{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:22:18Z","timestamp":1761740538686},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Bone Marrow Transplant"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1038\/bmt.2016.40","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T14:54:20Z","timestamp":1458572060000},"page":"1121-1126","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Does quality of life impact the decision to pursue stem cell transplantation for elderly patients with advanced MDS?"],"prefix":"10.1038","volume":"51","author":[{"given":"A","family":"El-Jawahri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H T","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Steensma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Cronin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R M","family":"Stone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C D","family":"Watts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y-B","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C S","family":"Cutler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Soiffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G A","family":"Abel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,21]]},"reference":[{"key":"BFbmt201640_CR1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.4065\/81.1.104","volume":"81","author":"DP Steensma","year":"2006","unstructured":"Steensma DP, Bennett JM . The myelodysplastic syndromes: diagnosis and treatment. Mayo Clin Proc 2006; 81: 104\u2013130.","journal-title":"Mayo Clin Proc"},{"key":"BFbmt201640_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.med.56.082103.104704","volume":"56","author":"WK Hofmann","year":"2005","unstructured":"Hofmann WK, Koeffler HP . Myelodysplastic syndrome. Annu Rev Med 2005; 56: 1\u201316.","journal-title":"Annu Rev Med"},{"key":"BFbmt201640_CR3","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1182\/blood.V89.6.2079","volume":"89","author":"P Greenberg","year":"1997","unstructured":"Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997; 89: 2079\u20132088.","journal-title":"Blood"},{"key":"BFbmt201640_CR4","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.leukres.2007.10.015","volume":"32","author":"DP Steensma","year":"2008","unstructured":"Steensma DP, Heptinstall KV, Johnson VM, Novotny PJ, Sloan JA, Camoriano JK et al. Common troublesome symptoms and their impact on quality of life in patients with myelodysplastic syndromes (MDS): results of a large Internet-based survey. Leuk Res 2008; 32: 691\u2013698.","journal-title":"Leuk Res"},{"key":"BFbmt201640_CR5","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1016\/S0145-2126(98)00055-1","volume":"22","author":"ML Thomas","year":"1998","unstructured":"Thomas ML . Quality of life and psychosocial adjustment in patients with myelodysplastic syndromes. Leuk Res 1998; 22: S41\u2013S47.","journal-title":"Leuk Res"},{"key":"BFbmt201640_CR6","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1046\/j.1365-2141.2003.04272.x","volume":"121","author":"AJ Jansen","year":"2003","unstructured":"Jansen AJ, Essink-Bot ML, Beckers EA, Hop WC, Schipperus MR, Van Rhenen DJ . Quality of life measurement in patients with transfusion-dependent myelodysplastic syndromes. Br J Haematol 2003; 121: 270\u2013274.","journal-title":"Br J Haematol"},{"key":"BFbmt201640_CR7","first-page":"246","volume":"3","author":"C Lucioni","year":"2013","unstructured":"Lucioni C, Finelli C, Mazzi S, Oliva EN . Costs and quality of life in patients with myelodysplastic syndromes. Am J Blood Res 2013; 3: 246\u2013259.","journal-title":"Am J Blood Res"},{"key":"BFbmt201640_CR8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/sj.bmt.1705879","volume":"41","author":"R Martino","year":"2008","unstructured":"Martino R, Valcarcel D, Brunet S, Sureda A, Sierra J . Comparable non-relapse mortality and survival after HLA-identical sibling blood stem cell transplantation with reduced or conventional-intensity preparative regimens for high-risk myelodysplasia or acute myeloid leukemia in first remission. Bone Marrow Transplant 2008; 41: 33\u201338.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201640_CR9","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1182\/blood-2007-02-076307","volume":"110","author":"C Chang","year":"2007","unstructured":"Chang C, Storer BE, Scott BL, Bryant EM, Shulman HM, Flowers ME et al. Hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patients with de novo disease and disease following prior therapy or antecedent hematologic disorders. Blood 2007; 110: 1379\u20131387.","journal-title":"Blood"},{"key":"BFbmt201640_CR10","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.bbmt.2007.11.012","volume":"14","author":"GG Laport","year":"2008","unstructured":"Laport GG, Sandmaier BM, Storer BE, Scott BL, Stuart MJ, Lange T et al. Reduced-intensity conditioning followed by allogeneic hematopoietic cell transplantation for adult patients with myelodysplastic syndrome and myeloproliferative disorders. Biol Blood Marrow Transplant 2008; 14: 246\u2013255.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt201640_CR11","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/01.moh.0000208466.63861.9f","volume":"13","author":"HJ Deeg","year":"2006","unstructured":"Deeg HJ . Transplant strategies for patients with myelodysplastic syndromes. Curr Opin Hematol 2006; 13: 61\u201366.","journal-title":"Curr Opin Hematol"},{"issue":"1","key":"BFbmt201640_CR12","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1182\/asheducation-2005.1.167","volume":"2005","author":"H. J. Deeg","year":"2005","unstructured":"Deeg HJ . Optimization of transplant regimens for patients with myelodysplastic syndrome (MDS). Hematology Am Soc Hematol Educ Program 2005, 167\u2013173.","journal-title":"Hematology"},{"key":"BFbmt201640_CR13","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/sj.bmt.1705259","volume":"37","author":"N Kroger","year":"2006","unstructured":"Kroger N, Shimoni A, Zabelina T, Schieder H, Panse J, Ayuk F et al. Reduced-toxicity conditioning with treosulfan, fludarabine and ATG as preparative regimen for allogeneic stem cell transplantation (alloSCT) in elderly patients with secondary acute myeloid leukemia (sAML) or myelodysplastic syndrome (MDS). Bone Marrow Transplant 2006; 37: 339\u2013344.","journal-title":"Bone Marrow Transplant"},{"key":"BFbmt201640_CR14","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.bbmt.2006.06.003","volume":"12","author":"EP Alyea","year":"2006","unstructured":"Alyea EP, Kim HT, Ho V, Cutler C, DeAngelo DJ, Stone R et al. Impact of conditioning regimen intensity on outcome of allogeneic hematopoietic cell transplantation for advanced acute myelogenous leukemia and myelodysplastic syndrome. Biol Blood Marrow Transplant 2006; 12: 1047\u20131055.","journal-title":"Biol Blood Marrow Transplant"},{"key":"BFbmt201640_CR15","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1182\/blood-2004-05-1947","volume":"105","author":"EP Alyea","year":"2005","unstructured":"Alyea EP, Kim HT, Ho V, Cutler C, Gribben J, DeAngelo DJ et al. Comparative outcome of nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation for patients older than 50 years of age. Blood 2005; 105: 1810\u20131814.","journal-title":"Blood"},{"key":"BFbmt201640_CR16","doi-asserted-by":"publisher","first-page":"2662","DOI":"10.1200\/JCO.2012.46.8652","volume":"31","author":"J Koreth","year":"2013","unstructured":"Koreth J, Pidala J, Perez WS, Deeg HJ, Garcia-Manero G, Malcovati L et al. Role of reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation in older patients with de novo myelodysplastic syndromes: an international collaborative decision analysis. J Clin Oncol 2013; 31: 2662\u20132670.","journal-title":"J Clin Oncol"},{"key":"BFbmt201640_CR17","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1007\/s00277-015-2422-z","volume":"94","author":"AR Smith","year":"2015","unstructured":"Smith AR, Warlick ED, Roesler MA, Poynter JN, Richardson M, Nguyen P et al. Factors associated with hematopoietic cell transplantation (HCT) among patients in a population-based study of myelodysplastic syndrome (MDS) in Minnesota. Ann Hematol 2015; 94: 1667\u20131675.","journal-title":"Ann Hematol"},{"key":"BFbmt201640_CR18","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/ajh.21503","volume":"84","author":"DJ Pinchon","year":"2009","unstructured":"Pinchon DJ, Stanworth SJ, Doree C, Brunskill S, Norfolk DR . Quality of life and use of red cell transfusion in patients with myelodysplastic syndromes. A systematic review. Am J Hematol 2009; 84: 671\u2013677.","journal-title":"Am J Hematol"},{"key":"BFbmt201640_CR19","doi-asserted-by":"publisher","first-page":"3686","DOI":"10.1182\/blood-2014-03-558981","volume":"123","author":"CS Cleeland","year":"2014","unstructured":"Cleeland CS, Williams LA . Symptom burden in hematologic malignancies. Blood 2014; 123: 3686\u20133687.","journal-title":"Blood"},{"key":"BFbmt201640_CR20","doi-asserted-by":"crossref","unstructured":"Wood WA, Le-Rademacher J, Fei M, Logan BR, Syrjala KL, Majhail NS et al. Patient-reported quality of life is an independent predictor of survival after allogeneic hematopoietic cell transplantation: a secondary analysis from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902. Abstract Presented at ASH 2014, 2014.","DOI":"10.1182\/blood.V124.21.206.206"},{"key":"BFbmt201640_CR21","doi-asserted-by":"crossref","unstructured":"Hamilton BKR, Abounder L, Dabney DM, Dean J, Duong RM, Hill HK et al. Prognostic significane of quality of life in patients undergoing allogeneic hematopoietic cell transplantation. Abstract Presented at ASH 2014, 2014.","DOI":"10.1182\/blood.V124.21.2637.2637"},{"key":"BFbmt201640_CR22","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3324\/haematol.2012.067892","volume":"98","author":"B Deschler","year":"2013","unstructured":"Deschler B, Ihorst G, Platzbecker U, Germing U, Marz E, de Figuerido M et al. Parameters detected by geriatric and quality of life assessment in 195 older patients with myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome. Haematologica 2013; 98: 208\u2013216.","journal-title":"Haematologica"},{"key":"BFbmt201640_CR23","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1097\/MOH.0b013e32835d8e8e","volume":"20","author":"GA Abel","year":"2013","unstructured":"Abel GA, Koreth J . Optimal positioning of hematopoietic stem cell transplantation for older patients with myelodysplastic syndromes. Curr Opin Hematol 2013; 20: 150\u2013156.","journal-title":"Curr Opin Hematol"},{"key":"BFbmt201640_CR24","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1200\/JCO.2006.08.5696","volume":"25","author":"L Malcovati","year":"2007","unstructured":"Malcovati L, Germing U, Kuendgen A, Della Porta MG, Pascutto C, Invernizzi R et al. Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes. J Clin Oncol 2007; 25: 3503\u20133510.","journal-title":"J Clin Oncol"},{"key":"BFbmt201640_CR25","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.1182\/blood-2007-03-082404","volume":"110","author":"D Haase","year":"2007","unstructured":"Haase D, Germing U, Schanz J, Pfeilstocker M, Nosslinger T, Hildebrandt B et al. New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients. Blood 2007; 110: 4385\u20134395.","journal-title":"Blood"},{"key":"BFbmt201640_CR26","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","volume":"85","author":"NK Aaronson","year":"1993","unstructured":"Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993; 85: 365\u2013376.","journal-title":"J Natl Cancer Inst"},{"key":"BFbmt201640_CR27","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1200\/JCO.2010.30.9245","volume":"29","author":"M Lubbert","year":"2011","unstructured":"Lubbert M, Suciu S, Baila L, Ruter BH, Platzbecker U, Giagounidis A et al. Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation for Research and Treatment of Cancer Leukemia Group and the German MDS Study Group. J Clin Oncol 2011; 29: 1987\u20131996.","journal-title":"J Clin Oncol"},{"key":"BFbmt201640_CR28","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","volume":"94","author":"JP Fine","year":"1999","unstructured":"Fine JP, Gray RJ . A proportional hazards model for the subdistribution of competing risk. J Am Stat Assoc 1999; 94: 496\u2013509.","journal-title":"J Am Stat Assoc"},{"key":"BFbmt201640_CR29","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/cncr.28369","volume":"120","author":"A El-Jawahri","year":"2014","unstructured":"El-Jawahri A, Traeger L, Park ER, Greer JA, Pirl WF, Lennes IT et al. Association among prognostic understanding, quality of life, and mood in patients with advanced cancer. Cancer 2014; 120: 278\u2013285.","journal-title":"Cancer"},{"key":"BFbmt201640_CR30","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1200\/JCO.2009.25.4672","volume":"28","author":"JW Mack","year":"2010","unstructured":"Mack JW, Weeks JC, Wright AA, Block SD, Prigerson HG . End-of-life discussions, goal attainment, and distress at the end of life: predictors and outcomes of receipt of care consistent with preferences. J Clin Oncol 2010; 28: 1203\u20131208.","journal-title":"J Clin Oncol"},{"key":"BFbmt201640_CR31","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1634\/theoncologist.2010-0199","volume":"16","author":"MA Sekeres","year":"2011","unstructured":"Sekeres MA, Maciejewski JP, List AF, Steensma DP, Artz A, Swern AS et al. Perceptions of disease state, treatment outcomes, and prognosis among patients with myelodysplastic syndromes: results from an Internet-based survey. Oncologist 2011; 16: 904\u2013911.","journal-title":"Oncologist"},{"key":"BFbmt201640_CR32","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1002\/cncr.28631","volume":"120","author":"DP Steensma","year":"2014","unstructured":"Steensma DP, Komrokji RS, Stone RM, List AF, Garcia-Manero G, Huber JM et al. Disparity in perceptions of disease characteristics, treatment effectiveness, and factors influencing treatment adherence between physicians and patients with myelodysplastic syndromes. Cancer 2014; 120: 1670\u20131676.","journal-title":"Cancer"},{"key":"BFbmt201640_CR33","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/annonc\/mdt557","volume":"25","author":"F Efficace","year":"2014","unstructured":"Efficace F, Gaidano G, Sprangers M, Cottone F, Breccia M, Voso MT et al. Preference for involvement in treatment decisions and request for prognostic information in newly diagnosed patients with higher-risk myelodysplastic syndromes. Ann Oncol 2014; 25: 447\u2013454.","journal-title":"Ann Oncol"},{"key":"BFbmt201640_CR34","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1038\/sj.leu.2403289","volume":"18","author":"MA Sekeres","year":"2004","unstructured":"Sekeres MA, Stone RM, Zahrieh D, Neuberg D, Morrison V, De Angelo DJ et al. Decision-making and quality of life in older adults with acute myeloid leukemia or advanced myelodysplastic syndrome. Leukemia 2004; 18: 809\u2013816.","journal-title":"Leukemia"},{"key":"BFbmt201640_CR35","first-page":"136","volume":"2","author":"EN Oliva","year":"2012","unstructured":"Oliva EN, Finelli C, Santini V, Poloni A, Liso V, Cilloni D et al. Quality of life and physicians' perception in myelodysplastic syndromes. Am J Blood Res 2012; 2: 136\u2013147.","journal-title":"Am J Blood Res"},{"key":"BFbmt201640_CR36","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1200\/JCO.2014.55.1564","volume":"32","author":"HD Klepin","year":"2014","unstructured":"Klepin HD, Rao AV, Pardee TS . Acute myeloid leukemia and myelodysplastic syndromes in older adults. J Clin Oncol 2014; 32: 2541\u20132552.","journal-title":"J Clin Oncol"},{"key":"BFbmt201640_CR37","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1182\/blood-2013-11-540021","volume":"123","author":"GA Abel","year":"2014","unstructured":"Abel GA, Klaassen R, Lee SJ, Young NL, Cannella L, Steensma DP et al. Patient-reported outcomes for the myelodysplastic syndromes: a new MDS-specific measure of quality of life. Blood 2014; 123: 451\u2013452.","journal-title":"Blood"}],"container-title":["Bone Marrow Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/bmt201640.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt201640","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/bmt201640.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T19:21:33Z","timestamp":1648063293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/bmt201640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,21]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["BFbmt201640"],"URL":"https:\/\/doi.org\/10.1038\/bmt.2016.40","relation":{},"ISSN":["0268-3369","1476-5365"],"issn-type":[{"value":"0268-3369","type":"print"},{"value":"1476-5365","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,21]]},"assertion":[{"value":"21 September 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}