{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:21:59Z","timestamp":1791220919108,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T00:00:00Z","timestamp":1391385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T00:00:00Z","timestamp":1391385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1038\/bmt.2013.235","type":"journal-article","created":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T07:13:12Z","timestamp":1391411592000},"page":"664-670","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["High burden of BK virus-associated hemorrhagic cystitis in patients undergoing allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1038","volume":"49","author":[{"given":"L","family":"Gilis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Morisset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Billaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ducastelle-Lepr\u00eatre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Labussi\u00e8re-Wallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F-E","family":"Nicolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Barraco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Detrait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Tedone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sobh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Chidiac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Ferry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Salles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Michallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Ader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Lyon BK virus Study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,3]]},"reference":[{"key":"BFbmt2013235_CR1","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/sj.bmt.1705909","volume":"41","author":"S Cesaro","year":"2008","unstructured":"Cesaro S, Facchin C, Tridello G, Messina C, Calore E, Biasolo MA et al. A prospective study of BK-virus-associated haemorrhagic cystitis in paediatric patients undergoing allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplant 2008; 41: 363\u2013370.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2013235_CR2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1086\/321813","volume":"33","author":"MD Reploeg","year":"2001","unstructured":"Reploeg MD, Storch GA, Clifford DB . Bk virus: a clinical review. Clin Infect Dis 2001; 33: 191\u2013202.","journal-title":"Clin Infect Dis"},{"key":"BFbmt2013235_CR3","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1093\/infdis\/147.4.676","volume":"147","author":"PM Chesters","year":"1983","unstructured":"Chesters PM, Heritage J, McCance DJ . Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues. J Infect Dis 1983; 147: 676\u2013684.","journal-title":"J Infect Dis"},{"key":"BFbmt2013235_CR4","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1099\/0022-1317-81-8-1967","volume":"81","author":"A Dolei","year":"2000","unstructured":"Dolei A, Pietropaolo V, Gomes E, Taranto CDi, Ziccheddu M, Spanu MA et al. Polyomavirus persistence in lymphocytes: prevalence in lymphocytes from blood donors and healthy personnel of a blood transfusion centre. J Gen Virol 2000; 81: 1967\u20131973.","journal-title":"J Gen Virol"},{"key":"BFbmt2013235_CR5","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/jmv.10450","volume":"71","author":"WA Knowles","year":"2003","unstructured":"Knowles WA, Pipkin P, Andrews N, Vyse A, Minor P, Brown DWG et al. Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40. J Med Virol 2003; 71: 115\u2013123.","journal-title":"J Med Virol"},{"key":"BFbmt2013235_CR6","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/S0140-6736(71)91776-4","volume":"1","author":"SD Gardner","year":"1971","unstructured":"Gardner SD, Field AM, Coleman DV, Hulme B . New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet 1971; 1: 1253\u20131257.","journal-title":"Lancet"},{"key":"BFbmt2013235_CR7","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1056\/NEJM200005043421809","volume":"342","author":"PS Randhawa","year":"2000","unstructured":"Randhawa PS, Demetris AJ . Nephropathy due to polyomavirus type BK. N Engl J Med 2000; 342: 1361\u20131363.","journal-title":"N Engl J Med"},{"key":"BFbmt2013235_CR8","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1056\/NEJM198607243150405","volume":"315","author":"RR Arthur","year":"1986","unstructured":"Arthur RR, Shah KV, Baust SJ, Santos GW, Saral R . Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. N Engl J Med 1986; 315: 230\u2013234.","journal-title":"N Engl J Med"},{"key":"BFbmt2013235_CR9","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1038\/sj.bmt.1704944","volume":"35","author":"AYH Leung","year":"2005","unstructured":"Leung AYH, Chan M, Cheng VCC, Lie AKW, Yuen K-Y, Kwong Y-L . Polyoma BK viruria in patients undergoing autologous hematopoietic stem cell transplantation. Bone Marrow Transplant 2005; 35: 1029\u20131030.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2013235_CR10","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.3324\/haematol.2009.016758","volume":"95","author":"L Silva","year":"2010","unstructured":"Silva L, de P, Patah PA, Saliba RM, Szewczyk NA, Gilman L et al. Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type. Haematologica 2010; 95: 1183\u20131190.","journal-title":"Haematologica"},{"key":"BFbmt2013235_CR11","first-page":"401","volume":"91","author":"G Giraud","year":"2006","unstructured":"Giraud G, Bogdanovic G, Priftakis P, Remberger M, Svahn B-M, Barkholt L et al. The incidence of hemorrhagic cystitis and BK-viruria in allogeneic hematopoietic stem cell recipients according to intensity of the conditioning regimen. Haematologica 2006; 91: 401\u2013404.","journal-title":"Haematologica"},{"key":"BFbmt2013235_CR12","first-page":"1311","volume":"26","author":"G Bogdanovic","year":"2006","unstructured":"Bogdanovic G, Priftakis P, Giraud G, Dalianis T . A related donor and reduced intensity conditioning reduces the risk of development of BK virus-positive haemorrhagic cystitis in allogeneic haematopoetic stem cell-transplanted patients. Anticancer Res 2006; 26: 1311\u20131318.","journal-title":"Anticancer Res"},{"key":"BFbmt2013235_CR13","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1097\/MPH.0b013e3181fce388","volume":"33","author":"O Megged","year":"2011","unstructured":"Megged O, Stein J, Ben-Meir D, Shulman LM, Yaniv I, Shalit I et al. BK-virus-associated hemorrhagic cystitis in children after hematopoietic stem cell transplantation. J Pediatr Hematol Oncol 2011; 33: 190\u2013193.","journal-title":"J Pediatr Hematol Oncol"},{"key":"BFbmt2013235_CR14","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1086\/511863","volume":"44","author":"ASY Wong","year":"2007","unstructured":"Wong ASY, Chan K-H, Cheng VCC, Yuen K-Y, Kwong Y-L, Leung AYH . Relationship of pretransplantation polyoma BK virus serologic findings and BK viral reactivation after hematopoietic stem cell transplantation. Clin Infect Dis 2007; 44: 830\u2013837.","journal-title":"Clin Infect Dis"},{"key":"BFbmt2013235_CR15","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/sj.bmt.1705962","volume":"41","author":"G Giraud","year":"2008","unstructured":"Giraud G, Priftakis P, Bogdanovic G, Remberger M, Dubrulle M, Hau A et al. BK-viruria and haemorrhagic cystitis are more frequent in allogeneic haematopoietic stem cell transplant patients receiving full conditioning and unrelated-HLA-mismatched grafts. Bone Marrow Transplant 2008; 41: 737\u2013742.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2013235_CR16","first-page":"746","volume":"47","author":"Y Xie","year":"2008","unstructured":"Xie Y, Han Y, Wu D-P . The role of BK polyomavirus in the development of hemorrhagic cystitis after hematopoietic stem cell transplantation. Zhonghua Nei Ke Za Zhi 2008; 47: 746\u2013749.","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"BFbmt2013235_CR17","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1200\/JCO.1995.13.5.1103","volume":"13","author":"A Bedi","year":"1995","unstructured":"Bedi A, Miller CB, Hanson JL, Goodman S, Ambinder RF, Charache P et al. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation. J Clin Oncol 1995; 13: 1103\u20131109.","journal-title":"J Clin Oncol"},{"key":"BFbmt2013235_CR18","doi-asserted-by":"publisher","first-page":"5394","DOI":"10.1128\/JCM.42.11.5394-5396.2004","volume":"42","author":"G Bogdanovic","year":"2004","unstructured":"Bogdanovic G, Priftakis P, Giraud G, Kuzniar M, Ferraldeschi R, Kokhaei P et al. Association between a high BK virus load in urine samples of patients with graft-versus-host disease and development of hemorrhagic cystitis after hematopoietic stem cell transplantation. J Clin Microbiol 2004; 42: 5394\u20135396.","journal-title":"J Clin Microbiol"},{"key":"BFbmt2013235_CR19","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1182\/blood.V98.6.1971","volume":"98","author":"AY Leung","year":"2001","unstructured":"Leung AY, Suen CK, Lie AK, Liang RH, Yuen KY, Kwong YL . Quantification of polyoma BK viruria in hemorrhagic cystitis complicating bone marrow transplantation. Blood 2001; 98: 1971\u20131978.","journal-title":"Blood"},{"key":"BFbmt2013235_CR20","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S1473-3099(03)00770-9","volume":"3","author":"HH Hirsch","year":"2003","unstructured":"Hirsch HH, Steiger J . Polyomavirus BK. Lancet Infect Dis 2003; 3: 611\u2013623.","journal-title":"Lancet Infect Dis"},{"key":"BFbmt2013235_CR21","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/j.1365-2141.2008.07254.x","volume":"142","author":"C Harkensee","year":"2008","unstructured":"Harkensee C, Vasdev N, Gennery AR, Willetts IE, Taylor C . Prevention and management of BK-virus associated haemorrhagic cystitis in children following haematopoietic stem cell transplantation\u2014a systematic review and evidence-based guidance for clinical management. Br J Haematol 2008; 142: 717\u2013731.","journal-title":"Br J Haematol"},{"key":"BFbmt2013235_CR22","doi-asserted-by":"publisher","first-page":"4674","DOI":"10.1182\/blood-2003-08-2815","volume":"103","author":"M El-Zimaity","year":"2004","unstructured":"El-Zimaity M, Saliba R, Chan K, Shahjahan M, Carrasco A, Khorshid O et al. Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: donor type matters. Blood 2004; 103: 4674\u20134680.","journal-title":"Blood"},{"key":"BFbmt2013235_CR23","first-page":"939","volume":"31","author":"T Dalianis","year":"2011","unstructured":"Dalianis T, Ljungman P . Full myeloablative conditioning and an unrelated HLA mismatched donor increase the risk for BK virus-positive hemorrhagic cystitis in allogeneic hematopoetic stem cell transplanted patients. Anticancer Res 2011; 31: 939\u2013944.","journal-title":"Anticancer Res"},{"key":"BFbmt2013235_CR24","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1182\/blood-2004-12-4988","volume":"106","author":"V Erard","year":"2005","unstructured":"Erard V, Kim HW, Corey L, Limaye A, Huang M-L, Myerson D et al. BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. Blood 2005; 106: 1130\u20131132.","journal-title":"Blood"},{"key":"BFbmt2013235_CR25","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/sj.bmt.1703415","volume":"29","author":"AYH Leung","year":"2002","unstructured":"Leung AYH, Mak R, Lie AKW, Yuen KY, Cheng VCC, Liang R et al. Clinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantation. Bone Marrow Transplant 2002; 29: 509\u2013513.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2013235_CR26","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/sj.bmt.1701523","volume":"23","author":"A Seber","year":"1999","unstructured":"Seber A, Shu XO, Defor T, Sencer S, Ramsay N . Risk factors for severe hemorrhagic cystitis following BMT. Bone Marrow Transplant 1999; 23: 35\u201340.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2013235_CR27","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.bbmt.2011.07.025","volume":"18","author":"Y Mori","year":"2012","unstructured":"Mori Y, Miyamoto T, Kato K, Kamezaki K, Kuriyama T, Oku S et al. Different risk factors related to adenovirus- or BK virus-associated hemorrhagic cystitis following allogeneic stem cell transplantation. Biol Blood Marrow Transplant 2012; 18: 458\u2013465.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt2013235_CR28","first-page":"235","volume":"14","author":"A Azzi","year":"1994","unstructured":"Azzi A, Fanci R, Bosi A, Ciappi S, Zakrzewska K, de Santis R et al. Monitoring of polyomavirus BK viruria in bone marrow transplantation patients by DNA hybridization assay and by polymerase chain reaction: an approach to assess the relationship between BK viruria and hemorrhagic cystitis. Bone Marrow Transplant 1994; 14: 235\u2013240.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2013235_CR29","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S1386-6532(99)00055-4","volume":"14","author":"A Azzi","year":"1999","unstructured":"Azzi A, Cesaro S, Laszlo D, Zakrzewska K, Ciappi S, De Santis R et al. Human polyomavirus BK (BKV) load and haemorrhagic cystitis in bone marrow transplantation patients. J Clin Virol 1999; 14: 79\u201386.","journal-title":"J Clin Virol"},{"key":"BFbmt2013235_CR30","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1086\/427291","volume":"40","author":"AYH Leung","year":"2005","unstructured":"Leung AYH, Chan MTL, Yuen K-Y, Cheng VCC, Chan K-H, Wong CLP et al. Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin Infect Dis 2005; 40: 528\u2013537.","journal-title":"Clin Infect Dis"},{"key":"BFbmt2013235_CR31","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1097\/00075200-200009000-00007","volume":"5","author":"I Binet","year":"2000","unstructured":"Binet I, Nickeleit V, Hirsch HH . Polyomavirus infections in transplant recipients. Curr Opin Organ Transplant 2000; 5: 210\u2013216.","journal-title":"Curr Opin Organ Transplant"},{"key":"BFbmt2013235_CR32","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1038\/sj.bmt.1705139","volume":"36","author":"AYH Leung","year":"2005","unstructured":"Leung AYH, Yuen K-Y, Kwong Y-L . Polyoma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation: a changing paradigm. Bone Marrow Transplant 2005; 36: 929\u2013937.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2013235_CR33","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1086\/426140","volume":"39","author":"V Erard","year":"2004","unstructured":"Erard V, Storer B, Corey L, Nollkamper J, Huang M-L, Limaye A et al. BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis. Clin Infect Dis 2004; 39: 1861\u20131865.","journal-title":"Clin Infect Dis"},{"key":"BFbmt2013235_CR34","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1016\/j.bbmt.2011.02.012","volume":"17","author":"HL Haines","year":"2011","unstructured":"Haines HL, Laskin BL, Goebel J, Davies SM, Yin HJ, Lawrence J et al. Blood, and not urine, BK viral load predicts renal outcome in children with hemorrhagic cystitis following hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2011; 17: 1512\u20131519.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt2013235_CR35","first-page":"19","volume":"2","author":"L Ost","year":"1987","unstructured":"Ost L, L\u00f6nnqvist B, Eriksson L, Ljungman P, Ringd\u00e9n O . Hemorrhagic cystitis\u2014a manifestation of graft versus host disease? Bone Marrow Transplant 1987; 2: 19\u201325.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2013235_CR36","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1038\/sj.bmt.1704252","volume":"32","author":"S Cesaro","year":"2003","unstructured":"Cesaro S, Brugiolo A, Faraci M, Uderzo C, Rondelli R, Favre C et al. Incidence and treatment of hemorrhagic cystitis in children given hematopoietic stem cell transplantation: a survey from the Italian association of pediatric hematology oncology-bone marrow transplantation group. Bone Marrow Transplant 2003; 32: 925\u2013931.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2013235_CR37","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/INF.0b013e3181812cb9","volume":"28","author":"M Faraci","year":"2009","unstructured":"Faraci M, Cuzzubbo D, Lanino E, Marco EDi, Cirillo C, Dallorso S et al. Low dosage cidofovir without probenecid as treatment for BK virus hamorrhagic cystitis after hemopoietic stem cell transplant. Pediatr Infect Dis J 2009; 28: 55\u201357.","journal-title":"Pediatr Infect Dis J"},{"key":"BFbmt2013235_CR38","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/j.1399-3062.2010.00513.x","volume":"12","author":"N Ganguly","year":"2010","unstructured":"Ganguly N, Clough LA, Dubois LK, Mcguirk JP, Abhyankar S, Aljitawi OS et al. Low-dose cidofovir in the treatment of symptomatic BK virus infection in patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective analysis of an algorithmic approach. Transpl Infect Dis 2010; 12: 406\u2013411.","journal-title":"Transpl Infect Dis"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bmt2013235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2013235","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2013235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T13:09:26Z","timestamp":1648040966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bmt2013235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,3]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["BFbmt2013235"],"URL":"https:\/\/doi.org\/10.1038\/bmt.2013.235","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,3]]},"assertion":[{"value":"23 May 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}