{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:11:43Z","timestamp":1765354303607},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T00:00:00Z","timestamp":1348444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T00:00:00Z","timestamp":1348444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1038\/bmt.2012.174","type":"journal-article","created":{"date-parts":[[2012,9,24]],"date-time":"2012-09-24T11:06:48Z","timestamp":1348484808000},"page":"502-507","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Stem cell source-dependent reconstitution of FOXP3+ T cells after pediatric SCT and the association with allo-reactive disease"],"prefix":"10.1038","volume":"48","author":[{"given":"L L","family":"Reubsaet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P J","family":"de Pagter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"van Baarle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Keukens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Nanlohy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E A M","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B J","family":"Prakken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Boelens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I M","family":"de Kleer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,9,24]]},"reference":[{"key":"BFbmt2012174_CR1","first-page":"231","volume":"8","author":"K Atkinson","year":"1991","unstructured":"Atkinson K, Turner J, Biggs JC, Dodds A, Concannon A . An acute pulmonary syndrome possibly representing acute graft-versus-host disease involving the lung interstitium. Bone Marrow Transplant 1991; 8: 231\u2013234.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2012174_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1365-2141.2007.06510.x","volume":"137","author":"ES Morris","year":"2007","unstructured":"Morris ES, Hill GR . Advances in the understanding of acute graft-versus-host disease. Br J Haematol 2007; 137: 3\u201319.","journal-title":"Br J Haematol"},{"key":"BFbmt2012174_CR3","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/nri2000","volume":"7","author":"WD Shlomchik","year":"2007","unstructured":"Shlomchik WD . Graft-versus-host disease. Nat Rev Immunol 2007; 7: 340\u2013352.","journal-title":"Nat Rev Immunol"},{"key":"BFbmt2012174_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1053\/j.seminhematol.2005.11.028","volume":"43","author":"JL Ferrara","year":"2006","unstructured":"Ferrara JL, Levine JE . Graft-versus-host disease in the 21st century: new perspectives on an old problem. Semin Hematol 2006; 43: 1\u20132.","journal-title":"Semin Hematol"},{"key":"BFbmt2012174_CR5","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1182\/blood-2006-02-003996","volume":"108","author":"K Rezvani","year":"2006","unstructured":"Rezvani K, Mielke S, Ahmadzadeh M, Kilical Y, Savani BN, Zeilah J et al. High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT. Blood 2006; 108: 1291\u20131297.","journal-title":"Blood"},{"key":"BFbmt2012174_CR6","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1084\/jem.20020399","volume":"196","author":"P Hoffmann","year":"2002","unstructured":"Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S . Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 2002; 196: 389\u2013399.","journal-title":"J Exp Med"},{"key":"BFbmt2012174_CR7","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1084\/jem.20020090","volume":"196","author":"JL Cohen","year":"2002","unstructured":"Cohen JL, Trenado A, Vasey D, Klatzmann D, Salomon BL . CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease. J Exp Med 2002; 196: 401\u2013406.","journal-title":"J Exp Med"},{"key":"BFbmt2012174_CR8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/83713","volume":"27","author":"CL Bennett","year":"2001","unstructured":"Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001; 27: 20\u201321.","journal-title":"Nat Genet"},{"key":"BFbmt2012174_CR9","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1126\/science.1079490","volume":"299","author":"S Hori","year":"2003","unstructured":"Hori S, Nomura T, Sakaguchi S . Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057\u20131061.","journal-title":"Science"},{"key":"BFbmt2012174_CR10","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/ni904","volume":"4","author":"JD Fontenot","year":"2003","unstructured":"Fontenot JD, Gavin MA, Rudensky AY . Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003; 4: 330\u2013336.","journal-title":"Nat Immunol"},{"key":"BFbmt2012174_CR11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/ni1572","volume":"9","author":"Q Tang","year":"2008","unstructured":"Tang Q, Bluestone JA . The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol 2008; 9: 239\u2013244.","journal-title":"Nat Immunol"},{"key":"BFbmt2012174_CR12","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/nm915","volume":"9","author":"M Edinger","year":"2003","unstructured":"Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, Strober S et al. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 2003; 9: 1144\u20131150.","journal-title":"Nat Med"},{"key":"BFbmt2012174_CR13","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1182\/blood.V99.10.3493","volume":"99","author":"PA Taylor","year":"2002","unstructured":"Taylor PA, Lees CJ, Blazar BR . The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 2002; 99: 3493\u20133499.","journal-title":"Blood"},{"key":"BFbmt2012174_CR14","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1056\/NEJMoa1108188","volume":"365","author":"J Koreth","year":"2011","unstructured":"Koreth J, Matsuoka K, Kim HT, McDonough SM, Bindra B, Alyea EP et al. Interleukin-2 and regulatory T cells in graft-versus-host disease. N Engl J Med 2011; 365: 2055\u20132066.","journal-title":"N Engl J Med"},{"key":"BFbmt2012174_CR15","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1056\/NEJM199602013340501","volume":"334","author":"E Goulmy","year":"1996","unstructured":"Goulmy E, Schipper R, Pool J, Blokland E, Falkenburg JH, Vossen J et al. Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation. N Engl J Med 1996; 334: 281\u2013285.","journal-title":"N Engl J Med"},{"key":"BFbmt2012174_CR16","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/bmt.2011.3","volume":"47","author":"J Gaziev","year":"2012","unstructured":"Gaziev J, Isgro A, Marziali M, Daniele N, Gallucci C, Sodani P et al. Higher CD3(+) and CD34(+) cell doses in the graft increase the incidence of acute GVHD in children receiving BMT for thalassemia. Bone Marrow Transplant 2012; 47: 107\u2013114.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2012174_CR17","doi-asserted-by":"publisher","first-page":"956","DOI":"10.3324\/haematol.2008.003103","volume":"94","author":"K Matthews","year":"2009","unstructured":"Matthews K, Lim Z, Afzali B, Pearce L, Abdallah A, Kordasti S et al. Imbalance of effector and regulatory CD4 T cells is associated with graft-versus-host disease after hematopoietic stem cell transplantation using a reduced intensity conditioning regimen and alemtuzumab. Haematologica 2009; 94: 956\u2013966.","journal-title":"Haematologica"},{"key":"BFbmt2012174_CR18","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.bbmt.2009.04.009","volume":"15","author":"C Fondi","year":"2009","unstructured":"Fondi C, Nozzoli C, Benemei S, Baroni G, Saccardi R, Guidi S et al. Increase in FOXP3+ regulatory T cells in GVHD skin biopsies is associated with lower disease severity and treatment response. Biol Blood Marrow Transplant 2009; 15: 938\u2013947.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt2012174_CR19","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1172\/JCI41072","volume":"120","author":"K Matsuoka","year":"2010","unstructured":"Matsuoka K, Kim HT, McDonough S, Bascug G, Warshauer B, Koreth J et al. Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation. J Clin Invest 2010; 120: 1479\u20131493.","journal-title":"J Clin Invest"},{"key":"BFbmt2012174_CR20","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.bbmt.2010.02.026","volume":"16","author":"JM Magenau","year":"2010","unstructured":"Magenau JM, Qin X, Tawara I, Rogers CE, Kitko C, Schlough M et al. Frequency of CD4(+)CD25(hi)FOXP3(+) regulatory T cells has diagnostic and prognostic value as a biomarker for acute graft-versus-host-disease. Biol Blood Marrow Transplant 2010; 16: 907\u2013914.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt2012174_CR21","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/j.bbmt.2011.10.039","volume":"18","author":"D Pastore","year":"2011","unstructured":"Pastore D, Delia M, Mestice A, Carluccio P, Perrone T, Gaudio F et al. CD3(+)\/Tregs ratio in donor grafts is linked to acute graft-versus-host disease and immunologic recovery after allogeneic peripheral blood stem cell transplantation. Biol Blood Marrow Transplant 2011; 18: 887\u2013893.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt2012174_CR22","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/sj.bmt.1705557","volume":"39","author":"H Olkinuora","year":"2007","unstructured":"Olkinuora H, Talvensaari K, Kaartinen T, Siitonen S, Saarinen-Pihkala U, Partanen J et al. T cell regeneration in pediatric allogeneic stem cell transplantation. Bone Marrow Transplant 2007; 39: 149\u2013156.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2012174_CR23","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/00007890-197410000-00001","volume":"18","author":"H Glucksberg","year":"1974","unstructured":"Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 1974; 18: 295\u2013304.","journal-title":"Transplantation"},{"key":"BFbmt2012174_CR24","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1164\/ajrccm\/147.6_Pt_1.1601","volume":"147","author":"JG Clark","year":"1993","unstructured":"Clark JG, Hansen JA, Hertz MI, Parkman R, Jensen L, Peavy HH . NHLBI workshop summary. Idiopathic pneumonia syndrome after bone marrow transplantation. Am Rev Respir Dis 1993; 147: 1601\u20131606.","journal-title":"Am Rev Respir Dis"},{"key":"BFbmt2012174_CR25","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0966-3274(02)00007-2","volume":"9","author":"JM Tiercy","year":"2002","unstructured":"Tiercy JM . Molecular basis of HLA polymorphism: implications in clinical transplantation. Transpl Immunol 2002; 9: 173\u2013180.","journal-title":"Transpl Immunol"},{"key":"BFbmt2012174_CR26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1128\/CDLI.7.3.336-343.2000","volume":"7","author":"CT Schnizlein-Bick","year":"2000","unstructured":"Schnizlein-Bick CT, Spritzler J, Wilkening CL, Nicholson JK, O'Gorman MR . Evaluation of TruCount absolute-count tubes for determining CD4 and CD8 cell numbers in human immunodeficiency virus-positive adults. Site Investigators and The NIAID DAIDS New Technologies Evaluation Group. Clin Diagn Lab Immunol 2000; 7: 336\u2013343.","journal-title":"Clin Diagn Lab Immunol"},{"key":"BFbmt2012174_CR27","doi-asserted-by":"publisher","first-page":"4543","DOI":"10.1182\/blood-2007-05-092130","volume":"110","author":"KV Komanduri","year":"2007","unstructured":"Komanduri KV, John LS, de LM, McMannis J, Rosinski S, McNiece I et al. Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing. Blood 2007; 110: 4543\u20134551.","journal-title":"Blood"},{"key":"BFbmt2012174_CR28","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.4049\/jimmunol.133.4.1710","volume":"133","author":"J Gerdes","year":"1984","unstructured":"Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H . Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984; 133: 1710\u20131715.","journal-title":"J Immunol"},{"key":"BFbmt2012174_CR29","doi-asserted-by":"publisher","first-page":"2903","DOI":"10.1182\/blood-2005-03-1257","volume":"106","author":"E Zorn","year":"2005","unstructured":"Zorn E, Kim HT, Lee SJ, Floyd BH, Litsa D, Arumugarajah S et al. Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease. Blood 2005; 106: 2903\u20132911.","journal-title":"Blood"},{"key":"BFbmt2012174_CR30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1080\/14653240701231014","volume":"9","author":"P Szabolcs","year":"2007","unstructured":"Szabolcs P, Niedzwiecki D . Immune reconstitution after unrelated cord blood transplantation. Cytotherapy 2007; 9: 111\u2013122.","journal-title":"Cytotherapy"},{"key":"BFbmt2012174_CR31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.beha.2006.09.009","volume":"20","author":"M Geddes","year":"2007","unstructured":"Geddes M, Storek J . Immune reconstitution following hematopoietic stem-cell transplantation. Best Pract Res Clin Haematol 2007; 20: 329\u2013348.","journal-title":"Best Pract Res Clin Haematol"},{"key":"BFbmt2012174_CR32","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1182\/blood-2007-06-094656","volume":"110","author":"DQ Tran","year":"2007","unstructured":"Tran DQ, Ramsey H, Shevach EM . Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood 2007; 110: 2983\u20132990.","journal-title":"Blood"},{"key":"BFbmt2012174_CR33","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1016\/j.jaci.2011.08.006","volume":"128","author":"S De Roock","year":"2011","unstructured":"De Roock S, Hoeks SB, Meurs L, Steur A, Hoekstra MO, Prakken BJ et al. Critical role for programmed death 1 signaling and protein kinase B in augmented regulatory T-cell induction in cord blood. J Allergy Clin Immunol 2011; 128: 1369\u20131371.","journal-title":"J Allergy Clin Immunol"},{"key":"BFbmt2012174_CR34","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1365-2567.2009.03122.x","volume":"128","author":"Y Miyagawa","year":"2009","unstructured":"Miyagawa Y, Kiyokawa N, Ochiai N, Imadome K, Horiuchi Y, Onda K et al. Ex vivo expanded cord blood CD4 T lymphocytes exhibit a distinct expression profile of cytokine-related genes from those of peripheral blood origin. Immunology 2009; 128: 405\u2013419.","journal-title":"Immunology"},{"key":"BFbmt2012174_CR35","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1182\/blood-2005-07-2800","volume":"107","author":"I de Kleer","year":"2006","unstructured":"de Kleer I, Vastert B, Klein M, Teklenburg G, Arkesteijn G, Yung GP et al. Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network. Blood 2006; 107: 1696\u20131702.","journal-title":"Blood"},{"key":"BFbmt2012174_CR36","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/ni816","volume":"3","author":"I Apostolou","year":"2002","unstructured":"Apostolou I, Sarukhan A, Klein L, von BH . Origin of regulatory T cells with known specificity for antigen. Nat Immunol 2002; 3: 756\u2013763.","journal-title":"Nat Immunol"},{"key":"BFbmt2012174_CR37","doi-asserted-by":"publisher","first-page":"5678","DOI":"10.4049\/jimmunol.171.11.5678","volume":"171","author":"C Cozzo","year":"2003","unstructured":"Cozzo C, Larkin J, Caton AJ . Cutting edge: self-peptides drive the peripheral expansion of CD4+CD25+ regulatory T cells. J Immunol 2003; 171: 5678\u20135682.","journal-title":"J Immunol"},{"key":"BFbmt2012174_CR38","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/86302","volume":"2","author":"MS Jordan","year":"2001","unstructured":"Jordan MS, Boesteanu A, Reed AJ, Petrone AL, Holenbeck AE, Lerman MA et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001; 2: 301\u2013306.","journal-title":"Nat Immunol"},{"key":"BFbmt2012174_CR39","doi-asserted-by":"publisher","first-page":"7667","DOI":"10.4049\/jimmunol.178.12.7667","volume":"178","author":"RK Selvaraj","year":"2007","unstructured":"Selvaraj RK, Geiger TL . A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta. J Immunol 2007; 178: 7667\u20137677.","journal-title":"J Immunol"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bmt2012174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2012174","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2012174.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T18:49:48Z","timestamp":1714416588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bmt2012174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,24]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["BFbmt2012174"],"URL":"https:\/\/doi.org\/10.1038\/bmt.2012.174","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,24]]},"assertion":[{"value":"3 May 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2012","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2012","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2012","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}