{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T07:07:33Z","timestamp":1772953653327,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T00:00:00Z","timestamp":1272844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T00:00:00Z","timestamp":1272844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1038\/bmt.2010.100","type":"journal-article","created":{"date-parts":[[2010,5,3]],"date-time":"2010-05-03T10:53:39Z","timestamp":1272884019000},"page":"330-337","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Allogeneic hematopoietic SCT as treatment option for patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): a consensus conference proposal for a standardized approach"],"prefix":"10.1038","volume":"46","author":[{"given":"J","family":"Halter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W M M","family":"Sch\u00fcpbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Casali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Elhasid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Fay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hammans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Illa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Kappeler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kr\u00e4henb\u00fchl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Mandel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Marti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Mattle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Orchard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C M","family":"Sue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Valcarcel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Gratwohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,5,3]]},"reference":[{"key":"BFbmt2010100_CR1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1126\/science.283.5402.689","volume":"283","author":"I Nishino","year":"1999","unstructured":"Nishino I, Spinazzola A, Hirano M . Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder. Science 1999; 283: 689\u2013692.","journal-title":"Science"},{"key":"BFbmt2010100_CR2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/01.nrl.0000106919.06469.04","volume":"10","author":"M Hirano","year":"2004","unstructured":"Hirano M, Nishigaki Y, Mart\u00ed R . Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): a disease of two genomes. Neurologist 2004; 10: 8\u201317.","journal-title":"Neurologist"},{"key":"BFbmt2010100_CR3","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1002\/ana.20615","volume":"58","author":"R Mart\u00ed","year":"2005","unstructured":"Mart\u00ed R, Verschuuren JJ, Buchman A, Hirano I, Tadesse S, van Kuilenburg AB et al. Late-onset MNGIE due to partial loss of thymidine phosphorylase activity. Ann Neurol 2005; 58: 649\u2013652.","journal-title":"Ann Neurol"},{"key":"BFbmt2010100_CR4","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1007\/BF00688189","volume":"74","author":"A Bardosi","year":"1987","unstructured":"Bardosi A, Creutzfeldt W, DiMauro S, Felgenhauer K, Friede RL, Goebel HH et al. Myo-, neuro-, gastrointestinal encephalopathy (MNGIE syndrome) due to partial deficiency of cytochrome-c-oxidase. A new mitochondrial multisystem disorder. Acta Neuropathol 1987; 74: 248\u2013258.","journal-title":"Acta Neuropathol"},{"key":"BFbmt2010100_CR5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1136\/jnnp.2005.078857","volume":"78","author":"M Needham","year":"2007","unstructured":"Needham M, Duley J, Hammond S, Herkes GK, Hirano M, Sue CM . Mitochondrial disease mimicking Charcot-Marie Tooth disease. J Neurol Neurosurg Psychiatry 2007; 78: 99\u2013100.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"BFbmt2010100_CR6","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1111\/j.1468-1331.2007.01720.x","volume":"14","author":"FJ Carod-Artal","year":"2007","unstructured":"Carod-Artal FJ, Herrero MD, Lara MC, L\u00f3pez-Gallardo E, Ruiz-Pesini E, Mart\u00ed R et al. Cognitive dysfunction and hypogonadotrophic hypogonadism in a Brazilian patient with mitochondrial neurogastrointestinal encephalomyopathy and a novel ECGF1 mutation. Eur J Neurol 2007; 14: 581\u2013585.","journal-title":"Eur J Neurol"},{"key":"BFbmt2010100_CR7","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1212\/01.WNL.0000141857.37073.97","volume":"63","author":"MA Mart\u00edn","year":"2004","unstructured":"Mart\u00edn MA, Bl\u00e1zquez A, Mart\u00ed R, Bautista J, Lara MC, Cabello A et al. Lack of gastrointestinal symptoms in a 60-year-old patient with MNGIE. Neurology 2004; 63: 1536\u20131537.","journal-title":"Neurology"},{"key":"BFbmt2010100_CR8","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1093\/hmg\/ddn401","volume":"18","author":"LC L\u00f3pez","year":"2009","unstructured":"L\u00f3pez LC, Akman HO, Garc\u00eda-Cazorla A, Dorado B, Mart\u00ed R, Nishino I et al. Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice. Hum Mol Genet 2009; 18: 714\u2013722.","journal-title":"Hum Mol Genet"},{"key":"BFbmt2010100_CR9","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.gene.2005.04.041","volume":"354","author":"M Hirano","year":"2005","unstructured":"Hirano M, Lagier-Tourenne C, Valentino ML, Mart\u00ed R, Nishigaki Y . Thymidine phosphorylase mutations cause instability of mitochondrial DNA. Gene 2005; 354: 152\u2013156.","journal-title":"Gene"},{"key":"BFbmt2010100_CR10","doi-asserted-by":"publisher","first-page":"22720","DOI":"10.1074\/jbc.M604498200","volume":"28","author":"G Pontarin","year":"2006","unstructured":"Pontarin G, Ferraro P, Valentino ML, Hirano M, Reichard P, Bianchi V . Mitochondrial DNA depletion and thymidine phosphate pool dynamics in a cellular model of mitochondrial neurogastrointestinal encephalomyopathy. J Biol Chem 2006; 28: 22720\u201322728.","journal-title":"J Biol Chem"},{"key":"BFbmt2010100_CR11","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1002\/9781444303537.ch77","volume-title":"Thomas\u2019 Hematopoietic Cell Transplantation","author":"C Peters","year":"2009","unstructured":"Peters C . Hematopoietic cell transplantation for storage diseases. In: Appelbaum FR, Forman SJ, Negrin RS, Blume K (eds). Thomas\u2019 Hematopoietic Cell Transplantation, 4th edn. Wiley-Blackwell Publishing Ltd: Chichester, West Sussex, UK, 2009, pp 1136\u20131162."},{"key":"BFbmt2010100_CR12","doi-asserted-by":"publisher","first-page":"4128","DOI":"10.1074\/jbc.M111028200","volume":"277","author":"A Spinazzola","year":"2002","unstructured":"Spinazzola A, Marti R, Nishino I, Andreu AL, Naini A, Tadesse S et al. Altered thymidine metabolism due to defects of thymidine phosphorylase. J Biol Chem 2002; 277: 4128\u20134133.","journal-title":"J Biol Chem"},{"key":"BFbmt2010100_CR13","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1001\/archneur.64.3.435","volume":"64","author":"H Yavuz","year":"2007","unstructured":"Yavuz H, Ozel A, Christensen M, Christensen E, Schwartz M, Elmaci M et al. Treatment of mitochondrial neurogastrointestinal encephalomyopathy with dialysis. Arch Neurol 2007; 64: 435\u2013438.","journal-title":"Arch Neurol"},{"key":"BFbmt2010100_CR14","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1212\/01.wnl.0000239824.95411.52","volume":"67","author":"MC Lara","year":"2006","unstructured":"Lara MC, Weiss B, Illa I, Madoz P, Massuet L, Andreu AL et al. Infusion of platelets transiently reduces nucleoside overload in MNGIE. Neurology 2006; 67: 1461\u20131463.","journal-title":"Neurology"},{"key":"BFbmt2010100_CR15","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1212\/01.wnl.0000240853.97716.24","volume":"67","author":"M Hirano","year":"2006","unstructured":"Hirano M, Mart\u00ed R, Casali C, Tadesse S, Uldrick T, Fine B et al. Allogeneic stem cell transplantation corrects biochemical derangements in MNGIE. Neurology 2006; 67: 1458\u20131460.","journal-title":"Neurology"},{"key":"BFbmt2010100_CR16","unstructured":"Hirano M, Casali C, Tadesse S et al. Sustained biochemical and clinical improvements two years postallogeneic stem cell transplantation in a patient with MNGIE. AAN Annual Meeting 2008 (Abstract S48.002, April 2008. Available from www.abstracts2view.com\/aan2008chicago\/ (accessed on 13 April 2010))."},{"key":"BFbmt2010100_CR17","first-page":"682","volume":"23","author":"I Illa Sendra","year":"2008","unstructured":"Illa Sendra I, Lara Castillo MC, Valcarel Ferreiras D, Nogues Galvez N, Dias Manera J, Rojas-Garcia R et al. Transplante alog\u00e9nico de c\u00e9lulas madre hematopoy\u00e9ticas en dos pacientes con MNGIE. Neurologia 2008; 23: 682.","journal-title":"Neurologia"},{"issue":"Suppl 1","key":"BFbmt2010100_CR18","first-page":"S184","volume":"43","author":"KS Hill","year":"2009","unstructured":"Hill KS, Richardson D, Hammans S, Stroud M, Fine D, Walker V et al. Successful allogeneic peripheral blood stem cell transplantation from an HLA-identical sibling in a patient with mitochondrial neurogastrointestinal encephalomyelopathy. Bone Marrow Transpl 2009; 43 (Suppl 1): S184 (abstract).","journal-title":"Bone Marrow Transpl"},{"key":"BFbmt2010100_CR19","doi-asserted-by":"crossref","unstructured":"Halter J, Schuepbach WMM, Casali C, Elhasid R, Fay K, Hammans S et al. Sustained complete metabolic remission after allogeneic hematopoietic stem cell transplantation in patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Blood (ASH Annual Meeting Abstracts) 2009; 114: abstract 1181.","DOI":"10.1182\/blood.V114.22.1181.1181"},{"key":"BFbmt2010100_CR20","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1373\/clinchem.2003.026179","volume":"50","author":"R Mart\u00ed","year":"2004","unstructured":"Mart\u00ed R, Spinazzola A, Tadesse S, Nishino I, Nishigaki Y, Hirano M . Definitive diagnosis of mitochondrial neurogastrointestinal encephalomyopathy by biochemical assays. Clin Chem 2004; 50: 120\u2013124.","journal-title":"Clin Chem"},{"key":"BFbmt2010100_CR21","doi-asserted-by":"publisher","first-page":"4246","DOI":"10.1200\/JCO.2006.09.7865","volume":"25","author":"ML Sorror","year":"2007","unstructured":"Sorror ML, Sandmaier BM, Storer BE, Maris MB, Baron F, Maloney DG et al. Comorbidity and disease status based risk stratification of outcomes among patients with acute myeloid leukemia or myelodysplasia receiving allogeneic hematopoietic cell transplantation. J Clin Oncol 2007; 25: 4246\u20134254.","journal-title":"J Clin Oncol"},{"key":"BFbmt2010100_CR22","doi-asserted-by":"publisher","first-page":"407","DOI":"10.7326\/0003-4819-144-6-200603210-00007","volume":"144","author":"T Parimon","year":"2006","unstructured":"Parimon T, Au DH, Martin PJ, Chien JW . A risk score for mortality after allogeneic hematopoietic cell transplantation. Ann Intern Med 2006; 144: 407\u2013414.","journal-title":"Ann Intern Med"},{"key":"BFbmt2010100_CR23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s10540-007-9043-2","volume":"27","author":"MC Lara","year":"2007","unstructured":"Lara MC, Valentino ML, Torres-Torronteras J, Hirano M, Mart\u00ed R . Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): biochemical features and therapeutic approaches. Biosci Rep 2007; 27: 151\u2013163.","journal-title":"Biosci Rep"},{"key":"BFbmt2010100_CR24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/j.1365-2141.1988.tb07597.x","volume":"69","author":"D Niederwieser","year":"1988","unstructured":"Niederwieser D, Pepe M, Storb R, Loughran Jr TP, Longton G . Improvement in rejection, engraftment rate and survival without increase in graft-versus-host disease by high marrow cell dose in patients transplanted for aplastic anaemia. Br J Haematol 1988; 69: 23\u201328.","journal-title":"Br J Haematol"},{"key":"BFbmt2010100_CR25","doi-asserted-by":"publisher","first-page":"4288","DOI":"10.1182\/blood-2006-05-024042","volume":"108","author":"N Schmitz","year":"2006","unstructured":"Schmitz N, Eapen M, Horowitz MM, Zhang MJ, Klein JP, Rizzo JD et al. International Bone Marrow Transplant Registry; European Group for Blood and Marrow Transplantation. Long-term outcome of patients given transplants of mobilized blood or bone marrow: a report from the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow Transplantation. Blood 2006; 108: 4288\u20134290.","journal-title":"Blood"},{"key":"BFbmt2010100_CR26","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/01.fjc.0000200658.89629.ba","volume":"47","author":"PT Sudharsan","year":"2006","unstructured":"Sudharsan PT, Mythili Y, Selvakumar E, Varalakshmi P . Lupeol and its ester exhibit protective role against cyclophosphamide-induced cardiac mitochondrial toxicity. J Cardiovasc Pharmacol 2006; 47: 205\u2013210.","journal-title":"J Cardiovasc Pharmacol"},{"key":"BFbmt2010100_CR27","first-page":"263","volume":"10","author":"Y Ogawa","year":"2002","unstructured":"Ogawa Y, Nishioka A, Kobayashi T, Kariya S, Hamasato S, Saibara T et al. Mitochondrial cytochrome c release in radiation-induced apoptosis of human peripheral T cells. Int J Mol Med 2002; 10: 263\u2013268.","journal-title":"Int J Mol Med"},{"key":"BFbmt2010100_CR28","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0300-483X(01)00332-8","volume":"161","author":"HC Chung","year":"2001","unstructured":"Chung HC, Kim SH, Lee MG, Cho CK, Kim TH, Lee DH et al. Mitochondrial dysfunction by gamma-irradiation accompanies the induction of cytochrome P450 2E1 (CYP2E1) in rat liver. Toxicology 2001; 161: 79\u201391.","journal-title":"Toxicology"},{"key":"BFbmt2010100_CR29","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1667\/RR1186.1","volume":"169","author":"JH Miller","year":"2008","unstructured":"Miller JH, Jin S, Morgan WF, Yang A, Wan Y, Aypar U et al. Profiling mitochondrial proteins in radiation-induced genome-unstable cell lines with persistent oxidative stress by mass spectrometry. Radiat Res 2008; 169: 700\u2013706.","journal-title":"Radiat Res"},{"key":"BFbmt2010100_CR30","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.clineuro.2007.10.014","volume":"110","author":"A De Weerdt","year":"2008","unstructured":"De Weerdt A, Claeys KG, De Jonghe P, Ysebaert D, Chapelle T, Roeyen G et al. Tacrolimus-related polyneuropathy: case report and review of the literature. Clin Neurol Neurosurg 2008; 110: 291\u2013294.","journal-title":"Clin Neurol Neurosurg"},{"key":"BFbmt2010100_CR31","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.transproceed.2006.02.038","volume":"38","author":"R Mu\u00f1oz","year":"2006","unstructured":"Mu\u00f1oz R, Espinoza M, Espinoza O, Andrade A, Bravo E, Gonz\u00e1lez F . Cyclosporine-associated leukoencephalopathy in organ transplant recipients: experience of three clinical cases. Transplant Proc 2006; 38: 921\u2013923.","journal-title":"Transplant Proc"},{"key":"BFbmt2010100_CR32","doi-asserted-by":"publisher","first-page":"36803","DOI":"10.1074\/jbc.M405297200","volume":"279","author":"ME Soriano","year":"2004","unstructured":"Soriano ME, Nicolosi L, Bernardi P . Desensitization of the permeability transition pore by cyclosporin A prevents activation of the mitochondrial apoptotic pathway and liver damage by tumor necrosis factor-alpha. J Biol Chem 2004; 279: 36803\u201336808.","journal-title":"J Biol Chem"},{"key":"BFbmt2010100_CR33","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/jat.1192","volume":"27","author":"LC Rodr\u00edguez","year":"2007","unstructured":"Rodr\u00edguez LC, Araujo CR, Posleman SE, Rey Mdel R . Hepatotoxic effect of cyclosporin A in the mitochondrial respiratory chain. J Appl Toxicol 2007; 27: 310\u2013317.","journal-title":"J Appl Toxicol"},{"key":"BFbmt2010100_CR34","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.nbd.2004.07.002","volume":"17","author":"S Almeida","year":"2004","unstructured":"Almeida S, Domingues A, Rodrigues L, Oliveira CR, Rego AC . FK506 prevents mitochondrial-dependent apoptotic cell death induced by 3-nitropropionic acid in rat primary cortical cultures. Neurobiol Dis 2004; 17: 435\u2013444.","journal-title":"Neurobiol Dis"},{"key":"BFbmt2010100_CR35","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1016\/j.transproceed.2006.06.033","volume":"38","author":"SY Han","year":"2006","unstructured":"Han SY, Chang EJ, Choi HJ, Kwak CS, Suh SI, Bae JH et al. Effect of tacrolimus on the production of oxygen free radicals in hepatic mitochondria. Transplant Proc 2006; 38: 2242\u20132243.","journal-title":"Transplant Proc"},{"key":"BFbmt2010100_CR36","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1016\/j.transproceed.2008.08.029","volume":"40","author":"SJ Choi","year":"2008","unstructured":"Choi SJ, You HS, Chung SY . Rapamycin-induced cytotoxic signal transduction pathway. Transplant Proc 2008; 40: 2737\u20132739.","journal-title":"Transplant Proc"},{"key":"BFbmt2010100_CR37","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1084\/jem.20081297","volume":"205","author":"C Chen","year":"2008","unstructured":"Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Liu Y et al. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med 2008; 205: 2397\u20132408.","journal-title":"J Exp Med"},{"key":"BFbmt2010100_CR38","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1182\/blood.V73.6.1729.1729","volume":"73","author":"R Storb","year":"1989","unstructured":"Storb R, Deeg HJ, Pepe M, Appelbaum F, Anasetti C, Beatty P et al. Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: long-term follow-up of a controlled trial. Blood 1989; 73: 1729\u20131734.","journal-title":"Blood"},{"key":"BFbmt2010100_CR39","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.tiv.2008.03.004","volume":"22","author":"NA Santos","year":"2008","unstructured":"Santos NA, Medina WS, Martins NM, Mingatto FE, Curti C, Santos AC . Aromatic antiepileptic drugs and mitochondrial toxicity: effects on mitochondria isolated from rat liver. Toxicol In Vitro 2008; 22: 1143\u20131152.","journal-title":"Toxicol In Vitro"},{"key":"BFbmt2010100_CR40","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.braindev.2007.12.006","volume":"30","author":"T Chiyonobu","year":"2008","unstructured":"Chiyonobu T, Noda R, Yoshida M, Fujiki A, Ishii R, Nukina S et al. Intestinal pseudo-obstruction in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) associated with phenytoin therapy. Brain Dev 2008; 30: 430\u2013433.","journal-title":"Brain Dev"},{"key":"BFbmt2010100_CR41","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1006\/taap.1996.8080","volume":"143","author":"RF Omar","year":"1997","unstructured":"Omar RF, Harvie P, Gourde P, D\u00e9sormeaux A, Tremblay M, Beauchamp D et al. Antiviral efficacy and toxicity of ribavirin and foscarnet each given alone or in combination in the murine AIDS model. Toxicol Appl Pharmacol 1997; 143: 140\u2013151.","journal-title":"Toxicol Appl Pharmacol"},{"key":"BFbmt2010100_CR42","doi-asserted-by":"publisher","first-page":"25159","DOI":"10.1074\/jbc.M703972200","volume":"282","author":"JW Hanes","year":"2007","unstructured":"Hanes JW, Zhu Y, Parris DS, Johnson KA . Enzymatic therapeutic index of acyclovir. Viral versus human polymerise gamma specificity. J Biol Chem 2007; 282: 25159\u201325167.","journal-title":"J Biol Chem"},{"key":"BFbmt2010100_CR43","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/(SICI)1522-7146(1996)11:3<127::AID-JBT4>3.0.CO;2-M","volume":"11","author":"RJ Rodriquez","year":"1996","unstructured":"Rodriquez RJ, Acosta Jr D . Inhibition of mitochondrial function in isolated rate liver mitochondria by azole antifungals. J Biochem Toxicol 1996; 11: 127\u2013131.","journal-title":"J Biochem Toxicol"},{"key":"BFbmt2010100_CR44","first-page":"165","volume":"91","author":"MP Guillaume","year":"1996","unstructured":"Guillaume MP, De Prez C, Cogan E . Subacute mitochondrial liver disease in a patient with AIDS: possible relationship to prolonged fluconazole administration. Am J Gastroenterol 1996; 91: 165\u2013168.","journal-title":"Am J Gastroenterol"},{"key":"BFbmt2010100_CR45","doi-asserted-by":"publisher","first-page":"e113","DOI":"10.1086\/430441","volume":"40","author":"L Palenzuela","year":"2005","unstructured":"Palenzuela L, Hahn NM, Nelson Jr RP, Arno JN, Schobert C, Bethel R et al. Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis? Clin Infect Dis 2005; 40: e113\u2013e116.","journal-title":"Clin Infect Dis"},{"key":"BFbmt2010100_CR46","doi-asserted-by":"publisher","first-page":"3896","DOI":"10.1128\/AAC.49.9.3896-3902.2005","volume":"49","author":"EE Nagiec","year":"2005","unstructured":"Nagiec EE, Wu L, Swaney SM, Chosay JG, Ross DE, Brieland JK et al. Oxazolidinones inhibit cellular proliferation via inhibition of mitochondrial protein synthesis. Antimicrob Agents Chemother 2005; 49: 3896\u20133902.","journal-title":"Antimicrob Agents Chemother"},{"key":"BFbmt2010100_CR47","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1016\/S0025-6196(12)62169-7","volume":"65","author":"NJ Talley","year":"1990","unstructured":"Talley NJ, Phillips SF, Wiltgen CM, Zinsmeister AR, Leton III LJ . Assessement of functional gastrointestinal disease: the bowel disease questionnaire. Mayo Clin Proc 1990; 65: 1456\u20131479.","journal-title":"Mayo Clin Proc"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bmt2010100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2010100","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2010100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T12:19:44Z","timestamp":1648037984000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bmt2010100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["BFbmt2010100"],"URL":"https:\/\/doi.org\/10.1038\/bmt.2010.100","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,3]]},"assertion":[{"value":"10 August 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}