{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:48:43Z","timestamp":1773892123293,"version":"3.50.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1038\/bmt.2016.39","type":"journal-article","created":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T14:43:28Z","timestamp":1457966608000},"page":"980-984","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Poor growth, thyroid dysfunction and vitamin D deficiency remain prevalent despite reduced intensity chemotherapy for hematopoietic stem cell transplantation in children and young adults"],"prefix":"10.1038","volume":"51","author":[{"given":"K C","family":"Myers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Howell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4001-9203","authenticated-orcid":false,"given":"C","family":"Dandoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"El-Bietar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Jodele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S R","family":"Rose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,14]]},"reference":[{"issue":"Suppl 5","key":"BFbmt201639_CR1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1398-2265.2004.00165.x","volume":"8","author":"JE Sanders","year":"2004","unstructured":"Sanders JE . Endocrine complications of high-dose therapy with stem cell transplantation. Pediatr Transplant 2004; 8 (Suppl 5): 39\u201350.","journal-title":"Pediatr Transplant"},{"key":"BFbmt201639_CR2","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1038\/leu.2010.210","volume":"24","author":"K Baker","year":"2010","unstructured":"Baker K, Ness K, Weisdorf D, Francisco L, Sun C, Forman S et al. Late effects in survivors of acute leukemia treated with hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study. Leukemia 2010; 24: 2039\u20132047.","journal-title":"Leukemia"},{"key":"BFbmt201639_CR3","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1038\/sj.bmt.1702384","volume":"25","author":"Z Afify","year":"2000","unstructured":"Afify Z, Shaw P, Clavano-Harding A, Cowell C . Growth and endocrine function in children with acute myeloid leukaemia after bone marrow transplantation using busulfan\/cyclophosphamide. Bone Marrow Transplant 2000; 25: 1087\u20131092.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201639_CR4","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1016\/j.bbmt.2011.10.006","volume":"17","author":"CC Dvorak","year":"2011","unstructured":"Dvorak CC, Gracia CR, Sanders JE, Cheng EY, Baker KS, Pulsipher MA et al. NCI, NHLBI\/PBMTC first international conference on late effects after pediatric hematopoietic cell transplantation: endocrine challenges-thyroid dysfunction, growth impairment, bone health, & reproductive risks. Biol Blood Marrow Transplant 2011; 17: 1725\u20131738.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt201639_CR5","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1016\/j.bbmt.2015.04.009","volume":"21","author":"RA Marsh","year":"2015","unstructured":"Marsh RA, Rao MB, Gefen A, Bellman D, Mehta PA, Khandelwal P et al. Experience with alemtuzumab, fludarabine, and melphalan reduced-intensity conditioning hematopoietic cell transplantation in patients with nonmalignant diseases reveals good outcomes and that the risk of mixed chimerism depends on underlying disease, stem cell source, and alemtuzumab regimen. Biol Blood Marrow Transplant 2015; 21: 1460\u20131470.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt201639_CR6","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s00216-010-3993-0","volume":"398","author":"S Ding","year":"2010","unstructured":"Ding S, Schoenmakers I, Jones K, Koulman A, Prentice A, Volmer D . Quantitative determination of vitamin D metabolites in plasma using UHPLC-MS\/MS. Anal Bioanal Chem 2010; 398: 779\u2013789.","journal-title":"Anal Bioanal Chem"},{"issue":"Suppl 2","key":"BFbmt201639_CR7","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.1038\/bmt.2008.54","volume":"41","author":"A Cohen","year":"2008","unstructured":"Cohen A, Bekassy AN, Gaiero A, Faraci M, Zecca S, Tichelli A et al. Endocrinological late complications after hematopoietic SCT in children. Bone Marrow Transplant 2008; 41 (Suppl 2): S43\u2013S48.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201639_CR8","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1182\/blood.V93.6.2013.406k25_2013_2024","volume":"93","author":"A Cohen","year":"1999","unstructured":"Cohen A, Rovelli A, Bakker B, Uderzo C, van Lint M-T, Esperou H et al. Final height of patients who underwent bone marrow transplantation for hematological disorders during childhood: a study by the working party for late effects\u2014EBMT. Blood 1999; 93: 4109\u20134115.","journal-title":"Blood"},{"key":"BFbmt201639_CR9","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1210\/jc.2013-4159","volume":"99","author":"BC Patterson","year":"2014","unstructured":"Patterson BC, Chen Y, Sklar CA, Neglia J, Yasui Y, Mertens A et al. Growth hormone exposure as a risk factor for the development of subsequent neoplasms of the central nervous system: a report from the childhood cancer survivor study. J Clin Endocrinol Metab 2014; 99: 2030\u20132037.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFbmt201639_CR10","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1182\/blood.V87.7.3045.bloodjournal8773045","volume":"87","author":"J Sanders","year":"1996","unstructured":"Sanders J, Hawley J, Levy W, Gooley T, Buckner C, Deeg H et al. Pregnancies following high-dose cyclophosphamide with or without high- dose busulfan or total-body irradiation and bone marrow transplantation. Blood 1996; 87: 3045\u20133052.","journal-title":"Blood"},{"key":"BFbmt201639_CR11","first-page":"59","volume":"13","author":"B Borgstr\u00f6m","year":"1994","unstructured":"Borgstr\u00f6m B, Bolme P . Thyroid function in children after allogeneic bone marrow transplantation. Bone Marrow Transplant 1994; 13: 59\u201364.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201639_CR12","first-page":"71","volume":"15","author":"F Boulad","year":"1995","unstructured":"Boulad F, Bromley M, Black P, Heller G, Sarafoglou K, Gillio A et al. Thyroid dysfunction following bone marrow transplantation using hyperfractionated radiation. Bone Marrow Transplant 1995; 15: 71\u201376.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201639_CR13","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.3346\/jkms.2009.24.6.1071","volume":"24","author":"MH Jung","year":"2009","unstructured":"Jung MH, Cho KS, Lee JW, Chung NG, Cho B, Suh BK et al. Endocrine complications after hematopoietic stem cell transplantation during childhood and adolescence. J Korean Med Sci 2009; 24: 1071\u20131077.","journal-title":"J Korean Med Sci"},{"key":"BFbmt201639_CR14","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1182\/blood-2008-08-173005","volume":"113","author":"JE Sanders","year":"2009","unstructured":"Sanders JE, Hoffmeister PA, Woolfrey AE, Carpenter PA, Storer BE, Storb RF et al. Thyroid function following hematopoietic cell transplantation in children: 30 years' experience. Blood 2009; 113: 306\u2013308.","journal-title":"Blood"},{"key":"BFbmt201639_CR15","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","volume":"96","author":"MF Holick","year":"2011","unstructured":"Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011; 96: 1911\u20131930.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFbmt201639_CR16","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1677\/JOE-08-0170","volume":"198","author":"RF Chun","year":"2008","unstructured":"Chun RF, Adams JS, Hewison M . Back to the future: a new look at 'old' vitamin D. J Endocrinol 2008; 198: 261\u2013269.","journal-title":"J Endocrinol"},{"key":"BFbmt201639_CR17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.jsbmb.2005.06.002","volume":"97","author":"E van Etten","year":"2005","unstructured":"van Etten E, Mathieu C . Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol 2005; 97: 93\u2013101.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"BFbmt201639_CR18","doi-asserted-by":"publisher","first-page":"109","DOI":"10.5581\/1516-8484.20120032","volume":"34","author":"NS Majhail","year":"2012","unstructured":"Majhail NS, Rizzo JD, Lee SJ, Aljurf M, Atsuta Y, Bonfim C et al. Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation. Rev Bras Hematol Hemoter 2012; 34: 109\u2013133.","journal-title":"Rev Bras Hematol Hemoter"},{"key":"BFbmt201639_CR19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1046\/j.1365-2141.2002.03527.x","volume":"118","author":"BM Brennan","year":"2002","unstructured":"Brennan BM, Shalet SM . Endocrine late effects after bone marrow transplant. Br J Haematol 2002; 118: 58\u201366.","journal-title":"Br J Haematol"},{"issue":"Suppl 1","key":"BFbmt201639_CR20","doi-asserted-by":"publisher","first-page":"S77","DOI":"10.1038\/sj.bmt.1704853","volume":"35","author":"MB Ranke","year":"2005","unstructured":"Ranke MB, Schwarze CP, Dopfer R, Klingebiel T, Scheel-Walter HG, Lang P et al. Late effects after stem cell transplantation (SCT) in children\u2014growth and hormones. Bone Marrow Transplant 2005; 35 (Suppl 1): S77\u2013S81.","journal-title":"Bone Marrow Transplant"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bmt201639.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt201639","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt201639.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T19:17:19Z","timestamp":1648063039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bmt201639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,14]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["BFbmt201639"],"URL":"https:\/\/doi.org\/10.1038\/bmt.2016.39","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,14]]},"assertion":[{"value":"10 September 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}