{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:07:49Z","timestamp":1791259669381,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2011,11,7]],"date-time":"2011-11-07T00:00:00Z","timestamp":1320624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,11,7]],"date-time":"2011-11-07T00:00:00Z","timestamp":1320624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1038\/bmt.2011.213","type":"journal-article","created":{"date-parts":[[2011,11,7]],"date-time":"2011-11-07T12:23:59Z","timestamp":1320668639000},"page":"1099-1104","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Prevention of relapse using granulocyte CSF-primed PBPCs following HLA-mismatched\/haploidentical, T-cell-replete hematopoietic SCT in patients with advanced-stage acute leukemia: a retrospective risk-factor analysis"],"prefix":"10.1038","volume":"47","author":[{"given":"Y","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D-H","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L-P","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K-Y","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X-H","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-H","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F-R","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-Z","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C-H","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X-J","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,11,7]]},"reference":[{"key":"BFbmt2011213_CR1","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/sj.bmt.1702519","volume":"26","author":"J Sierra","year":"2000","unstructured":"Sierra J, Storer B, Hansen JA, Martin PJ, Petersdorf EW, Woolfrey A et al. Unrelated donor marrow transplantation for acute myeloid leukemia: an update of the Seattle experience. Bone Marrow Transplant 2000; 26: 397\u2013404.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2011213_CR2","doi-asserted-by":"publisher","first-page":"3447","DOI":"10.1200\/JCO.2005.09.117","volume":"23","author":"F Aversa","year":"2005","unstructured":"Aversa F, Terenzi A, Tabilio A, Falzetti F, Carotti A, Ballanti S et al. Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse. J Clin Oncol 2005; 23: 3447\u20133454.","journal-title":"J Clin Oncol"},{"key":"BFbmt2011213_CR3","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.bbmt.2008.11.025","volume":"15","author":"XJ Huang","year":"2009","unstructured":"Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W et al. Treatment of acute leukaemia with unmanipulated HLA-mismatched\/haploidentical blood and bone marrow transplantation. Biol Blood Marrow Transplant 2009; 15: 257\u2013265.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt2011213_CR4","first-page":"736","volume":"116","author":"XJ Huang","year":"2003","unstructured":"Huang XJ, Guo NL, Ren HY, Zhang Y, Gao Z, Lu D . An improved anti-leukemic effect achieved with donor progenitor cell infusion for relapse patients after allogeneic bone marrow transplantation. Chinese Med Journal 2003; 116: 736\u2013741.","journal-title":"Chinese Med Journal"},{"key":"BFbmt2011213_CR5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/bmt.2009.26","volume":"44","author":"XJ Huang","year":"2009","unstructured":"Huang XJ, Wang Y, Liu DH, Liu KY, Xu LP, Chen H et al. Administration of short-term immunosuppressive agents after GPBPCI reduces the incidence of GPBPCI associated acute GVHD without influencing the GVL effect. Bone Marrow Transplant 2009; 44: 309\u2013316.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2011213_CR6","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s10875-007-9166-z","volume":"28","author":"XJ Huang","year":"2008","unstructured":"Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W et al. Modified donor lymphocyte infusion after HLA-mismatched\/haplo-identical T-cell-replete hematopoietic stem cell transplantation for prophylaxis of relapse of leukemia in patients with advanced leukemia. J Clin Immunol 2008; 28: 276\u2013283.","journal-title":"J Clin Immunol"},{"key":"BFbmt2011213_CR7","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.bbmt.2010.08.023","volume":"17","author":"Y Wang","year":"2011","unstructured":"Wang Y, Liu DH, Xu LP, Liu KY, Chen H, Han W et al. Superior graft-versus-leukemia effect associated with transplantation of haplo-identical compared with HLA-identical sibling donor grafts for high risk acute leukemia: a historical comparison. Biol Blood Marrow Transplant 2011; 17: 821\u2013830.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt2011213_CR8","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1038\/sj.bmt.1702690","volume":"26","author":"M Michallet","year":"2000","unstructured":"Michallet M, Thomas X, Vernant JP, Kuentz M, Soci\u00e9 G, Esp\u00e9rou-Bourdeau H et al. Long-term outcome after allogeneic hematopoietic stem cell transplantation for advanced stage acute myeloblastic leukemia: a retrospective study of 379 patients reported to the Societe Francaise de Greffe de Moelle (SFGM). Bone Marrow Transplant 2000; 26: 1157\u20131163.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2011213_CR9","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/sj.bmt.1705445","volume":"38","author":"XJ Huang","year":"2006","unstructured":"Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W et al. Haplo-identical hematopoietic stem cell transplantation without in vitro T cell depletion for the treatment of hematological malignancies. Bone Marrow Transplant 2006; 38: 291\u2013297.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2011213_CR10","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1038\/bmt.2010.197","volume":"46","author":"Y Wang","year":"2011","unstructured":"Wang Y, Xu LP, Liu KY, Liu DH, Wang J, Chen H et al. Low-dose methotrexate combined with low-dose methylprednisolone as a first-line therapy for the treatment of acute graft-versus-host disease \u2013 safety and feasibility. Bone Marrow Transplant 2011; 46: 892\u2013898.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2011213_CR11","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/S0889-8588(05)70111-8","volume":"13","author":"ME Flower","year":"1999","unstructured":"Flower ME, Kansu E, Sullivan KM . Pathophysiology and treatment of graft-versus-host disase. Hematol Oncol Clin North Am 1999; 13: 1091\u20131112.","journal-title":"Hematol Oncol Clin North Am"},{"key":"BFbmt2011213_CR12","first-page":"635","volume-title":"Thomas\u2032 Hematopoietic Cell Transplantation","author":"MS Keith","year":"2004","unstructured":"Keith MS . Graft-vs-Host Disease. In: Blume KG, Forman SJ, Appelbaum FR (eds). Thomas\u2032 Hematopoietic Cell Transplantation. Blackwell Publishing Ltd: Oxford, UK, 2004. p. 635\u2013664."},{"key":"BFbmt2011213_CR13","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1038\/bmt.2009.359","volume":"45","author":"L Scrucca","year":"2010","unstructured":"Scrucca L, Santucci A, Aversa F . Regression modeling of competing risk using R: an in depth guide for clinicians. Bone Marrow Transplant 2010; 45: 1388\u20131395.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2011213_CR14","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/S1083-8791(03)00149-6","volume":"9","author":"K Doney","year":"2003","unstructured":"Doney K, H\u00e4gglund H, Leisenring W, Chauncey T, Appelbaum FR, Storb R . Predictive factors for outcome of allogeneic hematopoietic cell transplantation for adult acute lymphoblastic leukemia. Biol Blood Marrow Transplant 2003; 9: 472\u2013481.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt2011213_CR15","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/sj.bmt.1703373","volume":"29","author":"S Singhal","year":"2002","unstructured":"Singhal S, Powles R, Henslee-Downey PJ, Chiang KY, Treleaven J, Godder K et al. Allogeneic transplantation from HLA-matched sibling or partially HLA-mismatched related donors for primary refractory acute leukemia. Bone Marrow Transplant 2002; 29: 291\u2013295.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2011213_CR16","first-page":"52","volume":"87","author":"A Mengarelli","year":"2002","unstructured":"Mengarelli A, Iori A, Guglielmi C, Romano A, Cerretti R, Torromeo C et al. Standard versus alternative myeloablative conditioning regimens in allogeneic hematopoietic stem cell transplantation for high-risk acute leukemia. Haematologica 2002; 87: 52\u201358.","journal-title":"Haematologica"},{"key":"BFbmt2011213_CR17","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1080\/10428190290006053","volume":"43","author":"T Robak","year":"2002","unstructured":"Robak T, Wrzesien-Kus A . The search for optimal treatment in relapsed and refractory acute myeloid leukemia. Leuk Lymphoma 2002; 43: 281\u2013291.","journal-title":"Leuk Lymphoma"},{"key":"BFbmt2011213_CR18","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1182\/blood.V87.6.2195.bloodjournal8762195","volume":"87","author":"S Slavin","year":"1996","unstructured":"Slavin S, Naparstek E, Nagler A, Ackerstein A, Samuel S, Kapelushnik J et al. Allogeneic cell therapy with donor peripheral blood cells and recombinant human interleukin-2 to treat leukemia relapse after allogeneic bone marrow transplantation. Blood 1996; 87: 2195\u20132204.","journal-title":"Blood"},{"key":"BFbmt2011213_CR19","doi-asserted-by":"publisher","first-page":"414","DOI":"10.3324\/haematol.10570","volume":"92","author":"XJ Huang","year":"2007","unstructured":"Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W et al. Donor lymphocyte infusion for the treatment of leukemia relapse after HLA-mismatched\/haplo-identical T-cell-replete hematopoietic stem cell transplantation. Haematologica 2007; 92: 414\u2013417.","journal-title":"Haematologica"},{"key":"BFbmt2011213_CR20","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1007\/s10875-008-9193-4","volume":"28","author":"XJ Huang","year":"2008","unstructured":"Huang XJ, Wang Y, Liu DH, Liu KY, Xu LP, Chen H et al. Modified donor lymphocyte infusion (GPBPCI) for the prophylaxis of leukemia relapse after hematopoietic stem cell transplantation in patients with advanced leukemia \u2013 feasibility and safety study. J Clin Immunol 2008; 28: 390\u2013397.","journal-title":"J Clin Immunol"},{"key":"BFbmt2011213_CR21","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/sj.leu.2403995","volume":"20","author":"XJ Huang","year":"2006","unstructured":"Huang XJ, Liu DH, Xu LP, Liu KY, Chen H, Han W et al. Prophylactic infusion of donor granulocyte colony stimulating factor mobilized peripheral blood progenitor cells after allogeneic hematological stem cell transplantation in patients with high-risk leukemia. Leukemia 2006; 20: 365\u2013368.","journal-title":"Leukemia"},{"key":"BFbmt2011213_CR22","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1182\/blood-2005-10-4165","volume":"108","author":"C Schmid","year":"2006","unstructured":"Schmid C, Schleuning M, Schwerdtfeger R, Hertenstein B, Mischak-Weissinger E, Bunjes D et al. Long-term survival in refractory acute myeloid leukemia after sequential treatment with chemotherapy and reduced-intensity conditioning for allogeneic stem cell transplantation. Blood 2006; 108: 1092\u20131099.","journal-title":"Blood"},{"key":"BFbmt2011213_CR23","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.trim.2006.10.002","volume":"17","author":"XJ Huang","year":"2007","unstructured":"Huang XJ, Chang YJ, Zhao XY . Maintaining hyporesponsiveness and polarization potential of T cells after in vitro mixture of G-CSF mobilized peripheral blood grafts and G-CSF primed bone marrow grafts in different proportions[J]. Transplant Immunol 2007; 17: 193\u2013197.","journal-title":"Transplant Immunol"},{"key":"BFbmt2011213_CR24","first-page":"1517","volume":"89","author":"XJ Huang","year":"2004","unstructured":"Huang XJ, Chang YJ, Zhao XY . In vivo induction of T-cell hyporesponsiveness and alteration of immunological cells of bone marrow grafts using granulocyte colony-stimulating factor. Haematologica 2004; 89: 1517\u20131524.","journal-title":"Haematologica"},{"key":"BFbmt2011213_CR25","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1532\/IJH97.A10227","volume":"79","author":"SH Chen","year":"2004","unstructured":"Chen SH, Li X, Huang XJ . Effect of recombinant granulocyte colony-stimulating factor on T-lymphocyte function and the mechanism of this effect. Int J Hematol 2004; 79: 178\u2013184.","journal-title":"Int J Hematol"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bmt2011213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2011213","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2011213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T14:54:03Z","timestamp":1648047243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bmt2011213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,7]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["BFbmt2011213"],"URL":"https:\/\/doi.org\/10.1038\/bmt.2011.213","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,7]]},"assertion":[{"value":"11 July 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}