B, Remes K, Juvonen E, Volin L, Remberger M et al. Ursodeoxycholic acid for the prevention of hepatic complications in allogeneic stem cell transplantation. Blood 2002; 100: 1977\u20131983.","journal-title":"Blood"},{"key":"BFbmt2008186_CR29","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1038\/sj.bmt.1704275","volume":"32","author":"J Bouligand","year":"2003","unstructured":"Bouligand J, Boland I, Valteau Couanet D, Deroussent A, Kalifa C, Hartmann O et al. In children and adolescents, the pharmacodynamics of high-dose busulfan is dependent on the second alkylating agent used in the combined regimen (melphalan or thiotepa). Bone Marrow Transplant 2003; 32: 979\u2013986.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR30","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.bbmt.2007.03.012","volume":"13","author":"JS McCune","year":"2007","unstructured":"McCune JS, Batchelder A, Deeg HJ, Gooley T, Cole S, Phillips B et al. Cyclophosphamide following targeted oral busulfan as conditioning for hematopoietic cell transplantation: pharmacokinetics, liver toxicity, and mortality. Biol Blood Marrow Transplant 2007; 13: 853\u2013862.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt2008186_CR31","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/sj.bmt.1703264","volume":"28","author":"AM Bolinger","year":"2001","unstructured":"Bolinger AM, Zangwill AB, Slattery JT, Risler LJ, Sultan DH, Glidden DV et al. Target dose adjustment of busulfan in pediatric patients undergoing bone marrow transplantation. Bone Marrow Transplant 2001; 28: 1013\u20131018.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR32","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1038\/sj.bmt.1703047","volume":"27","author":"EA Copelan","year":"2001","unstructured":"Copelan EA, Bechtel TP, Avalos BR, Elder PJ, Ezzone SA, Scholl MD et al. Busulfan levels are influenced by prior treatment and are associated with hepatic veno-occlusive disease and early mortality but not with delayed complications following marrow transplantation. Bone Marrow Transplant 2001; 27: 1121\u20131124.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008186_CR33","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/sj.clpt.6100168","volume":"82","author":"J Bouligand","year":"2007","unstructured":"Bouligand J, Maitre AL, Valteau-Couanet D, Grill J, Drouard-Troalen L, Paci A et al. Elevated plasma ferritin and busulfan pharmacodynamics during high-dose chemotherapy regimens in children with malignant solid tumors. Clin Pharmacol Ther 2007; 82: 402\u2013409.","journal-title":"Clin Pharmacol Ther"},{"key":"BFbmt2008186_CR34","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1200\/JCO.1988.6.10.1562","volume":"6","author":"SI Bearman","year":"1988","unstructured":"Bearman SI, Appelbaum FR, Buckner CD, Petersen FB, Fisher LD, Clift RA et al. Regimen-related toxicity in patients undergoing bone marrow transplantation. J Clin Oncol 1988; 6: 1562\u20131568.","journal-title":"J Clin Oncol"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bmt2008186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2008186","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2008186.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T11:41:24Z","timestamp":1648035684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bmt2008186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,30]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["BFbmt2008186"],"URL":"https:\/\/doi.org\/10.1038\/bmt.2008.186","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,30]]},"assertion":[{"value":"10 January 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}