{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:50:17Z","timestamp":1775742617213,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T00:00:00Z","timestamp":1299456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T00:00:00Z","timestamp":1299456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1038\/bmt.2011.36","type":"journal-article","created":{"date-parts":[[2011,3,7]],"date-time":"2011-03-07T17:00:42Z","timestamp":1299517242000},"page":"115-119","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Tear physiology in dry eye associated with chronic GVHD"],"prefix":"10.1038","volume":"47","author":[{"given":"S","family":"Khanal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,3,7]]},"reference":[{"key":"BFbmt201136_CR1","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1001\/archopht.1983.01040010580010","volume":"01","author":"LW Hirst","year":"1983","unstructured":"Hirst LW, Jabs DA, Tutschka PJ, Green WR, Santos GW . The eye in bone marrow transplantation. I Clinical study. Arch Ophthalmol 1983; 01: 580\u2013584.","journal-title":"Arch Ophthalmol"},{"key":"BFbmt201136_CR2","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1136\/bjo.83.10.1125","volume":"83","author":"Y Ogawa","year":"1999","unstructured":"Ogawa Y, Okamoto S, Wakui M, Watanabe R, Yamada M, Yoshino M et al. Dry eye after haematopoietic stem cell transplantation. Br J Ophthalmol 1999; 83: 1125\u20131130.","journal-title":"Br J Ophthalmol"},{"key":"BFbmt201136_CR3","first-page":"675","volume":"4","author":"B Calissendorff","year":"1989","unstructured":"Calissendorff B, el Azazi M, Lonnqvist B . Dry eye syndrome in long-term follow-up of bone marrow transplanted patients. Bone Marrow Transplant 1989; 4: 675\u2013678.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201136_CR4","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1016\/j.ophtha.2009.04.054","volume":"116","author":"KF Tabbara","year":"2009","unstructured":"Tabbara KF, Al-Ghamdi A, Al-Mohareb F, Ayas M, Chaudhri N, Al-Sharif F et al. Ocular findings after allogeneic hematopoietic stem cell transplantation. Ophthalmology 2009; 116: 1624\u20131629.","journal-title":"Ophthalmology"},{"key":"BFbmt201136_CR5","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1097\/00003226-200310001-00004","volume":"22","author":"Y Ogawa","year":"2003","unstructured":"Ogawa Y, Kuwana M . Dry eye as a major complication associated with chronic graft-versus-host disease after hematopoietic stem cell transplantation. Cornea 2003; 22: S19\u2013S27.","journal-title":"Cornea"},{"key":"BFbmt201136_CR6","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1600-0420.2007.01120.x","volume":"86","author":"KT Fahnehjelm","year":"2008","unstructured":"Fahnehjelm KT, Tornquist AL, Winiarski J . Dry-eye syndrome after allogeneic stem-cell transplantation in children. Acta Ophthalmologica 2008; 86: 253\u2013258.","journal-title":"Acta Ophthalmologica"},{"key":"BFbmt201136_CR7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/eye.2008.340","volume":"23","author":"Y Ban","year":"2009","unstructured":"Ban Y, Ogawa Y, Goto E, Uchino M, Terauchi N, Seki M et al. Tear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease. Eye 2009; 23: 202\u2013208.","journal-title":"Eye"},{"key":"BFbmt201136_CR8","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/sj.bmt.1705900","volume":"41","author":"Y Wang","year":"2008","unstructured":"Wang Y, Ogawa Y, Dogru M, Kawai M, Tatematsu Y, Uchino M et al. Ocular surface and tear functions after topical cyclosporine treatment in dry eye patients with chronic graft-versus-host disease. Bone Marrow Transplant 2008; 41: 293\u2013302.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201136_CR9","first-page":"159","volume":"26","author":"WD Mathers","year":"2000","unstructured":"Mathers WD . Why the eye becomes dry: a cornea and lacrimal gland feedback model. CLAO J 2000; 26: 159\u2013165.","journal-title":"CLAO J"},{"key":"BFbmt201136_CR10","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1097\/ICO.0b013e3180645cd7","volume":"26","author":"CC Chiang","year":"2007","unstructured":"Chiang CC, Lin JM, Chen WL, Tsai YY . Allogeneic serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease. Cornea 2007; 26: 861\u2013863.","journal-title":"Cornea"},{"key":"BFbmt201136_CR11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/01.ico.0000243956.22275.8c","volume":"26","author":"M Mohammadpour","year":"2007","unstructured":"Mohammadpour M . Progressive corneal vascularization caused by graft-versus-host disease. Cornea 2007; 26: 225\u2013226.","journal-title":"Cornea"},{"key":"BFbmt201136_CR12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S1542-0124(12)70157-X","volume":"3","author":"A Tomlinson","year":"2005","unstructured":"Tomlinson A, Khanal S . Assessment of tear film dynamics: quantification approach. Ocul Surf 2005; 3: 81\u201395.","journal-title":"Ocul Surf"},{"key":"BFbmt201136_CR13","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.ajo.2008.05.016","volume":"146","author":"MA Lemp","year":"2008","unstructured":"Lemp MA . Advances in understanding and managing dry eye disease. Am J Ophthalmol 2008; 146: 350\u2013356.","journal-title":"Am J Ophthalmol"},{"key":"BFbmt201136_CR14","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1038\/bmt.2009.312","volume":"45","author":"Y Wang","year":"2010","unstructured":"Wang Y, Ogawa Y, Dogru M, Tatematsu Y, Uchino M, Kamoi M et al. Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye. Bone Marrow Transplant 2010; 45: 1077\u20131083.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201136_CR15","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.bbmt.2005.09.004","volume":"11","author":"AH Filipovich","year":"2005","unstructured":"Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 2005; 11: 945\u2013956.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt201136_CR16","doi-asserted-by":"publisher","first-page":"995","DOI":"10.3109\/02713688809015145","volume":"7","author":"JR Occhipinti","year":"1988","unstructured":"Occhipinti JR, Mosier MA, LaMotte J, Monji GT . Fluorophotometric measurement of human tear turnover rate. Curr Eye Res 1988; 7: 995\u20131000.","journal-title":"Curr Eye Res"},{"key":"BFbmt201136_CR17","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1097\/00006324-199012000-00002","volume":"67","author":"GR Trees","year":"1990","unstructured":"Trees GR, Tomlinson A . Effect of artificial tear solutions and saline on tear film evaporation. Optom Vis Sci 1990; 67: 886\u2013890.","journal-title":"Optom Vis Sci"},{"key":"BFbmt201136_CR18","volume-title":"Dry Eye: Diagnosis and Management","author":"S Khanal","year":"2006","unstructured":"Khanal S . Dry Eye: Diagnosis and Management. PhD thesis: Glasgow Caledonian University, Glasgow, UK, 2006."},{"key":"BFbmt201136_CR19","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1097\/00006324-198906000-00008","volume":"66","author":"MG Doane","year":"1989","unstructured":"Doane MG . An instrument for in vivo tear film interferometry. Optom Vis Sci 1989; 66: 383\u2013388.","journal-title":"Optom Vis Sci"},{"key":"BFbmt201136_CR20","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/bmt.2009.173","volume":"45","author":"Y Ogawa","year":"2010","unstructured":"Ogawa Y, Dogru M, Uchino M, Tatematsu Y, Kamoi M, Yamamoto Y et al. Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD. Bone Marrow Transplant 2010; 45: 565\u2013569.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201136_CR21","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/sj.bmt.1705566","volume":"39","author":"KC Yoon","year":"2007","unstructured":"Yoon KC, Jeong IY, Im SK, Park YG, Kim HJ, Choi J . Therapeutic effect of umbilical cord serum eyedrops for the treatment of dry eye associated with graft-versus-host disease. Bone Marrow Transplant 2007; 39: 231\u2013235.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201136_CR22","first-page":"111","volume":"42","author":"Y Ogawa","year":"2001","unstructured":"Ogawa Y, Yamazaki K, Kuwana M, Mashima Y, Nakamura Y, Ishida S et al. A significant role of stromal fibroblasts in rapidly progressive dry eye in patients with chronic GVHD. Invest Ophthalmol Vis Sci 2001; 42: 111\u2013119.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFbmt201136_CR23","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1159\/000099268","volume":"92","author":"S Barabino","year":"2007","unstructured":"Barabino S, Dana MR . Dry eye syndromes. Chem Immunol Allergy 2007; 92: 176\u2013184.","journal-title":"Chem Immunol Allergy"},{"key":"BFbmt201136_CR24","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/09553009414550041","volume":"65","author":"PA Riley","year":"1994","unstructured":"Riley PA . Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol 1994; 65: 27\u201333.","journal-title":"Int J Radiat Biol"},{"key":"BFbmt201136_CR25","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.ajo.2005.12.047","volume":"141","author":"DD Altinors","year":"2006","unstructured":"Altinors DD, Akca S, Akova YA, Bilezikci B, Goto E, Dogru M et al. Smoking associated with damage to the lipid layer of the ocular surface. Am J Ophthalmol 2006; 141: 1016\u20131021.","journal-title":"Am J Ophthalmol"},{"key":"BFbmt201136_CR26","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0014-4835(03)00203-3","volume":"78","author":"JP McCulley","year":"2004","unstructured":"McCulley JP, Shine WE . The lipid layer of tears: dependent on meibomian gland function. Exp Eye Res 2004; 78: 361\u2013365.","journal-title":"Exp Eye Res"},{"key":"BFbmt201136_CR27","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1002\/cncr.10773","volume":"95","author":"L Tauchmanova","year":"2002","unstructured":"Tauchmanova L, Selleri C, Rosa GD, Pagano L, Orio F, Lombardi G et al. High prevalence of endocrine dysfunction in long-term survivors after allogeneic bone marrow transplantation for hematologic diseases. Cancer 2002; 95: 1076\u20131084.","journal-title":"Cancer"},{"key":"BFbmt201136_CR28","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S1542-0124(12)70081-2","volume":"5","author":"MA Lemp","year":"2007","unstructured":"Lemp MA, Baudouin C, Baum J, Dogru M, Fouls GN, Kinoshita S et al. The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye workshop. Ocul Surf 2007; 5: 75\u201392.","journal-title":"Ocul Surf"},{"key":"BFbmt201136_CR29","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1097\/01.ico.0000240101.66652.36","volume":"26","author":"SD Adrean","year":"2007","unstructured":"Adrean SD, Puklin JE . Perforated corneal ulcer with subsequent endophthalmitis in a patient with graft-versus-host disease. Cornea 2007; 26: 107\u2013108.","journal-title":"Cornea"},{"key":"BFbmt201136_CR30","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1159\/000325034","volume":"54","author":"H Hosseini","year":"2010","unstructured":"Hosseini H, Kumar PV, Geramizadeh B, Nowroozizadeh B, Ramzi M . Conjunctival scrape cytology findings in patients with chronic graft-versus-host disease following allogeneic bone marrow transplantation. Acta Cytol 2010; 54: 272\u2013276.","journal-title":"Acta Cytol"},{"key":"BFbmt201136_CR31","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1167\/iovs.03-0915","volume":"46","author":"P Mertzanis","year":"2005","unstructured":"Mertzanis P, Abetz L, Rajagopalan K, Espindle D, Chalmers R, Snyder C et al. The relative burden of dry eye in patients\u2032 lives: comparisons to a US normative sample. Invest Ophthalmol Vis Sci 2005; 46: 46\u201350.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFbmt201136_CR32","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1182\/blood-2008-10-182592","volume":"114","author":"J Pidala","year":"2009","unstructured":"Pidala J, Anasetti C, Jim H . Quality of life after allogeneic hematopoietic cell transplantation. Blood 2009; 114: 7\u201319.","journal-title":"Blood"},{"key":"BFbmt201136_CR33","first-page":"S102","volume":"14","author":"SC Pflugfelder","year":"2008","unstructured":"Pflugfelder SC . Prevalence, burden, and pharmacoeconomics of dry eye disease. Am J Manag Care 2008; 14: S102\u2013S106.","journal-title":"Am J Manag Care"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bmt201136.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt201136","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt201136.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T14:47:56Z","timestamp":1648046876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bmt201136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["BFbmt201136"],"URL":"https:\/\/doi.org\/10.1038\/bmt.2011.36","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,7]]},"assertion":[{"value":"4 August 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Professor Alan Tomlinson has received financial support from Pfizer Inc. and Allergan Inc. for research unrelated to this paper. Dr Khanal declares no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}