{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:05:24Z","timestamp":1782453924956,"version":"3.54.5"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T00:00:00Z","timestamp":1220832000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T00:00:00Z","timestamp":1220832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1038\/bmt.2008.299","type":"journal-article","created":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T10:46:31Z","timestamp":1220870791000},"page":"141-147","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["The Prospective Oral Mucositis Audit: relationship of severe oral mucositis with clinical and medical resource use outcomes in patients receiving high-dose melphalan or BEAM-conditioning chemotherapy and autologous SCT"],"prefix":"10.1038","volume":"43","author":[{"given":"S","family":"McCann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Schwenkglenks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Einsele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"D'Addio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Maertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Niederwieser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Rabitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Roosaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ruutu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Schouten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Vorkurka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Blijlevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the EBMT Mucositis Advisory Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,9,8]]},"reference":[{"key":"BFbmt2008299_CR1","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1200\/JCO.2007.13.6028","volume":"26","author":"N Blijlevens","year":"2008","unstructured":"Blijlevens N, Schwenkglenks M, Bacon P, D\u2019Addio A, Einsele H, Maertens J et al. Prospective oral mucositis audit: oral mucositis in patients receiving high-dose melphalan or BEAM conditioning chemotherapy\u2014European Blood and Marrow Transplantation Mucositis Advisory Group. J Clin Oncol 2008; 26: 1519\u20131525.","journal-title":"J Clin Oncol"},{"key":"BFbmt2008299_CR2","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1093\/annonc\/mdl332","volume":"18","author":"N Blijlevens","year":"2007","unstructured":"Blijlevens N, Sonis S . Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis. Ann Oncol 2007; 18: 817\u2013826.","journal-title":"Ann Oncol"},{"key":"BFbmt2008299_CR3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1093\/oxfordjournals.jncimonographs.a003440","volume":"29","author":"A Peterman","year":"2001","unstructured":"Peterman A, Cella D, Glandon G, Dobrez D, Yount S . Mucositis in head and neck cancer: economic and quality-of-life outcomes. J Natl Cancer Inst Monogr 2001; 29: 45\u201351.","journal-title":"J Natl Cancer Inst Monogr"},{"key":"BFbmt2008299_CR4","doi-asserted-by":"publisher","first-page":"5183","DOI":"10.1200\/JCO.2005.02.8340","volume":"24","author":"PJ Stiff","year":"2006","unstructured":"Stiff PJ, Emmanouilides C, Bensinger WI, Gentile T, Blazar B, Shea TC et al. Palifermin reduces patient-reported mouth and throat soreness and improves patient functioning in the hematopoietic stem-cell transplantation setting. J Clin Oncol 2006; 24: 5183\u20135185.","journal-title":"J Clin Oncol"},{"key":"BFbmt2008299_CR5","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1002\/cncr.11671","volume":"98","author":"LS Elting","year":"2003","unstructured":"Elting LS, Cooksley C, Chambers M, Cantor SB, Manzullo E, Rubenstein EB . The burdens of cancer therapy. Clinical and economic outcomes of chemotherapy-induced mucositis. Cancer 2003; 98: 1531\u20131539.","journal-title":"Cancer"},{"key":"BFbmt2008299_CR6","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1111\/j.1365-2141.2006.06323.x","volume":"135","author":"SR Fanning","year":"2006","unstructured":"Fanning SR, Rybicki L, Kalaycio M, Andresen S, Kuczkowski E, Pohlman B et al. Severe mucositis is associated with reduced survival after autologous stem cell transplantation for lymphoid malignancies. Br J Haematol 2006; 135: 374\u2013381.","journal-title":"Br J Haematol"},{"key":"BFbmt2008299_CR7","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1086\/322595","volume":"33","author":"RL Lark","year":"2001","unstructured":"Lark RL, McNeil SA, VanderHyde K, Noorani Z, Uberti J, Chenoweth C . Risk factors for anaerobic bloodstream infections in bone marrow transplant recipients. Clin Infect Dis 2001; 33: 338\u2013343.","journal-title":"Clin Infect Dis"},{"key":"BFbmt2008299_CR8","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1200\/JCO.2001.19.8.2201","volume":"19","author":"ST Sonis","year":"2001","unstructured":"Sonis ST, Oster G, Fuchs H, Bellm L, Bradford WZ, Edelsberg J et al. Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J Clin Oncol 2001; 19: 2201\u20132205.","journal-title":"J Clin Oncol"},{"key":"BFbmt2008299_CR9","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00520-006-0176-9","volume":"15","author":"M Vera-Llonch","year":"2007","unstructured":"Vera-Llonch M, Oster G, Ford CM, Lu J, Sonis S . Oral mucositis and outcomes of allogeneic hematopoietic stem-cell transplantation in patients with hematologic malignancies. Support Care Cancer 2007; 15: 491\u2013496.","journal-title":"Support Care Cancer"},{"issue":"Suppl 1","key":"BFbmt2008299_CR10","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/S1462-3889(07)70002-9","volume":"11","author":"R Stone","year":"2007","unstructured":"Stone R, Potting CM, Clare S, Uhlenhopp M, Davies M, Mank A et al. Management of oral mucositis at European transplantation centres. Eur J Oncol Nurs 2007; 11 (Suppl 1): S3\u2013S9.","journal-title":"Eur J Oncol Nurs"},{"key":"BFbmt2008299_CR11","unstructured":"World Health Organization. WHO Handbook for Reporting Results of Cancer Treatment. World Health Organization: Geneva, 1979."},{"issue":"Suppl 1","key":"BFbmt2008299_CR12","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/S1462-3889(07)70003-0","volume":"11","author":"B Quinn","year":"2007","unstructured":"Quinn B, Stone R, Uhlenhopp M, McCann S, Blijlevens N . Ensuring accurate oral mucositis assessment in the European Group for Blood and Marrow Transplantation Prospective Oral Mucositis Audit. Eur J Oncol Nurs 2007; 11 (Suppl 1): S10\u2013S18.","journal-title":"Eur J Oncol Nurs"},{"key":"BFbmt2008299_CR13","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1002\/(SICI)1097-0142(19980601)82:11<2275::AID-CNCR25>3.0.CO;2-Q","volume":"82","author":"TJ Ruescher","year":"1998","unstructured":"Ruescher TJ, Sodeifi A, Scrivani SJ, Kaban LB, Sonis ST . The impact of mucositis on alpha-hemolytic streptococcal infection in patients undergoing autologous bone marrow transplantation for hematologic malignancies. Cancer 1998; 82: 2275\u20132281.","journal-title":"Cancer"},{"key":"BFbmt2008299_CR14","doi-asserted-by":"publisher","first-page":"2590","DOI":"10.1056\/NEJMoa040125","volume":"351","author":"R Spielberger","year":"2004","unstructured":"Spielberger R, Stiff P, Bensinger W, Gentile T, Weisdorf D, Kewalramani T et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med 2004; 351: 2590\u20132598.","journal-title":"N Engl J Med"},{"key":"BFbmt2008299_CR15","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/sj.bmt.1702447","volume":"25","author":"NM Blijlevens","year":"2000","unstructured":"Blijlevens NM, Donnelly JP, De Pauw BE . Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview. Bone Marrow Transplant 2000; 25: 1269\u20131278.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008299_CR16","first-page":"21","volume":"2","author":"ST Sonis","year":"2004","unstructured":"Sonis ST . A biological approach to mucositis. J Support Oncol 2004; 2: 21\u201332; discussion 35\u20136.","journal-title":"J Support Oncol"},{"key":"BFbmt2008299_CR17","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1002\/ijc.11196","volume":"107","author":"E Tsuji","year":"2003","unstructured":"Tsuji E, Hiki N, Nomura S, Fukushima R, Kojima J, Ogawa T et al. Simultaneous onset of acute inflammatory response, sepsis-like symptoms and intestinal mucosal injury after cancer chemotherapy. Int J Cancer 2003; 107: 303\u2013308.","journal-title":"Int J Cancer"},{"key":"BFbmt2008299_CR18","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.ctrv.2007.03.001","volume":"33","author":"RM Logan","year":"2007","unstructured":"Logan RM, Stringer AM, Bowen JM, Yeoh AS, Gibson RJ, Sonis ST et al. The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs. Cancer Treat Rev 2007; 33: 448\u2013460.","journal-title":"Cancer Treat Rev"},{"key":"BFbmt2008299_CR19","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1001\/archsurg.1987.01400240042007","volume":"122","author":"RS Warren","year":"1987","unstructured":"Warren RS, Starnes Jr HF, Gabrilove JL, Oettgen HF, Brennan MF . The acute metabolic effects of tumor necrosis factor administration in humans. Arch Surg 1987; 122: 1396\u20131400.","journal-title":"Arch Surg"},{"key":"BFbmt2008299_CR20","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1182\/blood.V81.10.2496.2496","volume":"81","author":"DC Dale","year":"1993","unstructured":"Dale DC, Bonilla MA, Davis MW, Nakanishi AM, Hammond WP, Kurtzberg J et al. A randomized controlled phase III trial of recombinant human granulocyte colony-stimulating factor (filgrastim) for treatment of severe chronic neutropenia. Blood 1993; 81: 2496\u20132502.","journal-title":"Blood"},{"key":"BFbmt2008299_CR21","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1111\/j.1365-2141.1992.tb06472.x","volume":"82","author":"GJ Lieschke","year":"1992","unstructured":"Lieschke GJ, Ramenghi U, O\u2019Connor MP, Sheridan W, Szer J, Morstyn G . Studies of oral neutrophil levels in patients receiving G-CSF after autologous marrow transplantation. Br J Haematol 1992; 82: 589\u2013595.","journal-title":"Br J Haematol"},{"key":"BFbmt2008299_CR22","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0030-4220(79)90230-5","volume":"48","author":"PB Lockhart","year":"1979","unstructured":"Lockhart PB, Sonis ST . Relationship of oral complications to peripheral blood leukocyte and platelet counts in patients receiving cancer chemotherapy. Oral Surg Oral Med Oral Pathol 1979; 48: 21\u201328.","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"BFbmt2008299_CR23","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1002\/1097-0142(19930901)72:5<1612::AID-CNCR2820720520>3.0.CO;2-Q","volume":"72","author":"SB Woo","year":"1993","unstructured":"Woo SB, Sonis ST, Monopoli MM, Sonis AL . A longitudinal study of oral ulcerative mucositis in bone marrow transplant recipients. Cancer 1993; 72: 1612\u20131617.","journal-title":"Cancer"},{"key":"BFbmt2008299_CR24","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1046\/j.1365-2141.2000.02202.x","volume":"110","author":"AM Wardley","year":"2000","unstructured":"Wardley AM, Jayson GC, Swindell R, Morgenstern GR, Chang J, Bloor R et al. Prospective evaluation of oral mucositis in patients receiving myeloablative conditioning regimens and haemopoietic progenitor rescue. Br J Haematol 2000; 110: 292\u2013299.","journal-title":"Br J Haematol"},{"key":"BFbmt2008299_CR25","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1200\/JCO.1999.17.8.2446","volume":"17","author":"AP Rapoport","year":"1999","unstructured":"Rapoport AP, Miller Watelet LF, Linder T, Eberly S, Raubertas RF, Lipp J et al. Analysis of factors that correlate with mucositis in recipients of autologous and allogeneic stem-cell transplants. J Clin Oncol 1999; 17: 2446\u20132453.","journal-title":"J Clin Oncol"},{"key":"BFbmt2008299_CR26","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/00002820-199012000-00004","volume":"13","author":"SA Kenny","year":"1990","unstructured":"Kenny SA . Effect of two oral care protocols on the incidence of stomatitis in hematology patients. Cancer Nurs 1990; 13: 345\u2013353.","journal-title":"Cancer Nurs"},{"key":"BFbmt2008299_CR27","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/sj.bmt.1705025","volume":"36","author":"C Cheretakis","year":"2005","unstructured":"Cheretakis C, Dror Y, Glogauer M . A noninvasive oral rinse assay to monitor engraftment, neutrophil tissue delivery and susceptibility to infection following HSCT in pediatric patients. Bone Marrow Transplant 2005; 36: 227\u2013232.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008299_CR28","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1182\/blood.V67.4.1023.1023","volume":"67","author":"DG Wright","year":"1986","unstructured":"Wright DG, Meierovics AI, Foxley JM . Assessing the delivery of neutrophils to tissues in neutropenia. Blood 1986; 67: 1023\u20131030.","journal-title":"Blood"},{"key":"BFbmt2008299_CR29","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/sj.bmt.1705471","volume":"38","author":"ML Grazziutti","year":"2006","unstructured":"Grazziutti ML, Dong L, Miceli MH, Krishna SG, Kiwan E, Syed N et al. Oral mucositis in myeloma patients undergoing melphalan-based autologous stem cell transplantation: incidence, risk factors and a severity predictive model. Bone Marrow Transplant 2006; 38: 501\u2013506.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2008299_CR30","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/sj.clpt.6100336","volume":"83","author":"A K\u00fchne","year":"2008","unstructured":"K\u00fchne A, Sezer O, Heider U, Meineke I, Muhlke S, Niere W et al. Population Pharmacokinetics of Melphalan and Glutathione S-transferase Polymorphisms in Relation to Side Effects. Clin Pharmacol Ther 2008; 83: 749\u2013757.","journal-title":"Clin Pharmacol Ther"},{"key":"BFbmt2008299_CR31","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1002\/cncr.22484","volume":"109","author":"DM Keefe","year":"2007","unstructured":"Keefe DM, Schubert MM, Eting LS, Sonis ST, Epstein JB, Roher-Durlocher JE et al. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 2007; 109: 820\u2013831.","journal-title":"Cancer"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bmt2008299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2008299","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2008299.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T11:24:35Z","timestamp":1648034675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bmt2008299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,8]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["BFbmt2008299"],"URL":"https:\/\/doi.org\/10.1038\/bmt.2008.299","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,8]]},"assertion":[{"value":"24 April 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}