{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:17:16Z","timestamp":1778635036934,"version":"3.51.4"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T00:00:00Z","timestamp":1484524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T00:00:00Z","timestamp":1484524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1038\/bmt.2016.351","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T15:27:04Z","timestamp":1484580424000},"page":"762-764","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Use of defibrotide to treat transplant-associated thrombotic microangiopathy: a retrospective study of the Paediatric Diseases and Inborn Errors Working Parties of the European Society of Blood and Marrow Transplantation"],"prefix":"10.1038","volume":"52","author":[{"given":"L","family":"Yeates","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Slatter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Bonanomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F L W I","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S Y","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Dalissier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Barberi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Shulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Duval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Heilmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Willekens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W H Y","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Uderzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Bader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A R","family":"Gennery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,1,16]]},"reference":[{"key":"BFbmt2016351_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1177\/1076029615598221","volume":"22","author":"O Elsallabi","year":"2016","unstructured":"Elsallabi O, Bhatt VR, Dhakal P, Foster KW, Tendulkar KK . Hematopoietic stem cell transplant-associated thrombotic microangiopathy. Clin Appl Thromb Hemost 2016; 22: 12\u201320.","journal-title":"Clin Appl Thromb Hemost"},{"key":"BFbmt2016351_CR2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.blre.2014.11.001","volume":"29","author":"S Jodele","year":"2015","unstructured":"Jodele S, Laskin BL, Dandoy CE, Myers KC, El-Bietar J, Davies SM et al. A new paradigm: diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury. Blood Rev 2015; 29: 191\u2013204.","journal-title":"Blood Rev"},{"key":"BFbmt2016351_CR3","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1097\/01.tp.0000230373.82376.46","volume":"82","author":"C Uderzo","year":"2006","unstructured":"Uderzo C, Bonanomi S, Busca A, Renoldi M, Ferrari P, Iacobelli M et al. Risk factors and severe outcome in thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation. Transplantation 2006; 82: 638\u2013644.","journal-title":"Transplantation"},{"key":"BFbmt2016351_CR4","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/sj.bmt.1703710","volume":"30","author":"AS Daly","year":"2002","unstructured":"Daly AS, Xenocostas A, Lipton JH . Transplantation-associated thrombotic microangiopathy: twenty-two years later. Bone Marrow Transplant 2002; 30: 709\u2013715.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2016351_CR5","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/trf.12859","volume":"55","author":"SS Kim","year":"2015","unstructured":"Kim SS, Patel M, Yum K, Keyzner A . Hematopoietic stem cell transplant- associated thrombotic microangiopathy: review of pharmacologic treatment options. Transfusion 2015; 55: 452\u2013458.","journal-title":"Transfusion"},{"key":"BFbmt2016351_CR6","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1089\/oli.2006.16.105","volume":"16","author":"N Kornblum","year":"2006","unstructured":"Kornblum N, Ayyanar K, Benimetskaya L, Richardson P, Iacobelli M, Stein CA . Defibrotide, a polydisperse mixture of single-stranded phosphodiester oligonucleotides with lifesaving activity in severe hepatic veno-occlusive disease: clinical outcomes and potential mechanisms of action. Oligonucleotides 2006; 16: 105\u2013114.","journal-title":"Oligonucleotides"},{"key":"BFbmt2016351_CR7","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/sj.bmt.1704329","volume":"33","author":"S Corbacioglu","year":"2004","unstructured":"Corbacioglu S, Greil J, Peters C, Wulffraat N, Laws HJ, Dilloo D et al. Defibrotide in the treatment of children with veno-occlusive disease (VOD): a retrospective multicentre study demonstrates therapeutic efficacy upon early intervention. Bone Marrow Transplant 2004; 33: 189\u2013195.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2016351_CR8","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(11)61938-7","volume":"379","author":"S Corbacioglu","year":"2012","unstructured":"Corbacioglu S, Cesaro S, Faraci M, Valteau-Couanet D, Gruhn B, Rovelli A et al. Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomised controlled trial. Lancet 2012; 379: 1301\u20131309.","journal-title":"Lancet"},{"key":"BFbmt2016351_CR9","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1016\/j.bbmt.2016.04.011","volume":"22","author":"C Strouse","year":"2016","unstructured":"Strouse C, Richardson P, Prentice G, Korman S, Hume R, Nejadnik B et al. Defibrotide for treatment of severe veno-occlusive disease in pediatrics and adults: an exploratory analysis using data from the center for international blood and marrow transplant research. Biol Blood Marrow Transplant 2016; 22: 1306\u20131312.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt2016351_CR10","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1097\/TP.0b013e3181f24e8d","volume":"90","author":"BS Cho","year":"2010","unstructured":"Cho BS, Yahng SA, Lee SE, Eom KS, Kim YJ, Kim HJ et al. Validation of recently proposed consensus criteria for thrombotic microangiopathy after allogeneic hematopoietic stem-cell transplantation. Transplantation 2010; 90: 918\u2013926.","journal-title":"Transplantation"},{"key":"BFbmt2016351_CR11","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/sj.bmt.1703414","volume":"29","author":"P Corti","year":"2002","unstructured":"Corti P, Uderzo C, Tagliabue A, Della Volpe A, Annaloro C, Tagliaferri E et al. Defibrotide as a promising treatment for thrombotic thrombocytopenic purpura in patients undergoing bone marrow transplantation. Bone Marrow Transplant 2002; 29: 542\u2013543.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt2016351_CR12","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1038\/bmt.2016.87","volume":"51","author":"S Vasu","year":"2016","unstructured":"Vasu S, Wu H, Satoskar A, Puto M, Roddy J, Blum W et al. Eculizumab therapy in adults with allogeneic hematopoietic cell transplant-associated thrombotic microangiopathy. Bone Marrow Transplant 2016; 51: 1241\u20131244.","journal-title":"Bone Marrow Transplant"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bmt2016351.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2016351","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/bmt.2016.351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/bmt2016351.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T19:13:17Z","timestamp":1648062797000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bmt2016351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,16]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["BFbmt2016351"],"URL":"https:\/\/doi.org\/10.1038\/bmt.2016.351","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,16]]},"assertion":[{"value":"16 January 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}